{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:12:56Z","timestamp":1787155976570,"version":"build-2736575974"},"reference-count":64,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2014.00221","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T10:21:08Z","timestamp":1403605268000},"source":"Crossref","is-referenced-by-count":29,"title":["Tight junction physiology of pleural mesothelium"],"prefix":"10.3389","volume":"5","author":[{"given":"Alexander G.","family":"Markov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Amasheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0034-5687(90)90066-8","article-title":"Solute-coupled liquid absorption from the pleural space","volume":"81","author":"Agostoni","year":"1990","journal-title":"Respir. Physiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1242\/jcs.02406","article-title":"Overexpression of claudin-7 decreases the paracellular Cl\u00e2\u02c6\u2019 conductance and increases the paracellular Na+ conductance in LLC-PK1 cells","volume":"118","author":"Alexandre","year":"2005","journal-title":"J. Cell Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1242\/jcs.070896","article-title":"TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling","volume":"123","author":"Amasheh","year":"2010","journal-title":"J Cell Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s00384-009-0737-8","article-title":"Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease","volume":"24","author":"Amasheh","year":"2009a","journal-title":"Int. J. Colorectal. Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1749-6632.2000.tb05227.x","article-title":"Differential regulation of ENaC by aldosterone in rat early and late distal colon","volume":"915","author":"Amasheh","year":"2000","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1748-1716.2010.02148.x","article-title":"Claudins of intestine and nephron \u00e2\u20ac\u201c a correlation of molecular tight junction structure and barrier function","volume":"201","author":"Amasheh","year":"2011","journal-title":"Acta Physiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1242\/jcs.00165","article-title":"Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells","volume":"115","author":"Amasheh","year":"2002","journal-title":"J. Cell Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbrc.2008.10.164","article-title":"Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation","volume":"378","author":"Amasheh","year":"2009b","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00441-005-1101-0","article-title":"Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells","volume":"321","author":"Amasheh","year":"2005","journal-title":"Cell Tissue Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1053\/gast.2002.34784","article-title":"Mechanisms of diarrhea in collagenous colitis","volume":"123","author":"B\u00c3\u00bcrgel","year":"2002","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"crossref","first-page":"L1166","DOI":"10.1152\/ajplung.00182.2003","article-title":"Role of claudin interactions in airway tight junctional permeability","volume":"285","author":"Coyne","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1350-2","article-title":"Laurate permeates the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29\/B6 via opening the tight junctions by reversible relocation of claudin-5","author":"Dittmann","year":"2014","journal-title":"Pharm Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00428-007-0448-x","article-title":"Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions","volume":"451","author":"Facchetti","year":"2007","journal-title":"Virchows Arch"},{"key":"B15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ccc.2005.01.005","article-title":"Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level","volume":"21","author":"Fink","year":"2005","journal-title":"Crit. Care Clin"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1083\/jcb.141.7.1539","article-title":"Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin","volume":"141","author":"Furuse","year":"1998","journal-title":"J. Cell Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice","volume":"156","author":"Furuse","year":"2002","journal-title":"J. Cell Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1083\/jcb.123.6.1777","article-title":"Occludin: a novel integral membrane protein localizing at tight junctions","volume":"123","author":"Furuse","year":"1993","journal-title":"J. Cell Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1161\/HYPERTENSIONAHA.111.176727","article-title":"Ouabain and insulin induce sodium pump endocytosis in renal epithelium","volume":"59","author":"Gupta","year":"2012","journal-title":"Hypertension"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1152\/jappl.2001.90.4.1565","article-title":"Effects of SNP, ouabain, and amiloride on electrical potential profile of isolated sheep pleura","volume":"90","author":"Hatzoglou","year":"2001","journal-title":"J. Appl. Physiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","article-title":"Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"36117","DOI":"10.1074\/jbc.M608853200","article-title":"Study of claudin function by RNA interference","volume":"281","author":"Hou","year":"2006","journal-title":"J. Biol. Chem"},{"key":"B24","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1083\/jcb.200510043","article-title":"Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells","volume":"171","author":"Ikenouchi","year":"2005","journal-title":"J. Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"31936","DOI":"10.1074\/jbc.M506338200","article-title":"Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins","volume":"280","author":"Jacob","year":"2005","journal-title":"J. Biol. Chem"},{"key":"B27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.resp.2003.08.001","article-title":"Role of aquaporin and sodium channel in pleural water movement","volume":"139","author":"Jiang","year":"2003","journal-title":"Respir. Physiol. Neurobiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1465-9921-11-59","article-title":"Divergent expression of claudin-1, -3, -4, -5 and -7 in developing human lung","volume":"11","author":"Kaarteenaho","year":"2010","journal-title":"Respir. Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1093\/ndt\/gfq006","article-title":"Differential expression of claudin tight junction proteins in the human cortical nephron","volume":"250","author":"Kirk","year":"2010","journal-title":"Nephrol. Dial. Transplant"},{"key":"B30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1681\/ASN.V134875","article-title":"Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments","volume":"13","author":"Kiuchi-Saishin","year":"2002","journal-title":"J. Am. Soc. Nephrol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1510\/icvts.2007.172007","article-title":"Human parietal pleura present electrophysiology variations according to location in pleural cavity","volume":"7","author":"Kouritas","year":"2008","journal-title":"Interact. Cardiovasc. Thorac. Surg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mce.2010.11.003","article-title":"Effect of histamine on the electrophysiology of the human parietal pleura","volume":"332","author":"Kouritas","year":"2011","journal-title":"Mol. Cell. Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000336837","article-title":"Nonsteroidal anti-inflammatory drugs alter the human mesothelial pleural permeability via ion cellular transportation by inhibiting prostaglandin synthesis","volume":"84","author":"Kouritas","year":"2012","journal-title":"Respiration"},{"key":"B34","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1159\/000095963","article-title":"A simple method for rapid separation of endothelial and smooth muscle mRNA reveals Na+\/K+-ATPase alpha-subunit distribution in rat arteries","volume":"43","author":"Krenek","year":"2006","journal-title":"J. Vasc. Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1183\/09031936.97.10020476","article-title":"Diagnostic principles in pleural disease","volume":"10","author":"Light","year":"1997","journal-title":"Eur. Respir. J"},{"key":"B37","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/dc.21380","article-title":"Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions","volume":"39","author":"Lonardi","year":"2011","journal-title":"Diagn. Cytopathol"},{"key":"B38","first-page":"G367","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am. J. Physiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1460-z","article-title":"Comparative analysis of theophylline and cholera toxin in rat colon reveals an induction of sealing tight junction proteins","author":"Markov","year":"2014","journal-title":"Pfl\u00c3\u00bcgers Arch"},{"key":"B40","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00424-011-1034-2","article-title":"Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in mice","volume":"463","author":"Markov","year":"2012","journal-title":"Pfl\u00c3\u00bcgers Arch"},{"key":"B41","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00360-009-0440-7","article-title":"Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine","volume":"180","author":"Markov","year":"2010","journal-title":"J. Comp. Physiol. B"},{"key":"B42","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.resp.2010.12.012","article-title":"Tight junction proteins contribute to barrier properties in human pleura","volume":"175","author":"Markov","year":"2011","journal-title":"Resp. Physiol. Neurobiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1465-9921-8-75","article-title":"Role of TNF-\u00ce\u00b1 in lung tight junction alteration in mouse model of acute lung inflammation","volume":"8","author":"Mazzon","year":"2007","journal-title":"Respir. Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1016\/j.bbamem.2010.07.014","article-title":"Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes","volume":"1798","author":"Milatz","year":"2010","journal-title":"Biochim. Biophys. Acta Biomembr"},{"key":"B45","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1165\/rcmb.2008-0166OC","article-title":"Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells","volume":"40","author":"Nie","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1083\/jcb.200302070","article-title":"Size-selective loosening of the blood\u00e2\u20ac\u201cbrain barrier in claudin-5-deficient mice","volume":"161","author":"Nitta","year":"2003","journal-title":"J. Cell Biol"},{"key":"B47","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1152\/jappl.1988.65.6.2558","article-title":"Comparative permeability of canine visceral and parietal pleura","volume":"65","author":"Payne","year":"1988","journal-title":"J. Appl. Physiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e118","DOI":"10.5301\/JBM.2012.9197","article-title":"Role