{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:31:12Z","timestamp":1787923872924,"version":"build-2784847793"},"reference-count":118,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The global health crisis driven by Antimicrobial Resistance (AMR) necessitates a pivot toward novel therapeutic agents, yet the Asteraceae genus\n                    <jats:italic>Verbesina<\/jats:italic>\n                    remains significantly under-characterized. Despite comprising over 300 species, early assessments indicated that only approximately 10% had been biologically investigated. This review provides a critical synthesis of the pharmacological landscape of\n                    <jats:italic>Verbesina<\/jats:italic>\n                    , focusing on the structural duality of its major specialized metabolites, the Sesquiterpene Lactones (SLs). The review systematically analyzes reported\n                    <jats:italic>in vitro<\/jats:italic>\n                    data, emphasizing high-potency scaffolds such as 6\u03b2-cinnamoyloxy-3\u03b2,4\u03b1-dihydroxyeudesmane (MIC = 3.9\u00a0\u03bcg\/mL) and Verbesindiol (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 4.0 \u00b1 0.6\u00a0\u03bcM) against prostate cancer cells. A core focus is placed on the Selectivity Index (SI = IC\n                    <jats:sub>50<\/jats:sub>\n                    \/MIC); to address the translational challenge of non-selective toxicity. Notably, an Arbusculin derivative demonstrates a superior SI of up to 88.2, significantly outperforming standard drugs like meglumine antimoniate (SI = 40.0). Furthermore, the review evaluates the molecular mechanisms of action, such as the role of the \u03b1-methylene-\u03b3-lactone moiety in alkylating cellular targets, while distinguishing structure-specific effects like mitochondrial uncoupling and respiratory chain inhibition. By bridging ethnopharmacology with modern mechanistic and quantitative data, this review critically assesses the translational potential of\n                    <jats:italic>Verbesina<\/jats:italic>\n                    metabolites, exposes current methodological limitations in the literature, and highlights clear directions for bioassay-guided isolation and chemical optimization as next-generation anti-resistance scaffolds.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1899545","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:54:12Z","timestamp":1787921652000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical diversity and therapeutic potential of Verbesina metabolites: a critical review of sesquiterpene lactones and translational feasibility"],"prefix":"10.3389","volume":"17","author":[{"given":"Karla Irazu","family":"Ventura-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada, Universidad Veracruzana","place":["Xalapa, Veracruz, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar Janardan","family":"Pawar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n, Universidad Anahuac Quer\u00e9taro","place":["El Marqu\u00e9s, Quer\u00e9taro, Mexico"]},{"name":"Escuela de Ingenier\u00eda Qu\u00edmica, Universidad Anahuac Quer\u00e9taro","place":["El Marqu\u00e9s, Quer\u00e9taro, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rafael","family":"Ramos-Morales","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada, Universidad Veracruzana","place":["Xalapa, Veracruz, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant S.","family":"Nilewar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Uka Tarsadia University","place":["Bardoli, Gujarat, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"L\u00f3pez-Rosas","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica, Universidad Veracruzana","place":["Xalapa, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Hern\u00e1ndez-Rosas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n, Universidad Anahuac Quer\u00e9taro","place":["El Marqu\u00e9s, Quer\u00e9taro, Mexico"]},{"name":"Escuela de Ingenier\u00eda Biom\u00e9dica, Divisi\u00f3n de Ingenier\u00eda, Universidad An\u00e1huac Quer\u00e9taro","place":["El Marqu\u00e9s, Quer\u00e9taro, Mexico"]},{"name":"Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro","place":["Santiago de Quer\u00e9taro, Quer\u00e9taro, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"B1","first-page":"108","article-title":"Phytochemical and biological studies of Verbesina encelioides (cav.) benth. And hook","volume":"4","author":"Abbas","year":"2016","journal-title":"Asian J. Phytomed Clin. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21608\/jesp.2017.77965","article-title":"Scanning electron microscopic changes in Habronema muscae after in vitro exposure to plant extract (Verbesina alternifolia)","volume":"47","author":"Abdel-Wahab","year":"2017","journal-title":"J. Egypt Soc. Parasitol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12906-016-1106-0","article-title":"Verbesina encelioides: cytotoxicity, cell cycle arrest, and oxidative DNA damage in human liver cancer (HepG2) cell line","volume":"16","author":"Al-Oqail","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/arrb\/2018\/40492","article-title":"Diversity of soil cyanobacteria in relation to dominant wild plants and edaphic factors at Western Saudi Arabia","volume":"26","author":"Al-Sodany","year":"2018","journal-title":"Annu. Res. Rev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.17265\/1934-7391\/2015.07.006","article-title":"Anticancer and antifolate activities of extracts of six Saudi Arabian wild plants used in folk medicine","volume":"9","author":"Albalawi","year":"2015","journal-title":"J. Life Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/ffj.1632","article-title":"Essential oil composition of Verbesina diversifolia DC","volume":"21","author":"Albuquerque","year":"2006","journal-title":"Flavour Fragr. J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"8127","DOI":"10.1021\/ja00467a001","article-title":"Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms","volume":"99","author":"Allinger","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1590\/S0103-50532002000300010","article-title":"Eudesmane derivatives from Verbesina turbacensis","volume":"13","author":"Amaro-Luis","year":"2002","journal-title":"J. Braz Chem. Soc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"104183","DOI":"10.1016\/j.bse.2020.104183","article-title":"Cadinenes and other metabolites from Verbesina sphaerocephala A. Gray","volume":"93","author":"Arciniegas","year":"2020","journal-title":"Biochem. Syst. Ecol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"plt028","DOI":"10.1093\/aobpla\/plt028","article-title":"Linear glandular trichomes of helianthus (asteraceae): morphology, localization, metabolite activity and occurrence","volume":"5","author":"Aschenbrenner","year":"2013","journal-title":"AoB Plants"},{"key":"B11","volume-title":"Anti-Termite Herbal Composition and Process for Preparation Thereof","year":"2017"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S0031-9422(00)83198-2","article-title":"A rearranged eudesmane and further verbesindiol derivatives from Verbesina eggersii","volume":"24","author":"Banerjee","year":"1985","journal-title":"Phytochemistry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/plb.12700","article-title":"Leaf blade structure of Verbesina macrophylla (cass.) F. S. Blake (asteraceae): ontogeny, duct secretion mechanism and essential oil composition","volume":"20","author":"Bezerra","year":"2018","journal-title":"Plant Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e71523","DOI":"10.4025\/actascibiolsci.v46i1.71523","article-title":"Fungicidal and trypanocidal activity of aqueous extracts of leaves and inflorescences of Verbesina macrophylla (asteraceae)","volume":"46","author":"Bezerra","year":"2024","journal-title":"Acta Sci. Biol. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3906\/biy-1212-7","article-title":"Biopotential of Verbesina encelioides (stem and leaf powders) in silver nanoparticle fabrication","volume":"37","author":"Bhati-Kushwaha","year":"2013","journal-title":"Turkish J. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/cber.19781110124","article-title":"Nat\u00fcrlich vorkommende Terpen-Derivate, 109: Neue Eudesman-Derivate und andere Sesquiterpene aus Verbesina-Arten","volume":"111","author":"Bohlmann","year":"1978","journal-title":"Chem. Ber."