{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:06:54Z","timestamp":1788937614985,"version":"build-2803163510"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chemotherapy-induced cognitive impairment, commonly referred to as \u201cchemobrain\u201d, represents a frequent and distressing complication of cancer therapy. Doxorubicin (DOX), a widely used chemotherapeutic agent, contributes to these deficits partly through mechanisms involving oxidative stress, inflammatory cascades, and disruption of glutamate homeostasis, but unfortunately, the precise role of altered glutamate transport and neurotrophic signaling remains poorly addressed. Lurasidone (LURA), an atypical antipsychotic, exhibits potent 5-HT7 receptor antagonism and pro-cognitive properties, making it a strong candidate to counteract these deficits. However, its potential to rescue glutamate homeostasis and neuroplasticity pathways in chemobrain has not been explored. This study investigated whether LURA could counteract DOX-induced chemobrain by restoring CREB\/BDNF\/Glt-1 signaling and re-establishing glutamate homeostasis in the hippocampus and prefrontal cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-eight male Wistar rats were assigned to control, LURA, DOX, or DOX\/LURA groups. Behavioral performance was assessed using the open field, novel object recognition, and Morris water maze tests. Hippocampal and prefrontal tissues were evaluated for protein expression of the CREB\/BDNF\/Glt-1 pathway, glutamate and GABA levels, oxidative stress indices, and histopathological and immunohistochemical markers of neurodegeneration, apoptosis, and astrocytic activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DOX administration resulted in pronounced cognitive decline, oxidative stress, neuroinflammation, neuronal loss, and substantial downregulation of CREB\/BDNF\/Glt-1 signaling, accompanied by elevated glutamate and reduced GABA levels. LURA co-treatment markedly improved behavioral outcomes, reinstated CREB\/BDNF\/Glt-1 expression, ameliorated glutamate\/GABA balance, and reduced neurodegeneration, caspase-3 activation, and astrocytic reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study provides the first evidence that lurasidone mitigates doxorubicin-induced chemobrain. This neuroprotective effect is associated with the restoration of glutamate homeostasis and the upregulation of hippocampal and prefrontal CREB\/BDNF\/Glt-1 signaling, highlighting lurasidone as a promising therapeutic option for chemotherapy-induced cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1901510","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:30:55Z","timestamp":1788935455000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lurasidone ameliorates doxorubicin-induced chemobrain in male Wistar rats: involvement of the hippocampal and prefrontal cortex CREB\/BDNF\/Glt-1 axis and glutamate homeostasis"],"prefix":"10.3389","volume":"17","author":[{"given":"Mohamed Z.","family":"Habib","sequence":"first","affiliation":[{"name":"Basic Medical Sciences Department, Faculty of Dentistry, Al-Ahliyya Amman University (AAU)","place":["Amman, Jordan"]},{"name":"Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif A.","family":"Kamar","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences Department, Faculty of Dentistry, Al-Ahliyya Amman University (AAU)","place":["Amman, Jordan"]},{"name":"Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Atef","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences Department, Faculty of Dentistry, Al-Ahliyya Amman University (AAU)","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin M.","family":"Aboul-Ela","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]},{"name":"Biomedical Sciences Department, College of Medicine, Gulf Medical University","place":["Ajman, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Mahmoud Abdelrahim","family":"Elshaer","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan","family":"Moussa","sequence":"additional","affiliation":[{"name":"Histology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran K.","family":"Olama","sequence":"additional","affiliation":[{"name":"Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Elsayed","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed R.","family":"Rabei","sequence":"additional","affiliation":[{"name":"Basic Health Sciences Department, College of Applied Medical Sciences, Qassim University","place":["Buraydah, Saudi Arabia"]},{"name":"Medical Physiology Department, Faculty of Medicine, Mansoura University","place":["Mansoura, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Salama","sequence":"additional","affiliation":[{"name":"College of Dentistry, Gulf Medical University","place":["Ajman, United Arab Emirates"]},{"name":"Pediatric Dentistry Department, Faculty of Dentistry, Cairo University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa M.","family":"Elnahas","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103797","DOI":"10.1016\/j.jpet.2025.103797","article-title":"Lithium, a GSK-3\u03b2 inhibitor, attenuates depression and chemobrain induced by doxorubicin in rats: emphasis on brain BDNF\/TrkB\/Akt\/GSK-3\u03b2\/mTOR\/Nrf2\/HO-1 axis","volume":"393","author":"Aboul-Fotouh","year":"2026","journal-title":"J. Pharmacol. Exper. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1251917","DOI":"10.3389\/fphar.2023.1251917","article-title":"Doxorubicin impairs cognitive function by upregulating AMPAR and NMDAR subunit expression and increasing neuroinflammation, oxidative stress, and apoptosis in the brain","volume":"14","author":"Alhowail","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3390\/molecules30071549","article-title":"Remote co-loading of doxorubicin and hydralazine into PEGylated liposomes: in vitro anti-proliferative effect against breast cancer","volume":"30","author":"Alshaer","year":"2025","journal-title":"Mol. (Basel, Switz.)