{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:06:34Z","timestamp":1789117594713,"version":"build-2803163510"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Fetal dextro-transposition of the great arteries (d-TGA) represents a severe cyanotic congenital heart defect. Without effective intracardiac communication, affected neonates face life-threatening hypoxemia and acidosis shortly after birth. Recent investigations have unveiled an additional dimension: d-TGA patients experience compromised cerebral development and inadequate oxygen delivery beginning\n                    <jats:italic>in utero<\/jats:italic>\n                    , subsequently manifesting as executive dysfunction and other neurodevelopmental challenges throughout childhood and adolescence\u2014obstacles that now constitute the primary barriers to favorable long-term outcomes. Advances in prenatal ultrasonographic diagnosis, artificial intelligence-assisted technologies, and integrated multidisciplinary perinatal management have substantially elevated survival rates in recent years. Nevertheless, persistent clinical challenges remain: suboptimal prenatal detection rates, incomplete genetic counseling frameworks, insufficiently delineated perinatal treatment pathways, and delayed interventions for neurodevelopmental impairments. This narrative review integrates current knowledge regarding fetal d-TGA, endeavoring to provide actionable insights for clinical diagnosis, therapeutic strategies, and comprehensive management.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1926005","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:15:15Z","timestamp":1789114515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal dextro-transposition of the great arteries: a narrative review of management and neurodevelopmental outcomes"],"prefix":"10.3389","volume":"17","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"Cd011417","DOI":"10.1002\/14651858.CD011417.pub2","article-title":"Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions","volume":"2","author":"Akkinapally","year":"2018","journal-title":"Cochrane Database Syst. 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