{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:02:55Z","timestamp":1792674175827,"version":"4.5.0"},"reference-count":112,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2016.00141","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T11:31:13Z","timestamp":1461324673000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":140,"title":["Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+\/K+-ATPase Subunit Isoforms"],"prefix":"10.3389","volume":"7","author":[{"given":"Brian Roland","family":"Larsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Stoica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"MacAulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1113\/jphysiol.1987.sp016361","article-title":"Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices","volume":"382","author":"Ballanyi","year":"1987","journal-title":"J. Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1046\/j.1471-4159.1997.69062571.x","article-title":"Distribution of glutamate transporter subtypes during human brain development","volume":"69","author":"Bar-Peled","year":"1997","journal-title":"J. Neurochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.neuint.2012.01.013","article-title":"The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism","volume":"61","author":"Bauer","year":"2012","journal-title":"Neurochem. Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1212\/WNL.0b013e3182074c2f","article-title":"Na+, K+-ATPase: Functions in the nervous system and involvement in neurologic disease","volume":"76","author":"Benarroch","year":"2011","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1097-4547(19980501)52:3<307::AID-JNR7>3.0.CO;2-H","article-title":"Ionic mechanisms in glutamate-induced astrocyte swelling: role of K+ influx","volume":"52","author":"Bender","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/S0896-6273(00)80420-1","article-title":"Synaptic activation of glutamate transporters in hippocampal astrocytes","volume":"19","author":"Bergles","year":"1997","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.semnephrol.2005.03.004","article-title":"Na,K-ATPase subunit heterogeneity as a mechanism for tissue-specific ion regulation","volume":"25","author":"Blanco","year":"2005","journal-title":"Semin. Nephrol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1021\/bi00001a039","article-title":"Kinetic Properties of the.alpha.2.beta.1 and.alpha.2.beta.2 Isoenzymes of the Na,K-ATPase","volume":"34","author":"Blanco","year":"1995","journal-title":"Biochemistry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.neubiorev.2011.10.005","article-title":"Migraine- and dystonia-related disease-mutations of Na+\/K+-ATPases: relevance of behavioral studies in mice to disease symptoms and neurological manifestations in humans","volume":"36","author":"B\u00f8ttger","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"22047","DOI":"10.1038\/srep22047","article-title":"Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model","volume":"6","author":"B\u00f8ttger","year":"2016","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/cne.22524","article-title":"Distribution of Na\/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain","volume":"519","author":"B\u00f8ttger","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0169-328X(94)90264-X","article-title":"Neurons and astroglia express distinct subsets of Na,K-ATPase alpha and beta subunits","volume":"21","author":"Cameron","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1046\/j.1460-9568.2000.00269.x","article-title":"A quantitative analysis of l-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics","volume":"12","author":"Chatton","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"15769","DOI":"10.1523\/JNEUROSCI.2078-10.2010","article-title":"Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice","volume":"30","author":"Chever","year":"2010","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/cercor\/12.5.515","article-title":"Similar perisynaptic glial localization for the Na+,K+-ATPase \u03b12 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex","volume":"12","author":"Cholet","year":"2002","journal-title":"Cereb. Cortex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"14085","DOI":"10.1073\/pnas.0904817106","article-title":"Mutation I810N in the \u03b13 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS","volume":"106","author":"Clapcote","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0165-3806(98)00078-9","article-title":"Ontogeny of cation\u2013Cl\u2212 cotransporter expression in rat neocortex","volume":"109","author":"Clayton","year":"1998","journal-title":"Dev. Brain Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1074\/jbc.275.3.1976","article-title":"Transport and pharmacological properties