{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:15:12Z","timestamp":1783412112353,"version":"3.54.6"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Moxibustion has been shown to protect against myocardial ischemia-reperfusion injury (MIRI) by regulating mitochondrial function. Whether it preserves the structural integrity essential for this function remains unknown. Based on the critical role of cardiolipin (CL) in mitochondrial membranes, this study aimed to investigate whether CL serves as a novel target of moxibustion-mediated cardioprotection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A rat model of MIRI was established by ligating the left anterior descending (LAD) coronary artery for 30\u00a0min followed by 7\u00a0days of reperfusion. Moxibustion was applied to Neiguan acupoint (PC6) every other day during reperfusion. Moxibustion exerted significant cardioprotective effects by reducing interstitial fibrosis, alleviating cardiac hypertrophy, and improving cardiac function. Mechanistically, moxibustion attenuated oxidative stress-mediated mitochondrial injury, as shown by decreased ROS, 4-hydroxynonenal (4-HNE), total oxidative status (TOS), and oxidative stress index (OSI) levels, increased total antioxidant capacity (TAC), and preserved mitochondrial cristae structure. Moreover, moxibustion restored total CL levels, concomitant with downregulation of Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) and reduction of cytosolic cytochrome c (Cyt c). Moxibustion also upregulated AMP-activated protein kinase (AMPK) phosphorylation, an effect reversed by Compound C which also largely abolished the cardioprotective effects, suggesting AMPK involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides evidence for the involvement of the AMPK-oxidative stress-CL axis in moxibustion-mediated cardioprotection, highlighting the potential of moxibustion as a non-pharmacological intervention for ischemic heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1864586","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:26:13Z","timestamp":1783409173000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the effects of moxibustion on pathological remodeling in rats with myocardial ischemia-reperfusion injury based on mitochondrial cardiolipin protection"],"prefix":"10.3389","volume":"17","author":[{"given":"Chunmei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlei","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilan","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuang","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research, Ministry of Education, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Acupuncture and Tuina College, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dan\u2019an Shuyuan, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-021-00433-y","article-title":"Molecular mechanisms and consequences of mitochondrial permeability transition","volume":"23","author":"Bonora","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"165768","DOI":"10.1016\/j.bbadis.2020.165768","article-title":"Mitochondrial ROS in myocardial ischemia reperfusion and remodeling","volume":"1866","author":"Bugger","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1002\/jcp.30875","article-title":"AMPK: the key to ischemia-reperfusion injury","volume":"237","author":"Cai","year":"2022","journal-title":"J. Cell Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1680326","DOI":"10.3389\/fimmu.2025.1680326","article-title":"Cardiolipin's multifaceted role in immune response: a focus on interacting proteins","volume":"16","author":"Chai","year":"2025","journal-title":"Front. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.freeradbiomed.2005.10.043","article-title":"Depletion of cardiolipin and cytochrome c during ischemia increases hydrogen peroxide production from the electron transport chain","volume":"40","author":"Chen","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1693441","DOI":"10.3389\/fphar.2025.1693441","article-title":"The unmet promise: a critical review of antioxidant strategies in myocardial ischemia-reperfusion injury and the path towards precision medicine","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13020-025-01182-2","article-title":"Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis","volume":"20","author":"Chen","year":"2025","journal-title":"Chin. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"379291","DOI":"10.1155\/2013\/379291","article-title":"The mechanism of moxibustion: ancient theory and modern research","volume":"2013","author":"Deng","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"118385","DOI":"10.1016\/j.biopha.2025.118385","article-title":"Emerging role of the cardiac lipidome in the progression of heart failure","volume":"190","author":"Flori","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"B11","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ejhf.2493","article-title":"Cardiac remodelling - part 1: from cells and tissues to circulating biomarkers. A review from the study group on biomarkers of the heart failure association of the european society of cardiology","volume":"24","author":"Gonz\u00e1lez","year":"2022","journal-title":"Eur. J. Heart Fail"},{"key":"B12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13293-021-00394-z","article-title":"Spatiotemporal AMPK\u03b12 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only","volume":"12","author":"Grimbert","year":"2021","journal-title":"Biol. Sex. Differ."