{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:41:18Z","timestamp":1777092078600,"version":"3.51.4"},"reference-count":180,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1140275"],"award-info":[{"award-number":["1140275"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1140968"],"award-info":[{"award-number":["1140968"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11121133"],"award-info":[{"award-number":["11121133"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1120214"],"award-info":[{"award-number":["1120214"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["ACT1104"],"award-info":[{"award-number":["ACT1104"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2015.00350","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T06:52:11Z","timestamp":1448952731000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis"],"prefix":"10.3389","volume":"6","author":[{"given":"Rodrigo","family":"Del Rio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A.","family":"Quintanilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio A.","family":"Retamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/glia.22785","article-title":"Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes","volume":"63","author":"Abudara","year":"2015","journal-title":"Glia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1001\/jama.2015.4260","article-title":"Prevalence of the metabolic syndrome in the united states, 2003-2012","volume":"313","author":"Aguilar","year":"2015","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1042\/bj20011572","article-title":"Post-translational integration and oligomerization of connexin 26 in plasma membranes and evidence of formation of membrane pores: implications for the assembly of gap junctions","volume":"365","author":"Ahmad","year":"2002","journal-title":"Biochem. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte-neuron metabolic relationships: for better and for worse","volume":"34","author":"Allaman","year":"2011","journal-title":"Trends Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"15294","DOI":"10.1073\/pnas.261560998","article-title":"Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection","volume":"98","author":"Almeida","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1471-4159.2004.02204.x","article-title":"ATP-induced ATP release from astrocytes","volume":"88","author":"Anderson","year":"2004","journal-title":"J. Neurochem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2009.04.030","article-title":"Metabolic syndrome and oxidative stress","volume":"47","author":"Ando","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"10460","DOI":"10.1523\/JNEUROSCI.0045-15.2015","article-title":"Functional oxygen sensitivity of astrocytes","volume":"35","author":"Angelova","year":"2015","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"issue":"326","key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00326","article-title":"Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice","volume":"8","author":"Ardiles","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1242\/jcs.034827","article-title":"Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA","volume":"122","author":"Avalos","year":"2009","journal-title":"J. Cell Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1002\/glia.22877","article-title":"Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival","volume":"63","author":"Avenda\u00f1o","year":"2015","journal-title":"Glia"},{"key":"B13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4049\/jimmunol.161.1.467","article-title":"SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes","volume":"161","author":"Badger","year":"1998","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbamem.2012.01.002","article-title":"The participation of plasma membrane hemichannels to purinergic signaling","volume":"1828","author":"Baroja-Mazo","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/glia.440060309","article-title":"Heterogeneity in gap junction expression in astrocytes cultured from different brain regions","volume":"6","author":"Batter","year":"1992","journal-title":"Glia"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.brainres.2012.08.042","article-title":"Connexin and pannexin hemichannels in inflammatory responses of glia and neurons","volume":"1487","author":"Bennett","year":"2012","journal-title":"Brain Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nn1246","article-title":"Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate","volume":"7","author":"Bezzi","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3940(95)11703-Y","article-title":"Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration","volume":"193","author":"Brown","year":"1995","journal-title":"Neurosci. Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jtemb.2015.07.001","article-title":"Modulation of copper accumulation and copper-induced toxicity by antioxidants and copper chelators in cultured primary brain astrocytes","volume":"32","author":"Bulcke","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/jcbfm.2014.48","article-title":"Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus","volume":"34","author":"Calvo-Ochoa","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B22","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00864.x","article-title":"Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool","volume":"81","author":"Ch\u00e9nais","year":"2002","journal-title":"J. Neurochem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"11228","DOI":"10.1523\/JNEUROSCI.0015-14.2014","article-title":"Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission","volume":"34","author":"Chever","year":"2014a","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"20130596","DOI":"10.1098\/rstb.2013.0596","article-title":"Astroglial