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e12749","DOI":"10.1111\/ecc.12749","article-title":"Verbal memory in breast cancer patients treated with chemotherapy with doxorubicin and cyclophosphamide","volume":"27","author":"Andryszak","year":"2018","journal-title":"Eur. J. Cancer Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"111503","DOI":"10.1016\/j.pnpbp.2025.111503","article-title":"Cognitive and psychotic effects of ketamine \u201cshort-vs. long-term\u201d therapy in a rat model of depression: hippocampal TrkB\/Akt\/GSK-3\u03b2\/mTOR\/autophagy trajectories","volume":"142","author":"Aref","year":"2025","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"110885","DOI":"10.1016\/j.pnpbp.2023.110885","article-title":"Transcriptomic analyses of rats exposed to chronic mild stress: modulation by chronic treatment with the antipsychotic drug lurasidone","volume":"129","author":"Begni","year":"2024","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4736","DOI":"10.3390\/ijms26104736","article-title":"Different mechanisms in doxorubicin-induced neurotoxicity: impact of BRCA mutations","volume":"26","author":"Bhatt","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.exer.2015.07.022","article-title":"Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress","volume":"140","author":"Biswal","year":"2015","journal-title":"Exp. Eye Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"102531","DOI":"10.1016\/j.eclinm.2024.102531","article-title":"Antipsychotic use during pregnancy and risk of specific neurodevelopmental disorders and learning difficulties in children: a multinational cohort study","volume":"70","author":"Bruno","year":"2024","journal-title":"EClinicalMedicine"},{"key":"B11","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1177\/0269881119895547","article-title":"Effect of lurasidone treatment on chronic mild stress-induced behavioural deficits in male rats: the potential role for glucocorticoid receptor signalling","volume":"34","author":"Calabrese","year":"2020","journal-title":"J. Psychopharmacol. Oxf. Engl."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3390\/ph15111403","article-title":"Lurasidone versus quetiapine for cognitive impairments in young patients with bipolar depression: a randomized, controlled Study","volume":"15","author":"Diao","year":"2022","journal-title":"Pharm. (Basel, Switz.)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"112750","DOI":"10.1016\/j.biopha.2022.112750","article-title":"Impact of 5-HT7 receptor inverse agonism of lurasidone on monoaminergic tripartite synaptic transmission and pathophysiology of lower risk of weight gain","volume":"148","author":"Fukuyama","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1017\/S1461145711000150","article-title":"Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress","volume":"15","author":"Fumagalli","year":"2012","journal-title":"Inter. J. Neuropsychopharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"35765","DOI":"10.1038\/s41598-025-95380-5","article-title":"The chemobrain in breast cancer patients: a systematic review and meta-analysis","volume":"15","author":"Godaert","year":"2025","journal-title":"Sci. Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","article-title":"Neuroinflammatory TNF\u03b1 impairs memory via astrocyte signaling","volume":"163","author":"Habbas","year":"2015","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"104958","DOI":"10.1016\/j.jpet.2026.104958","article-title":"Purmorphamine mitigates 3-nitropropionic acid-induced neurodegeneration via enhancing the brain-derived neurotrophic factor\/protein kinase B\/glycogen synthase kinase-3\u03b2 signaling and attenuation of oxidative\/nitrosative stress, neuroinflammation, and apoptosis","volume":"393","author":"Habib","year":"2026","journal-title":"J. Pharmacol. Exper. Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1007\/s00213-021-05977-7","article-title":"Animal models of chemotherapy-induced cognitive decline in preclinical drug development","volume":"238","author":"John","year":"2021","journal-title":"Psychopharmacology"},{"key":"B19","article-title":"Doxorubicin","volume-title":"Statpearls","author":"Johnson-Arbor","year":"2026"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/glia.22679","article-title":"Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes","volume":"62","author":"Karki","year":"2014","journal-title":"Glia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s41100-020-00268-x","article-title":"Understanding Serotonin 5-HT2A Receptors-regulated cellular and molecular mechanisms of chronic kidney diseases","volume":"6","author":"Kaur","year":"2020","journal-title":"Ren. Replace. Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"30324","DOI":"10.18632\/oncotarget.25718","article-title":"Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (\u201cchemobrain\u201d)","volume":"9","author":"Keeney","year":"2018","journal-title":"Oncotarget"},{"key":"B23","doi-asserted-by":"publisher","first-page":"111709","DOI":"10.1016\/j.intimp.2024.111709","article-title":"Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of canagliflozin against methotrexate-induced cognitive impairment","volume":"130","author":"Khedr","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1581524","DOI":"10.3389\/fpsyt.2025.1581524","article-title":"Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos","volume":"16","author":"Li","year":"2025","journal-title":"Front. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00213-015-4128-2","article-title":"Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression","volume":"233","author":"Liu","year":"2016","journal-title":"Psychopharmacology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.euroneuro.2013.12.010","article-title":"Delayed BDNF alterations in the prefrontal cortex of rats exposed to prenatal stress: preventive effect of lurasidone treatment during adolescence","volume":"24","author":"Luoni","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"pyu061","DOI":"10.1093\/ijnp\/pyu061","article-title":"Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex","volume":"18","author":"Luoni","year":"2015","journal-title":"Inter. J. Neuropsychopharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.euroneuro.2016.12.001","article-title":"Chronic lurasidone treatment normalizes GABAergic marker alterations in the dorsal hippocampus of mice exposed to prenatal immune activation","volume":"27","author":"Luoni","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1007\/s00213-025-06834-7","article-title":"Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K\/Akt\/mTOR