of monocyte chemoattractant protein-1, tumor necrosis factor-alpha and interleukin-6 in the control of malignant pleural effusion and survival in patients with primary lung adenocarcinoma","volume":"27","author":"Qian","year":"2012","journal-title":"Int. J. Biol. Markers"},{"key":"B49","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1152\/ajplegacy.1973.224.4.857","article-title":"Pleural fluid-plasma bicarbonate gradients in oxygen and normal rats","volume":"224","author":"Rolf","year":"1973","journal-title":"Am. J. Physiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1749-6632.2012.06562.x","article-title":"Analysis of absorption enhancers in epithelial cell models","volume":"1258","author":"Rosenthal","year":"2012","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1242\/jcs.060665","article-title":"Claudin-2, a component of the tight junction, forms a paracellular water channel","volume":"123","author":"Rosenthal","year":"2010","journal-title":"J. Cell Sci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/BF02713992","article-title":"Characteristics of normal rabbit pleural fluid: physiologic and biochemical implications","volume":"156","author":"Sahn","year":"1979","journal-title":"Lung"},{"key":"B53","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S1569-9048(02)00077-0","article-title":"Effect of amiloride in human and sheep parietal pleura","volume":"132","author":"Sarkos","year":"2002","journal-title":"Respir. Physiol. Neurobiol"},{"key":"B54","first-page":"L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger","year":"1992","journal-title":"Am. J. Physiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbamem.2005.01.008","article-title":"Epithelial transport and barrier function in occludin-deficient mice","volume":"1669","author":"Schulzke","year":"2005","journal-title":"Biochim. Biophys. Acta Biomembr"},{"key":"B56","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.resp.2008.02.013","article-title":"Na+\u00e2\u20ac\u201cglucose cotransporter is also expressed in mesothelium of species with thick visceral pleura","volume":"161","author":"Sironi","year":"2008","journal-title":"Resp. Physiol. Neurobiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.resp.2007.05.012","article-title":"Expression of Na+\u00e2\u20ac\u201cglucose cotransporter (SGLT1) in visceral and parietal mesothelium of rabbit pleura","volume":"159","author":"Sironi","year":"2007","journal-title":"Respir. Physiol. Neurobiol"},{"key":"B58","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1242\/jcs.13.3.763","article-title":"Further observations on the fine structure of freeze-cleaved tight junctions","volume":"13","author":"Staehelin","year":"1973","journal-title":"J. Cell Sci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1471-2121-10-95","article-title":"Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family","volume":"10","author":"Steed","year":"2009","journal-title":"BMC Cell Biol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"Tsukita","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ejphar.2005.11.050","article-title":"mu-Opioid influence on transmesothelial resistance of isolated sheep pleura and parietal pericardium","volume":"530","author":"Vogiatzidis","year":"2006","journal-title":"Eur. J. Pharmacol"},{"key":"B61a","first-page":"623","article-title":"The regional difference of pleural mesothelial cells in rabbits","volume":"110","author":"Wang","year":"1974","journal-title":"Am. Rev. Respir. Dis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1440-1681.2007.04549.x","article-title":"Comparison of the electrophysiological properties of the sheep isolated costal and diaphragmatic parietal pleura","volume":"34","author":"Zarogiannis","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.resp.2005.04.006","article-title":"Effect of adrenaline on transmesothelial resistance of isolated sheep pleura","volume":"150","author":"Zarogiannis","year":"2006","journal-title":"Respir. Physiol. Neurobiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/gut.2006.094375","article-title":"Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease","volume":"56","author":"Zeissig","year":"2007","journal-title":"Gut"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1183\/09031936.02.00062102","article-title":"Physiology and pathophysiology of pleural fluid turnover","volume":"20","author":"Zocchi","year":"2002","journal-title":"Eur. Respir. J"},{"key":"B66","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0034-5687(91)90044-J","article-title":"Electrolyte transport across the pleura of rabbits","volume":"86","author":"Zocchi","year":"1991","journal-title":"Respir. Physiol"},{"key":"B68","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1113\/expphysiol.1996.sp003996","article-title":"Effect of phloridzin on net rate of liquid absorption from the pleural space of rabbits","volume":"81","author":"Zocchi","year":"1996","journal-title":"Exp. Physiol"}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T04:32:20Z","timestamp":1649478740000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2014.00221\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":64,"URL":"https:\/\/doi.org\/10.3389\/fphys.2014.00221","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]}}}