of nine different human Na,K-ATPase isozymes","volume":"275","author":"Crambert","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1152\/jn.00240.2001","article-title":"Differential role of KIR channel and Na+\/K+-pump in the regulation of extracellular K+ in rat hippocampus","volume":"87","author":"D'Ambrosio","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0306-4522(92)90316-T","article-title":"An [Na+ + K+]coupledl-glutamate transporter purified from rat brain is located in glial cell processes","volume":"51","author":"Danbolt","year":"1992","journal-title":"Neuroscience"},{"key":"B22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuron.2004.06.028","article-title":"Mutations in the Na+\/K+-ATPase \u03b13 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism","volume":"43","author":"de Carvalho Aguiar","year":"2004","journal-title":"Neuron"},{"key":"B23","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/ng1081","article-title":"Haploinsufficiency of ATP1A2 encoding the Na+\/K+ pump [alpha]2 subunit associated with familial hemiplegic migraine type 2","volume":"33","author":"De Fusco","year":"2003","journal-title":"Nat. Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00439-009-0684-z","article-title":"Molecular genetics of migraine","volume":"126","author":"de Vries","year":"2009","journal-title":"Hum. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"26245","DOI":"10.1074\/jbc.M110.123976","article-title":"The rapid-onset dystonia parkinsonism mutation D923N of the Na+,K+-ATPase \u03b13 isoform disrupts Na+ interaction at the third Na+ site","volume":"285","author":"Einholm","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1113\/jphysiol.1956.sp005467","article-title":"The after-effects of impulses in the giant nerve fibres of Loligo","volume":"131","author":"Frankenhaeuser","year":"1956","journal-title":"J. Physiol."},{"key":"B27","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1523\/JNEUROSCI.17-21-08363.1997","article-title":"Glutamate transporter protein subtypes are expressed differentially during rat CNS development","volume":"17","author":"Furuta","year":"1997","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0006-8993(74)90767-7","article-title":"Potassium activity in rabbit cortex","volume":"75","author":"Futamachi","year":"1974","journal-title":"Brain Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1113\/jphysiol.1983.sp014539","article-title":"A study of the mechanisms by which potassium moves through brain tissue in the rat","volume":"335","author":"Gardner-Medwin","year":"1983","journal-title":"J. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1139\/y87-164","article-title":"Cellular mechanisms of potassium homeostasis in the mammalian nervous system","volume":"65","author":"Grafe","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0006-8993(83)91285-4","article-title":"Glial contribution to seizure: K+ activation of (Na+, K+)-ATPase in bulk isolated glial cells and synaptosomes of epileptogenic cortex","volume":"261","author":"Grisar","year":"1983","journal-title":"Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0197-0186(80)90038-8","article-title":"Glial control of neuronal excitability in mammals: II. Enzymatic evidence: two molecular forms of the (Na+,K+)-ATPase in brain","volume":"2","author":"Grisar","year":"1980","journal-title":"Neurochem. Int."},{"key":"B33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/jnr.490290212","article-title":"Phosphorylation of brain (NA+,K+)-ATPase alpha catalytic subimits in normal and epileptic cerebral cortex: II. Partial seizures in human epilepsy","volume":"29","author":"Guillaume","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"13025","DOI":"10.1523\/JNEUROSCI.0220-13.2013","article-title":"A sodium-pump-mediated afterhyperpolarization in pyramidal neurons","volume":"33","author":"Gulledge","year":"2013","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1152\/jn.1990.63.2.225","article-title":"Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices","volume":"63","author":"Haglund","year":"1990","journal-title":"J. Neurophysiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0197-0186(95)00081-X","article-title":"Acute and chronic effects of potassium and noradrenaline on Na+, K+-ATPase activity in cultured mouse neurons and astrocytes","volume":"28","author":"Hajek","year":"1996","journal-title":"Neurochem. Int."