pathway","volume":"242","author":"Magdy","year":"2025","journal-title":"Psychopharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.rvsc.2021.09.009","article-title":"Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment","volume":"140","author":"Moretti","year":"2021","journal-title":"Res. Veterinary Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"6521","DOI":"10.3390\/ijms25126521","article-title":"Glutamate-mediated excitotoxicity in the pathogenesis and treatment of neurodevelopmental and adult mental disorders","volume":"25","author":"Nicosia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4002","DOI":"10.1111\/bph.14804","article-title":"Lurasidone inhibits NMDA receptor antagonist-induced functional abnormality of thalamocortical glutamatergic transmission via 5-HT7 receptor blockade","volume":"176","author":"Okada","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.2174\/1570159X21666230727140843","article-title":"Cognitive effects of lurasidone and cariprazine: a mini systematic review","volume":"21","author":"Olivola","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"113118","DOI":"10.1016\/j.expneurol.2019.113118","article-title":"Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions","volume":"324","author":"Ongnok","year":"2020","journal-title":"Exp. Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s13311-021-01092-9","article-title":"Donepezil protects against doxorubicin-induced chemobrain in rats via attenuation of inflammation and oxidative stress without interfering with doxorubicin efficacy","volume":"18","author":"Ongnok","year":"2021","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"107559","DOI":"10.1016\/j.neuropharm.2019.03.002","article-title":"The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics","volume":"161","author":"Pajarillo","year":"2019","journal-title":"Neuropharmacology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuropharm.2018.02.013","article-title":"Physical exercise prevents cognitive impairment by enhancing hippocampal neuroplasticity and mitochondrial function in doxorubicin-induced chemobrain","volume":"133","author":"Park","year":"2018","journal-title":"Neuropharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"110945","DOI":"10.1016\/j.intimp.2023.110945","article-title":"Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt\/GSK-3\u03b2\/\u03b2-catenin signaling in Wistar rats","volume":"124","author":"Raafat","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.breast.2017.01.018","article-title":"Cognitive impairment in the first year after breast cancer diagnosis: a prospective cohort study","volume":"32","author":"Ramalho","year":"2017","journal-title":"Breastedinbg. Scotl."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e0246068","DOI":"10.1371\/journal.pone.0246068","article-title":"Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy","volume":"16","author":"Ramandi","year":"2021","journal-title":"PLoS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e71383","DOI":"10.1002\/cam4.71383","article-title":"Chemobrain and cancer survivorship: a scoping review of the literature","volume":"14","author":"Rovito","year":"2025","journal-title":"Cancer Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ibneur.2025.05.017","article-title":"Brain pericytes upregulate glutamate uptake by astrocytes in vitro through sodium-dependent transporter","volume":"19","author":"Sakai","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s00213-022-06140-6","article-title":"Altered responsiveness of the antioxidant system in chronically stressed animals: modulation by chronic lurasidone treatment","volume":"239","author":"Spero","year":"2022","journal-title":"Psychopharmacology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.3332\/ecancer.2025.1958","article-title":"The challenge of chemotherapy-related cognitive impairment: assessing and managing cognitive decline after cancer treatment","volume":"19","author":"Stangler","year":"2025","journal-title":"Ecancermedicalscience"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1073\/pnas.0136555100","article-title":"Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)","volume":"100","author":"Su","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1517\/17460441.2013.815163","article-title":"The preclinical profile of lurasidone: clinical relevance for the treatment of schizophrenia","volume":"8","author":"Tarazi","year":"2013","journal-title":"Expert Opinion Drug Discovery"},{"key":"B50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2017.07.003","article-title":"Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus","volume":"1672","author":"Thomas","year":"2017","journal-title":"Brain Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnsyn.2019.00010","article-title":"Control of long-term plasticity by glutamate transporters","volume":"11","author":"Valtcheva","year":"2019","journal-title":"Front. Synaptic Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1007\/s12035-019-1524-3","article-title":"The ERK pathway: molecular mechanisms and treatment of depression","volume":"56","author":"Wang","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11064-025-04400-3","article-title":"Excitatory amino acid transporters as therapeutic targets in the treatment of neurological disorders: their roles and therapeutic prospects","volume":"50","author":"Zhang","year":"2025","journal-title":"Neurochem. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s13311-023-01360-w","article-title":"Memantine\/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal CREB\/BDNF signaling and glutamate homeostasis","volume":"20","author":"Zohny","year":"2023","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"B55","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.brainres.2004.11.014","article-title":"TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition","volume":"1034","author":"Zou","year":"2005","journal-title":"Brain Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1901510\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:30:57Z","timestamp":1788935457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1901510\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":55,"alternative-id":["10.3389\/fphar.2026.1901510"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1901510","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"article-number":"1901510"}}