{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:58:46Z","timestamp":1790773126193,"version":"4.1.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Bergenia purpurascens<\/jats:italic>\n                    (Hook.f.et Thoms.) Engl., a perennial herb belonging to the genus\n                    <jats:italic>Bergenia<\/jats:italic>\n                    (family Saxifragaceae), is primarily distributed in southwestern China and mountainous regions of Nepal, Bhutan, and northeastern India, where it has a long history of medicinal use. A systematic retrieval of relevant literature was conducted on PubMed, Scopus, CNKI, and Web of Science using \u201c\n                    <jats:italic>Bergenia purpurascens<\/jats:italic>\n                    \u201d and \u201c\n                    <jats:italic>Bergenia<\/jats:italic>\n                    \u201d as primary keywords, supplemented by \u201cchemical metabolite,\u201d \u201cpharmacological action,\u201d and \u201cresource distribution\u201d as search terms. This review systematically summarizes the research progress on the botanical characteristics, resource distribution, medicinal parts, chemical metabolites, pharmacological activity, toxicology, and modern applications of\n                    <jats:italic>B. purpurascens.<\/jats:italic>\n                    Its primary active metabolites include phenolics, including bergenin, gallic acid, and arbutin, which exhibit expectorant, antitussive, anti-inflammatory, hepatoprotective, antitumor, and neuroprotective activities. Recent studies elucidating the bergenin biosynthetic pathway provide a basis for industrial production. Additionally,\n                    <jats:italic>B. purpurascens<\/jats:italic>\n                    shows broad development potential in pharmaceuticals, health products, cosmetics, and landscaping. This review provides a scientific basis for further research and comprehensive utilization of\n                    <jats:italic>B. purpurascens<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1863591","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:17:27Z","timestamp":1790770647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on Bergenia purpurascens: a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Li","family":"Chang-xi","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]},{"name":"College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]},{"name":"College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Ying","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Zongyi","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin-zhe","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]},{"name":"College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jie","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]},{"name":"College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xue-fang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]},{"name":"College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Traditional Chinese Medicine","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0306-3623(80)90100-7","article-title":"Effects of bergenin on experimental ulcers--prevention of stress induced ulcers in rats","volume":"11","author":"Abe","year":"1980","journal-title":"Gen. 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