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/0031-9422(76)85099-6","article-title":"Neue terpen-inhaltsstoffe aus Verbesina-arten","volume":"15","author":"Bohlmann","year":"1976","journal-title":"Phytochemistry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/0031-9422(79)80206-X","article-title":"Zur konfiguration von \u03b1-und \u03b2-Verbesinolcumarat","volume":"18","author":"Bohlmann","year":"1979","journal-title":"Phytochemistry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1016\/S0031-9422(00)91034-3","article-title":"Eudesmane derivatives from verbesina species","volume":"19","author":"Bohlmann","year":"1980","journal-title":"Phytochemistry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/S0031-9422(82)85036-X","article-title":"Two new eudesmane cinnamates from Verbesina sordescens","volume":"21","author":"Bohlmann","year":"1982","journal-title":"Phytochemistry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2478\/s11756-019-00363-3","article-title":"Fingerprinting the genetic variation and intergeneric hybrid dynamics in the family asteraceae (Genera Helianthus, echinaceae, tagetes and verbesina) using iPBS markers","volume":"75","author":"Bonchev","year":"2020","journal-title":"Biol. Bratisl."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.2174\/0929867033456990","article-title":"Novel hypotensive agents from verbesina caracasana: structure, synthesis and pharmacology","volume":"10","author":"Botta","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0031-9422(75)85137-5","article-title":"Terpenoids from Verbesina rupestris","volume":"14","author":"Box","year":"1975","journal-title":"Phytochemistry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.1016\/S0040-4039(01)97444-1","article-title":"The structure of rupestrol - a new sesquiterpenoid from Verbesina rupestris (URB.) blake","volume":"46","author":"Box","year":"1971","journal-title":"Tetrahedron Lett."},{"key":"B25","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0031-9422(00)86706-0","article-title":"Enantio-eudesmane sesquiterpenes from it Verbesina rupestris","volume":"16","author":"Box","year":"1977","journal-title":"Phytochemistry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10870-009-9610-4","article-title":"Absolute configuration of two eudesmane derivatives from Verbesina turbacensis H.B.K","volume":"40","author":"Bruno-Colmen\u00e1rez","year":"2010","journal-title":"J. Chem. Crystallogr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.envpol.2005.12.009","article-title":"Seasonal profiles of leaf ascorbic acid content and redox state in ozone-sensitive wildflowers","volume":"143","author":"Burkey","year":"2006","journal-title":"Environ. Pollut."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.3390\/plants12142686","article-title":"Cytotoxicity of Nine Medicinal Plants from San Basilio de Palenque (Colombia) on HepG2 Cells","volume":"12","author":"Caballero-Gallardo","year":"","journal-title":"Plants"},{"key":"B29","first-page":"1342","article-title":"On the structure of triolcinnamate from Verbesina persicifolia","volume":"54","author":"Cadanedo","year":"2015","journal-title":"Indian J. Chem. B"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1021\/jm991004l","article-title":"Novel hypotensive agents from verbesina caracasana. 6. Synthesis and pharmacology of caracasandiamide","volume":"42","author":"Carmignani","year":"1999","journal-title":"J. Med. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1021\/jm001017v","article-title":"Novel hypotensive agents from verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N1-agmatine and synthetic analogues","volume":"44","author":"Carmignani","year":"2001","journal-title":"J. Med. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1080\/15226514.2016.1156639","article-title":"Riparian plants on mine runoff in zimapan, Hidalgo, Mexico: useful for phytoremediation?","volume":"18","author":"Carmona-Chit","year":"2016","journal-title":"Int. J. Phytoremediation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/BF02859353","article-title":"Tennessee plant species screened for renewable energy sources","volume":"41","author":"Carr","year":"1987","journal-title":"Econ. Bot."},{"key":"B34","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/1097-458X(200007)38:7<494::AID-MRC668>3.0.CO;2-C","article-title":"1H and13C NMR study of copteroside E derivatives","volume":"38","author":"Cerda-Garc\u00eda-Rojas","year":"2000","journal-title":"Magnetic Reson. Chem."