connexin 43 sustains glutamatergic synaptic efficacy","volume":"369","author":"Chever","year":"2014b","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1006\/jmcc.1999.1040","article-title":"Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes","volume":"31","author":"Clerk","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1073\/pnas.012589799","article-title":"Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture","volume":"99","author":"Contreras","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.abb.2010.05.014","article-title":"Cellular pathways for transport and efflux of ascorbate and dehydroascorbate","volume":"500","author":"Corti","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/glia.20728","article-title":"Adhesive properties of connexin hemichannels","volume":"56","author":"Cotrina","year":"2008","journal-title":"Glia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/B978-0-444-59565-2.00013-7","article-title":"Metabolic neuropathies and myopathies","volume":"113","author":"D'Amico","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.expneurol.2013.06.026","article-title":"Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep","volume":"248","author":"Davidson","year":"2013","journal-title":"Exp. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1038\/jcbfm.2011.86","article-title":"Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability","volume":"31","author":"De Bock","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1113\/expphysiol.2014.079350","article-title":"The carotid body and its relevance in pathophysiology","volume":"100","author":"Del Rio","year":"2015","journal-title":"Exp. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.jacc.2013.07.079","article-title":"Carotid chemoreceptor ablation improves survival in heart failure: rescuing autonomic control of cardiorespiratory function","volume":"62","author":"Del Rio","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"10148","DOI":"10.1073\/pnas.86.24.10148","article-title":"Differential expression of three gap junction proteins in developing and mature brain tissues","volume":"86","author":"Dermietzel","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/jnr.20650","article-title":"Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons","volume":"82","author":"Dobrenis","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"B37","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1523\/JNEUROSCI.23-04-01320.2003","article-title":"P2X7 receptor-mediated release of excitatory amino acids from astrocytes","volume":"23","author":"Duan","year":"2003","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1167\/iovs.10-6200","article-title":"Properties of connexin 46 hemichannels in dissociated lens fiber cells","volume":"52","author":"Ebihara","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"B40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.tins.2008.02.007","article-title":"Gap junctions: multifaceted regulators of embryonic cortical development","volume":"31","author":"Elias","year":"2008","journal-title":"Trends Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrn1928","article-title":"Purinergic signalling in neuron-glia interactions","volume":"7","author":"Fields","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0166-2236(00)01674-X","article-title":"ATP: an extracellular signaling molecule between neurons and glia","volume":"23","author":"Fields","year":"2000","journal-title":"Trends Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1126\/science.298.5593.556","article-title":"New insights into neuron-glia communication","volume":"298","author":"Fields","year":"2002","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.bbamem.2012.12.006","article-title":"Linoleic acid induces opening of connexin26 hemichannels through a PI3K\/Akt\/Ca(2+)-dependent pathway","volume":"1828","author":"Figueroa","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B45","doi-asserted-by":"publisher","first-page":"7541","DOI":"10.1073\/pnas.96.13.7541","article-title":"Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures","volume":"96","author":"Fr\u00f3es","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"182","key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00182","article-title":"Extracellular vesicles as mediators of neuron-glia communication","volume":"7","author":"Fr\u00fchbeis","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/glia.22580","article-title":"Hormones and diet, but not body weight, control hypothalamic microglial activity","volume":"62","author":"Gao","year":"2014","journal-title":"Glia"},{"key":"B48","doi-asserted-by":"publisher","first-page":"22659","DOI":"10.1073\/pnas.1013793107","article-title":"FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels","volume":"107","author":"Garr\u00e9","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"88","key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00088","article-title":"Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles","volume":"4","author":"Giaume","year":"2013","journal-title":"Front. