{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:20:29Z","timestamp":1791426029897,"version":"4.3.3"},"reference-count":53,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02166"],"award-info":[{"award-number":["PI13\/02166"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2016.00280","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T07:25:56Z","timestamp":1467271556000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevention of Bone Loss in a Model of Postmenopausal Osteoporosis through Adrenomedullin Inhibition"],"prefix":"10.3389","volume":"7","author":[{"given":"Sonia","family":"Mart\u00ednez-Herrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio M.","family":"Larrayoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ochoa-Callejero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Allueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/art.33426","article-title":"Adrenomedullin(22-52) combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis","volume":"64","author":"Ah Kioon","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev-med-070313-022841","article-title":"Management of postmenopausal osteoporosis","volume":"66","author":"Andreopoulou","year":"2015","journal-title":"Annu. Rev. Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jneumeth.2008.08.024","article-title":"Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice","volume":"176","author":"B\u00e4ckman","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"B4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1073\/pnas.98.2.615","article-title":"Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene","volume":"98","author":"Caron","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1530\/EJE-11-0513","article-title":"Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene","volume":"165","author":"Cheung","year":"2011","journal-title":"Eur. J. Endocrinol"},{"key":"B6","first-page":"E1113","article-title":"Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo.","volume":"273","author":"Cornish","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0167-0115(03)00025-9","article-title":"Adrenomedullin\u2013a regulator of bone formation","volume":"112","author":"Cornish","year":"2003","journal-title":"Regul. Pept"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1128\/MCB.26.7.2511-2518.2006","article-title":"Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene","volume":"26","author":"Dackor","year":"2006","journal-title":"Mol. Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/biof.1120","article-title":"Ghrelin and bone","volume":"40","author":"Delhanty","year":"2014a","journal-title":"Biofactors"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1210\/en.2013-2055","article-title":"Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling","volume":"155","author":"Delhanty","year":"2014b","journal-title":"Endocrinology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1113\/expphysiol.2007.041962","article-title":"Stimulation of intramembranous bone repair in rats by ghrelin","volume":"93","author":"Deng","year":"2008","journal-title":"Exp. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1210\/en.2010-0121","article-title":"Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity","volume":"151","author":"Fern\u00e1ndez","year":"2010","journal-title":"Endocrinology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"12581","DOI":"10.1073\/pnas.0803174105","article-title":"Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions","volume":"105","author":"Fern\u00e1ndez","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1172\/JCI33302","article-title":"Adrenomedullin signaling is necessary for murine lymphatic vascular development","volume":"118","author":"Fritz-Six","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1359\/JBMR.041237","article-title":"Ghrelin directly regulates bone formation","volume":"20","author":"Fukushima","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.14670\/HH-11-704","article-title":"Adrenomedullin regulates club cell recovery following lung epithelial injury.","volume":"31","author":"Garc\u00eda-Sanmart\u00edn","year":"2016","journal-title":"Histol. Histopathol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1101\/sqb.2011.76.010447","article-title":"Surviving starvation: essential role of the ghrelin-growth hormone axis","volume":"76","author":"Goldstein","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/sj.onc.1206207","article-title":"Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis","volume":"22","author":"Ishikawa","year":"2003","journal-title":"Oncogene"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1007\/s00198-013-2371-0","article-title":"The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing","volume":"24","author":"Jeyabalan","year":"2013","journal-title":"Osteoporos. Int"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1096\/fj.08-127852","article-title":"Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice","volume":"23","author":"Kaafarani","year":"2009","journal-title":"FASEB J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.acra.2013.12.009","article-title":"CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice","volume":"21","author":"Kang","year":"2014","journal-title":"Acad. Radiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/CIRCULATIONAHA.112.000756","article-title":"Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis","volume":"127","author":"Koyama","year":"2013","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12967-014-0339-2","article-title":"Adrenomedullin and tumour microenvironment","volume":"12","author":"Larr\u00e1yoz","year":"2014","journal-title":"J. Transl. Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.2174\/13892037113149990059","article-title":"Is the cytoskeleton an intracellular receptor for adrenomedullin and PAMP?","volume":"14","author":"Larr\u00e1yoz","year":"2013","journal-title":"Curr. Protein Pept. Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11010-014-2318-6","article-title":"Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells","volume":"402","author":"Liang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"B26","first-page":"841","article-title":"Study on the level of plasma calcitonin gene-related peptide and adrenomedullin in subjects with primary osteoporosis.","volume":"81","author":"Lin","year":"2001","journal-title":"Zhonghua Yi. Xue. Za Zhi"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7696(02)21010-4","article-title":"Cell and molecular biology of the multifunctional peptide, adrenomedullin","volume":"221","author":"L\u00f3pez","year":"2002","journal-title":"Int. Rev. Cytol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.molmet.2015.01.002","article-title":"Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling","volume":"4","author":"Ma","year":"2015","journal-title":"Mol. Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.metabol.2015.07.011","article-title":"Novel therapies for osteoporosis","volume":"64","author":"Makras","year":"2015","journal-title":"Metabolism"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/S0196-9781(99)00158-8","article-title":"Is adrenomedullin a causal agent in some cases of type 2 diabetes?","volume":"20","author":"Mart\u00ednez","year":"1999","journal-title":"Peptides"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1210\/en.2003-1251","article-title":"Identification of vasoactive nonpeptidic positive and negative modulators of adrenomedullin using a neutralizing antibody-based screening strategy","volume":"145","author":"Mart\u00ednez","year":"2004a","journal-title":"Endocrinology"},{"key":"B32","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1210\/endo.136.9.7649118","article-title":"Expression of adrenomedullin in normal human lung and in pulmonary tumors","volume":"136","author":"Martinez","year":"1995","journal-title":"Endocrinology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1042\/BJ20040920","article-title":"Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator","volume":"383","author":"Mart\u00ednez","year":"2004b","journal-title":"Biochem. J"},{"key":"B34","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1210\/endo.137.6.8641217","article-title":"Regulation of insulin secretion and blood glucose metabolism by adrenomedullin","volume":"137","author":"Mart\u00ednez","year":"1996","journal-title":"Endocrinology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"E807","DOI":"10.1210\/jc.2012-4193","article-title":"Cancer protection elicited by a single nucleotide polymorphism close to the adrenomedullin gene","volume":"98","author":"Mart\u00ednez-Herrero","year":"2013","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B36","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"McLatchie","year":"1998","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1210\/endo.138.1.4881","article-title":"Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action","volume":"138","author":"Montuenga","year":"1997","journal-title":"Endocrinology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1210\/endo.142.5.8152","article-title":"A potential role for adrenomedullin as a local regulator of bone growth","volume":"142","author":"Naot","year":"2001","journal-title":"Endocrinology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","author":"NIH Consensus Development Panel on Osteoporosis Prevention","year":"2001","journal-title":"JAMA"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0002-9440(10)62555-2","article-title":"Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo","volume":"160","author":"Ouafik","year":"2002","journal-title":"Am. J. Pathol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"12292","DOI":"10.1074\/jbc.M007822200","article-title":"Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners","volume":"276","author":"Pio","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1158\/0008-5472.CAN-06-3362","article-title":"Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR","volume":"67","author":"Ramachandran","year":"2007","journal-title":"Cancer Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"7264","DOI":"10.1074\/jbc.M305332200","article-title":"Intermedin is a calcitonin\/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor\/receptor activity-modifying protein receptor complexes","volume":"279","author":"Roh","year":"2004","journal-title":"J. Biol. Chem"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/cmdc.200800066","article-title":"Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study","volume":"3","author":"Rold\u00f3s","year":"2008","journal-title":"ChemMedChem"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","article-title":"Osteoporosis","volume":"367","author":"Sambrook","year":"2006","journal-title":"Lancet"},{"key":"B46","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0014-2999(94)00693-2","article-title":"Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat","volume":"272","author":"Santiago","year":"1995","journal-title":"Eur. J. Pharmacol"},{"key":"B47","first-page":"957","article-title":"Distribution and possible function of an adrenomedullin-like peptide in the developing chick limb bud.","volume":"46","author":"Seghatoleslami","year":"2002","journal-title":"Int. J. Dev. Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1161\/hc4101.097111","article-title":"Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene","volume":"104","author":"Shindo","year":"2001","journal-title":"Circulation"},{"key":"B49","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1186\/s13058-014-0458-y","article-title":"Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis","volume":"16","author":"Siclari","year":"2014","journal-title":"Breast Cancer Res"},{"key":"B50","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/ajh\/7.5.478","article-title":"Centrally induced vasopressor and sympathetic responses to a novel endogenous peptide, adrenomedullin, in anesthetized rats.","volume":"7","author":"Takahashi","year":"1994","journal-title":"Am. J. Hypertens"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1210\/jc.2012-2012","article-title":"Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans","volume":"97","author":"Tong","year":"2012","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B52","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/jcp.21294","article-title":"Adrenomedullin is anti-apoptotic in osteoblasts through CGRP1 receptors and MEK-ERK pathway","volume":"215","author":"Uzan","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/bonekey.2014.83","article-title":"The hunger games of skeletal metabolism","volume":"3","author":"Wee","year":"2014","journal-title":"Bonekey. Rep"}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T13:32:00Z","timestamp":1498311120000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphys.2016.00280\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,30]]},"references-count":53,"URL":"https:\/\/doi.org\/10.3389\/fphys.2016.00280","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,30]]}}}