{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:17:54Z","timestamp":1776460674062,"version":"3.51.2"},"reference-count":37,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2016.00484","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T07:06:09Z","timestamp":1477638369000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Late Gadolinium Enhancement Amount As an Independent Risk Factor for the Incidence of Adverse Cardiovascular Events in Patients with Stage C or D Heart Failure"],"prefix":"10.3389","volume":"7","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shukuan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deli","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanming","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/S0735-1097(96)00380-4","article-title":"Relation between gender, etiology and survival in patients with symptomatic heart failure","volume":"28","author":"Adams","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2459\/JCM.0b013e32832bba35","article-title":"Natural history of dilated cardiomyopathy: from asymptomatic left ventricular dysfunction to heart failure\u2013a subgroup analysis from the Trieste Cardiomyopathy Registry","volume":"10","author":"Aleksova","year":"2009","journal-title":"J. Cardiovasc. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"849571","DOI":"10.1155\/2015\/849571","article-title":"Durable mechanical circulatory support versus organ transplantation: past, present, and future","volume":"2015","author":"Anand","year":"2015","journal-title":"Biomed Res. Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1016\/j.jacc.2006.07.049","article-title":"Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy","volume":"48","author":"Assomull","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"Pt 2 Su","key":"B5","doi-asserted-by":"crossref","first-page":"S216","DOI":"10.1016\/S0002-8703(98)70252-2","article-title":"The pathophysiology of advanced heart failure.","volume":"135","author":"Baig","year":"1998","journal-title":"Am. Heart J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S0735-1097(97)00235-0","article-title":"Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy","volume":"30","author":"Bart","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.113.007094","article-title":"Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy","volume":"130","author":"Chan","year":"2014","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.11909\/j.issn.1671-5411.2015.01.007","article-title":"Dilemmas in end-stage heart failure","volume":"12","author":"Chen-Scarabelli","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijcard.2015.08.153","article-title":"Assessment of the relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients","volume":"202","author":"Contaldi","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","article-title":"Idiopathic dilated cardiomyopathy","volume":"331","author":"Dec","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s001470100339","article-title":"Histopathologic findings in explanted heart tissue from patients with end-stage idiopathic dilated cardiomyopathy","volume":"14","author":"de Leeuw","year":"2001","journal-title":"Transpl. Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e283","DOI":"10.1161\/CIR.0b013e318276ce9b","article-title":"2012 ACCF\/AHA\/HRS focused update incorporated into the ACCF\/AHA\/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"127","author":"Epstein","year":"2013","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcmg.2010.11.015","article-title":"Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance","volume":"4","author":"Flett","year":"2011","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S1071-9164(96)80026-1","article-title":"Determinants of prognosis in nonischemic dilated cardiomyopathy","volume":"2","author":"Grzybowski","year":"1996","journal-title":"J. Card. Fail."},{"key":"B15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1001\/jama.2013.1363","article-title":"Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy","volume":"309","author":"Gulati","year":"2013","journal-title":"JAMA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1023\/A:1021109130276","article-title":"Electrophysiology studies in patients with dilated cardiomyopathies","volume":"6","author":"Hsia","year":"2002","journal-title":"Card. Electrophysiol. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jacc.2005.08.022","article-title":"ACC\/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure)","volume":"46","author":"Hunt","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.jacc.2010.06.062","article-title":"Myocardial fibrosis predicts appropriate device therapy in patients with implantable cardioverter-defibrillators for primary prevention of sudden cardiac death","volume":"57","author":"Iles","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1161\/CIRCULATIONAHA.109.192064","article-title":"2009 focused update: ACCF\/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"119","author":"Jessup","year":"2009","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1056\/NEJM199001113220206","article-title":"Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure","volume":"322","author":"Katz","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1161\/CIRCIMAGING.113.001144","article-title":"Late gadolinium enhancement on cardiac magnetic resonance predicts adverse cardiovascular outcomes in nonischemic cardiomyopathy: a systematic review and meta-analysis","volume":"7","author":"Kuruvilla","year":"2014","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","article-title":"Mechanisms and models in heart failure: the biomechanical model and beyond","volume":"111","author":"Mann","year":"2005","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","article-title":"Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"B24","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jcmg.2012.10.028","article-title":"Contrast-enhanced CMR in HCM: what lies behind the bright light of LGE and why it now matters","volume":"6","author":"Maron","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B25","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jcmg.2012.09.018","article-title":"Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR","volume":"6","author":"Moravsky","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1253\/circj.CJ-08-0965","article-title":"Correlation between left ventricular diastolic function and ejection fraction in dilated cardiomyopathy using magnetic resonance imaging with late gadolinium enhancement","volume":"73","author":"Nanjo","year":"2009","journal-title":"Circulation J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.jcmg.2013.05.013","article-title":"CMR quantification of myocardial scar provides additive prognostic information in nonischemic cardiomyopathy","volume":"6","author":"Neilan","year":"2013","journal-title":"JACC Cardiovasc. Imaging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.hrthm.2014.01.014","article-title":"Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy","volume":"11","author":"Perazzolo Marra","year":"2014","journal-title":"Heart Rhythm"},{"key":"B29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1471-2261-14-110","article-title":"Quantifying late gadolinium enhancement on CMR provides additional prognostic information in early risk-stratification of nonischemic cardiomyopathy: a cohort study","volume":"14","author":"P\u00f6yh\u00f6nen","year":"2014","journal-title":"BMC Cardiovasc. Disord."},{"key":"B30","first-page":"841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies","volume-title":"Circulation","author":"Richardson","year":"1996"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1161\/01.CIR.90.6.2772","article-title":"Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis","volume":"90","author":"Rihal","year":"1994","journal-title":"Circulation"},{"key":"B32","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1161\/01.CIR.83.2.504","article-title":"Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy","volume":"83","author":"Schaper","year":"1991","journal-title":"Circulation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"478","DOI":"10.4330\/wjc.v6.i6.478","article-title":"Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies","volume":"6","author":"Sisakian","year":"2014","journal-title":"World J. Cardiol."},{"key":"B34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1016\/j.jacc.2008.03.018","article-title":"Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy","volume":"51","author":"Wu","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1161\/CIR.0b013e31829e8776","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jtcvs.2011.09.032","article-title":"Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature","volume":"143","author":"Yarbrough","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2016.00484\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T03:47:46Z","timestamp":1568519266000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2016.00484\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3389\/fphys.2016.00484","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]}}}