{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:07:39Z","timestamp":1788934059723,"version":"build-2803163510"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573454"],"award-info":[{"award-number":["32573454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Breast cancer is the most common malignant tumor in women. Garcinia bracteata fruit is a plant considered to possess high nutritional and medicinal value and is edible in its raw state. Neobractatin (NBT) is a natural compound isolated from Garcinia bracteata. In this study, we select EMT6 cells to establish an EMT6 mouse breast cancer model, and to investigate the tumor suppression effect of NBT\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . CCK-8, cell cloning, flow measurement of cell cycle and apoptosis, LDH, ROS, MMP, q-PCR, WB, HE staining and transcriptome sequencing were used in this study. We find that NBT effectively reduces the viability of EMT6 cells and causes cell cycle arrest.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments have shown that the survival status of mice has generally improved, and the tumor volume has significantly decreased with NBT. NBT ameliorates breast cancer progression by ZBP1-mediated PANoptosis\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    . This study aims to provide a theoretical basis for the development of NBT as a novel anti-breast tumor drug.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1913482","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:58:47Z","timestamp":1788933527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neobractatin mediated ZBP1 induces PANoptosis of xenografted breast tumors"],"prefix":"10.3389","volume":"17","author":[{"given":"Ying","family":"Guo","sequence":"first","affiliation":[{"name":"College of Animal Science &Veterinary Medicine, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]},{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science &Veterinary Medicine, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]},{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department Veterinary Diagnostic Imaging, College of Veterinary Medicine, Konkuk University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Animal Science &Veterinary Medicine, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]},{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science &Veterinary Medicine, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]},{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University","place":["Shenyang, Liaoning Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/ijc.33693","article-title":"Oligometastatic breast cancer: are we there yet?","volume":"149","author":"AlSendi","year":"2021","journal-title":"Int. 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