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Clinically, it manifests as reduced bowel movement frequency, hard stools, straining during defecation, or incomplete evacuation, significantly impairing patients\u2019 quality of life. While numerous constipation treatments are commercially available, they generally exhibit limited efficacy, pronounced adverse effects, and poor patient compliance. In recent years, the development and application of bioactive compounds from Medicinal-food homology (MFH) have garnered significant attention. Numerous studies indicate that various such compounds demonstrate marked efficacy in ameliorating FC. This paper systematically reviews the mechanisms by which bioactive substances from these plants alleviate FC through gut microbiota interactions, providing theoretical guidance for developing functional foods or health supplements with promising therapeutic effects for FC.<\/jats:p>","DOI":"10.3389\/fphar.2026.1880189","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:23:10Z","timestamp":1786440190000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive components of medicinal-food homology substances alleviating constipation via gut microbiota modulation: a review"],"prefix":"10.3389","volume":"17","author":[{"given":"Xinyuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine Research, Naval Medical University","place":["Shanghai, China"]},{"name":"College of Food Sciences and Technology, Shanghai Ocean University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Song","sequence":"additional","affiliation":[{"name":"College of Food Sciences and Technology, Shanghai Ocean University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Third Affiliated Hospital of Naval Medical University (Shanghai Eastern Hepatobiliary Surgery Hospital)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"Ma","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Research, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liang","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Research, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Research, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Ma","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Research, Naval Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol. 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