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1161\/ATVBAHA.107.151092","article-title":"Metabolic syndrome pandemic","volume":"28","author":"Grundy","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"8083","DOI":"10.1074\/jbc.272.12.8083","article-title":"p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta","volume":"272","author":"Guan","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1161\/HYPERTENSIONAHA.113.01847","article-title":"Increasing angiotensin-(1-7) levels in the brain attenuates metabolic syndrome-related risks in fructose-fed rats","volume":"63","author":"Guimaraes","year":"2014","journal-title":"Hypertension"},{"key":"B54","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.lfs.2004.12.015","article-title":"Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides","volume":"77","author":"Guti\u00e9rrez-Venegas","year":"2005","journal-title":"Life Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/glia.20649","article-title":"Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes","volume":"56","author":"Hamilton","year":"2008","journal-title":"Glia"},{"key":"B57","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/sj.jcbfm.9600343","article-title":"Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis\/glycogenolysis","volume":"27","author":"Hertz","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B59","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ajpath.2014.10.022","article-title":"Astrocytic Dynamin-Like Protein 1 Regulates Neuronal Protection against Excitotoxicity in Parkinson Disease","volume":"185","author":"Hoekstra","year":"2015","journal-title":"Am. J. Pathol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1179\/1743132814Y.0000000330","article-title":"Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats","volume":"36","author":"Hwang","year":"2014","journal-title":"Neurol. Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"7092","DOI":"10.1523\/JNEUROSCI.6062-08.2009","article-title":"Pannexin 1: the molecular substrate of astrocyte \u201chemichannels.\u201d","volume":"29","author":"Iglesias","year":"2009","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"C752","DOI":"10.1152\/ajpcell.00228.2008","article-title":"P2X7 receptor-Pannexin1 complex: pharmacology and signaling","volume":"295","author":"Iglesias","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1002\/glia.22517","article-title":"Microglia release ATP by exocytosis","volume":"61","author":"Imura","year":"2013","journal-title":"Glia"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/j.1471-4159.2007.04824.x","article-title":"The role of nucleotides in the neuron\u2013glia communication responsible for the brain functions","volume":"102","author":"Inoue","year":"2007","journal-title":"J. Neurochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1523\/JNEUROSCI.5247-10.2011","article-title":"Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity","volume":"31","author":"Karpuk","year":"2011","journal-title":"J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1109\/RBME.2012.2232651","article-title":"Understanding the metabolic syndrome: a modeling perspective","volume":"6","author":"Khoo","year":"2013","journal-title":"IEEE Rev. Biomed. Eng."},{"key":"B68","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.tem.2011.12.004","article-title":"Insulin resistance in the nervous system","volume":"23","author":"Kim","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"B69","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1523\/JNEUROSCI.10-05-01583.1990","article-title":"Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures","volume":"10","author":"Kimelberg","year":"1990","journal-title":"J. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"S130","DOI":"10.1139\/y92-254","article-title":"Oxidative metabolism in neuronal and non-neuronal mitochondria","volume":"70","author":"Lai","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.freeradbiomed.2009.06.003","article-title":"Ascorbate and plasma membrane electron transport\u2013enzymes vs efflux","volume":"47","author":"Lane","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1042\/BJ20101317","article-title":"Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron","volume":"432","author":"Lane","year":"2010","journal-title":"Biochem. J."},{"key":"B73","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","article-title":"Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain","volume":"39","author":"Lawson","year":"1990","journal-title":"Neuroscience"},{"key":"B74","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1126\/science.1184334","article-title":"Channel-mediated tonic GABA release from glia","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1113\/jphysiol.2007.149732","article-title":"Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats","volume":"586","author":"Li","year":"2008","journal-title":"J. Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1210\/jc.2012-3104","article-title":"Dysregulation of the autonomic nervous system predicts the development of the metabolic syndrome","volume":"98","author":"Licht","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1210\/jc.2009-2801","article-title":"Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities","volume":"95","author":"Licht","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"20","key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00020","article-title":"Nitric oxide and mitochondria in metabolic syndrome","volume":"6","author":"Litvinova","year":"2015","journal-title":"Front. Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.febslet.2005.12.004","article-title":"Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium","volume":"580","author":"Locovei","year":"2006","journal-title":"FEBS Lett."