{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:54:29Z","timestamp":1791381269178,"version":"4.3.3"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Triple-negative breast cancer remains a formidable clinical challenge owing to its immunosuppressive microenvironment and inherently low immunogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To address this, we developed a multifunctional Pickering emulsion (Fe-PDA-PE-R837) stabilized by iron-doped polydopamine (Fe-PDA) nanoparticles, which function dually as photothermal agents and localized iron donors, while the soybean oil core encapsulates the immunoadjuvant R837. The Fe-PDA nanoparticles exhibited uniform spherical morphology, excellent colloidal stability, and a broad absorption band extending to the NIR region. Upon 808\u00a0nm laser irradiation, the Fe-PDA shell generates local hyperthermia with a photothermal conversion efficiency of 38.5%, disrupts intracellular iron homeostasis to provoke ferroptotic cell death, as evidenced by GSH depletion and MDA accumulation, while the stimuli-responsive release of R837 coupled with immunogenic cell death (ICD) elicits potent local and systemic pro-inflammatory responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      assays demonstrated that the combination treatment achieved \u223c80% cell killing, markedly inhibited cell migration, and significantly upregulated TNF-\u03b1 and IL-12 secretion.\n                      <jats:italic>In vivo<\/jats:italic>\n                      evaluation using the 4T1 murine breast cancer model confirmed that this nanoplatform significantly suppressed primary tumor growth and pulmonary metastasis, with no appreciable systemic toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Collectively, this interfacial engineering strategy underscores the promising translational potential of Pickering emulsion-based nanoplatforms for aggressive solid tumor therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1956784","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:15:01Z","timestamp":1791378901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fe-doped polydopamine pickering emulsion as a nanoplatform for synergistic photothermal-ferroptosis immunotherapy in breast cancer"],"prefix":"10.3389","volume":"17","author":[{"given":"Ling-Yu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Changzhou Cancer Hospital (The Fourth People\u2019s Hospital of Changzhou)","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Changzhou University","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Changzhou Cancer Hospital (The Fourth People\u2019s Hospital of Changzhou)","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Ran","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Changzhou University","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Changzhou Cancer Hospital (The Fourth People\u2019s Hospital of Changzhou)","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Changzhou Cancer Hospital (The Fourth People\u2019s Hospital of Changzhou)","place":["Changzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e011173","DOI":"10.1136\/jitc-2024-011173","article-title":"Topical Tlr7 agonist and radiotherapy in patients with metastatic breast cancer","volume":"13","author":"Adams","year":"2025","journal-title":"J. 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