{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:50:33Z","timestamp":1777517433126,"version":"3.51.4"},"reference-count":51,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2016.00370","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T23:09:16Z","timestamp":1472512156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension"],"prefix":"10.3389","volume":"7","author":[{"given":"Andrea","family":"Hartner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Jagusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Cordasic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Veelken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14448","DOI":"10.1073\/pnas.0703577104","article-title":"Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions","volume":"104","author":"Advani","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1161\/01.HYP.33.4.998","article-title":"Structural skin capillary rarefaction in essential hypertension","volume":"33","author":"Antonios","year":"1999a","journal-title":"Hypertension"},{"issue":"4 Pt 1","key":"B3","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1161\/01.HYP.34.4.655","article-title":"Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality","volume":"34","author":"Antonios","year":"1999b","journal-title":"Hypertension"},{"key":"B4","doi-asserted-by":"publisher","first-page":"R1512","DOI":"10.1152\/ajpregu.00014.2008","article-title":"Contrasting effect of exercise and angiotensin II hypertension on in vivo and in vitro cardiac angiogenesis in rats","volume":"295","author":"Belabbas","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0002-9149(00)01512-5","article-title":"Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension","volume":"87","author":"Belgore","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/hr.2010.123","article-title":"Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure","volume":"33","author":"Biala","year":"2010","journal-title":"Hypertens. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1046\/j.1523-1755.2000.00277.x","article-title":"Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo","volume":"58","author":"Brown","year":"2000","journal-title":"Kidney Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/jch.12052","article-title":"Malignant hypertension in patients treated with vascular endothelial growth factor inhibitors","volume":"15","author":"Caro","year":"2013","journal-title":"J. Clin. Hypertens."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e54668","DOI":"10.1371\/journal.pone.0054668","article-title":"Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/HYPERTENSIONAHA.109.129973","article-title":"Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression","volume":"54","author":"Facemire","year":"2009","journal-title":"Hypertension"},{"key":"B11","first-page":"718","article-title":"The disc angiogenesis system","volume":"58","author":"Fajardo","year":"1988","journal-title":"Lab. Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1101\/gr.6.10.995","article-title":"A novel method for real time quantitative RT-PCR","volume":"6","author":"Gibson","year":"1996","journal-title":"Genome Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1093\/ndt\/gfq143","article-title":"Long-term renal survival in malignant hypertension","volume":"25","author":"Gonz\u00e1lez","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"B14","doi-asserted-by":"publisher","first-page":"R142","DOI":"10.1152\/ajpregu.90972.2008","article-title":"Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats","volume":"297","author":"Gu","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1093\/ndt\/gfl065","article-title":"Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats","volume":"21","author":"Hartner","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/hc3601.095576","article-title":"Angiotensin II type 1 receptor blockade prevents lethal malignant hypertension: relation to kidney inflammation","volume":"104","author":"Hilgers","year":"2001","journal-title":"Circulation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/annonc\/mdi247","article-title":"Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors","volume":"16","author":"Holden","year":"2005","journal-title":"Ann. Oncol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1097\/01.hjh.0000174607.18780.62","article-title":"Angiogenesis and arteriogenesis are increased in fibrin gel chambers implanted in prehypertensive spontaneously hypertensive rats","volume":"23","author":"Hudlett","year":"2005","journal-title":"J. Hypertens."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1038\/sj.ki.5000448","article-title":"Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats","volume":"69","author":"Jacobi","year":"2006","journal-title":"Kidney Int."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1161\/01.CIR.0000158487.80483.09","article-title":"Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis","volume":"111","author":"Jacobi","year":"2005","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1161\/01.CIR.102.12.1414","article-title":"Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine","volume":"102","author":"Jang","year":"2000","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1046\/j.1523-1755.1999.00571.x","article-title":"Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats","volume":"56","author":"Kantachuvesiri","year":"1999","journal-title":"Kidney Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-4800(92)90019-8","article-title":"Characterization and applications of the disc angiogenesis system","volume":"56","author":"Kowalski","year":"1992","journal-title":"Exp. Mol. Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/0895-7061(96)00100-8","article-title":"Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats","volume":"9","author":"Li","year":"1996","journal-title":"Am. J. Hypertens."},{"key":"B27","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1097\/00004872-199508000-00013","article-title":"Complications and survival of 315 patients with malignant-phase hypertension","volume":"13","author":"Lip","year":"1995","journal-title":"J. Hypertens."