},{"key":"B35","first-page":"53","article-title":"Ozone injury on cutleaf coneflower (Rudbeckia laciniata) and crown-beard (Verbesina occidentalis) in great smoky Mountains national park","volume-title":"Environmental Pollution","author":"Chappelka","year":"2003"},{"key":"B36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0031-9422(91)84096-B","article-title":"Acetylenes and related compounds in heliantheae","volume":"30","author":"Christensen","year":"1991","journal-title":"Phytochemistry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1177\/1934578X0800300407","article-title":"New guanidine alkaloids from the leaves of Verbesina peraffinis","volume":"3","author":"Compagnone","year":"2008","journal-title":"Nat. Prod. Commun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/0960-894X(96)00079-0","article-title":"Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product","volume":"6","author":"Corelli","year":"1996","journal-title":"Bioorg Med. Chem. Lett."},{"key":"B39","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2174\/13816128113199990028","article-title":"An eudesman derivative from Verbesina persicifolia D.C. as a natural mild uncou-pler in liver mitochondria","volume":"20","author":"Dalla Via","year":"2014","journal-title":"A New Potential Anti-obesity Agent?. Curr. Pharm. Des"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1016\/j.bmc.2015.07.002","article-title":"Anti-inflammatory and antiproliferative evaluation of 4\u03b2-cinnamoyloxy,1\u03b2,3\u03b1-dihydroxyeudesm-7,8-ene from Verbesina persicifolia and derivatives","volume":"23","author":"Dalla Via","year":"2015","journal-title":"Bioorg Med. Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"113248","DOI":"10.1016\/j.jep.2020.113248","article-title":"The essential oil of the leaves of Verbesina macrophylla (cass.) s.F.Blake has antimicrobial, anti-inflammatory and antipyretic activities and is toxicologically safe","volume":"265","author":"de Veras","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B42","article-title":"Guanidine derivatives having hypotensive activity","volume-title":"Composition Containing them and Process for Obtaining them","author":"Delle Monache","year":"1991"},{"key":"B43","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0960-894X(00)80159-6","article-title":"Caracasanamide, a novel hypotensive agent from Verbesina caracasana","volume":"2","author":"Delle Monache","year":"1992","journal-title":"Bioorg Med. Chem. Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1021\/jm00072a016","article-title":"Novel hypotensive agents from verbesina caracasana. 2. Synthesis and pharmacology of caracasanamide","volume":"36","author":"Delle Monache","year":"1993","journal-title":"J. Med. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0960-894X(96)00007-8","article-title":"Caracasandiamide, a truxinic hypotensive agent from Verbesina caracasana","volume":"6","author":"Delle Monache","year":"1996","journal-title":"Bioorg Med. Chem. Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1016\/S0960-894X(99)00569-7","article-title":"Further hypotensive metabolites from Verbesina caracasana","volume":"9","author":"Delle Monache","year":"1999","journal-title":"Bioorg Med. Chem. Lett."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.20546\/ijcmas.2017.612.396","article-title":"Biochemical and antimicrobial characterization of an underexploited medicinal plant - verbesina encelioides","volume":"6","author":"Divya Ramakrishnan","year":"2017","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.29059\/cienciauat.v9i2.708","article-title":"Plantas de uso medicinal de la Reserva Ecol\u00f3gica \u201cSierra de Otontepec\u201d, municipio de Chontla, Veracruz, M\u00e9xico","volume":"9","author":"Dom\u00ednguez-Barradas","year":"2015","journal-title":"CienciaUAT"},{"key":"B49","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0031-9422(82)80021-6","article-title":"Galegine and a new di hydroxyalkyl acetamide from verbesina encelioides","volume":"21","author":"Eichholzer","year":"1982","journal-title":"Phytochemistry"},{"key":"B50","article-title":"Stable liquid formulations and methods of using the same","author":"Essinger","year":"2020","journal-title":"U.S. Pat. Appl"},{"key":"B51","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3390\/plants2040635","article-title":"Verbesina alternifolia tolerance to the holoparasite Cuscuta gronovii and the impact of drought","volume":"2","author":"Evans","year":"2013","journal-title":"Plants"},{"key":"B52","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/14786419.2016.1180604","article-title":"Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides","volume":"31","author":"Ezzat","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"21530","DOI":"10.1039\/d0ra03697h","article-title":"Confirmatory non-invasive and non-destructive identification of poison ivy using a hand-held raman spectrometer","volume":"10","author":"Farber","year":"2020","journal-title":"RSC Adv."