},{"key":"B80","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1039\/c0mt00006j","article-title":"Copper handling machinery of the brain","volume":"2","author":"Lutsenko","year":"2010","journal-title":"Metallomics"},{"key":"B81","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.lfs.2014.07.018","article-title":"Mitochondrial dysfunction and oxidative damage in the brain of diet-induced obese rats but not in diet-resistant rats","volume":"110","author":"Ma","year":"2014","journal-title":"Life Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.exer.2015.01.012","article-title":"Calcium entry via connexin hemichannels in lens epithelium","volume":"132","author":"Mandal","year":"2015","journal-title":"Exp. Eye Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00395-012-0317-x","article-title":"Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats","volume":"108","author":"Marina","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"H1139","DOI":"10.1152\/ajpheart.00881.2005","article-title":"IL-1beta stimulates rat cardiac fibroblast migration via MAP kinase pathways","volume":"292","author":"Mitchell","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neuroscience.2014.11.048","article-title":"Hemichannels: new pathways for gliotransmitter release","volume":"286C","author":"Montero","year":"2014","journal-title":"Neuroscience"},{"key":"B86","doi-asserted-by":"publisher","first-page":"E3919","DOI":"10.1073\/pnas.1405253111","article-title":"Connexion hemichannels contribute to spontaneous electrical activity in the human fetal cortex","volume":"111","author":"Moore","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"234","key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00234","article-title":"Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?","volume":"6","author":"Moreira","year":"2015","journal-title":"Front. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/glia.20471","article-title":"Dual regulation of astrocyte gap junction hemichannels by growth factors and a pro-inflammatory cytokine via the mitogen-activated protein kinase cascade","volume":"55","author":"Morita","year":"2007","journal-title":"Glia"},{"key":"B89","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1046\/j.1460-9568.2001.01418.x","article-title":"Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function","volume":"13","author":"Moss","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.cmet.2013.11.005","article-title":"Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance","volume":"18","author":"Motori","year":"2013","journal-title":"Cell Metab."},{"key":"B91","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.neurobiolaging.2004.05.010","article-title":"Glia and their cytokines in progression of neurodegeneration","volume":"26","author":"Mrak","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"B92","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tins.2006.08.004","article-title":"Astrocytic complexity distinguishes the human brain","volume":"29","author":"Oberheim","year":"2006","journal-title":"Trends Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1089\/ars.2008.2130","article-title":"Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration","volume":"11","author":"Orellana","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4962","DOI":"10.1523\/JNEUROSCI.6417-10.2011","article-title":"Amyloid \u03b2-induced death in neurons involves glial and neuronal hemichannels","volume":"31","author":"Orellana","year":"2011a","journal-title":"J. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/j.1471-4159.2011.07210.x","article-title":"ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels","volume":"118","author":"Orellana","year":"2011b","journal-title":"J. Neurochem."},{"key":"B96","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/glia.21246","article-title":"Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels","volume":"60","author":"Orellana","year":"2012a","journal-title":"Glia"},{"key":"B97","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1515\/revneuro-2011-0065","article-title":"Glial hemichannels and their involvement in aging and neurodegenerative diseases","volume":"23","author":"Orellana","year":"2012b","journal-title":"Rev. Neurosci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1002\/glia.22573","article-title":"Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: involvement of ATP released via pannexin 1 channels","volume":"61","author":"Orellana","year":"2013a","journal-title":"Glia"},{"key":"B99","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.neuropharm.2013.02.020","article-title":"Gap junction channels and hemichannels in the CNS: regulation by signaling molecules","volume":"75","author":"Orellana","year":"2013b","journal-title":"Neuropharmacology"},{"issue":"193","key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00193","article-title":"Hemichannels: new roles in astroglial function","volume":"5","author":"Orellana","year":"2014","journal-title":"Front. Physiol."},{"issue":"102","key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00102","article-title":"Restraint stress increases hemichannel activity in hippocampal glial cells and neurons","volume":"9","author":"Orellana","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1097\/01.hjh.0000234118.25401.1c","article-title":"Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity","volume":"24","author":"Palatini","year":"2006","journal-title":"J. Hypertens."