{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:57:22Z","timestamp":1790575042868,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease with progressive joint damage, functional disability and systemic comorbidity. Available therapies are not satisfactory, including low rates of remission and about 30% of patients with poor response to first-line treatment. Thus, more effective therapeutic strategies are urgently needed. Sanguinarine, a benzophenanthridine alkaloid primarily isolated from Sanguinaria canadensis and other members of the Papaveraceae family, has been documented to possess notable anti-bacterial, anti-inflammatory, and anti-neoplastic properties. Nevertheless, its potential utility as a targeted therapeutic modality for RA has yet to be systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we demonstrate that sanguinarine can effectively ameliorate the development of adjuvant-induced arthritis in rats and decrease arthritis scores, attenuate the inflammatory response, and prevent bone and joint damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Flow cytometry and ELISA both confirmed its anti-inflammatory activity, reducing the levels of PGE2, TNF-\u03b1, IL-1, and IL-6. In human fibroblast-like synoviocytes from RA patients (HFLS-RA), sanguinarine triggered cell apoptosis accompanied by elevated intracellular ROS, loss of mitochondrial membrane potential and activation of caspase-3, and activated the Hippo\/YAP pathway both\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These results suggest that sanguinarine ameliorates RA by activation of the Hippo-YAP\/TAZ pathway to induce apoptosis and suppress inflammation, highlighting its potential as a novel therapeutic candidate for RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1887163","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:45:32Z","timestamp":1790574332000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sanguinarine ameliorates rheumatoid arthritis by activating the Hippo-YAP\/TAZ pathway to induce apoptosis and suppress inflammation in fibroblast-like synoviocytes"],"prefix":"10.3389","volume":"17","author":[{"given":"Jun","family":"Cai","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Guangdong Medical University","place":["Dongguan, China"]},{"name":"Innovation Center of Cardiometabolic Diseases, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gu","family":"Cai","sequence":"additional","affiliation":[{"name":"Innovation Center of Cardiometabolic Diseases, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Innovation Center of Cardiometabolic Diseases, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Jun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Innovation Center of Cardiometabolic Diseases, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation Center of Cardiometabolic Diseases, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Yuan","family":"Ye","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1007\/s10787-026-02185-7","article-title":"\u03b1-Pinene alleviates inflammatory responses and oxidative stress in freund's complete adjuvant induced arthritic rat model and associated risk factors of atherosclerosis","volume":"34","author":"Ali","year":"2026","journal-title":"Inflammopharmacology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1080\/1744666x.2017.1351297","article-title":"Update of sarilumb to treat rheumatoid arthritis based on randomized clinical trials: a systematic review","volume":"13","author":"Aly","year":"2017","journal-title":"Expert Rev. 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