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1007\/s11756-021-00781-2","article-title":"Verbesina encelioides-induced cytotoxicity and mitochondria-mediated apoptosis in human Colon cancer cells through ROS generation","volume":"76","author":"Farshori","year":"2021","journal-title":"Biol. Bratisl."},{"key":"B55","article-title":"Phytochemical constituents and allelopathic effects of some medicinal plants extract on the soil algal diversity","author":"Fawzy","year":"2013"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1016\/j.sjbs.2020.08.038","article-title":"Verbesina crocata: a pharmacognostic study for the treatment of wound healing","volume":"27","author":"Garc\u00eda-Bores","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1021\/ja01467a053","article-title":"-and \u03b2-Verbesinol. Sesquiterpene alcohols of the cis-Decalin series","volume":"83","author":"Gardner","year":"1961","journal-title":"J. Am. Chem. Soc."},{"key":"B58","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0031-9422(80)85040-0","article-title":"Flavonol 3,7-diglycosides of Verbesina encelioides","volume":"19","author":"Glennie","year":"1980","journal-title":"Phytochemistry"},{"key":"B59","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/978-3-031-75661-0_30","article-title":"Verbesina encelioides (cav.) benth. and hook. F. Ex","volume-title":"Medicinal and Aromatic Plants of India","author":"Gorja","year":"2024"},{"key":"B60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3146\/i0095-3679-25-1-10","article-title":"Control of golden crownbeard (Verbesina encelioides) in peanut (Arachis hypogaea) with postemergence herbicides","volume":"25","author":"Grichar","year":"1998","journal-title":"Peanut Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cropro.2012.01.017","article-title":"Weed control and peanut (Arachis hypogaea L.) response to formulations of imazapic","volume":"36","author":"Grichar","year":"2012","journal-title":"Crop Prot."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5586\/aa\/201390","article-title":"Effect of botanical extracts from Verbesina sphaerocephala on the growth and yield of tomato in greenhouse conditions","volume":"78","author":"Hern\u00e1ndez-P\u00e9rez","year":"2025","journal-title":"Acta Agrobot."},{"key":"B63","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0031-9422(81)85100-X","article-title":"Aromatic and other constituents of four verbesina species: structure and stereochemistry of verbesindiol","volume":"20","author":"Herz","year":"1981","journal-title":"Phytochemistry"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1021\/jo00348a044","article-title":"Crystal structure and stereochemistry of verbesindiol","volume":"47","author":"Herz","year":"1982","journal-title":"J. Org. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"51","DOI":"10.22127\/RJP.2022.363697.1985","article-title":"A brief review of Verbesina crocata (cav.) less., a scantly studied medicinal plant","volume":"10","author":"Heyerdahl-Viau","year":"2023","journal-title":"Res. J. Pharmacogn."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1139\/b99-097","article-title":"Allelopathic potential of Verbesina encelioides root leachate in soil","volume":"77","author":"Inderjit","year":"2000","journal-title":"Can. J. Bot."},{"key":"B67","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/bs.podrm.2020.07.005","article-title":"Validation of in-vitro bioassay methods: application in herbal drug research","volume":"46","author":"Indrayanto","year":"2021","journal-title":"Profiles Drug Subst. Excip. Relat. Methodol."},{"key":"B68","first-page":"273","article-title":"Chapter six - validation of in-vitro bioassay methods: application in herbal drug research","volume-title":"Profiles of Drug Substances Excipients and Related Methodology","author":"Indrayanto","year":"2021"},{"key":"B69","first-page":"224","article-title":"Biopotentialities of Verbesina encelioides cell cultures","volume":"13","author":"Jain","year":"2009","journal-title":"Indian J. Plant Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1055\/s-2006-962614","article-title":"Further eudesmane derivatives from verbesina species","volume":"53","author":"Jakupovic","year":"1987","journal-title":"Planta Med."