},{"key":"B103","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/glia.22790","article-title":"P2X7 R-mediated Ca(2+)-independent d-serine release via pannexin-1 of the P2X7 R-pannexin-1 complex in astrocytes","volume":"63","author":"Pan","year":"2015","journal-title":"Glia"},{"issue":"Pt 8","key":"B104","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1242\/jeb.01547","article-title":"Evolution of gap junction proteins\u2013the pannexin alternative","volume":"208","author":"Panchin","year":"2005","journal-title":"J. Exp. Biol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neulet.2014.10.016","article-title":"Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-\u03baB pathways","volume":"584","author":"Park","year":"2015","journal-title":"Neurosci. Lett."},{"key":"B106","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1161\/HYPERTENSIONAHA.111.00064","article-title":"The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases","volume":"61","author":"Paton","year":"2013","journal-title":"Hypertension"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"B108","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e51767","DOI":"10.1371\/journal.pone.0051767","article-title":"Pannexin1 stabilizes synaptic plasticity and is needed for learning","volume":"7","author":"Prochnow","year":"2012","journal-title":"PLoS ONE"},{"key":"B110","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.arcmed.2012.10.016","article-title":"Understanding risk factors for Alzheimer's Disease: interplay of neuroinflammation, connexin-based communication and oxidative stress","volume":"43","author":"Quintanilla","year":"2012","journal-title":"Arch. Med. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2006.12.043","article-title":"Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytes","volume":"415","author":"Rana","year":"2007","journal-title":"Neurosci. Lett."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1159\/000373947","article-title":"Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain","volume":"35","author":"Raza","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1073\/pnas.0511118103","article-title":"S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents","volume":"103","author":"Retamal","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B114","doi-asserted-by":"publisher","first-page":"13781","DOI":"10.1523\/JNEUROSCI.2042-07.2007","article-title":"Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia","volume":"27","author":"Retamal","year":"2007","journal-title":"J. Neurosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00424-011-0936-3","article-title":"Biphasic effect of linoleic acid on connexin 46 hemichannels","volume":"461","author":"Retamal","year":"2011","journal-title":"Pflugers Arch."},{"issue":"80","key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00080","article-title":"Connexin and Pannexin hemichannels are regulated by redox potential","volume":"5","author":"Retamal","year":"2014","journal-title":"Front. Physiol."},{"issue":"267","key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00267","article-title":"Diseases associated with leaky hemichannels","volume":"9","author":"Retamal","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"123","key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00123","article-title":"Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals","volume":"8","author":"Reyes","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1089\/ars.2009.2629","article-title":"Functional aspects of redox control during neuroinflammation","volume":"13","author":"Rosales-Corral","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"B120","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/jir.2006.26.719","article-title":"MKK3\/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells","volume":"26","author":"Rossa","year":"2006","journal-title":"J. Interferon Cytokine Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1126\/science.1164022","article-title":"Astroglial metabolic networks sustain hippocampal synaptic transmission","volume":"322","author":"Rouach","year":"2008","journal-title":"Science"},{"key":"B123","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1159\/000048729","article-title":"Gap junction-mediated bidirectional signaling between human fetal hippocampal neurons and astrocytes","volume":"23","author":"Rozental","year":"2001","journal-title":"Dev. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1111\/j.1471-4159.2008.05312.x","article-title":"Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes","volume":"105","author":"Rudkouskaya","year":"2008","journal-title":"J. Neurochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"S\u00e1ez","year":"2003","journal-title":"Physiol. Rev."},{"key":"B126","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbamem.2005.01.014","article-title":"Connexin-based gap junction hemichannels: gating mechanisms","volume":"1711","author":"S\u00e1ez","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1210\/en.2010-1435","article-title":"SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development","volume":"152","author":"Sandau","year":"2011","journal-title":"Endocrinology"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e25178","DOI":"10.1371\/journal.pone.0025178","article-title":"Targeting pannexin1 improves seizure outcome","volume":"6","author":"Santiago","year":"2011","journal-title":"PLoS ONE"},{"key":"B129","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/(SICI)1098-1136(199809)24:1<65::AID-GLIA7>3.0.CO;2-#","article-title":"Calcium waves between astrocytes from Cx43 knockout mice","volume":"24","author":"Scemes","year":"1998","journal-title":"Glia"},{"key":"B130","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/glia.22389","article-title":"The \u201cquad-partite\u201d synapse: microglia-synapse interactions in the developing and mature CNS","volume":"61","author":"Schafer","year":"2013","journal-title":"Glia"},{"key":"B131","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuint.2009.12.002","article-title":"Copper accumulation by cultured astrocytes","volume":"56","author":"Scheiber","year":"2010a","journal-title":"Neurochem. Int."