{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T22:19:53Z","timestamp":1787523593267,"version":"build-2736575974"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric data for sulbactam-durlobactam (SUL-DUR) are extremely scarce, and no standard pediatric dosing exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We report a 6-year-old boy with cerebral palsy and epilepsy who developed recurrent ventilator-associated pneumonia caused by OXA-23-producing carbapenem-resistant\n                      <jats:italic>Acinetobacter<\/jats:italic>\n                      baumannii (CRAB).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Due to financial constraints, a reduced-dose SUL-DUR regimen (150\u00a0mg\/kg\/day, q6h, 3-h infusion) was combined with cefoperazone-sulbactam to achieve a total sulbactam dose of 150\u00a0mg\/kg\/day. The patient defervesced within 48\u00a0h, inflammatory markers declined, chest imaging improved markedly, and he was transferred out of the PICU after 12 days of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A PK\/PD-driven low-dose SUL-DUR strategy may represent a feasible and potential cost-saving strategy for pediatric CRAB pneumonia in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1905442","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T22:10:19Z","timestamp":1787523019000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-dose sulbactam-durlobactam for recurrent CRAB pneumonia in a child with cerebral palsy: a Case Report from a resource-limited setting"],"prefix":"10.3389","volume":"17","author":[{"given":"Mengting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children\u2019s Diseases and Birth Defects, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatrics, WCSUH-Tianfu\u00b7Sichuan Provincial Children\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1633982","DOI":"10.3389\/fphar.2025.1633982","article-title":"Sulbactam-durlobactam combination therapy for carbapenem-resistant Acinetobacter baumannii sepsis with cutaneous involvement in an infant with acute monocytic leukemia: a case report","volume":"16","author":"Fu","year":"2025","journal-title":"Front. 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