{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:59:17Z","timestamp":1790848757283,"version":"4.1.0"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    In physiological settings, inflammation is not passively terminated but actively resolved through coordinated endogenous programs. A central component of this response is the biosynthesis of specialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins. These SPMs arise from polyunsaturated fatty acid precursors that are partially shared with those of classical pro-inflammatory mediators, such as prostaglandins and leukotrienes. Rather than broadly suppressing immunity, SPMs promote the restoration of tissue homeostasis by limiting excessive leukocyte recruitment, enhancing efferocytosis, and reprogramming inflammatory responses. Inflammation is a recognized enabler of cancer, contributing to the main hallmarks of tumor progression, such as sustained proliferative signaling, angiogenesis, and immune evasion. A chronically inflamed tumor microenvironment fosters cancer progression in a complex, tumor- and stage-specific manner. This persistent inflammatory context has supported the prescient view of tumors as \u201cwounds that do not heal.\u201d While the pro-tumorigenic functions of inflammatory lipid mediators, such as prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    , are well established, the contribution of defective resolution programs to cancer progression remains less clear. This review examines the lipid mediator networks linking the initiation and resolution of inflammation in solid tumors, focusing on the mechanistic roles of SPMs in the tumor microenvironment and the emerging translational opportunities to restore pro-resolving signaling. This supports a re-evaluation of cancer-associated inflammation from the perspective of failed resolution, opening avenues for therapeutic strategies targeting resolution to mitigate therapy resistance. We develop this idea by bringing together direct and indirect scientific evidence, explicitly distinguished throughout the text and summarized in a dedicated evidence table, and by focusing on a prospective pharmacological scenario. This is a narrative review; its scope, literature search strategy, and limitations are described in Sections 1.1, 1.2, and 8.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1907377","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:41:21Z","timestamp":1790847681000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Specialized pro-resolving mediators and cancer: news and promises from the other side of the moon"],"prefix":"10.3389","volume":"17","author":[{"given":"V.","family":"Gatti","sequence":"first","affiliation":[{"name":"Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, Campus Bio Medico University of Rome","place":["Rome, Italy"]},{"name":"Institute of Translational Pharmacology, National Research Council of Italy (CNR)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Colella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, Campus Bio Medico University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Violante","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, Campus Bio Medico University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, Campus Bio Medico University of Rome","place":["Rome, Italy"]},{"name":"Institute of Translational Pharmacology, National Research Council of Italy (CNR)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cioce","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Molecular Medicine and Biotechnology, Campus Bio Medico University of Rome","place":["Rome, Italy"]},{"name":"Institute of Translational Pharmacology, National Research Council of Italy (CNR)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1111\/bph.16009","article-title":"Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity","volume":"180","author":"Abdalla","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4049\/jimmunol.2300650","article-title":"Modulating the sEH\/EETs axis restrains specialized proresolving mediator impairment and regulates T cell imbalance in experimental periodontitis","volume":"212","author":"Abdalla","year":"2024","journal-title":"J. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev. Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1248547","DOI":"10.3389\/fimmu.2023.1248547","article-title":"Arachidonate 15-lipoxygenase-mediated production of resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion","volume":"14","author":"Aguirre","year":"2023","journal-title":"Front. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1338239","DOI":"10.1080\/2162402X.2017.1338239","article-title":"EP4 antagonism by E7046 diminishes myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity","volume":"6","author":"Albu","year":"2017","journal-title":"Oncoimmunology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"22847","DOI":"10.1074\/jbc.M603766200","article-title":"Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions","volume":"281","author":"Arita","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.4049\/jimmunol.178.6.3912","article-title":"Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation","volume":"178","author":"Arita","year":"2007","journal-title":"J. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12885-016-2466-z","article-title":"The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model","volume":"16","author":"Bellamkonda","year":"2016","journal-title":"BMC Cancer"},{"key":"B10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/CIRCULATIONAHA.106.629907","article-title":"Augmentation of myocardial production of 15-Epi-Lipoxin-A 4 by pioglitazone and atorvastatin in the rat","volume":"114","author":"Birnbaum","year":"2006","journal-title":"Circulation"},{"key":"B11","doi-asserted-by":"publisher","first-page":"757073","DOI":"10.3389\/fonc.2021.757073","article-title":"Lipoxins and resolvins in patients with pancreatic cancer: a preliminary report","volume":"11","author":"Blogowski","year":"2021","journal-title":"Front. Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0003770","DOI":"10.1371\/journal.pntd.0003770","article-title":"Simvastatin and Benznidazole-Mediated prevention of trypanosoma cruzi-Induced endothelial activation: role of 15-epi-lipoxin A4 in the action of simvastatin","volume":"9","author":"Campos-Estrada","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1146\/annurev.med.57.121304.131253","article-title":"NSAIDs and cancer prevention: targets downstream of COX-2","volume":"58","author":"Cha","year":"2007","journal-title":"Annu. Rev. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1182\/blood.2018886317","article-title":"Resolvin D4 attenuates the severity of pathological thrombosis in mice","volume":"134","author":"Cherpokova","year":"2019","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","first-page":"842","DOI":"10.4049\/jimmunol.1601650","article-title":"Novel resolvin D2 receptor axis in infectious inflammation","volume":"198","author":"Chiang","year":"2017","journal-title":"J. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1042\/EBC20200018","article-title":"Specialized pro-resolving mediator network: an update on production and actions","volume":"64","author":"Chiang","year":"2020","journal-title":"Essays Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s13046-021-02118-y","article-title":"Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma","volume":"40","author":"Cioce","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1172\/JCI67484","article-title":"Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis","volume":"123","author":"Cools-Lartigue","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"18232","DOI":"10.1073\/pnas.1308253110","article-title":"Ligand-specific conformational change of the G-protein\u2013coupled receptor ALX\/FPR2 determines proresolving functional responses","volume":"110","author":"Cooray","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"119186","DOI":"10.1016\/j.biopha.2026.119186","article-title":"Cannabinoid receptors orchestrate distinct anti-tumour pathways in gastric cancer via and beyond specialized pro-resolving mediators","volume":"197","author":"Costanzo","year":"2026","journal-title":"Biomed. Pharmacother."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1182\/blood-2012-04-423525","article-title":"Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators","volume":"120","author":"Dalli","year":"2012","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1096\/fj.14-268441","article-title":"Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways","volume":"29","author":"Dalli","year":"2015","journal-title":"FASEB J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"12232","DOI":"10.1073\/pnas.1607003113","article-title":"Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages","volume":"113","author":"Dalli","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev-pathol-012615-044359","article-title":"Obesity, inflammation, and cancer","volume":"11","author":"Deng","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"104049","DOI":"10.1016\/j.xphs.2025.104049","article-title":"Delivery systems for incorporation of specialized pro-resolving mediators","volume":"115","author":"de Azevedo","year":"2026","journal-title":"J. Pharm. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"eabl5420","DOI":"10.1126\/sciadv.abl5420","article-title":"Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer","volume":"8","author":"De Matteis","year":"2022","journal-title":"Sci. Adv."},{"key":"B75","doi-asserted-by":"publisher","first-page":"106833","DOI":"10.1016\/j.prostaglandins.2024.106833","article-title":"Anti-inflammatory actions of aspirin-triggered resolvin D1 (AT-RvD1) in bronchial epithelial cells stimulated by cigarette smoke extract","volume":"172","author":"de Oliveira","year":"2024","journal-title":"Prostagl. Other Lipid Mediat"},{"key":"B86","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.ajpath.2018.01.004","article-title":"Identification and complete stereochemical assignments of the new resolvin conjugates in tissue regeneration in human tissues that stimulate proresolving phagocyte functions and tissue regeneration","volume":"188","author":"de la Rosa","year":"2018","journal-title":"Am. J. Pathol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1158\/1535-7163.MCT-21-0414","article-title":"NAP1051, a lipoxin A4 biomimetic analogue, demonstrates antitumor activity against the tumor microenvironment","volume":"20","author":"Dong","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1007\/s12013-024-01299-5","article-title":"Resolvin D1 inhibits IL-6-Induced epithelial-mesenchymal transition of colorectal cancer cells by targeting IL-6\/STAT3 signaling","volume":"82","author":"Du","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.ajpath.2026.04.017","article-title":"Resolvin E1 and maresin 1 attenuate nucleotide-binding oligomerization domain-like receptor protein 3-Associated inflammation and invasion in oral squamous cell carcinoma","volume":"196","author":"Durmus","year":"2026","journal-title":"Am. J. Pathol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/2326-6066.CIR-14-0209","article-title":"Tumors: wounds that do not heal-redux","volume":"3","author":"Dvorak","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"101165","DOI":"10.1016\/j.plipres.2022.101165","article-title":"Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the understanding of their biosynthesis, structures, and functions","volume":"86","author":"Dyall","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1200\/JCO.2016.71.3743","article-title":"Phase III randomized, placebo-controlled, double-blind trial of celecoxib in addition to standard chemotherapy for advanced Non\u2013small-cell lung cancer with Cyclooxygenase-2 overexpression: CALGB 30801 (alliance)","volume":"35","author":"Edelman","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1432-1033.1991.tb16137.x","article-title":"On the mechanism of transcellular lipoxin formation in human platelets and granulocytes","volume":"199","author":"Edenius","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1172\/JCI0214869","article-title":"Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo","volume":"109","author":"Fabre","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/biology9120434","article-title":"Prostaglandin E2 and cancer: insight into tumor progression and immunity","volume":"9","author":"Finetti","year":"2020","journal-title":"Biol. (Basel)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"107670","DOI":"10.1016\/j.pharmthera.2020.107670","article-title":"Carcinogenesis: failure of resolution of inflammation?","volume":"218","author":"Fishbein","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e70077","DOI":"10.1002\/cam4.70077","article-title":"Systemic administration of resolvin D1 reduces cancer-induced bone pain in mice: lack of sex dependency in pain development and analgesia","volume":"13","author":"Flippen","year":"2024","journal-title":"Cancer Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e00463","DOI":"10.14309\/ctg.0000000000000463","article-title":"Chronic pancreatitis is a risk factor for pancreatic cancer, and incidence increases with duration of disease: a systematic review and meta-analysis","volume":"13","author":"Gandhi","year":"2022","journal-title":"Clin. Transl. Gastroenterol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2026.33","article-title":"Lack of resolution of inflammation marks malignant pleural mesothelioma progression","volume":"23","author":"Gatti","year":"2026","journal-title":"Cancer Drug Resist."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.3390\/cancers13194959","article-title":"Superior overall survival in patients with colorectal cancer, regular aspirin use, and combined wild-type PIK3CA and KRAS-mutated tumors","volume":"13","author":"Gebauer","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fphys.2015.00129","article-title":"Curcuminoids and \u03c9-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon \u03b3 production","volume":"6","author":"Halder","year":"2015","journal-title":"Front. Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"704163","DOI":"10.3389\/fimmu.2021.704163","article-title":"Safety and preliminary efficacy of a novel host-modulatory therapy for reducing gingival inflammation","volume":"12","author":"Hasturk","year":"2021","journal-title":"Front. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/5584_2019_363","article-title":"Malignant helicobacter pylori-Associated diseases: Gastric cancer and MALT lymphoma","volume":"1149","author":"Hatakeyama","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"104857","DOI":"10.1016\/j.phrs.2020.104857","article-title":"The role of the LTB4-BLT1 axis in health and disease","volume":"158","author":"He","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"101034","DOI":"10.1016\/j.plipres.2020.101034","article-title":"Maresin-1 resolution with ROR\u03b1 and LGR6","volume":"78","author":"Im","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/nrd2875","article-title":"Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases","volume":"8","author":"Imig","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"B50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.prostaglandins.2006.05.004","article-title":"Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)","volume":"82","author":"Inceoglu","year":"2007","journal-title":"Prostagl. Other Lipid Mediat"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.1167\/iovs.08-2462","article-title":"Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators","volume":"50","author":"Jin","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.ajpath.2022.07.004","article-title":"Resolvin E1 reduces tumor growth in a xenograft model of lung cancer","volume":"192","author":"Kantarci","year":"2022","journal-title":"Am. J. Pathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e2314085121","DOI":"10.1073\/pnas.2314085121","article-title":"Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase","volume":"121","author":"Kelly","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"106479","DOI":"10.1016\/j.prostaglandins.2020.106479","article-title":"Intrathecal administration of resolvin D1 and E1 decreases hyperalgesia in mice with bone cancer pain: involvement of endocannabinoid signaling","volume":"151","author":"Khasabova","year":"2020","journal-title":"Prostagl. Other Lipid Mediat."