},{"key":"B132","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pneurobio.2014.01.002","article-title":"Metabolism and functions of copper in brain","volume":"116","author":"Scheiber","year":"2014","journal-title":"Prog. Neurobiol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuint.2010.06.010","article-title":"Zinc prevents the copper-induced damage of cultured astrocytes","volume":"57","author":"Scheiber","year":"2010b","journal-title":"Neurochem. Int."},{"key":"B134","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S2213-8587(14)70033-6","article-title":"Metabolic syndrome: a sympathetic disease?","volume":"3","author":"Schlaich","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bbrc.2008.01.054","article-title":"ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro","volume":"368","author":"Schock","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B136","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.exer.2013.11.004","article-title":"Connexins form functional hemichannels in porcine ciliary epithelium","volume":"118","author":"Shahidullah","year":"2014","journal-title":"Exp. Eye Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1007\/s11064-013-1123-z","article-title":"Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage","volume":"38","author":"Sheng","year":"2013","journal-title":"Neurochem. Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1620\/tjem.217.87","article-title":"Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice","volume":"217","author":"Shijie","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"key":"B139","doi-asserted-by":"crossref","first-page":"9254","DOI":"10.1523\/JNEUROSCI.23-27-09254.2003","article-title":"Signaling at the gliovascular interface","volume":"23","author":"Simard","year":"2003","journal-title":"J. Neurosci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cardiores.2003.11.013","article-title":"Gap junctions and the connexin protein family","volume":"62","author":"S\u00f6hl","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1096\/fj.11-198416","article-title":"Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala","volume":"26","author":"Stehberg","year":"2012","journal-title":"FASEB J."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1042\/BST20140195","article-title":"Mitochondrial dynamics in astrocytes","volume":"42","author":"Stephen","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B143","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.autneu.2012.12.009","article-title":"Bidirectional neuro-glial signaling modalities in the hypothalamus: role in neurohumoral regulation","volume":"175","author":"Stern","year":"2013","journal-title":"Auton. Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"10482","DOI":"10.1074\/jbc.M109902200","article-title":"Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels","volume":"277","author":"Stout","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1210\/jc.2011-2320","article-title":"Baseline sympathetic nervous system activity predicts dietary weight loss in obese metabolic syndrome subjects","volume":"97","author":"Straznicky","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B146","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0161-813X(01)00033-X","article-title":"Microglia and macrophages in the developing CNS","volume":"22","author":"Streit","year":"2001","journal-title":"Neurotoxicology"},{"key":"B147","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1074\/jbc.M704153200","article-title":"Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels","volume":"283","author":"Stridh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1523\/JNEUROSCI.3902-05.2006","article-title":"P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling","volume":"26","author":"Suadicani","year":"2006","journal-title":"J. Neurosci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1146\/annurev.ne.06.030183.001413","article-title":"Hypothalamic integration: organization of theparaventricular and supraoptic nuclei","volume":"6","author":"Swanson","year":"1983","journal-title":"Annu. Rev. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"16466","DOI":"10.1073\/pnas.0506382102","article-title":"Receptor-mediated glutamate release from volume sensitive channels in astrocytes","volume":"102","author":"Takano","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B151","doi-asserted-by":"publisher","first-page":"21362","DOI":"10.1074\/jbc.M600504200","article-title":"Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner","volume":"281","author":"Takeuchi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B152","doi-asserted-by":"publisher","first-page":"e21108","DOI":"10.1371\/journal.pone.0021108","article-title":"Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease","volume":"6","author":"Takeuchi","year":"2011","journal-title":"PLoS ONE"},{"issue":"189","key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00189","article-title":"Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases","volume":"8","author":"Takeuchi","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1196\/annals.1367.010","article-title":"Sympathetic system activity in obesity and metabolic syndrome","volume":"1083","author":"Tentolouris","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B156","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","article-title":"The relationship of autonomic imbalance, heart rate variability and cardiobascular disease risk factor","volume":"141","author":"Thayer","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1126\/science.1126241","article-title":"Ischemia opens neuronal gap junction hemichannels","volume":"312","author":"Thompson","year":"2006","journal-title":"Science"},{"key":"B158","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2013.03.025","article-title":"Astrogliosis in the brain of obese Zucker rat: a model of metabolic syndrome","volume":"543","author":"Tomassoni","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002160","article-title":"Extracellular Ca2+ acts as a mediator of communication from neurons to glia","author":"Torres","year":"2012","journal-title":"Sci. Signal."