},{"key":"B71","volume-title":"Process for Obtaining Eudesmane Sesquiterpene 4a-cinnamoiloxy-1b,3a-dihydroxyeudesm-7,8-eno(4CDE)","author":"Jimenez","year":"2015"},{"key":"B72","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1508\/cytologia.80.353","article-title":"Cyto-morphological studies of some dicot plants from Rajasthan (india)","volume":"80","author":"Kaur","year":"2015","journal-title":"Cytol. (Tokyo)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.3390\/molecules26175347","article-title":"Parthenin\u2014A sesquiterpene lactone with multifaceted biological activities: insights and prospects","volume":"26","author":"Kaur","year":"2021","journal-title":"Molecules"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.13040\/IJPSR.0975-8232.13(10).3824-32","article-title":"A systematic review of an invasive plant species: verbesina encelioides (cav.) benth. and hook. F. Ex A. Gray","volume":"13","author":"Kaur","year":"2022","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/S40009-012-0097-8","article-title":"Nanofabrication of silver nanoparticles from the stem and leaf extract of Verbesina encelioides","volume":"35","author":"Kushwaha","year":"2012","journal-title":"Natl. Acad. Sci. Lett."},{"key":"B76","doi-asserted-by":"publisher","first-page":"150","DOI":"10.5004\/dwt.2023.29936","article-title":"First assessment of the anti-cyanobacterial potentialities of the invasive weed Verbesina encelioides against microcystis aeruginosa growth","volume":"310","author":"Lahlali","year":"2023","journal-title":"Desalination Water Treat."},{"key":"B77","doi-asserted-by":"publisher","first-page":"22758","DOI":"10.1074\/jbc.M113.482596","article-title":"Crystal structure of a human I\u03baB kinase \u03b2 asymmetric dimer","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/plants14071078","article-title":"Anticonvulsant potential and toxicological profile of Verbesina persicifolia leaf extracts: evaluation in zebrafish seizure and Artemia salina toxicity models","volume":"14","author":"L\u00f3pez-Rosas","year":"2025","journal-title":"Plants"},{"key":"B79","article-title":"Cat\u00e1logo de plantas \u00fatiles de la Sierra Norte de Puebla, M\u00e9xico","volume":"27","author":"Mart\u00ednez Alfaro","year":"1995","journal-title":"Cuadernos del Instituto de Biolog\u00eda"},{"key":"B80","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/0031-9422(83)85035-3","article-title":"Eudesmane triols from Verbesina virgata","volume":"22","author":"Mart\u00ednez","year":"1983","journal-title":"Phytochemistry"},{"key":"B81","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00709-022-01761-2","article-title":"Investigating the phytotoxic potential of verbesina encelioides: effect on growth and performance of co-occurring weed species","volume":"260","author":"Mehal","year":"2023","journal-title":"Protoplasma"},{"key":"B82","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1055\/s-0032-1328542","article-title":"New antibacterial germacrene from Verbesina negrensis","volume":"79","author":"Mora","year":"2013","journal-title":"Planta Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2174\/2210315511303020009","article-title":"Chemical and biological aspects of the genus verbesina","volume":"3","author":"Mora","year":"2013","journal-title":"Nat. Prod. J."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1177\/1934578X1501000743","article-title":"Chemical composition and in vitro antibacterial activity of the essential oil of Verbesina negrensis from the Venezuelan andes","volume":"10","author":"Mora","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1021\/np50018a029","article-title":"Isolation of galegine from verbesina enceloiodes","volume":"44","author":"Oelrichs","year":"1981","journal-title":"J. Nat. Prod."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1177\/1934578X1000500801","article-title":"Phytochemical investigation of Verbesina turbacensis kunth: trypanosome cysteine protease inhibition by (\u2013)-Bornyl esters","volume":"5","author":"Ogungbe","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"B87","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11104-011-1100-8","article-title":"Nematicidal activity of Verbesina encelioides against the root-knot nematode Meloidogyne javanica and effects on plant growth","volume":"355","author":"Oka","year":"2012","journal-title":"Plant Soil"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/S0031-9422(00)82546-7","article-title":"Elemanolides from verbesina seattonii","volume":"24","author":"Ortega","year":"1985","journal-title":"Phytochemistry"},{"key":"B89","doi-asserted-by":"publisher","first-page":"16808","DOI":"10.1073\/pnas.1300118110","article-title":"How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function","volume":"110","author":"Otero","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2307\/2656762","article-title":"Phylogenetic relationships of subtribe ecliptinae (asteraceae: heliantheae) based on chloroplast DNA restriction site data","volume":"86","author":"Panero","year":"1999","journal-title":"Am. J. Bot."