{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:57:18Z","timestamp":1790675838838,"version":"4.1.0"},"reference-count":123,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Withania somnifera<\/jats:italic>\n                    (WS) is an Ayurvedic botanical which has been extensively studied for thousands of years. Withanolides are the main pharmacologically active ingredients isolated from WS and withaferin A (WA) is the most extensively studied and therapeutically effective withanolide compound. WS and WA have anti-ischemia-reperfusion injury effects. To summarize and investigate the protective roles of WS and WA and their underlying mechanisms in organ ischemia-reperfusion injury, a comprehensive literature search was conducted using databases including PubMed and Web of Science. Relevant\n                    <jats:italic>in vitro<\/jats:italic>\n                    and preclinical regarding WS and WA in the treatment of organ ischemia-reperfusion injury. By analyzing the existing research advances, we found that the anti-organ ischemia-reperfusion injury effects of WS and WA, primarily mediated through anti-apoptosis, anti-oxidative stress, anti-inflammatory, anti-mitochondrial dysfunctions, induction of neuronal regeneration and inhibition of migration. This review systematically summarizes the different roles and mechanisms of WS and WA in organ ischemia-reperfusion injury and provides a basis for future therapeutic investigation of organ ischemia\/reperfusion injury.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1961846","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:13:41Z","timestamp":1790673221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A review of protective effects of Withania somnifera and its bioactive component withaferin A in organ ischemia-reperfusion injury"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiabing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]},{"name":"School of Medicine, Taizhou University","place":["Taizhou, Zhejiang, China"]},{"name":"Zhejiang Key Laboratory of New Drug Development for Central Nervous System Diseases, Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.2174\/1566524023666230418094708","article-title":"The therapeutic effects of withaferin A against cancer: overview and updates","volume":"24","author":"Abeesh","year":"2024","journal-title":"Curr. 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