{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:05:10Z","timestamp":1790165110522,"version":"4.1.0"},"reference-count":226,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    is a fundamental environmental factor for the origin of life, providing an energetic basis for the emergence of primitive life. Through its selective antioxidant, anti-inflammatory, and anti-apoptotic activities, as well as its regulatory effects on cell signaling pathways and gene expression, H\n                    <jats:sub>2<\/jats:sub>\n                    exerts broad biological effects and has emerged as a favorable pleiotropic therapeutic agent. To date, hydrogen medicine research has covered almost all types of diseases across organ systems, with more than 170 disease models under investigation. Amid the growing demand for translational applications of hydrogen medicine, clinical research has gradually become a research hotspot. Here, we extensively reviewed the latest mechanistic understanding of H\n                    <jats:sub>2<\/jats:sub>\n                    and comprehensively summarized the progress of clinical studies on H\n                    <jats:sub>2<\/jats:sub>\n                    in diseases of different systems, with the goal of informing future large-scale, multi-center clinical trials and supporting the multidisciplinary development of H\n                    <jats:sub>2<\/jats:sub>\n                    medicine.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1884091","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:44:13Z","timestamp":1790163853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress in clinical utilization of H2 as a pleiotropic agent"],"prefix":"10.3389","volume":"17","author":[{"given":"Qinghui","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Physical Culture, Huanghuai University","place":["Zhu Madian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengchong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Physical Culture, Huanghuai University","place":["Zhu Madian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongke","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Physical Culture, Huanghuai University","place":["Zhu Madian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Physical Culture, Huanghuai University","place":["Zhu Madian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Li","sequence":"additional","affiliation":[{"name":"Zhumadian Central Hospital","place":["Zhu Madian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3892\/or.2018.6841","article-title":"Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis","volume":"41","author":"Akagi","year":"2019","journal-title":"Oncol. 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