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1073\/pnas.0907342107","article-title":"Resolvin D1 binds human phagocytes with evidence for proresolving receptors","volume":"107","author":"Krishnamoorthy","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1161\/CIRCULATIONAHA.117.032801","article-title":"ERV1\/ChemR23 signaling protects against atherosclerosis by modifying oxidized low-density lipoprotein uptake and phagocytosis in macrophages","volume":"138","author":"Laguna-Fernandez","year":"2018","journal-title":"Circulation"},{"key":"B57","doi-asserted-by":"publisher","first-page":"702785","DOI":"10.3389\/fimmu.2021.702785","article-title":"Specialized pro-resolving mediators mitigate cancer-related inflammation: role of tumor-associated macrophages and therapeutic opportunities","volume":"12","author":"Lavy","year":"2021","journal-title":"Front. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1016\/j.biocel.2013.09.018","article-title":"Resolvin D1 inhibits TGF-\u03b21-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor\/formyl peptide receptor 2 and GPR32","volume":"45","author":"Lee","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/89759","article-title":"Lipid mediator class switching during acute inflammation: signals in resolution","volume":"2","author":"Levy","year":"2001","journal-title":"Nat. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jaci.2019.09.028","article-title":"Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes","volume":"145","author":"Levy","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43556-025-00400-5","article-title":"Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication","volume":"7","author":"Li","year":"2026","journal-title":"Mol. Biomed."},{"key":"B62","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1039\/D5FO05648A","article-title":"Therapeutic effects of selenium-enriched rapeseed against triple-negative breast cancer: involvement of resolvin D5 activation and IL-17 signaling inhibition","volume":"17","author":"Lin","year":"2026","journal-title":"Food Funct."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.3390\/cancers14143333","article-title":"The impact of resolution of inflammation on tumor microenvironment: exploring new ways to control cancer progression","volume":"14","author":"Liotti","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3892\/ijmm.2016.2721","article-title":"Aspirin-triggered resolvin D1 inhibits TGF-\u03b21-induced EMT through the inhibition of the mTOR pathway by reducing the expression of PKM2 and is closely linked to oxidative stress","volume":"38","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.7150\/jca.32456","article-title":"Colorectal cancer is associated with a deficiency of lipoxin A 4, an endogenous anti-inflammatory mediator","volume":"10","author":"Liu","year":"2019","journal-title":"J. Cancer"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.3892\/etm.2018.6651","article-title":"Resolvin D1 inhibits the proliferation of lipopolysaccharide-treated HepG2 hepatoblastoma and PLC\/PRF\/5 hepatocellular carcinoma cells by targeting the MAPK pathway","volume":"23","author":"Lu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.3390\/cells10092340","article-title":"Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines","volume":"10","author":"Malkov","year":"2021","journal-title":"Cells"},{"key":"B68","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1096\/fj.14-264515","article-title":"15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6\/STAT3 signaling pathway","volume":"29","author":"Mao","year":"2015","journal-title":"FASEB J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13046-021-01937-3","article-title":"Resolvin D1 reduces cancer growth stimulating a protective neutrophil-dependent recruitment of anti-tumor monocytes","volume":"40","author":"Mattoscio","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"6473","DOI":"10.3390\/ijms23126473","article-title":"Gene expression of the D-Series resolvin pathway predicts activation of anti-tumor immunity and clinical outcomes in head and neck cancer","volume":"23","author":"Mattoscio","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3325\/cmj.2018.59.97","article-title":"Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma - where do we stand?","volume":"59","author":"Mikola\u0161evi\u0107","year":"2018","journal-title":"Croat. Med. J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"eaax4895","DOI":"10.1126\/sciadv.aax4895","article-title":"Resolution metabolomes activated by hypoxic environment","volume":"5","author":"Norris","year":"2019","journal-title":"Sci. Adv."},{"key":"B76","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1111\/bph.13331","article-title":"Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?","volume":"172","author":"O\u2019Callaghan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1586\/17474124.2014.913478","article-title":"The role of inflammation in cancer of the esophagus","volume":"8","author":"O\u2019Sullivan","year":"2014","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3390\/brainsci13010152","article-title":"Resolvin D2 reduces chronic neuropathic pain and bone cancer pain via spinal inhibition of IL-17 secretion, CXCL1 release and astrocyte activation in mice","volume":"13","author":"Pang","year":"2023","journal-title":"Brain Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"107879","DOI":"10.1016\/j.pharmthera.2021.107879","article-title":"Resolution of inflammation: an organizing principle in biology and medicine","volume":"227","author":"Panigrahy","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ki.1995.184","article-title":"Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis","volume":"47","author":"Papayianni","year":"1995","journal-title":"Kidney Int."