},{"key":"B28","first-page":"2115","article-title":"Plasma VEGF and soluble VEGF receptor FLT-1 in proliferative retinopathy: relationship to endothelial dysfunction and laser treatment","volume":"41","author":"Lip","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1 Pt 2","key":"B29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1161\/01.HYP.33.1.212","article-title":"Hypertension-induced end-organ damage: a new transgenic approach to an old problem","volume":"33","author":"Luft","year":"1999","journal-title":"Hypertension"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/sj.ki.5000201","article-title":"Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury","volume":"69","author":"Ma","year":"2006","journal-title":"Kidney Int."},{"issue":"4 Pt 2","key":"B31","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.HYP.25.4.674","article-title":"Expression of angiotensin-converting enzyme in renovascular hypertensive rat kidney","volume":"25","author":"Mai","year":"1995","journal-title":"Hypertension"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e20369","DOI":"10.1371\/journal.pone.0020369","article-title":"Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction","volume":"6","author":"Menendez-Castro","year":"2011","journal-title":"PLoS ONE"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/ndt\/gfs517","article-title":"Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations","volume":"28","author":"Menendez-Castro","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"B34","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/pr.2014.27","article-title":"Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction","volume":"75","author":"Menendez-Castro","year":"2014","journal-title":"Pediatr. Res."},{"key":"B35","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1152\/ajplegacy.1976.230.3.849","article-title":"Effects of saline drinking on malignant course of renal hypertension in rats","volume":"230","author":"M\u00f6hring","year":"1976","journal-title":"Am. J. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/01.HYP.36.2.282","article-title":"Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage","volume":"36","author":"Muller","year":"2000","journal-title":"Hypertension"},{"key":"B37","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1365-2796.2005.01550.x","article-title":"Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]","volume":"258","author":"Nadar","year":"2005","journal-title":"J. Intern. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1172\/JCI119354","article-title":"Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure","volume":"99","author":"Noon","year":"1997","journal-title":"J. Clin. Invest."},{"key":"B39","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1161\/01.HYP.31.4.995","article-title":"Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats","volume":"31","author":"Orth","year":"1998","journal-title":"Hypertension"},{"issue":"12 Pt 2","key":"B40","doi-asserted-by":"publisher","first-page":"4258s","DOI":"10.1158\/1078-0432.CCR-040023","article-title":"Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer","volume":"10","author":"Sandler","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1111\/j.1600-6143.2005.01047.x","article-title":"Sirolimus-induced thrombotic microangiopathy is associated with decreased expression of vascular endothelial growth factor in kidneys","volume":"5","author":"Sartelet","year":"2005","journal-title":"Am. J. Transplant."},{"key":"B42","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/ki.1993.89","article-title":"Reversible compensatory hypertrophy in rat kidneys: morphometric characterization","volume":"43","author":"Schwartz","year":"1993","journal-title":"Kidney Int."},{"key":"B43","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1161\/01.RES.0000182677.89816.38","article-title":"Complement activation in angiotensin II-induced organ damage","volume":"97","author":"Shagdarsuren","year":"2005","journal-title":"Circ. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/HYPERTENSIONAHA.110.166314","article-title":"Persistent macrovascular and microvascular dysfunction in patients with malignant hypertension","volume":"57","author":"Shantsila","year":"2011","journal-title":"Hypertension"},{"key":"B45","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2174\/157016110793563834","article-title":"Malignant hypertension: a rare problem or is it underdiagnosed?","volume":"8","author":"Shantsila","year":"2010","journal-title":"Curr. Vasc. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.2174\/1381612033454621","article-title":"Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling","volume":"9","author":"Stefansson","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"B47","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1074\/jbc.M007609200","article-title":"Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1","volume":"276","author":"Stefansson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e108862","DOI":"10.1371\/journal.pone.0108862","article-title":"Association of angiopoietin-2 with renal outcome in chronic kidney disease","volume":"9","author":"Tsai","year":"2014","journal-title":"PLoS ONE"},{"issue":"6 Pt 1","key":"B49","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1161\/01.HYP.26.6.925","article-title":"Endothelin in the kidney in malignant phase hypertension","volume":"26","author":"Whitworth","year":"1995","journal-title":"Hypertension"},{"key":"B50","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1172\/JCI101051","article-title":"A simple method for determining the systolic blood pressure of the unanesthetized rat","volume":"18","author":"Williams","year":"1939","journal-title":"J. Clin. Invest."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1161\/HYPERTENSIONAHA.107.109066","article-title":"Hypertension impairs postnatal vasculogenesis: role of antihypertensive agents","volume":"51","author":"You","year":"2008","journal-title":"Hypertension"}],"container-title":["Frontiers in Physiology"],"original-title":[],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T21:53:39Z","timestamp":1568325219000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fphys.2016.00370\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":51,"URL":"https:\/\/doi.org\/10.3389\/fphys.2016.00370","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}