{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:08:03Z","timestamp":1789056483845,"version":"build-2803163510"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515220148"],"award-info":[{"award-number":["2021A1515220148"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171446"],"award-info":[{"award-number":["82171446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671288"],"award-info":[{"award-number":["81671288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic Inflammatory pain can lead to emotional abnormalities such as anxiety and a decreased appetite. However, the specific mechanisms underlying these abnormalities remain unclear. The anterior cingulate cortex (ACC), which plays a crucial role in integrating nociceptive perception and emotional responses to chronic inflammatory pain, is an ideal region for studying how pain influences anxiety and appetite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we employed a variety of techniques, including fiber photometry recordings, neuroanatomical tract tracing, optogenetics, pharmacogenetics, and behavioral experiments, to investigate the neuronal circuits in the ACC of mice with chronic inflammatory pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified two distinct CaMKII neurons in the ACC: one that projects to the basolateral amygdala (BLA) and is associated with anxiety-like behavior and another that projects to the nucleus accumbens (NAc) and regulates appetite suppression. Furthermore, we found that these two circuits are largely independent. And the intrinsic excitability and synaptic inputs in ACCC\n                      <jats:sub>aMKII<\/jats:sub>\n                      \u2192BLA neurons and ACCC\n                      <jats:sub>aMKII<\/jats:sub>\n                      \u2192NAc neurons are differentially influenced by chronic inflammatory pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings offer valuable insights into the circuit mechanisms in the ACC that regulate anxiety-like and appetite-suppression behaviors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1897103","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:51:22Z","timestamp":1788429082000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct CaMKII neurons in anterior cingulate cortex regulate anxiety-like behavior and appetite suppression in a model of inflammatory pain"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiandong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyue","family":"Han","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehan","family":"You","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjing","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guan","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Gu","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Department of Pathophysiology, Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Ge","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Psychiatric Disease, Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Department of Pathophysiology, Bengbu Medical University","place":["Bengbu, Anhui, China"]},{"name":"Longhu Laboratory of Bengbu Medical University","place":["Bengbu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3803\/EnM.2021.979","article-title":"Dopaminergic control of the feeding circuit","volume":"36","author":"Baik","year":"2021","journal-title":"Endocrinol. 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