{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:29:46Z","timestamp":1787056186730,"version":"build-2736575974"},"reference-count":268,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Ovarian cancer (OC) cells promote rapid proliferation\n                    <jats:italic>via<\/jats:italic>\n                    aerobic glycolysis and build an immunosuppressive microenvironment at the same time; therefore, this glycolytic pathway is now a potential drug target. Existing glycolysis inhibitors are limited by off-target toxicity, drug resistance, and variable efficacy across tumor subtypes. Natural compounds offer an alternative by modulating multiple glycolytic nodes, lowering lactate production, and reshaping the tumor microenvironment (TME). Therefore, this review summarizes 33 natural compounds that target glycolysis in OC. Their mechanisms of action focus on inhibiting glucose uptake, downregulating the PI3K\/AKT\/mTOR signaling pathway, suppressing the activities of glycolytic enzymes (HK2, PFK, PKM2, and LDHA) and HIF-1\u03b1 transcription, reducing lactate production, ameliorating the TME, and ultimately inhibiting OC cell proliferation, migration, and invasion, thereby demonstrating the potential for developing novel anti-OC drugs. Clinical translation is still limited by inefficient extraction, low bioavailability, incomplete mechanistic characterization and a lack of clinical validation. Based on the current evidence and the aforementioned bottlenecks, this review offers a development path for natural glycolysis inhibitors in precision anti-OC therapy.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1877824","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:47:45Z","timestamp":1787053665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural compounds targeting glycolysis and TME in ovarian cancer: from metabolic crosstalk to therapeutic potential"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongli","family":"Lv","sequence":"first","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntian","family":"Kan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Department of Basic Medicine, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1002\/ptr.6171","article-title":"Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases","volume":"32","author":"Abenavoli","year":"2018","journal-title":"Phytother. 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