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e184309","DOI":"10.1172\/jci.insight.184309","article-title":"A ratiometric catalog of protein isoform shifts in the cardiac fetal gene program","volume":"10","author":"Han","year":"2025","journal-title":"JCI Insight"},{"key":"B14","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1161\/CIRCRESAHA.124.323800","article-title":"Mitochondrial structure and function in human heart failure","volume":"135","author":"Hinton","year":"2024","journal-title":"Circ. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bbrc.2022.01.029","article-title":"Icariin inhibits isoproterenol-induced cardiomyocyte hypertropic injury through activating autophagy via the AMPK\/mTOR signaling pathway","volume":"593","author":"Hu","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1016\/j.ymthe.2021.06.007","article-title":"Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction","volume":"29","author":"Jia","year":"2021","journal-title":"Mol. Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial reactive oxygen species: a double edged sword in ischemia\/reperfusion vs preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7884","DOI":"10.3390\/ijms25147884","article-title":"The protective role of molecular hydrogen in ischemia\/reperfusion injury","volume":"25","author":"Kura","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.bbabio.2008.05.444","article-title":"Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat","volume":"1777","author":"Lesnefsky","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"B21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev-pharmtox-010715-103335","article-title":"Mitochondrial dysfunction and myocardial ischemia-reperfusion: implications for novel therapies","volume":"57","author":"Lesnefsky","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s41423-025-01288-5","article-title":"Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy","volume":"22","author":"Li","year":"2025","journal-title":"Cell Mol. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"101382","DOI":"10.1016\/j.mam.2025.101382","article-title":"Ischemia - Reperfusion injury: a roadmap to precision therapies","volume":"104","author":"Li","year":"2025","journal-title":"Mol. Asp. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"10672","DOI":"10.1074\/jbc.M117.783068","article-title":"The phospholipase iPLA2\u03b3 is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling","volume":"292","author":"Liu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e70109","DOI":"10.1111\/cpr.70109","article-title":"Pioglitazone ameliorates mitochondrial oxidative stress and inflammation via AMPK-dependent inhibition of mitochondrial fission in leigh syndrome","volume":"59","author":"Luo","year":"2026","journal-title":"Cell Prolif."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e070210","DOI":"10.1136\/bmjopen-2022-070210","article-title":"Persistent mortality and heart failure burden of anterior ST-segment elevation myocardial infarction following primary percutaneous coronary intervention: real-world evidence from the US medicare data set","volume":"13","author":"Martin","year":"2023","journal-title":"BMJ Open"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1073\/pnas.241655498","article-title":"Cytochrome c release from mitochondria proceeds by a two-step process","volume":"99","author":"Ott","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"H1341","DOI":"10.1152\/ajpheart.00028.2018","article-title":"Mitochondrial bioenergetics and cardiolipin alterations in myocardial ischemia-reperfusion injury: implications for pharmacological cardioprotection","volume":"315","author":"Paradies","year":"2018","journal-title":"Am. J. Physiology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s00395-023-01002-4","article-title":"Preventing mitochondrial reverse electron transport as a strategy for cardioprotection","volume":"118","author":"Prag","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e771","DOI":"10.1161\/CIR.0000000000001309","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American college of cardiology\/american heart association joint committee on clinical practice guidelines","volume":"151","author":"Rao","year":"2025","journal-title":"Circulation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/apnm-2024-0406","article-title":"Passive heat therapy for cardiovascular disease: current evidence and future directions","volume":"50","author":"Rodrigues","year":"2025","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/antiox15020185","article-title":"Plasma, urinary, and salivary total redox status in critically ill patients with brain injury and secondary organ failure","volume":"15","author":"Rynkiewicz-Szczepanska","year":"2026","journal-title":"Antioxidants (Basel)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1016\/j.bbamem.2009.04.019","article-title":"The role of cardiolipin in the structural organization of mitochondrial membranes","volume":"1788","author":"Schlame","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"02479","DOI":"10.1016\/j.healun.2025.12.021","article-title":"Mechanical stretch reduces fibroblast activation in heart failure with reduced ejection fraction","author":"Silverman","year":"2025","journal-title":"J. Heart Lung Transpl."