},{"key":"B91","article-title":"Effect of Agarista mexicana and verbesina persicifoh on blood glucose level of normoglycaemic and alloxan-diabetic mice and rats","author":"Perez","year":"1996"},{"key":"B92","doi-asserted-by":"publisher","first-page":"5242","DOI":"10.1039\/c6ra28587b","article-title":"First total synthesis of the only known 2-isopropyliden-2: h -benzofuran-3-one isolated from V. luetzelburgii","volume":"7","author":"Pergomet","year":"2017","journal-title":"RSC Adv."},{"key":"B93","doi-asserted-by":"publisher","first-page":"38","DOI":"10.29057\/aactm.v12i12.15183","article-title":"Verbesina crocata como agente biosint\u00e9tico de nanopart\u00edculas de plata\/cloruro de plata y su evaluaci\u00f3n en pl\u00e1ntulas de r\u00e1bano","volume":"12","author":"Ram\u00edrez-Herrera","year":"2025","journal-title":"T\u00f3picos Investig. Ciencias Tierra Mater."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1021\/acs.jnatprod.7b00868","article-title":"Eudesmane sesquiterpenes from Verbesina lanata with inhibitory activity against grapevine downy mildew","volume":"80","author":"Ramseyer","year":"2017","journal-title":"J. Nat. Prod."},{"key":"B95","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/jse.12681","article-title":"The importance of the Mexican taxa of asteraceae in the family phylogeny","volume":"59","author":"Rivera","year":"2021","journal-title":"J. Syst. Evol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/plants10030475","article-title":"Quantitative analysis of rutin by hptlc and in vitro antioxidant and antibacterial activities of phenolic-rich extracts from Verbesina sphaerocephala","volume":"10","author":"Rodr\u00edguez-Valdovinos","year":"2021","journal-title":"Plants"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.3390\/plants13192791","article-title":"Antioxidant and antifungal activities and characterization of phenolic compounds using ultra-high performance liquid chromatography and mass spectrometry (UPLC-MS) of aqueous extracts and fractions from Verbesina sphaerocephala stems","volume":"13","author":"Rodr\u00edguez-Valdovinos","year":"2024","journal-title":"Plants"},{"key":"B98","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1021\/jo00221a044","article-title":"Verocephol, a unique amorphane sesquiterpene.gamma.-lactol","volume":"50","author":"Salmon","year":"1985","journal-title":"J. Org. Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.22037\/ijpr.2019.14491.12430","article-title":"Anti-trypanosoma cruzi activity of extracts from argentinean Asteraceae species","volume":"18","author":"Selener","year":"2019","journal-title":"Iran. J. Pharm. Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1021\/acs.jnatprod.5b00908","article-title":"Texas native plants yield compounds with cytotoxic activities against prostate cancer cells","volume":"79","author":"Shaffer","year":"2016","journal-title":"J. Nat. Prod."},{"key":"B101","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s13337-018-0495-8","article-title":"A new variant of croton yellow vein mosaic virus naturally infecting wild sunflower in India","volume":"29","author":"Sharma","year":"2018","journal-title":"Virus Disease"},{"key":"B102","first-page":"113","article-title":"Pharmacognostical and preliminary phytochemical investigations on Verbesina encelioides benth. Roots","volume":"4","author":"Sindhu","year":"2010","journal-title":"J. Herb. Med. Toxicol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"16","DOI":"10.20510\/ukjpb\/6\/i6\/179229","article-title":"Chemical Constituents From the Aerial Roots of Ficus benghalensis L., Leaves of Nyctanthes arbor-tristis L. and Roots of Verbesina encelioides (Cav.) Benth. et Hook. f","volume":"6","author":"Sultana","year":"2018","journal-title":"J. Pharm. Biosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1429494","DOI":"10.3389\/fpls.2024.1429494","article-title":"Comparative plastome assembly of the yellow ironweed (Verbesina alternifolia) using nanopore and illumina reads","volume":"15","author":"Tomasello","year":"2024","journal-title":"Front. Plant Sci."