},{"key":"B37","doi-asserted-by":"publisher","first-page":"30826","DOI":"10.1074\/jbc.273.46.30826","article-title":"Role of \u03b2-subunit domains in the assembly, stable expression, intracellular routing, and functional properties of Na,K-ATPase","volume":"273","author":"Hasler","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0006-8993(77)90903-9","article-title":"Ceiling of stimulus induced rises in extracellular potassium concentration in the cerebral cortex of cat","volume":"120","author":"Heinemann","year":"1977","journal-title":"Brain Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S1474-4422(14)70011-0","article-title":"Distinct neurological disorders with ATP1A3 mutations","volume":"13","author":"Heinzen","year":"2014","journal-title":"Lancet Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s11064-014-1505-x","article-title":"Role of the astrocytic Na+, K+-ATPase in K+ Homeostasis in brain: K+ uptake, signaling pathways and substrate utilization","volume":"40","author":"Hertz","year":"2015","journal-title":"Neurochem. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"20442","DOI":"10.1038\/srep20442","article-title":"Tuning of the Na,K-ATPase by the beta subunit","volume":"6","author":"Hilbers","year":"2016","journal-title":"Sci. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1113\/jphysiol.2001.013201","article-title":"Functional differences between \u03b1 subunit isoforms of the rat Na,K-ATPase expressed in Xenopus oocytes","volume":"539","author":"Horisberger","year":"2002","journal-title":"J. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/epi.12878","article-title":"Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization","volume":"56","author":"Hunanyan","year":"2015","journal-title":"Epilepsia"},{"key":"B44","doi-asserted-by":"publisher","first-page":"10693","DOI":"10.1523\/JNEUROSCI.2909-04.2004","article-title":"Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase \u03b12 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons","volume":"24","author":"Ikeda","year":"2004","journal-title":"J. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1113\/jphysiol.2012.247817","article-title":"Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice","volume":"591","author":"Ikeda","year":"2013","journal-title":"J. Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e98469","DOI":"10.1371\/journal.pone.0098469","article-title":"Role of Na,K-ATPase \u03b11 and \u03b12 isoforms in the support of astrocyte glutamate uptake","volume":"9","author":"Illarionava","year":"2014","journal-title":"PLoS ONE"},{"key":"B47","doi-asserted-by":"crossref","first-page":"16925","DOI":"10.1016\/S0021-9258(18)55391-6","article-title":"Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells","volume":"266","author":"Jewell","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1073\/pnas.94.5.1800","article-title":"Na+ pump low and high ouabain affinity \u03b1 subunit isoforms are differently distributed in cells","volume":"94","author":"Juhaszova","year":"1997","journal-title":"Proc. Natl. Acad. Sci.U.S.A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1126\/science.2785716","article-title":"Spatial buffering of light-evoked potassium increases by retinal m\u00fcller (Glial) cells","volume":"244","author":"Karwoski","year":"1989","journal-title":"Science"},{"key":"B50","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0006-8993(78)90200-7","article-title":"ATPase and carbonic anhydrase activities of bulk-isolated neuron, glia and synaptosome fractions from rat brain","volume":"141","author":"Kimelberg","year":"1978","journal-title":"Brain Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1037\/bne0000097","article-title":"Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation","volume":"129","author":"Kirshenbaum","year":"2015","journal-title":"Behav. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/j.1601-183X.2011.00691.x","article-title":"Decreased neuronal Na+,K+-ATPase activity in Atp1a3 heterozygous mice increases susceptibility to depression-like endophenotypes by chronic variable stress","volume":"10","author":"Kirshenbaum","year":"2011","journal-title":"Genes Brain Behav."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.neuroscience.2004.06.008","article-title":"Potassium buffering in the central nervous system","volume":"129","author":"Kofuji","year":"2004","journal-title":"Neuroscience"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1139\/y72-177","article-title":"Extracellular K + activity and slow potential changes in spinal cord and medulla","volume":"50","author":"Krnjevic","year":"1972","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B55","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF00348592","article-title":"Glial cells in the central nervous system of the leech; their membrane potential and potassium content","volume":"248","author":"Kuffler","year":"1964","journal-title":"Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol."},{"key":"B56","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1152\/jn.1964.27.2.290","article-title":"Glia in the leech central nervous system: physiological properties and neuron-glia relationship","volume":"27","author":"Kuffler","year":"1964","journal-title":"J. Neurophysiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.1113\/jphysiol.2009.182279","article-title":"Synaptically induced sodium signals in hippocampal astrocytes in situ","volume":"587","author":"Langer","year":"2009","journal-title":"J. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/glia.21259","article-title":"Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ","volume":"60","author":"Langer","year":"2012","journal-title":"Glia"},{"key":"B59","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/glia.22629","article-title":"Contributions of the Na+\/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses","volume":"62","author":"Larsen","year":"2014","journal-title":"Glia"},{"key":"B60","doi-asserted-by":"publisher","first-page":"544","DOI":"10.4161\/19336950.2014.970448","article-title":"Kir4.1-mediated spatial buffering of K+: experimental challenges in determination of its temporal and quantitative contribution to K+ clearance in the brain","volume":"8","author":"Larsen","year":"2014","journal-title":"Channels"},{"key":"B61","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e1002129","DOI":"10.1371\/journal.pgen.1002129","article-title":"Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2","volume":"7","author":"Leo","year":"2011","journal-title":"PLoS Genet."},{"key":"B63","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1523\/JNEUROSCI.18-23-09620.1998","article-title":"Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake","volume":"18","author":"Levy","year":"1998","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1528-1157.1977.tb04997.x","article-title":"Potassium clearance and reactive gliosis in the alumina gel lesion","volume":"18","author":"Lewis","year":"1977","journal-title":"Epilepsia"},{"key":"B65","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1007\/s11064-013-0986-3","article-title":"Cell-specific mRNA alterations in Na+, K+-ATPase \u03b1 and \u03b2 isoforms and FXYD in mice treated chronically with carbamazepine, an anti-bipolar drug","volume":"38","author":"Li","year":"2013","journal-title":"Neurochem. Res."},{"key":"B66","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1016\/S0021-9258(17)39214-1","article-title":"Insulin affects the sodium affinity of the rat adipocyte (Na+,K+)-ATPase","volume":"260","author":"Lytton","year":"1985","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1007\/s11064-012-0731-3","article-title":"Glial K+ clearance and cell swelling: key roles for cotransporters and pumps","volume":"37","author":"MacAulay","year":"2012","journal-title":"Neurochem. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/1098-1136(200009)31:3206::AID-GLIA203.0.CO;2-1","article-title":"Oligodendrocytes in brain and optic nerve express the \u03b23 subunit isoform of Na,K-ATPase","volume":"31","author":"Mart\u00edn-Vasallo","year":"2000","journal-title":"Glia"},{"key":"B69","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1523\/JNEUROSCI.11-02-00381.1991","article-title":"Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase","volume":"11","author":"McGrail","year":"1991","journal-title":"J. Neurosci."},{"key":"B70","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1523\/JNEUROSCI.06-05-01272.1986","article-title":"Immunofluorescent localization of two different Na,K-ATPases in the rat retina and in identified dissociated retinal cells","volume":"6","author":"McGrail","year":"1986","journal-title":"J. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1074\/jbc.M211315200","article-title":"The Na,K-ATPase \u03b12 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice","volume":"278","author":"Moseley","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B72","doi-asserted-by":"crossref","first-page":"C1355","DOI":"10.1152\/ajpcell.2001.281.4.C1355","article-title":"Ouabain and substrate affinities of human Na+-K+-ATPase \u03b11\u03b21, \u03b12\u03b21, and \u03b13\u03b21when expressed separately in yeast cells","volume":"281","author":"M\u00fcller-Ehmsen","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/cbf.1217","article-title":"Glutamate modulates sodium-potassium-ATPase through cyclic GMP and cyclic GMP-dependent protein kinase in rat striatum","volume":"23","author":"Munhoz","year":"2005","journal-title":"Cell Biochem. Funct."},{"key":"B74","doi-asserted-by":"crossref","first-page":"16668","DOI":"10.1016\/S0021-9258(19)89442-5","article-title":"Tissue- and isoform-specific kinetic behavior of the Na,K-ATPase","volume":"269","author":"Munzer","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1152\/jn.1966.29.4.788","article-title":"Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia","volume":"29","author":"Orkand","year":"1966","journal-title":"J. Neurophysiol."