{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:19:17Z","timestamp":1790770757758,"version":"4.1.0"},"reference-count":17,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"publisher","award":["1002-039"],"award-info":[{"award-number":["1002-039"]}],"id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00119","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T02:02:57Z","timestamp":1490580177000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Plasma Ghrelin Levels Are Associated with Anorexia but Not Cachexia in Patients with NSCLC"],"prefix":"10.3389","volume":"8","author":[{"given":"Susanne","family":"Blauwhoff-Buskermolen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A. E.","family":"Langius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke C.","family":"Heijboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian A. E.","family":"de van der Schueren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk M. W.","family":"Verheul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00520-015-2826-2","article-title":"The assessment of anorexia in patients with cancer: cut-off values for the FAACT-A\/CS and the VAS for appetite","volume":"24","author":"Blauwhoff-Buskermolen","year":"2016","journal-title":"Support Care Cancer"},{"key":"B2","volume-title":"FACIT Manual: Manual of the Functional Assessment of Chronic Illness Therapy (FACIT) Scales","author":"Cella","year":"1997"},{"key":"B3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1124\/pr.109.001958","article-title":"Ghrelin gene products and the regulation of food intake and gut motility","volume":"61","author":"Chen","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopha.2006.08.007","article-title":"Circulating gastrin and ghrelin levels in patients with colorectal cancer: correlation with tumour stage, Helicobacter pylori infection and BMI","volume":"61","author":"D'Onghia","year":"2007","journal-title":"Biomed. Pharmacother"},{"key":"B5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"B6","first-page":"595","article-title":"What does a patient's outfit weight?","volume":"32","author":"Frank","year":"2000","journal-title":"Fam. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00520-012-1500-1","article-title":"Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study","volume":"21","author":"Garcia","year":"2013","journal-title":"Support Care Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1210\/jc.2004-1788","article-title":"Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia","volume":"90","author":"Garcia","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s10620-006-9508-3","article-title":"Circulating ghrelin in patients with gastric or colorectal cancer","volume":"52","author":"Huang","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.lungcan.2009.02.006","article-title":"Increased serum levels of ghrelin at diagnosis mediate body weight loss in non-small cell lung cancer (NSCLC) patients","volume":"66","author":"Karapanagiotou","year":"2009","journal-title":"Lung Cancer"},{"key":"B11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/jappl.1998.85.1.115","article-title":"Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography","volume":"85","author":"Mitsiopoulos","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1210\/jc.2003-031768","article-title":"Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial","volume":"89","author":"Neary","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1023\/A:1016670403148","article-title":"Re-validation and shortening of the Functional Assessment of Anorexia\/Cachexia Therapy (FAACT) questionnaire","volume":"9","author":"Ribaudo","year":"2000","journal-title":"Qual. Life Res."},{"key":"B15","first-page":"774","article-title":"Increased plasma ghrelin level in lung cancer cachexia","volume":"9","author":"Shimizu","year":"2003","journal-title":"Clin.Cancer Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1470-2045(15)00558-6","article-title":"Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials","volume":"17","author":"Temel","year":"2016","journal-title":"Lancet Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1517\/14656566.2015.1041500","article-title":"Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC","volume":"16","author":"Zhang","year":"2015","journal-title":"Expert Opin. Pharmacother"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00119\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T02:06:11Z","timestamp":1568945171000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00119\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":17,"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00119","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}