{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:05:40Z","timestamp":1791018340475,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2015.00162","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T03:02:59Z","timestamp":1432090979000},"source":"Crossref","is-referenced-by-count":25,"title":["Air pollution and adverse cardiac remodeling: clinical effects and basic mechanisms"],"prefix":"10.3389","volume":"6","author":[{"given":"Yonggang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M.","family":"Goodson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1161\/CIRCRESAHA.107.164970","article-title":"Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress","volume":"102","author":"Araujo","year":"2008","journal-title":"Circ. Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/EDE.0b013e318276ccb8","article-title":"Long-term exposure to outdoor air pollution and incidence of cardiovascular diseases","volume":"24","author":"Atkinson","year":"2013","journal-title":"Epidemiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1001\/archinte.168.9.920","article-title":"Exposure to particulate air pollution and risk of deep vein thrombosis","volume":"168","author":"Baccarelli","year":"2008","journal-title":"Arch. Intern. Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1289\/ehp.1205914","article-title":"Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease","volume":"121","author":"Bartell","year":"2013","journal-title":"Environ. Health Perspect"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e000212","DOI":"10.1161\/JAHA.113.000212","article-title":"DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments","volume":"2","author":"Bellavia","year":"2013","journal-title":"J. Am. Heart Assoc"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/2047487313505821","article-title":"Traffic-related air pollution and noise and children's blood pressure: results from the PIAMA birth cohort study","volume":"22","author":"Bilenko","year":"2015","journal-title":"Eur. J. Prev. Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1161\/01.CIR.0000128587.30041.C8","article-title":"Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the american heart association","volume":"109","author":"Brook","year":"2004","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e18525","DOI":"10.1371\/journal.pone.0018525","article-title":"Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms","volume":"6","author":"Budinger","year":"2011","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3109\/08958378.2013.809393","article-title":"Induction of cardiac fibrosis and transforming growth factor-beta1 by motorcycle exhaust in rats","volume":"25","author":"Chen","year":"2013","journal-title":"Inhal. Toxicol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1172\/JCI75157","article-title":"beta(2)-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis","volume":"124","author":"Chiarella","year":"2014","journal-title":"J. Clin. Invest"},{"key":"B12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1136\/heartjnl-2014-306379","article-title":"Basic mechanisms for adverse cardiovascular events associated with air pollution","volume":"101","author":"Chin","year":"2015","journal-title":"Heart"},{"key":"B13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1289\/ehp.1205575","article-title":"Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity","volume":"121","author":"Dadvand","year":"2013","journal-title":"Environ. Health Perspect"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1056\/NEJMoa040610","article-title":"The effect of air pollution on lung development from 10 to 18 years of age","volume":"351","author":"Gauderman","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(07)60037-3","article-title":"Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study","volume":"369","author":"Gauderman","year":"2007","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/toxsci\/kfn005","article-title":"Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes","volume":"102","author":"Ghelfi","year":"2008","journal-title":"Toxicol. Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5288","DOI":"10.1038\/ncomms6288","article-title":"Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease","volume":"5","author":"Gilsbach","year":"2014","journal-title":"Nat. Commun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.tox.2007.10.013","article-title":"Examination of mRNA expression in rat hearts and lungs for analysis of effects of exposure to concentrated ambient particles on cardiovascular function","volume":"243","author":"Ito","year":"2008","journal-title":"Toxicology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/toxsci\/71.2.237","article-title":"Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat","volume":"71","author":"Kodavanti","year":"2003","journal-title":"Toxicol. Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1289\/ehp.10379","article-title":"The role of particulate matter-associated zinc in cardiac injury in rats","volume":"116","author":"Kodavanti","year":"2008","journal-title":"Environ. Health Perspect"},{"key":"B22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1743-8977-10-49","article-title":"Inhalation of diesel exhaust does not exacerbate cardiac hypertrophy or heart failure in two mouse models of cardiac hypertrophy","volume":"10","author":"Liu","year":"2013","journal-title":"Part. Fibre Toxicol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1093\/eurheartj\/ehn464","article-title":"Diesel exhaust inhalation increases thrombus formation in man","volume":"29","author":"Lucking","year":"2008","journal-title":"Eur. Heart J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1056\/NEJMoa054409","article-title":"Long-term exposure to air pollution and incidence of cardiovascular events in women","volume":"356","author":"Miller","year":"2007","journal-title":"N. Engl. J. Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1289\/ehp.11016","article-title":"Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease","volume":"116","author":"Mills","year":"2008","journal-title":"Environ. Health Perspect"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1172\/JCI30639","article-title":"Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway","volume":"117","author":"Mutlu","year":"2007","journal-title":"J. Clin. Invest"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1161\/01.CIR.0000053568.13058.67","article-title":"Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis","volume":"107","author":"Nemmar","year":"2003a","journal-title":"Circulation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1161\/01.CIR.0000142053.13921.21","article-title":"Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters","volume":"110","author":"Nemmar","year":"2004","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1164\/rccm.200110-026OC","article-title":"Ultrafine particles affect experimental thrombosis in an in vivo hamster model","volume":"166","author":"Nemmar","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1164\/rccm.200306-801OC","article-title":"Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine","volume":"168","author":"Nemmar","year":"2003b","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tox.2011.03.018","article-title":"Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension","volume":"285","author":"Nemmar","year":"2011","journal-title":"Toxicology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1080\/08958370701665384","article-title":"Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers","volume":"19","author":"Peretz","year":"2007","journal-title":"Inhal. Toxicol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3109\/08958378.2012.654856","article-title":"Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation","volume":"24","author":"Pettit","year":"2012","journal-title":"Inhal. Toxicol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/CIRCRESAHA.115.304666","article-title":"CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure","volume":"115","author":"Rao","year":"2014","journal-title":"Circ. Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bbagen.2005.05.025","article-title":"PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation","volume":"1725","author":"Rhoden","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s11906-014-0428-x","article-title":"Alterations in cardiac structure and function in hypertension","volume":"16","author":"Santos","year":"2014","journal-title":"Curr. Hypertens. Rep"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/S0140-6736(13)60898-3","article-title":"Global association of air pollution and heart failure: a systematic review and meta-analysis","volume":"382","author":"Shah","year":"2013","journal-title":"Lancet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1189\/jlb.1008587","article-title":"Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter","volume":"86","author":"Shoenfelt","year":"2009","journal-title":"J. Leukoc. Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1289\/ehp.1307301","article-title":"Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project","volume":"122","author":"Stafoggia","year":"2014","journal-title":"Environ. Health Perspect"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1001\/jama.294.23.3003","article-title":"Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model","volume":"294","author":"Sun","year":"2005","journal-title":"JAMA"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/ATVBAHA.108.166967","article-title":"Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho\/ROCK","volume":"28","author":"Sun","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tox.2014.07.002","article-title":"DNA methylation in cardiac fibrosis: new advances and perspectives","volume":"323","author":"Tao","year":"2014","journal-title":"Toxicology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1289\/ehp.11898","article-title":"Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation","volume":"117","author":"Tarantini","year":"2009","journal-title":"Environ. Health Perspect"},{"key":"B44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1743-8977-7-41","article-title":"Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells","volume":"7","author":"Totlandsdal","year":"2010","journal-title":"Part. Fibre Toxicol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1743-8977-9-24","article-title":"Effects of particulate matter on inflammatory markers in the general adult population","volume":"9","author":"Tsai","year":"2012","journal-title":"Part. Fibre Toxicol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1743-8977-5-19","article-title":"Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats","volume":"5","author":"Upadhyay","year":"2008","journal-title":"Part. Fibre Toxicol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1289\/ehp.7785","article-title":"Acute blood pressure responses in healthy adults during controlled air pollution exposures","volume":"113","author":"Urch","year":"2005","journal-title":"Environ. Health Perspect"},{"key":"B48","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3109\/08958370903173666","article-title":"Concentrated ambient fine particles and not ozone induce a systemic interleukin-6 response in humans","volume":"22","author":"Urch","year":"2010","journal-title":"Inhal. Toxicol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1164\/rccm.200808-1344OC","article-title":"Exposure to traffic and left ventricular mass and function: the multi-ethnic study of atherosclerosis","volume":"179","author":"Van Hee","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1289\/ehp.0901535","article-title":"Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis","volume":"118","author":"Van Hee","year":"2010","journal-title":"Environ. Health Perspect"},{"key":"B51","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1289\/ehp.1307419","article-title":"Prenatal air pollution exposure and newborn blood pressure","volume":"123","author":"van Rossem","year":"2015","journal-title":"Environ. Health Perspect"},{"key":"B52","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1743-8977-10-59","article-title":"In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice","volume":"10","author":"Weldy","year":"2013","journal-title":"Part. Fibre Toxicol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e88582","DOI":"10.1371\/journal.pone.0088582","article-title":"In utero exposure to diesel exhaust air pollution promotes adverse intrauterine conditions, resulting in weight gain, altered blood pressure, and increased susceptibility to heart failure in adult mice","volume":"9","author":"Weldy","year":"2014","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1289\/ehp.5775","article-title":"Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs","volume":"111","author":"Wellenius","year":"2003","journal-title":"Environ. Health Perspect"},{"key":"B55","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1161\/CIRCHEARTFAILURE.112.966580","article-title":"Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution","volume":"5","author":"Wold","year":"2012","journal-title":"Circ. Heart Fail"},{"key":"B56","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1136\/heartjnl-2014-306165","article-title":"Relationship between fine particulate air pollution and ischaemic heart disease morbidity and mortality","volume":"101","author":"Xie","year":"2015","journal-title":"Heart"},{"key":"B57","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1073\/pnas.0705896105","article-title":"Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban\/industrial location","volume":"105","author":"Yauk","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1289\/ehp.1307151","article-title":"Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation","volume":"122","author":"Ying","year":"2014","journal-title":"Environ. Health Perspect"},{"key":"B59","doi-asserted-by":"publisher","first-page":"H1540","DOI":"10.1152\/ajpheart.01270.2008","article-title":"Air pollution and cardiac remodeling: a role for RhoA\/Rho-kinase","volume":"296","author":"Ying","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e001423","DOI":"10.1161\/JAHA.114.001423","article-title":"Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake","volume":"4","author":"Zhong","year":"2015","journal-title":"J. Am. Heart Assoc"}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T08:02:18Z","timestamp":1435046538000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.frontiersin.org\/Striated_Muscle_Physiology\/10.3389\/fphys.2015.00162\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,20]]},"references-count":60,"URL":"https:\/\/doi.org\/10.3389\/fphys.2015.00162","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,20]]}}}