},{"key":"B76","doi-asserted-by":"crossref","first-page":"10436","DOI":"10.1016\/S0021-9258(19)81535-1","article-title":"Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs","volume":"263","author":"Orlowski","year":"1988","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1046\/j.1471-4159.1997.69052132.x","article-title":"Glutamate uptake stimulates Na+,K+-ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain","volume":"69","author":"Pellerin","year":"1997","journal-title":"J. Neurochem."},{"key":"B78","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1523\/JNEUROSCI.17-10-03488.1997","article-title":"Isoforms of Na,K-ATPase \u03b1 and \u03b2 subunits in the rat cerebellum and in granule cell cultures","volume":"17","author":"Peng","year":"1997","journal-title":"J. Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.nurt.2007.01.008","article-title":"Familial hemiplegic migraine","volume":"4","author":"Pietrobon","year":"2007","journal-title":"Neurotherapeutics"},{"key":"B80","doi-asserted-by":"crossref","first-page":"C173","DOI":"10.1152\/ajpcell.1997.272.1.C173","article-title":"Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system","volume":"272(Pt 1)","author":"Plotkin","year":"1997","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0006-8993(73)90758-0","article-title":"Measurement of extracellular potassium activity in cat cortex","volume":"50","author":"Prince","year":"1973","journal-title":"Brain Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/bf02207286","article-title":"Culturing induced expression of basolateral Na+-K+-2Cl- cotransporter BSC2 in proximal tubule, aortic endothelium, and vascular smooth muscle","volume":"431","author":"Raat","year":"1996","journal-title":"Pflugers Arch."},{"key":"B83","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1469-7793.2000.00427.x","article-title":"Activity-dependent extracellular K+ accumulation in rat optic nerve: the role of glial and axonal Na+ pumps","volume":"522","author":"Ransom","year":"2000","journal-title":"J. Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1113\/jphysiol.2007.144733","article-title":"Differential expression of Na+\/K+-ATPase \u03b1-subunits in mouse hippocampal interneurones and pyramidal cells","volume":"585","author":"Richards","year":"2007","journal-title":"J. Physiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/glia.22492","article-title":"Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions","volume":"61","author":"Rose","year":"2013","journal-title":"Glia"},{"key":"B86","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.1523\/JNEUROSCI.1081-09.2009","article-title":"Glutamate transporter coupling to Na,K-ATPase","volume":"29","author":"Rose","year":"2009","journal-title":"J. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/j.1468-2982.2007.01267.x","article-title":"Abnormalities of Na\/K ATPase in migraine with aura","volume":"27","author":"Scarrone","year":"2007","journal-title":"Cephalalgia"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1074\/jbc.M111.323022","article-title":"Inhibition of Phosphorylation of Na+,K+-ATPase by mutations causing familial hemiplegic migraine","volume":"287","author":"Schack","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"11106","DOI":"10.1073\/pnas.0504323102","article-title":"Alterations in the \u03b12 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2","volume":"102","author":"Segall","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B90","doi-asserted-by":"publisher","first-page":"43692","DOI":"10.1074\/jbc.M407471200","article-title":"Kinetic alterations due to a missense mutation in the Na,K-ATPase \u03b12 subunit cause familial hemiplegic migraine type 2","volume":"279","author":"Segall","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/glia.22735","article-title":"Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance","volume":"63","author":"Seidel","year":"2015","journal-title":"Glia"},{"key":"B92","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.neuroscience.2013.09.043","article-title":"Links between l-glutamate transporters, Na+\/K+-ATPase and cytoskeleton in astrocytes: Evidence following inhibition with rottlerin","volume":"254","author":"Sheean","year":"2013","journal-title":"Neuroscience"},{"key":"B93","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/0006-8993(75)90751-9","article-title":"Extracellular potassium gradients and visual receptive fields in the cat striate cortex","volume":"96","author":"Singer","year":"1975","journal-title":"Brain Res."