},{"key":"B81","doi-asserted-by":"publisher","first-page":"117662","DOI":"10.1016\/j.bcp.2025.117662","article-title":"Eicosanoids and inflammation: a delicate balance of pro-inflammatory and pro-resolving mediators","volume":"245","author":"Park","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3389\/fphar.2018.01273","article-title":"Lipoxin and resolvin receptors transducing the resolution of inflammation in cardiovascular disease","volume":"9","author":"Pirault","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e1293213","DOI":"10.1080\/2162402X.2017.1293213","article-title":"Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways","volume":"6","author":"Prevete","year":"2017","journal-title":"Oncoimmunology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/imcb.70076","article-title":"Unpacking the lipid-immune axis in health and disease","volume":"104","author":"Raeisi","year":"2026","journal-title":"Immunol. Cell Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1002\/sctm.19-0078","article-title":"Proresolving lipid mediators and receptors in stem cell biology: concise review","volume":"8","author":"Romano","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","article-title":"Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials","volume":"377","author":"Rothwell","year":"2011","journal-title":"Lancet"},{"key":"B88","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fimmu.2012.00107","article-title":"Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer","volume":"3","author":"Rubin","year":"2012","journal-title":"Front. Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"175257","DOI":"10.1016\/j.ejphar.2022.175257","article-title":"Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor","volume":"934","author":"S\u00e4fholm","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S1734-1140(10)70306-6","article-title":"Transcellular biosynthesis of eicosanoids","volume":"62","author":"Sala","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"7064","DOI":"10.1038\/ncomms8064","article-title":"Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth","volume":"6","author":"Satpathy","year":"2015","journal-title":"Nat. Commun."},{"key":"B92","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.canlet.2018.01.072","article-title":"Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer","volume":"420","author":"Schnittert","year":"2018","journal-title":"Cancer Lett."},{"key":"B93","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"B94","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1172\/JCI114503","article-title":"Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro","volume":"85","author":"Serhan","year":"1990","journal-title":"J. Clin. Invest."},{"key":"B95","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-19","article-title":"Formation of endogenous \u201cantiinflammatory\u201d lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability","volume":"161","author":"Serhan","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20081880","article-title":"Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions","volume":"206","author":"Serhan","year":"2009","journal-title":"J. Exp. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"8045","DOI":"10.1111\/jcmm.15436","article-title":"Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization","volume":"24","author":"Shan","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/ijc.30424","article-title":"Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression","volume":"140","author":"Sim\u00f5es","year":"2017","journal-title":"Int. J. Cancer"},{"key":"B99","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1136\/gutjnl-2024-332535","article-title":"Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer","volume":"74","author":"Soundararajan","year":"2025","journal-title":"Gut"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1161\/CIRCRESAHA.110.223883","article-title":"Novel lipid mediators promote resolution of acute inflammation","volume":"107","author":"Spite","year":"2010","journal-title":"Circ. Res."},{"key":"B101","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1084\/jem.20170681","article-title":"Resolvins suppress tumor growth and enhance cancer therapy","volume":"215","author":"Sulciner","year":"","journal-title":"J. Exp. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10555-018-9754-9","article-title":"Targeting lipid mediators in cancer biology","volume":"37","author":"Sulciner","year":"","journal-title":"Cancer Metastasis Rev."},{"key":"B103","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.plefa.2009.09.004","article-title":"Anti-inflammatory and pro-resolving properties of benzo-lipoxin A4 analogs","volume":"81","author":"Sun","year":"2009","journal-title":"Prostagl. Leukot. Essent. Fat. Acids"},{"key":"B104","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13046-019-1163-6","article-title":"Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP","volume":"38","author":"Sun","year":"2019","journal-title":"J. Exp. & Clin. Cancer Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/17474124.2018.1473761","article-title":"Diagnosis of cholangiocarcinoma in primary sclerosing cholangitis","volume":"12","author":"Taghavi","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.2174\/0929867331666230727100123","article-title":"Molecular mechanisms and therapeutic potential of resolvins in cancer - current status and perspectives","volume":"31","author":"Tajbakhsh","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"B107","volume-title":"Lipid Mediators & Cancer: Montelukast, SPM, and Almonds. Report no: NCT06887673","year":"2026"},{"key":"B31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034514557331","article-title":"Proresolving nanomedicines activate bone regeneration in periodontitis","volume":"94","author":"Van Dyke","year":"2015","journal-title":"J. Dent. Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1524980","DOI":"10.3389\/fphar.2025.1524980","article-title":"Aspirin-triggered DHA metabolites inhibit angiogenesis","volume":"16","author":"Vara-Messler","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bcp.2014.05.019","article-title":"ATL-1, a synthetic analog of lipoxin, modulates endothelial permeability and interaction with tumor cells through a VEGF-dependent mechanism","volume":"90","author":"Vieira","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fonc.2021.791696","article-title":"The prostaglandin E2 pathway and breast cancer stem cells: evidence of increased signaling and potential targeting","volume":"19","author":"Walker","year":"2022","journal-title":"Front. Oncol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrc2809","article-title":"Eicosanoids and cancer","volume":"10","author":"Wang","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"B113","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/mc.20320","article-title":"Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway","volume":"46","author":"Wang","year":"2007","journal-title":"Mol. Carcinog."},{"key":"B114","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.canlet.2015.04.030","article-title":"Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells","volume":"364","author":"Wang","year":"2015","journal-title":"Cancer Lett."},{"key":"B115","doi-asserted-by":"publisher","first-page":"812171","DOI":"10.3389\/fimmu.2021.812171","article-title":"Pro-resolving factor administration limits cancer progression by enhancing immune response against cancer cells","volume":"12","author":"Wetzel","year":"2021","journal-title":"Front. Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.prostaglandins.2018.05.007","article-title":"Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis","volume":"137","author":"Xu","year":"2018","journal-title":"Prostagl. Other Lipid Mediat"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1177\/1535370219885320","article-title":"ResolvinD1 attenuates high-mobility group box 1-induced epithelial-to-mesenchymal transition in nasopharyngeal carcinoma cells","volume":"244","author":"Yang","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"13316","DOI":"10.1038\/s41598-019-49649-1","article-title":"Adipocytes promote ovarian cancer chemoresistance","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","article-title":"DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1124\/pr.109.001578","article-title":"International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family","volume":"61","author":"Ye","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.neuropharm.2018.07.016","article-title":"Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma","volume":"139","author":"Ye","year":"2018","journal-title":"Neuropharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41401-025-01614-7","article-title":"Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer","volume":"47","author":"Yi","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e1003880","DOI":"10.1371\/journal.pmed.1003880","article-title":"Low-dose aspirin and incidence of lung carcinoma in patients with chronic obstructive pulmonary disease in Hong Kong: a cohort study","volume":"19","author":"Yu","year":"2022","journal-title":"PLoS Med."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.cell.2015.08.015","article-title":"Cyclooxygenase-dependent tumor growth through evasion of immunity","volume":"162","author":"Zelenay","year":"2015","journal-title":"Cell"},{"key":"B125","doi-asserted-by":"publisher","first-page":"321","DOI":"10.2174\/1567202619666220913124627","article-title":"Simvastatin upregulates lipoxin A4 and accelerates neuroinflammation resolution after intracerebral hemorrhage","volume":"19","author":"Zhang","year":"2022","journal-title":"Curr. Neurovasc Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bbrc.2017.12.171","article-title":"RvD1 inhibits TNF\u03b1-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells","volume":"496","author":"Zhong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B127","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1872-034X.2009.00520.x","article-title":"Lipoxin A 4 inhibited hepatocyte growth factor-induced invasion of human hepatoma cells","volume":"39","author":"Zhou","year":"2009","journal-title":"Hepatology Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"6815727","DOI":"10.1155\/2016\/6815727","article-title":"Lipoxin A 4 attenuates cell invasion by inhibiting ROS\/ERK\/MMP pathway in pancreatic cancer","volume":"2016","author":"Zong","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"B129","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13046-017-0655-5","article-title":"Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-\u03b21 signaling in pancreatic cancer","volume":"36","author":"Zong","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1907377\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:41:22Z","timestamp":1790847682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1907377\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":129,"alternative-id":["10.3389\/fphar.2026.1907377"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1907377","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"1907377"}}