{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:05:57Z","timestamp":1790679957196,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Butylphthalide (DL-NBP) is a widely used neuroprotective agent for acute ischemic stroke. Although generally well-tolerated, severe thrombocytopenia as a rare adverse reaction has not been fully recognized. Herein, we report a severe case of probable DL-NBP-associated thrombocytopenia to increase clinical awareness and inform clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 69-year-old male with hypertension was admitted for acute brainstem infarction. His hospitalization was complicated by catastrophic thrombocytopenia (min 1.0 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L), suggestive of a possible immune-mediated thrombocytopenia. Subsequent complications included hypoxemia, pneumonia, occult gastrointestinal blood loss, and muscular venous thrombosis of the right calf, creating complex management challenges. Through multidisciplinary collaboration, multimodal tailored treatment was delivered to balance the risks of stroke recurrence and bleeding: corticosteroids, platelet transfusion, recombinant human thrombopoietin and recombinant human interleukin-11 were administered for presumed immune-mediated thrombocytopenia, and antiplatelet therapy was sequentially modified. The patient\u2019s condition stabilized with normalized platelet counts, and he was transferred for rehabilitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe thrombocytopenia showed a temporal association with DL-NBP treatment. After excluding alternative etiologies, probable DL-NBP-associated thrombocytopenia was considered in this case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1903450","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:10Z","timestamp":1790679190000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Butylphthalide-associated severe thrombocytopenia, a rare adverse drug reaction"],"prefix":"10.3389","volume":"17","author":[{"given":"Chenyi","family":"Gong","sequence":"first","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Feng","sequence":"additional","affiliation":[{"name":"The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengya","family":"Zhu","sequence":"additional","affiliation":[{"name":"Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tmrv.2013.05.005","article-title":"Approach to the diagnosis and management of drug-induced immune thrombocytopenia","volume":"27","author":"Arnold","year":"2013","journal-title":"Transfus. 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