{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:57:43Z","timestamp":1792065463308,"version":"4.4.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current international hereditary angioedema (HAE) guidelines and treat-to-target recommendations emphasize accurate diagnosis, early on-demand treatment, procedure-related short-term prophylaxis, individualized long-term prophylaxis (LTP), and routine assessment of disease control and quality of life. Evidence on implementation in Latin America remains limited. We aimed to assess concordance between international guidance and the consensus of a selected Latin American expert panel and to identify expert-reported implementation barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A scientific committee developed and externally validated a 74-item questionnaire (domains summarized in\n                      <jats:xref>Supplementary Table S1<\/jats:xref>\n                      ) and conducted a two-round Delphi process among Latin American HAE experts. Consensus items were rated on a nine-point agreement scale, with consensus defined\n                      <jats:italic>a priori<\/jats:italic>\n                      as at least two-thirds of respondents scoring within a three-point band in the agreement or disagreement range. Descriptive items captured expert-reported diagnostic testing, treatment patterns, monitoring practices, and perceived implementation determinants. Consensus findings are summarized as meeting the prespecified threshold; descriptive findings are reported with item-specific n\/N when available. Instrument validation (July-November 2024) showed high inter-rater agreement (Kendall W = 0.84; p &amp;lt; 0.001) and excellent internal consistency (Cronbach alpha = 0.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty experts from 10 countries completed the process (Argentina, Brazil, Chile, Colombia, Ecuador, Mexico, Panama, Peru, Uruguay, and Venezuela). The prespecified consensus threshold was met for core biochemical diagnostic work-up, selective genetic evaluation, first-line targeted LTP (pdC1-INH, lanadelumab, and berotralstat), continued availability of on-demand therapy, routine monitoring, and management of special populations. The principal expert-reported implementation signal was limited feasibility: frequent or constant prophylaxis-supply interruptions were reported by 19\/30 experts (63%), including 13\/23 (57%) practicing in settings where public or insurance coverage was reported. Cost (19\/30; 63%) and medicine availability (8\/30; 27%) were the most frequently reported barriers. These reports were not independently verified against reimbursement, procurement, formulary, or inventory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within this selected panel, expert consensus was broadly concordant with international HAE guidance. Panelists reported barriers involving diagnostic testing, financing, medicine availability, and continuity of supply; however, these findings are perceptions and reported practices, not representative national or regional estimates or audited health-system data. They identify candidate implementation priorities that require confirmation through patient-level registries and objective access data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1933477","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:40:23Z","timestamp":1790833223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hereditary angioedema in Latin America: international recommendations, expert consensus, and reported implementation barriers"],"prefix":"10.3389","volume":"17","author":[{"given":"Guillermo Arturo","family":"Guidos-Fogelbach","sequence":"first","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, SEPI\/ENMH","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Aida","family":"Velasco-Medina","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department, Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya Helena","family":"Campos-Romero","sequence":"additional","affiliation":[{"name":"Hospital Central Sur de Alta Especialidad","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital General IEESS Portoviejo","place":["Manab\u00ed, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Albarr\u00e1n-God\u00ednez","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department, Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bonifacino","sequence":"additional","affiliation":[{"name":"Unidad Integral de Alergia","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Cl\u00ednica SANNA el Golf de San Isidro","place":["Lima, Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Cherrez-Ojeda","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo","place":["Samborond\u00f3n, Ecuador"]},{"name":"Respiralab Research Group","place":["Guayaquil, Ecuador"]},{"name":"Charit\u00e9 \u2013 University Medical Center Berlin, a corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, Institute of Allergology","place":["Berlin, Germany"]},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herberto Jos\u00e9","family":"Chong-Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Parana Hospital de Clinicas","place":["Curitiba, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Chorzepa","sequence":"additional","affiliation":[{"name":"Sanatorio Parque","place":["Rosario, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Craig","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania","place":["Philadelphia, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libia Susana","family":"Diez","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos Fern\u00e1ndez de","family":"C\u00f3rdova-Aguirre","sequence":"additional","affiliation":[{"name":"Hospital del R\u00edo","place":["Cuenca, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de los Andes","place":["Las Condes, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Grau-Tanabe","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Alemana","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Rosario","family":"Grauert","sequence":"additional","affiliation":[{"name":"Hospital Central de las Fuerzas Armadas","place":["Montevideo, Uruguay"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anete S","family":"Grumach","sequence":"additional","affiliation":[{"name":"Clinical Immunology, Centro