},{"key":"B105","first-page":"76","article-title":"Why is Verbesina virginica (frostweed, asteraceae) not found in grasslands?","volume":"98","author":"Van Auken","year":"2016","journal-title":"Phytologia"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e79853","DOI":"10.1371\/journal.pone.0079853","article-title":"Fire promotes pollinator visitation: implications for ameliorating declines of pollination services","volume":"8","author":"Van Nuland","year":"2013","journal-title":"PLoS One"},{"key":"B107","doi-asserted-by":"publisher","first-page":"29","DOI":"10.17268\/agroind.sci.2022.01.04","article-title":"Verbesina sphaerocephala and Verbesina fastigiata extracts promote the pot development of Fragaria ananassa","volume":"12","author":"Velasco-Ram\u00edrez","year":"","journal-title":"Agroindustrial Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3390\/horticulturae8070652","article-title":"The impact of aqueous extracts of Verbesina sphaerocephala and Verbesina fastigiata on germination and growth in Solanum lycopersicum and Cucumis sativus seedlings","volume":"8","author":"Velasco-Ram\u00edrez","year":"","journal-title":"Horticulturae"},{"key":"B109","doi-asserted-by":"publisher","first-page":"575","DOI":"10.14719\/PST.2019.6.SP1.675","article-title":"Antioxidative properties of isolated saponins of Verbesina encelioides (cav.) benth. and hook. F. Ex gray and SEM studies of synthesized green nanoparticles for acne management","volume":"6","author":"Verma","year":"2019","journal-title":"Plant Sci. Today"},{"key":"B110","doi-asserted-by":"publisher","first-page":"12602","DOI":"10.1007\/s12035-025-05056-4","article-title":"Spirilloxanthin from Verbesina encelioides flower extract has neuroprotective benefits in scopolamine-induced memory impaired rats that resemble alzheimer\u2019s disease","volume":"62","author":"Verma","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"259","DOI":"10.21829\/abm100.2012.37","article-title":"La familia Asteraceae en la Flora del Baj\u00edo y de regiones adyacentes","volume":"100","author":"Villase\u00f1or","year":"2012","journal-title":"Acta Bot. Mex."},{"key":"B112","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0031-9422(00)91241-X","article-title":"Rhamnocitrin-3-glucuronid in verbesina myricephala","volume":"13","author":"Wagner","year":"1974","journal-title":"Phytochemistry"},{"key":"B113","unstructured":"A product and process of extraction of asteraceae plant material for treatment of dermatophyte infections\n          \n          \n            \n              Wankhade\n              S.\n            \n            \n              Rai\n              M.\n            \n          \n          \n          2010"},{"key":"B114","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1039\/B606168K","article-title":"Eudesmane sesquiterpenoids from the asteraceae family","volume":"23","author":"Wu","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"e35270","DOI":"10.1016\/j.heliyon.2024.e35270","article-title":"Eudesmane-type sesquiterpenoids: structural diversity and biological activity","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1021\/np900180y","article-title":"Verbesinosides A\u2212F, 15,27-Cyclooleanane saponins from the American native plant Verbesina virginica","volume":"72","author":"Xu","year":"2009","journal-title":"J. Nat. Prod."},{"key":"B117","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cclet.2010.01.009","article-title":"Two new eudesmane derivatives from Verbesina virginica","volume":"21","author":"Xu","year":"2010","journal-title":"Chin. Chem. Lett."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines5030040","article-title":"In vitro testing of crude natural plant extracts from Costa Rica for their ability to boost innate immune cells against Staphylococcus aureus","volume":"5","author":"Yaseen","year":"2017","journal-title":"Biomedicines"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1899545\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:54:17Z","timestamp":1787921657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1899545\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":118,"alternative-id":["10.3389\/fphar.2026.1899545"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1899545","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"article-number":"1899545"}}