{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:19:00Z","timestamp":1787548740618,"version":"build-2736575974"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Excessive alcohol consumption, particularly binge drinking, is associated with cognitive impairments, emotional dysregulation and an increased vulnerability to alcohol use disorders. Emerging evidence suggests that docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, modulates neuroinflammatory processes and influences dopaminergic signaling involved in reward-related behaviors. However, its acute effect on binge-like consumption remains poorly understood. The present study investigated the effects of acute oral administration of DHA-rich fish oil on binge-like drinking of ethanol in male and female C57BL\/6J mice, utilizing caloric and non-caloric reinforcers to evaluate behavioral specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Drinking-in-the-Dark (DID) paradigm, voluntary intake of ethanol, sucrose and saccharin were evaluated following DHA administration. To control potential confounds, spontaneous locomotor activity and anxiety-like behavior were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute DHA administration significantly reduced binge-like consumption of ethanol in both sexes, with a parallel reduction observed in sucrose and saccharin intake. Importantly, DHA did not alter locomotor activity or anxiety-like behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that DHA exerts a rapid and robust dampening effect on binge consumption of both ethanol and natural rewards, supporting a potential role of DHA in modulating reward-driven intake. Collectively, this study highlights DHA as a promising candidate modulator of neurobehavioral processes associated with excessive and non-homeostatic consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1891616","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:23:20Z","timestamp":1787545400000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute docosahexaenoic acid administration reduces binge-like ethanol consumption and palatable substances in C57BL\/6J mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Ainhoa","family":"S\u00e1nchez-Gil","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Almeria","place":["Almeria, Spain"]},{"name":"Health Research Center, CEINSA, University of Almeria","place":["Almeria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Almeria","place":["Almeria, Spain"]},{"name":"Health Research Center, CEINSA, University of Almeria","place":["Almeria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Cardona","sequence":"additional","affiliation":[{"name":"Health Research Center, CEINSA, University of Almeria","place":["Almeria, Spain"]},{"name":"Department of Nursing, Physiotherapy and Medicine, University of Almeria","place":["Almeria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Lerma-Cabrera","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Almeria","place":["Almeria, Spain"]},{"name":"Health Research Center, CEINSA, University of Almeria","place":["Almeria, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12624","DOI":"10.1038\/s41598-018-29311-y","article-title":"Binge drinking among adolescents is related to the development of alcohol use disorders: results from a cross-sectional study","volume":"8","author":"Addolorato","year":"2018","journal-title":"Sci. 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