Universit\u00e1rio Faculdade de Medicina ABC","place":["Santo Andr\u00e9, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Josviack","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Respiratoria","place":["SantaF\u00e9, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Jesus","family":"L\u00f3pez-Tiro","sequence":"additional","affiliation":[{"name":"Hospital Regional Licenciado Adolfo L\u00f3pez Mateos","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Mar\u00eda","family":"Madrigal-Beas","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Especialidades del CMNO, IMSS","place":["Guadalajara, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Mansour","sequence":"additional","affiliation":[{"name":"Allergy and Immunology, Department of Internal Medicine, School of Medical Scieces, University of Campinas\/UNICAMP","place":["Campinas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Matta-Campos","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional, SXXI, IMSS","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Morales","sequence":"additional","affiliation":[{"name":"Unidad Alergologica","place":["Medellin, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca Mar\u00eda del Refugio","family":"Morfin-Maciel","sequence":"additional","affiliation":[{"name":"Hospital San \u00c1ngel Inn","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Agustina","family":"Nieto-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatr\u00eda","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Olivares","sequence":"additional","affiliation":[{"name":"Unidad Alergologica","place":["Medellin, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Enrique","family":"Pi\u00f1eyro-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Clinica de ISSSTE Especialidades Dr. Pedro Barcena Hiriart","place":["San Luis Potosi, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n Dar\u00edo","family":"Ram\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Italiano Regional del Sur","place":["Bah\u00eda Blanca, Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Mario","family":"S\u00e1nchez-Caraballo","sequence":"additional","affiliation":[{"name":"Clinic \u201cIPS Universitaria\u201d, University of Antioquia","place":["Medellin, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Sarrazola-Sanjuan","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Grupo GIPPAM, Universidad de Pamplona","place":["C\u00facuta, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joselit","family":"Torres","sequence":"additional","affiliation":[{"name":"Asthma, Allergy and Immunology, Vargas Hospital Caracas","place":["Caracas, Venezuela"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Vargas-Cama\u00f1o","sequence":"additional","affiliation":[{"name":"Centro Medico Nacional 20 de Noviembre","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Diagn\u00f3stico Meeks","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Valle","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho Universidade Federal do Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Zwiener","sequence":"additional","affiliation":[{"name":"Servicio de Alergia e Inmunolog\u00eda Cl\u00ednica, Hospital Universitario Austral","place":["Pilar, Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1001\/jama.2018.16773","article-title":"Effect of lanadelumab compared with placebo on prevention of hereditary angioedema attacks: a randomized clinical trial","volume":"320","author":"Banerji","year":"2018","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13223-024-00903-w","article-title":"The complexities of decision-making associated with on-demand treatment of hereditary angioedema (HAE) attacks","volume":"20","author":"Betschel","year":"2024","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra1808012","article-title":"Hereditary angioedema","volume":"382","author":"Busse","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA Medical Advisory Board 2020 guidelines for the management of hereditary angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1186\/s13023-025-03739-8","article-title":"Unmet needs in hereditary angioedema: an international survey of physicians","volume":"20","author":"Buttgereit","year":"2025","journal-title":"Orphanet J. Rare Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"238","DOI":"10.18176\/jiaci.0875","article-title":"Expert review and consensus on the treat-to-target management of hereditary angioedema: from scientific evidence to clinical practice","volume":"33","author":"Caballero","year":"2023","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000553023","article-title":"Prevalence and incidence of hereditary angioedema: a systematic literature review","volume":"22","author":"Craig","year":"2026","journal-title":"Int. Arch. Allergy Immunol."},{"key":"B8","volume-title":"Latin American Delphi Consensus Report on Hereditary Angioedema: Diagnosis, long-term Prophylaxis, and Implementation Barriers","year":"2025"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1111\/all.70207","article-title":"International Guideline on the diagnosis and management of pediatric patients with hereditary angioedema","volume":"81","author":"Farkas","year":"2026","journal-title":"Allergy"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1016\/j.jaip.2025.08.026","article-title":"Insights from the first 820 patients from the Brazilian multicenter registry of hereditary angioedema: the key role of genetic testing and targeted therapies","volume":"13","author":"Ferriani","year":"2025","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.alit.2020.07.008","article-title":"Management of hereditary angioedema in Japan: focus on icatibant for the treatment of acute attacks","volume":"70","author":"Hide","year":"2021","journal-title":"Allergol. Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1413547","DOI":"10.3389\/fimmu.2024.1413547","article-title":"Centralized care model for hereditary angioedema overcomes geographical barriers","volume":"15","author":"Holmes","year":"2024","journal-title":"Front. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13023-022-02360-3","article-title":"The symptom experience of hereditary angioedema (HAE) patients beyond HAE attacks: literature review and clinician interviews","volume":"17","author":"Jean-Baptiste","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13223-025-01008-8","article-title":"From guidelines to global impact: updates to address disparities in hereditary angioedema care","volume":"22","author":"Jindal","year":"2025","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"101400","DOI":"10.1016\/j.waojou.2026.101400","article-title":"Characterization of hereditary angioedema population in Argentina: a nationwide study","volume":"19","author":"Josviak","year":"2026","journal-title":"World Allergy Organ J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1177\/0269216317690685","article-title":"Guidance on Conducting and REporting DElphi Studies (CREDES) in palliative care: recommendations based on a methodological systematic review","volume":"31","author":"J\u00fcnger","year":"2017","journal-title":"Palliat. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e0329585","DOI":"10.1371\/journal.pone.0329585","article-title":"Barriers and promoters to adapting research findings to clinical care in hereditary angioedema in the United States: a qualitative study","volume":"20","author":"Langmack","year":"2025","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12016-021-08839-4","article-title":"The enigma of prodromes in hereditary angioedema (HAE)","volume":"61","author":"Leibovich-Nassi","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1056\/NEJMoa1613627","article-title":"Prevention of hereditary angioedema attacks with a subcutaneous C1 inhibitor","volume":"376","author":"Longhurst","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s12016-024-09006-1","article-title":"Hereditary angioedema attacks in patients receiving long-term prophylaxis: a systematic review","volume":"67","author":"Longhurst","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/00006199-198611000-00017","article-title":"Determination and quantification of content validity","volume":"35","author":"Lynn","year":"1986","journal-title":"Nurs. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/all.15214","article-title":"The international WAO\/EAACI guideline for the management of hereditary Angioedema\u2014The 2021 revision and update","volume":"77","author":"Maurer","year":"2022","journal-title":"Allergy"},{"key":"B23","doi-asserted-by":"publisher","first-page":"100812","DOI":"10.1016\/j.waojou.2023.100812","article-title":"Real-world experience of hereditary angioedema (HAE) in Mexico: a mixed-methods approach to describe epidemiology, diagnosis, and treatment patterns","volume":"16","author":"Nieto","year":"2023","journal-title":"World Allergy Organ J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"101083","DOI":"10.1016\/j.waojou.2025.101083","article-title":"Impact of hereditary angioedema attacks on health-related quality of life and work productivity","volume":"18","author":"O'Connor","year":"2025","journal-title":"World Allergy Organ J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/nur.20147","article-title":"The content validity index: are you sure you know what's being reported? Critique and recommendations","volume":"29","author":"Polit","year":"2006","journal-title":"Res. Nurs. Health"},{"key":"B26","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.anai.2021.09.026","article-title":"Optimization of care for patients with hereditary angioedema living in rural areas","volume":"128","author":"Riedl","year":"2022","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jaip.2024.09.019","article-title":"Disparities in hereditary angioedema in an urban medical district","volume":"13","author":"Trickett","year":"2025","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B28","doi-asserted-by":"publisher","first-page":"101407","DOI":"10.1016\/j.waojou.2026.101407","article-title":"Concurrent hereditary angioedema type I and common variable immunodeficiency presenting as suspected antibiotic hypersensitivity: case report and literature discussion","volume":"19","author":"Urdea","year":"2026","journal-title":"World Allergy Organ J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.29262\/ram.v70i3.1250","article-title":"Hereditary angioedema: patient journey approach in Mexico","volume":"70","author":"Vargas Cama\u00f1o","year":"2023","journal-title":"Rev. Alerg. Mex."},{"key":"B30","doi-asserted-by":"publisher","first-page":"101335","DOI":"10.1016\/j.waojou.2026.101335","article-title":"The 2025 WAO guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities","volume":"19","author":"V\u00e1zquez","year":"2026","journal-title":"World Allergy Organ J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1016\/j.jaip.2021.03.057","article-title":"Randomized trial of the efficacy and safety of berotralstat (BCX7353) as an oral prophylactic therapy for hereditary angioedema: results of APeX-2 through 48 weeks (part 2)","volume":"9","author":"Wedner","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1016\/j.jaip.2020.02.038","article-title":"Validation of the Angioedema Control Test (AECT)\u2014A patient-reported outcome instrument for assessing angioedema control","volume":"8","author":"Weller","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000545808","article-title":"Expert consensus on the diagnosis and treatment of hereditary angioedema in China (2024 edition)","volume":"187","author":"Xu","year":"2026","journal-title":"Int. Arch. Allergy Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1080\/14656566.2025.2509782","article-title":"Hereditary angioedema treatment beyond biologics: current state of preventive and on-demand approaches and new perspectives","volume":"26","author":"Zanichelli","year":"2025","journal-title":"Expert Opin. Pharmacother."},{"key":"B35","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jaci.2020.10.015","article-title":"Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: a randomized, double-blind, placebo-controlled phase 3 trial","volume":"148","author":"Zuraw","year":"2021","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1933477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:39:27Z","timestamp":1792064367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1933477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":35,"alternative-id":["10.3389\/fphar.2026.1933477"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1933477","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"1933477"}}