{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:19:48Z","timestamp":1787937588308,"version":"build-2784847793"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral small vessel disease\u2013related cognitive impairment (CSVD-CI) is a common and clinically important challenge of cerebral small vessel disease, but effective therapeutic options remain limited. Chinese medicine interventions (CMIs) may be beneficial, although the evidence is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of CMIs for adults with CSVD-CI and assess evidence certainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis of randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight databases were systematically searched from inception to 31 December 2025. Primary outcomes were cognitive function, mainly assessed by the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Secondary outcomes included total effective rate, Traditional Chinese Medicine syndrome score, selected biochemical and hemorheological indicators, and adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias tool, and certainty of evidence was evaluated using GRADE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty RCTs involving 4,454 participants were included. Compared with conventional therapy alone, CMIs plus conventional therapy were associated with higher end-of-treatment MoCA and MMSE scores, and the pooled incidence of AEs did not differ significantly between the intervention and control groups. The overall risk of bias was predominantly unclear, whereas the certainty of evidence was low or very low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CMIs were associated with higher end-of-treatment cognitive scores; however, extreme heterogeneity, unclear risk of bias, and low evidence certainty substantially limit confidence in these findings. Available data are insufficient to establish long-term efficacy or safety. Multicenter, prospectively registered RCTs with standardized diagnostic criteria, intervention reporting, outcome selection, and safety monitoring are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251176394<\/jats:ext-link>\n                      , identifier, CRD420251176394.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1894066","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:46:50Z","timestamp":1787935610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chinese medicine interventions for cerebral small vessel disease-related cognitive impairment: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Miaomiao","family":"Zhao","sequence":"first","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Mu","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxing","family":"Lai","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Institute for Brain Disorders, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00415-025-13087-z","article-title":"Risk factors and clinical significance of neurodegenerative co-pathologies in symptomatic cerebral small vessel disease","volume":"272","author":"Arndt","year":"2025","journal-title":"J. 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