{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:00:33Z","timestamp":1785128433448,"version":"3.55.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Stathmin, a highly conserved microtubule-destabilizing protein in eukaryotes, plays a pivotal role in regulating cytoskeletal dynamics by promoting microtubule depolymerization. This process is indispensable for fundamental biological events, including cell division, migration, differentiation, and intracellular signal transduction. This review systematically elucidates stathmin\u2019s genomic architecture, molecular functions, and mechanistic contributions under both physiological and pathological contexts. The functional output of stathmin is tightly modulated by post-translational modifications, particularly phosphorylation, as well as its protein expression levels. Aberrant stathmin expression or activity is strongly implicated in tumorigenesis, driving cancer cell proliferation, invasion, metastasis, and chemoresistance. Conversely, in non-neoplastic diseases, stathmin orchestrates skin and mucosal repair, maintains neurological function, influences pulmonary fibrosis, modulates metabolic homeostasis, and supports pregnancy maintenance through its cytoskeletal regulatory capacity. Furthermore, this study highlights stathmin\u2019s significant potential as a diagnostic biomarker and a promising therapeutic target. Finally, we propose future research directions that prioritize deciphering tissue-specific regulatory mechanisms and accelerating the translation of basic scientific discoveries into clinical applications.<\/jats:p>","DOI":"10.3389\/fphar.2026.1888339","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:25:17Z","timestamp":1785126317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stathmin in human health and diseases: from cytoskeletal dynamics to clinical implications"],"prefix":"10.3389","volume":"17","author":[{"given":"Luqi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University","place":["Chongqing, China"]},{"name":"Department of Dermatology, The 991th Hospital of Joint Logistic Support Force of People\u2019s Liberation Army","place":["Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University","place":["Chongqing, China"]},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University","place":["Chongqing, China"]},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhai","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Daping Hospital, Army Medical University","place":["Chongqing, China"]},{"name":"Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00401-023-02655-0","article-title":"Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated alzheimer's disease","volume":"147","author":"Agra Almeida Quadros","year":"2024","journal-title":"Acta Neuropathol."},{"key":"B2","first-page":"2795","article-title":"An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas","volume":"8","author":"Allen","year":"2015","journal-title":"Int. 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