{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:06:49Z","timestamp":1770833209323,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2016.00584","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T03:50:53Z","timestamp":1480391453000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["M-currents (Kv7.2-7.3\/KCNQ2-KCNQ3) Are Responsible for Dysfunctional Autonomic Control in Hypertensive Rats"],"prefix":"10.3389","volume":"7","author":[{"given":"Torill","family":"Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0014-2999(02)02306-3","article-title":"Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine","volume":"452","author":"Berg","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0014-2999(03)01555-3","article-title":"The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats","volume":"466","author":"Berg","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.cardiores.2005.04.006","article-title":"Increased counteracting effect of eNOS and nNOS on an \u03b11-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats","volume":"67","author":"Berg","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fneur.2015.00260","article-title":"Voltage-sensitive K+ channels inhibit parasympathetic ganglion transmission and vagal control of heart rate in hypertensive rats","volume":"6","author":"Berg","year":"2015","journal-title":"Front. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fneur.2011.00071","article-title":"Simultaneous parasympathetic and sympathetic activation reveals altered autonomic control of heart rate, vascular tension, and epinephrine release in anesthetized hypertensive rats","volume":"2","author":"Berg","year":"2011","journal-title":"Front. Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fneur.2013.00019","article-title":"Tyramine reveals failing \u03b12-adrenoceptor control of catecholamine release and total peripheral vascular resistance in hypertensive rats","volume":"4","author":"Berg","year":"2013","journal-title":"Front. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fneur.2012.00160","article-title":"Plasma norepinephrine in hypertensive rats reflects \u03b12-adrenoceptor release control only when re-uptake is inhibited","volume":"3","author":"Berg","year":"2012","journal-title":"Front. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10741-010-9190-6","article-title":"Evidence for impaired vagus nerve activity in heart failure","volume":"16","author":"Bibevski","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/0735-1097(91)90602-6","article-title":"Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model of ventricular failure","volume":"18","author":"Binkley","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/j.1476-5381.2009.00111.x","article-title":"Neural KCNQ (Kv7) channels","volume":"156","author":"Brown","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1046\/j.1460-9568.2003.02588.x","article-title":"Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity","volume":"17","author":"Bymaster","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/HYPERTENSIONAHA.111.187427","article-title":"Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired \u03b2-adrenoceptor-mediated relaxation of renal arteries in hypertension","volume":"59","author":"Chadha","year":"2012","journal-title":"Hypertension"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1113\/jphysiol.2012.235606","article-title":"Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels","volume":"590","author":"Glasscock","year":"2012","journal-title":"J. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/BF00594177","article-title":"Electrophysiological function of the delayed rectifier (IK) in bullfrog sympathetic ganglion neurones","volume":"413","author":"Goh","year":"1989","journal-title":"Pfl\u00fcgers Arch."},{"key":"B15","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/BF00053022","article-title":"Nicotine and sympathetic neurotransmission","volume":"10","author":"Haass","year":"1997","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1161\/CIRCULATIONAHA.111.032136","article-title":"Downregulation of Kv7.4 channel activity in primary and secondary hypertension","volume":"124","author":"Jepps","year":"2011","journal-title":"Circulation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/exer.1994.1005","article-title":"M2-type muscarinic receptors mediate prejunctional inhibition of norepinephrine release in the human iris-ciliary body","volume":"58","author":"Jumblatt","year":"1994","journal-title":"Exp. Eye Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0920-1211(95)00050-X","article-title":"The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro","volume":"22","author":"Kapetanovic","year":"1995","journal-title":"Epilepsy Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/0002-9149(87)90795-8","article-title":"Decreased heart rate variability and its association with increased mortality after acute myocardial infarction","volume":"59","author":"Kleiger","year":"1987","journal-title":"Am. J. Cardiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1124\/jpet.107.135764","article-title":"Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance","volume":"325","author":"Mackie","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B22","first-page":"S3","article-title":"Elevated heart rate as a predictor of increased cardiovascular morbidity","volume":"17","author":"Palatini","year":"1999","journal-title":"J. Hypertens."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1523\/JNEUROSCI.4314-05.2006","article-title":"A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon","volume":"26","author":"Pan","year":"2006","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/HCO.0b013e32834dc4e8","article-title":"Neural mechanisms of atrial fibrillation","volume":"27","author":"Park","year":"2012","journal-title":"Curr. Opin. Cardiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ejmech.2011.01.010","article-title":"Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7\/KCNQ potassium channel activators","volume":"46","author":"Qi","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1055\/s-0031-1300346","article-title":"Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels","volume":"50","author":"Rundfeldt","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"B27","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/01.CIR.0000081775.72651.B6","article-title":"Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy","volume":"108","author":"Schlaich","year":"2003","journal-title":"Circulation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"R819","DOI":"10.1152\/ajpregu.00813.2004","article-title":"Baroreceptors, baroreceptor unloading, and the long-term control of blood pressure","volume":"288","author":"Thrasher","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B29","first-page":"519","article-title":"3,4-Diaminopyridine induced stimulus-bound repetitive firing in frog sympathetic ganglion: no changes in postsynaptic membrane excitability","volume":"39","author":"Vlckov\u00e1","year":"1990","journal-title":"Physiol. Bohemoslov."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1126\/science.282.5395.1890","article-title":"KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel","volume":"282","author":"Wang","year":"1998","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/bf00173395","article-title":"Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo","volume":"338","author":"Wess","year":"1988","journal-title":"Naunyn Schmiedebergs. Arch. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1124\/mol.58.3.591","article-title":"Retigabine, a novel anti-convulsant, enhances activation of KCNQ2\/Q3 potassium channels","volume":"58","author":"Wickenden","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1046\/j.1540-8167.2004.03632.x","article-title":"Electrophysiologic effects of nicorandil on the guinea pig long QT1 syndrome model","volume":"15","author":"Yang","year":"2004","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/sj.bjp.0707284","article-title":"Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity","volume":"151","author":"Yeung","year":"2007","journal-title":"Br. J. Pharmacol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2016.00584\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T03:50:54Z","timestamp":1480391454000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2016.00584\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":34,"URL":"https:\/\/doi.org\/10.3389\/fphys.2016.00584","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,29]]}}}