},{"key":"B160","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1017\/S0007114513002493","article-title":"Capsaicin-induced metabolic and cardiovascular autonomic improvement in an animal model of the metabolic syndrome","volume":"111","author":"Tremarin","year":"2014","journal-title":"Br. J. Nutr."},{"key":"B161","doi-asserted-by":"publisher","first-page":"e1000527","DOI":"10.1371\/journal.pbio.1000527","article-title":"Microglial interactions with synapses are modulated by visual experience","volume":"8","author":"Tremblay","year":"2010","journal-title":"PLoS Biol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/syn.21832","article-title":"A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats","volume":"69","author":"Trevi\u00f1o","year":"2015","journal-title":"Synapse"},{"key":"B163","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1523\/JNEUROSCI.3105-14.2015","article-title":"PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors","volume":"35","author":"Vance","year":"2015","journal-title":"J. Neurosci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1469-7793.1999.0477t.x","article-title":"Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat","volume":"517","author":"Verberne","year":"1999","journal-title":"J. Physiol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.febslet.2013.01.067","article-title":"Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75\/mortalin","volume":"587","author":"Voloboueva","year":"2013","journal-title":"FEBS Lett."},{"key":"B166","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: the revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B167","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/ars.2011.4082","article-title":"Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms","volume":"16","author":"von Bernhardi","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"B168","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci"},{"key":"B169","doi-asserted-by":"publisher","first-page":"e47429","DOI":"10.1371\/journal.pone.0047429","article-title":"Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS ONE"},{"key":"B170","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","article-title":"Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases","volume":"32","author":"Weilinger","year":"2012","journal-title":"J. Neurosci."},{"key":"B171","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B172","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1139\/y97-146","article-title":"Antioxidant defense of the brain: a role for astrocytes","volume":"75","author":"Wilson","year":"1997","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0006-8993(99)02433-6","article-title":"Glutamate stimulates ascorbate transport by astrocytes","volume":"858","author":"Wilson","year":"2000","journal-title":"Brain Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1210\/jc.2015-1748","article-title":"Autonomic imbalance as a predictor of metabolic risks, cardiovascular disease, diabetes, and mortality","volume":"100","author":"Wulsin","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.lfs.2006.06.023","article-title":"ERK1\/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury","volume":"79","author":"Xu","year":"2006","journal-title":"Life Sci."},{"key":"B176","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1523\/JNEUROSCI.23-09-03588.2003","article-title":"Functional hemichannels in astrocytes: a novel mechanism of glutamate release","volume":"23","author":"Ye","year":"2003","journal-title":"J. Neurosci."},{"key":"B177","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1016\/j.neurobiolaging.2015.07.022","article-title":"Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe\/PS1dE9 mice","volume":"36","author":"Yeh","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B178","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1002\/jnr.21675","article-title":"Role for nitric oxide in permeability of hippocampal neuronal hemichannels during oxygen glucose deprivation","volume":"86","author":"Zhang","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"9441","DOI":"10.1073\/pnas.0401960101","article-title":"Synaptotagmin IV regulates glial glutamate release","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B180","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.hfc.2011.08.007","article-title":"Neurohumoral stimulation","volume":"8","author":"Zucker","year":"2012","journal-title":"Heart Fail. Clin."}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T01:06:16Z","timestamp":1692147976000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2015.00350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":180,"URL":"https:\/\/doi.org\/10.3389\/fphys.2015.00350","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}