},{"key":"B94","doi-asserted-by":"crossref","first-page":"C1710","DOI":"10.1152\/ajpcell.2000.279.6.C1710","article-title":"Regulation of Na+-K+-Cl\u2212cotransporter in primary astrocytes by dibutyryl cAMP and high [K+]o","volume":"279","author":"Su","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbr.2014.06.048","article-title":"Heterozygous mice deficient in Atp1a3 exhibit motor deficits by chronic restraint stress","volume":"272","author":"Sugimoto","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B96","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1016\/S0021-9258(17)39059-2","article-title":"Enzymatic properties of separated isozymes of the Na,K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry","volume":"260","author":"Sweadner","year":"1985","journal-title":"J. Biol. Chem."},{"key":"B97","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pediatrneurol.2014.09.015","article-title":"The expanding spectrum of neurological phenotypes in children with ATP1A3 mutations, alternating hemiplegia of childhood, rapid-onset dystonia-parkinsonism, CAPOS and beyond","volume":"52","author":"Sweney","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0006-8993(74)90428-4","article-title":"Changes of extracellular potassium concentration during spontaneous activity in the mesencephalic reticular formation of the rat","volume":"79","author":"Sykov\u00e1","year":"1974","journal-title":"Brain Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"7104","DOI":"10.1074\/jbc.271.12.7104","article-title":"Tissue-specific versus isoform-specific differences in cation activation kinetics of the Na,K-ATPase","volume":"271","author":"Therien","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"26115","DOI":"10.1074\/jbc.M112.370734","article-title":"Subunit isoform selectivity in assembly of Na,K-ATPase \u03b1-\u03b2 heterodimers","volume":"287","author":"Tokhtaeva","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.1021\/bi002367m","article-title":"Mutational effects on conformational changes of the dephospho- and phospho-forms of the Na+,K+-ATPase\u2020","volume":"40","author":"Toustrup-Jensen","year":"2001","journal-title":"Biochemistry"},{"key":"B102","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1074\/jbc.M113.543272","article-title":"Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease","volume":"289","author":"Toustrup-Jensen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B103","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/oxfordjournals.jbchem.a132654","article-title":"Organ specificity of rat sodium- and potassium-activated adenosine triphosphatase","volume":"86","author":"Urayama","year":"1979","journal-title":"J. Biochem."},{"key":"B104","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0197-0186(99)00137-0","article-title":"Role of astrocytes in the clearance of excess extracellular potassium","volume":"36","author":"Walz","year":"2000","journal-title":"Neurochem. Int."},{"key":"B105","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1471-4159.1982.tb04702.x","article-title":"Ouabain-sensitive and ouabain-resistant net uptake of potassium into astrocytes and neurons in primary cultures","volume":"39","author":"Walz","year":"1982","journal-title":"J. Neurochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/jcbfm.1984.42","article-title":"Intense furosemide-sensitive potassium accumulation in astrocytes in the presence of pathologically high extracellular potassium levels","volume":"4","author":"Walz","year":"1984","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B107","doi-asserted-by":"publisher","first-page":"ra26","DOI":"10.1126\/scisignal.2002334","article-title":"Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+","volume":"5","author":"Wang","year":"2012","journal-title":"Sci. Signal"},{"key":"B108","doi-asserted-by":"publisher","first-page":"7425","DOI":"10.1073\/pnas.88.16.7425","article-title":"Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system","volume":"88","author":"Watts","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.bbadis.2014.03.002","article-title":"Alternating Hemiplegia of Childhood mutations have a differential effect on Na+,K+-ATPase activity and ouabain binding","volume":"1842","author":"Weigand","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B110","doi-asserted-by":"publisher","first-page":"S263","DOI":"10.1139\/y92-271","article-title":"Effect of elevated potassium on the ion content of mouse astrocytes and neurons","volume":"70","author":"White","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1085\/jgp.110.2.201","article-title":"Sodium kinetics of Na,K-ATPase \u03b1 isoforms in intact transfected HeLa cells","volume":"110","author":"Zahler","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:04:47Z","timestamp":1692284687000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphys.2016.00141\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":112,"URL":"https:\/\/doi.org\/10.3389\/fphys.2016.00141","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}