{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:18Z","timestamp":1788415998839,"version":"build-2803163510"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice, and hypersensitivity reactions to them are not uncommon. Although ibuprofen and indobufen have different clinical indications, both exert their effects through cyclooxygenase inhibition, suggesting a potential risk of cross-reactivity. This report describes a 52-year-old female patient who experienced pruritus, facial and eyelid edema, tearing, and ocular itching approximately half an hour after two separate exposures to ibuprofen in the past. During the current hospitalization for cerebral infarction, she received indobufen for antiplatelet therapy and developed similar symptoms\u2014eyelid edema, tearing, and pruritus of the head and face\u2014within approximately 10\u00a0min. The suspected drug was discontinued and antihistamine therapy was administered, following which the symptoms resolved. Subsequent continued use of other concomitant medications, along with antiplatelet therapy with clopidogrel and cilostazol, did not elicit any allergic reactions; this case suggests indobufen as a possible culprit allergen, and its shared COX-1 inhibitory mechanism with ibuprofen\u2014despite their different chemical groups\u2014raises the possibility of cross-reactive hypersensitivity between the two agents, although this inference remains to be confirmed. Although allergic reactions to indobufen are rare in clinical practice, clinicians should remain vigilant about the potential risk of cross-reactivity when prescribing indobufen to patients with a history of NSAID hypersensitivity.<\/jats:p>","DOI":"10.3389\/fphar.2026.1932735","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:47Z","timestamp":1788412907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Suspected NIUAA after indobufen in a patient with ibuprofen allergy: a case report suggesting possible cross-reactivity"],"prefix":"10.3389","volume":"17","author":[{"given":"Long","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neurology, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2165\/00002512-200118050-00007","article-title":"Indobufen: an updated review of its use in the management of atherothrombosis","volume":"5","author":"Bhana","year":"2001","journal-title":"Drugs & Aging"},{"key":"B2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.aller.2012.03.006","article-title":"Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?","volume":"3","author":"\u00c7elik","year":"2013","journal-title":"Allergologia Immunopathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/s1081-1206(10)60409-7","article-title":"Safety of parecoxib in patients with nonsteroidal anti-inflammatory drug-induced urticaria or angioedema","volume":"1","author":"Colanardi","year":"2008","journal-title":"Ann. 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