{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:48:00Z","timestamp":1787237280555,"version":"build-2736575974"},"reference-count":214,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006206","name":"\u010cesk\u00e1 Zem\u011bd\u011blsk\u00e1 Univerzita v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The past decade, particularly the post-pandemic period, has intensified the challenge of managing bacterial infections. Multidrug-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MDR-SA) has emerged as a dominant cause of hospital-acquired infections, creating a sustained public health emergency and underscoring the need for alternative antimicrobial strategies. Plant-derived secondary metabolites have gained attention as promising antibacterial agents; however, their therapeutic potential is constrained by poor solubility, limited target selectivity, low drug-loading capacity, rapid metabolism, and reduced systemic bioavailability. Nanoparticle carriers provide a corrective platform by improving physicochemical stability, enhancing solubility, enabling controlled release, and strengthening pharmacokinetic and pharmacodynamic behavior. Phytochemical-based nanoparticles (phyto-NPs) form a multitarget antibacterial architecture capable of weakening bacterial defense networks through efflux pump interference, disruption of metal-ion homeostasis, and alteration of membrane permeability. These systems also induce reactive oxygen species, leading to DNA damage, protein denaturation, mitochondrial impairment, and peptidoglycan disruption. In parallel, phyto-NPs inhibit biofilm formation and quorum-sensing pathways, reducing virulence and limiting dissemination. Their ability to penetrate the extracellular matrix enhances antibiotic access and restores susceptibility in resistant strains. Recent investigations demonstrate strong activity of phyto-NPs both as independent therapeutics and as synergistic partners to conventional antibiotics. Microenvironment-responsive release, intracellular targeting, and improved delivery efficiency further strengthen their translational relevance. Curcumin-loaded nanosystems disrupt MRSA membranes and impair biofilm formation, while quercetin-loaded liposomes penetrate\n                    <jats:italic>S. aureus<\/jats:italic>\n                    biofilms more effectively than free quercetin. These examples illustrate the capacity of nanoscale engineering to overcome the pharmacological constraints of phytochemicals. This review examines recent advances in phyto-NP strategies targeting MDR-SA, with emphasis on phytochemical selection, nanoscale design principles, and the multifunctional antibacterial mechanisms underpinning next-generation antimicrobial development.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1866492","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:10:15Z","timestamp":1781043015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in phytochemical-derived nanotherapeutics for multimodal eradication of multidrug-resistant Staphylococcus aureus"],"prefix":"10.3389","volume":"17","author":[{"given":"Neha","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague","place":["Prague, Czechia"]},{"name":"Department of Economic Theories, Faculty of Economics and Management, Czech University of Life Sciences Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Agroecology and Crop Production, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Lela","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Basilicata","place":["Potenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrish","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Faraone","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Basilicata","place":["Potenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Fern\u00e1ndez-Cusimamani","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit D.","family":"Sarker","sequence":"additional","affiliation":[{"name":"Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University","place":["Liverpool, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Basilicata","place":["Potenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfun","family":"Nahar","sequence":"additional","affiliation":[{"name":"Laboratory of Growth Regulators, Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences","place":["Olomouc, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Leuner","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7641","DOI":"10.2147\/IDR.S428103","article-title":"Methicillin resistant staphylococcus Aureus: molecular mechanisms underlying drug resistance development and novel strategies to combat","volume":"16","author":"Abebe","year":"2023","journal-title":"Infect. 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