{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:48:09Z","timestamp":1774921689996,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00086","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T06:20:26Z","timestamp":1490595626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Two Phase Modulation of NH4+ Entry and Cl\u2212\/HCO3- Exchanger in Submandibular Glands Cells by Dexmedetomidine"],"prefix":"10.3389","volume":"8","author":[{"given":"Minjeong","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook Yang","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuk Hui","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ceca.2014.01.006","article-title":"cAMP and Ca2+ signaling in secretory epithelia: crosstalk and synergism","volume":"55","author":"Ahuja","year":"2014","journal-title":"Cell Calcium"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1055\/s-2007-998867","article-title":"[Alpha 2-agonists in anesthesia and intensive medicine]","volume":"28","author":"Bischoff","year":"1993","journal-title":"Anasthesiol. Intensivmed. Notfallmed. Schmerzther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000356624","article-title":"Parallel changes in intracellular water volume and pH induced by NH3\/NH4+ exposure in single neuroblastoma cells","volume":"32","author":"Blanco","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/labinvest.3700366","article-title":"Lipopolysaccharide signaling in endothelial cells","volume":"86","author":"Dauphinee","year":"2006","journal-title":"Lab. Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/00000542-200202000-00034","article-title":"Effect of the \u03b12-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats","volume":"96","author":"Engelhard","year":"2002","journal-title":"Anesthesiology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tripleo.2011.03.016","article-title":"DNA damage in salivary gland tissue in patients with chronic kidney disease, measured by the comet assay","volume":"112","author":"Ersson","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"Pt 2","key":"B7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1113\/jphysiol.1997.sp021932","article-title":"Upregulation of Na+-K+\u22122Cl\u2212 cotransporter activity in rat parotid acinar cells by muscarinic stimulation","volume":"499","author":"Evans","year":"1997","journal-title":"J. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e87239","DOI":"10.1371\/journal.pone.0087239","article-title":"NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity","volume":"9","author":"F\u00e9raille","year":"2014","journal-title":"PLoS ONE"},{"key":"B10","doi-asserted-by":"publisher","first-page":"G493","DOI":"10.1152\/ajpgi.00178.2009","article-title":"AE2 Cl\u2212\/HCO3\u2212 exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon","volume":"298","author":"Gawenis","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1113\/JP271378","article-title":"Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 \u2212 secretion revealed by disease causing human mutation","volume":"593","author":"Hong","year":"2015","journal-title":"J. Physiol. (Lond)."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s00424-013-1390-1","article-title":"Mechanism and synergism in epithelial fluid and electrolyte secretion","volume":"466","author":"Hong","year":"2014","journal-title":"Pflugers Arch."},{"key":"B13","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/19336950.2015.1134068","article-title":"Governing effect of regulatory proteins for Cl\u2212\/HCO3\u2212 exchanger 2 activity","volume":"10","author":"Jeong","year":"2016","journal-title":"Channels (Austin)"},{"key":"B14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1365-2125.1991.tb05505.x","article-title":"Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers","volume":"31","author":"Karhuvaara","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jss.2012.03.073","article-title":"The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits","volume":"178","author":"Kili\u00e7","year":"2012","journal-title":"J. Surg. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.curtheres.2008.04.003","article-title":"Preconditionin effects of dexmedetomidine on myocardial ischemia\/reperfusion injury in rats","volume":"69","author":"Kocoglu","year":"2008","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3745961","DOI":"10.1155\/2016\/3745961","article-title":"The regulatory role of rolipram on inflammatory mediators and cholinergic\/adrenergic stimulation-induced signals in isolated primary mouse submandibular gland cells","volume":"2016","author":"Lee","year":"2016","journal-title":"Mediators Inflamm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1152\/physrev.00011.2011","article-title":"Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion","volume":"92","author":"Lee","year":"2012","journal-title":"Physiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1590\/S0102-865020160010000002","article-title":"Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia\/reperfusion injury in rats","volume":"31","author":"Liu","year":"2016","journal-title":"Acta Cir. Bras."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s13277-014-2639-9","article-title":"NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer","volume":"36","author":"Liu","year":"2015","journal-title":"Tumour Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1007\/s00540-010-1011-5","article-title":"Management of a tumor in the distal trachea while maintaining spontaneous ventilation","volume":"24","author":"Marks","year":"2010","journal-title":"J. Anesth."},{"key":"B22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.archoralbio.2012.06.017","article-title":"Activation of central \u03b12-adrenoceptors mediates salivary gland vasoconstriction","volume":"58","author":"Moreira","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-9255-9-1","article-title":"LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gialpha dependent PI-3kinase signalling","volume":"9","author":"Ngkelo","year":"2012","journal-title":"J. Inflamm. (Lond)."},{"key":"B24","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.resuscitation.2007.01.032","article-title":"The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts","volume":"74","author":"Okada","year":"2007","journal-title":"Resuscitation"},{"key":"B25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"Omori","year":"2007","journal-title":"Circ. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1053\/j.gastro.2013.03.047","article-title":"Irbit mediates synergy between ca2+ and cAMP signaling pathways during epithelial transport in mice","volume":"145","author":"Park","year":"2013","journal-title":"Gastroenterology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e219","DOI":"10.1016\/j.jss.2012.05.047","article-title":"Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia","volume":"179","author":"Peng","year":"2013","journal-title":"J. Surg. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0091-3057(96)00118-9","article-title":"Dissociation of hypnotic-anesthetic actions of \u03b12 agonists from cyclic AMP in the rat","volume":"57","author":"Rabin","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/sj.bjp.0704457","article-title":"Assessing the emetic potential of PDE4 inhibitors in rats","volume":"135","author":"Robichaud","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-3565(24)36631-5","article-title":"Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct","volume":"281","author":"Rouch","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.3892\/etm.2013.1317","article-title":"Effect of dexmedetomidine pretreatment on lung injury following intestinal ischemia-reperfusion","volume":"6","author":"Shen","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","article-title":"Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren's syndrome","volume":"147","author":"Spachidou","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3892\/etm.2015.2561","article-title":"Protective effects of dexmedetomidine on intestinal ischemia-reperfusion injury","volume":"10","author":"Sun","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3892\/ijmm.2014.1863","article-title":"Dexmedetomidine suppresses interleukin-1beta-induced interleukin-6 synthesis in rat glial cells","volume":"34","author":"Tanabe","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.bbrc.2007.11.039","article-title":"Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation","volume":"366","author":"Tateishi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.bbamcr.2014.01.011","article-title":"Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells","volume":"1843","author":"Vieceli Dalla Sega","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B39","doi-asserted-by":"publisher","first-page":"G14","DOI":"10.1152\/ajpgi.00196.2003","article-title":"Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior","volume":"286","author":"Worrell","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.4196\/kjpp.2015.19.5.413","article-title":"Dexmedetomidine modulates histamine-induced Ca2+ signaling and pro-inflammatory cytokine expression","volume":"19","author":"Yang","year":"2015","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1172\/JCI36983","article-title":"IRBIT coordinates epithelial fluid and HCO3\u2212 secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct","volume":"119","author":"Yang","year":"2009","journal-title":"J. Clin. Invest."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00086\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T17:41:40Z","timestamp":1750182100000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00086\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":38,"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00086","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}