},{"key":"B35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1161\/CIRCULATIONAHA.123.065298","article-title":"Novel role for cardiolipin as a target of therapy to mitigate myocardial injury caused by venoarterial extracorporeal membrane oxygenation","volume":"149","author":"Swain","year":"2024","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"731015","DOI":"10.3389\/fcell.2021.731015","article-title":"Role of cardiac AMP-activated protein kinase in a non-pathological setting: evidence from cardiomyocyte-specific, inducible AMP-activated protein kinase \u03b11\u03b12-Knockout mice","volume":"9","author":"Tokarska-Schlattner","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1142\/S0192415X04002557","article-title":"Electroacupuncture on PC6 (neiguan) attenuates ischemia\/reperfusion injury in rat hearts","volume":"32","author":"Tsou","year":"2004","journal-title":"Am. J. Chin. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur. J. Heart Fail"},{"key":"B40","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41392-021-00542-2","article-title":"FGF1\u0394HBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK\/Nur77 suppression","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6362","DOI":"10.1038\/s41467-024-50557-w","article-title":"Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","article-title":"Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement","volume":"83","author":"Welt","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.3390\/ijms21144987","article-title":"AMPK, mitochondrial function, and cardiovascular disease","volume":"21","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/13880209.2022.2041675","article-title":"Acacetin alleviates myocardial ischaemia\/reperfusion injury by inhibiting oxidative stress and apoptosis via the Nrf-2\/HO-1 pathway","volume":"60","author":"Wu","year":"2022","journal-title":"Pharm. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"116936","DOI":"10.1016\/j.biopha.2024.116936","article-title":"Cardiolipin in myocardial ischaemia-reperfusion injury: from molecular mechanisms to clinical strategies","volume":"176","author":"Xing","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e15316","DOI":"10.1016\/j.heliyon.2023.e15316","article-title":"Grain-sized moxibustion at zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK\/mTOR signaling pathway","volume":"9","author":"Xu","year":"2023","journal-title":"Heliyon"},{"key":"B47","doi-asserted-by":"publisher","first-page":"121283","DOI":"10.1016\/j.lfs.2022.121283","article-title":"Moxibustion mitigates mitochondrial dysfunction and NLRP3 inflammatory activation in cyclophosphamide-induced premature ovarian insufficiency rats","volume":"314","author":"Yin","year":"2023","journal-title":"Life Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.freeradbiomed.2024.02.015","article-title":"An upstream open reading frame (5'-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2\u03b1","volume":"214","author":"Zhang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/s0828-282x(09)70095-9","article-title":"Protective effect of electroacupuncture at the neiguan point in a rabbit model of myocardial ischemia-reperfusion injury","volume":"25","author":"Zhang","year":"2009","journal-title":"Can. J. Cardiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"559","DOI":"10.21037\/atm.2019.09.66","article-title":"Effect of moxibustion preconditioning on autophagy-related proteins in rats with myocardial ischemia reperfusion injury","volume":"7","author":"Zhang","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/j.cmet.2021.08.014","article-title":"Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"B52","doi-asserted-by":"publisher","first-page":"103124","DOI":"10.1016\/j.redox.2024.103124","article-title":"Endogenous sulfur dioxide deficiency as a driver of cardiomyocyte senescence through abolishing sulphenylation of STAT3 at cysteine 259","volume":"71","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e70073","DOI":"10.1111\/apha.70073","article-title":"Cardiolipin remodeling in cardiovascular diseases: implication for mitochondrial dysfunction","volume":"241","author":"Zhang","year":"2025","journal-title":"Acta Physiol. (Oxf)"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1864586\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:26:15Z","timestamp":1783409175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1864586\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":53,"alternative-id":["10.3389\/fphar.2026.1864586"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1864586","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"article-number":"1864586"}}