{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:54Z","timestamp":1790586054782,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Perilla frutescens, an edible medicinal plant from East Asia, produces diverse bioactive phytochemicals with anticancer activity, including perillaldehyde (PAH), rosmarinic acid (RA), luteolin, apigenin, and alpha-linolenic acid (ALA). These compounds exert multi-target anticancer effects through apoptosis, autophagy, and ferroptosis. PAH triggers ferroptosis in gastric cancer via the System Xc-\/GSH\/GPX4 axis and P62-Keap1-Nrf2 pathway, while inducing protective autophagy in colorectal cancer through SRD5A1 and PI3K\/AKT modulation. RA directly binds KRAS(G12C) and suppresses NSCLC via KRAS\/AKT\/ERK, and inhibits stress-induced TNBC metastasis through Src inactivation.\n                    <jats:italic>Perilla<\/jats:italic>\n                    leaf extracts activate Hippo-YAP\/TAZ signaling in breast cancer. ALA-rich perilla seed oil (PSO) mitigates tumorigenesis in colitis-associated colorectal cancer models and restores gut microbial homeostasis. This review synthesizes current molecular evidence on perilla compounds in cancer therapy, focusing on apoptosis-autophagy-ferroptosis crosstalk. The multi-target characteristics position perilla-derived compounds as adjuvant cancer therapy candidates, though bioavailability and clinical translation still challenges remain.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1956245","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:53:03Z","timestamp":1790585583000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive compounds from Perilla frutescens modulate multiple cell death pathways and signaling networks in cancer therapy"],"prefix":"10.3389","volume":"17","author":[{"given":"Hai","family":"Xu","sequence":"first","affiliation":[{"name":"Huangjiahu Hospital, Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Province International Science and Technology Cooperation Base for Innovative Research and Development of Food and Drug Resources and Targeted Delivery","place":["Wuhan, China"]},{"name":"Hubei Shizhen Laboratory, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Liu","sequence":"additional","affiliation":[{"name":"First Clinical College, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huikun","family":"Wu","sequence":"additional","affiliation":[{"name":"Huangjiahu Hospital, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Sabit","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangquan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Science, Hubei University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Oncology Department, Hubei Provincial Hospital of Traditional Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1136\/gutjnl-2021-326362","article-title":"Omega-3 polyunsaturated fatty acids: moving towards precision use for prevention and treatment of colorectal cancer","volume":"71","author":"Aldoori","year":"2022","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3390\/nu18040606","article-title":"Lifelong n-3 PUFA consumption reduces HER2+ mammary tumour growth and alters immune markers compared to safflower- or corn oil-based sources of n-6 PUFA","volume":"18","author":"Ashraf","year":"2026","journal-title":"Nutrients"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1056\/NEJMoa2105281","article-title":"Acquired resistance to KRASG12C inhibition in cancer","volume":"384","author":"Awad","year":"2021","journal-title":"N. 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