{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:57:46Z","timestamp":1790675866042,"version":"4.1.0"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Medicinal plants are widely used to control bleeding and support wound care, but the hemostatic and reparative evidence attributed to a species often derives from different plant parts, extracts, or formulations. This critical narrative review examines the ethnomedicinal, experimental, clinical, safety, and translational evidence for plant-derived preparations reported to modulate one or more stages of the hemostasis-wound-healing axis. Structured searches of PubMed\/MEDLINE, Scopus, and Web of Science were updated through 19 July 2026 using terms related to medicinal plants, coagulation, platelet function, wound healing, formulation, standardization, toxicity, and safety. The literature retained for detailed synthesis encompassed crude extracts, enriched fractions, latex-derived proteases, isolated plant metabolites, hydrogels, nanoparticles, and other formulated materials. Mechanistically, direct evidence was concentrated primarily in fibrinogen-cleaving plant proteases and notoginsenoside Ft1\u2013mediated platelet signaling. In contrast, anti-inflammatory, pro-angiogenic, antimicrobial, and extracellular-matrix-related effects were supported mainly at the extract, fraction, or formulation level. The strength and mechanistic depth of the evidence varied substantially among species, preparations, experimental models, and outcomes, and hemostatic and wound-repair effects were frequently demonstrated using different materials from the same species. Thus, the available evidence supports the hemostasis-wound-healing axis as a useful framework for prioritizing candidates, but current evidence does not support medicinal plants as a uniformly effective therapeutic class. Translation should initially prioritize chemically and biologically standardized topical or locally retained products, component-specific controls, clinically relevant preclinical models, exposure\u2013response and safety characterization, and adequately powered indication-specific trials. Taxonomic validity, material traceability, sustainable sourcing, and ethical governance of traditional knowledge should be integrated from the outset.<\/jats:p>","DOI":"10.3389\/fphar.2026.1902225","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:14:43Z","timestamp":1790673283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant-derived modulators of the hemostasis-wound healing axis: mechanisms, evidence, and translational potential"],"prefix":"10.3389","volume":"17","author":[{"given":"Zoila","family":"Mora-Guzm\u00e1n","sequence":"first","affiliation":[{"name":"SECIHTI, Faculty of Medicine and Surgery, Autonomous University \u201cBenito Ju\u00e1rez\u201d of Oaxaca","place":["Oaxaca, Mexico"]},{"name":"Centro de Investigaci\u00f3n Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca","place":["Oaxaca, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibzan Jahzeel","family":"Salvador Ibarra","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, Hospital General de Zona con Medicina Familiar No. 18","place":["Coahuila de Zaragoza, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Dolores","family":"Chel\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico, Instituto Tecnol\u00f3gico de M\u00e9rida","place":["Yucat\u00e1n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"Elizalde D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Del Socorro","family":"Pina-Canseco","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca","place":["Oaxaca, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"G\u00f3mez Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca","place":["Oaxaca, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez-Campos","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Tecnol\u00f3gico Nacional de M\u00e9xico, Instituto Tecnol\u00f3gico de Oaxaca","place":["Oaxaca, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector Alejandro","family":"Cabrera-Fuentes","sequence":"additional","affiliation":[{"name":"Hospital General de Zona No. 1 Dr. Demetrio Mayoral Pardo, Instituto Mexicano del Seguro Social (IMSS)","place":["Oaxaca, Mexico"]},{"name":"R&D Group, Vice Presidency for Scientific Research and Innovation, Imam Abdulrahman Bin Faisal University","place":["Dammam, Saudi Arabia"]},{"name":"Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Tecnol\u00f3gico Nacional de M\u00e9xico, Instituto Tecnol\u00f3gico de Tijuana","place":["Tijuana, Baja California, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Hern\u00e1ndez-Huerta","sequence":"additional","affiliation":[{"name":"SECIHTI, Faculty of Medicine and Surgery, Autonomous University \u201cBenito Ju\u00e1rez\u201d of Oaxaca","place":["Oaxaca, Mexico"]},{"name":"Centro de Investigaci\u00f3n Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca","place":["Oaxaca, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4274\/tjps.galenos.2021.14603","article-title":"In vitro activity of some medicinal plants on blood coagulation","volume":"19","author":"Abdallah","year":"2022","journal-title":"Turk J. 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