{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:09:16Z","timestamp":1777468156193,"version":"3.51.4"},"reference-count":61,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00315","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T03:45:41Z","timestamp":1495079141000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Moderate Treadmill Exercise Training Improves Cardiovascular and Nitrergic Response and Resistance to Trypanosoma cruzi Infection in Mice"],"prefix":"10.3389","volume":"8","author":[{"given":"Bruno F. C.","family":"Lucchetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1gela G.","family":"Zanluqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiviny","family":"de Ataides Raquel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Lovo-Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L. H.","family":"Tatakihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"de Oliveira Bel\u00e9m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisete C.","family":"Michelini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo J.","family":"de Almeida Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phileno","family":"Pinge-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli C.","family":"Martins-Pinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1006\/expr.1996.0109","article-title":"Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection","volume":"84","author":"Abrahamsohn","year":"1996","journal-title":"Exp. Parasitol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1590\/S0100-879X2011007500055","article-title":"Effect of gender on training-induced vascular remodeling in SHR","volume":"44","author":"Amaral","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B3","first-page":"389","article-title":"Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi","volume":"4","author":"Brener","year":"1962","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1161\/01.HYP.36.6.1018","article-title":"Exercise training increases baroreceptor gain sensitivity in normal and hypertensive rats","volume":"36","author":"Brum","year":"2000","journal-title":"Hypertension"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/S1567-5769(01)00090-X","article-title":"Nitric oxide in parasitic infections","volume":"1","author":"Brunet","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1590\/S0074-02761909000200008","article-title":"Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n.gen., n. sp., ajente etiolojico de nova entidade morbida do homem","volume":"1","author":"Chagas","year":"1909","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B7","doi-asserted-by":"publisher","first-page":"H354","DOI":"10.1152\/ajpheart.00898.2007","article-title":"Sympathetic control of heart rate in nNOS knockout mice","volume":"294","author":"Choate","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1524-6175.2003.01734.x","article-title":"The association between physical activity and the development of acute coronary syndromes in treated and untreated hypertensive subjects","volume":"5","author":"Chrysohoou","year":"2003","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"key":"B9","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1038\/nature09220","article-title":"Chagas disease 101","volume":"465","author":"Clayton","year":"2010","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.actatropica.2010.03.008","article-title":"Chagas disease: 100 years after its discovery. A systemic review","volume":"115","author":"Coura","year":"2010","journal-title":"Acta Trop"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e604","DOI":"10.1371\/journal.pntd.0000604","article-title":"IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis","volume":"4","author":"da Matta Guedes","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1161\/01.HYP.30.3.767","article-title":"Exercise training in aging: hemodynamic, metabolic, and oxidative stress evaluations","volume":"30","author":"De Angelis","year":"1997","journal-title":"Hypertension"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1152\/japplphysiol.00870.2003","article-title":"Exercise training changes autonomic cardiovascular balance in mice","volume":"96","author":"De Angelis","year":"2004","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B14","first-page":"H212","article-title":"Exercise training enhances cardiac afferent inhibition of baroreflex function","volume":"258","author":"DiCarlo","year":"1990","journal-title":"Am. J. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1742-4658.2007.05660.x","article-title":"Nitric oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease","volume":"274","author":"Elahi","year":"2007","journal-title":"FEBS J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/hr.2010.106","article-title":"Early physical activity promotes lower prevalence of chronic diseases in adulthood","volume":"33","author":"Fernandes","year":"2010","journal-title":"Hypertens. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1111\/j.1440-1681.2007.04635.x","article-title":"Maximal lactate steady state in running mice: effect of exercise training","volume":"34","author":"Ferreira","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1590\/S0066-782X1998000200006","article-title":"[Effect of exercise duration on the magnitude and duration of post-exercise hypotension]","volume":"70","author":"Forjaz","year":"1998","journal-title":"Arq. Bras. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.2174\/0929867322666151015120804","article-title":"Current and future chemotherapy for chagas disease","volume":"22","author":"Gaspar","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"C254","DOI":"10.1152\/ajpcell.00315.2016","article-title":"Nitric oxide: what's new to NO?","volume":"312","author":"Ghimire","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s12170-015-0463-4","article-title":"Effects of exercise on gene expression of inflammatory markers in human peripheral blood cells: a systematic review","volume":"9","author":"Gjevestad","year":"2015","journal-title":"Curr. Cardiovasc. Risk Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.4269\/ajtmh.14-0433","article-title":"AKT network of genes and impaired myocardial contractility during murine acute Chagasic myocarditis","volume":"92","author":"Henao-Mart\u00ednez","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/HJR.0b013e3281eacef1","article-title":"Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training","volume":"14","author":"Hoydal","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"B24","doi-asserted-by":"publisher","first-page":"6241","DOI":"10.1113\/JP272730","article-title":"Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure","volume":"594","author":"Ichige","year":"2016","journal-title":"J. Physiol. (Lond)."},{"key":"B25","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.parint.2015.02.005","article-title":"Chronic Chagas disease with advanced cardiac complications in Japan: case report and literature review","volume":"64","author":"Imai","year":"2015","journal-title":"Parasitol. Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/tmi.12235","article-title":"Chagas disease in Australia and New Zealand: risks and needs for public health interventions","volume":"19","author":"Jackson","year":"2014","journal-title":"Trop. Med. Int. Health"},{"key":"B27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0733-8651(05)70232-0","article-title":"Exercise as hypertension therapy","volume":"19","author":"Kokkinos","year":"2001","journal-title":"Cardiol. Clin."},{"key":"B28","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1749-6632.2001.tb03689.x","article-title":"Effects of exercise training on baroreflex control of the cardiovascular system","volume":"940","author":"Krieger","year":"2001","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00281-012-0351-7","article-title":"Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease","volume":"34","author":"Machado","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1249\/00005768-199112000-00008","article-title":"Diminished baroreflex control of forearm vascular resistance following training","volume":"23","author":"Mack","year":"1991","journal-title":"Med. Sci. Sports Exerc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.lfs.2006.05.014","article-title":"Heart rate dynamics in iNOS knockout mice","volume":"79","author":"Mani","year":"2006","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1590\/S0100-879X2011007500102","article-title":"Cardiovascular and autonomic modulation by the central nervous system after aerobic exercise training","volume":"44","author":"Martins-Pinge","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.brainres.2010.12.049","article-title":"Nitric oxide inhibition in paraventricular nucleus on cardiovascular and autonomic modulation after exercise training in unanesthetized rats","volume":"1375","author":"Mastelari","year":"2011","journal-title":"Brain Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1161\/01.HYP.0000086201.27420.33","article-title":"Training-induced, pressure-lowering effect in SHR: wide effects on circulatory profile of exercised and nonexercised muscles","volume":"42","author":"Melo","year":"2003","journal-title":"Hypertension"},{"key":"B35","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1042\/bst0160484","article-title":"Characterization and biological significance of endothelium-derived relaxing factor","volume":"16","author":"Moncada","year":"1988","journal-title":"Biochem. Soc. Trans."},{"key":"B36","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s10620-013-2901-9","article-title":"Moderate physical exercise protects myenteric metabolically more active neurons in mice infected with Trypanosoma cruzi","volume":"59","author":"Moreira","year":"","journal-title":"Dig. Dis. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/iep.12049","article-title":"Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi","volume":"94","author":"Moreira","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.exppara.2014.03.005","article-title":"Physical exercise protects myenteric neurons and reduces parasitemia in Trypanosoma cruzi infection","volume":"141","author":"Moreira","year":"","journal-title":"Exp. Parasitol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1161\/CIRCULATIONAHA.113.000891","article-title":"Infection with Trypanosoma cruzi and progression to cardiomyopathy: what is the evidence and is the tide finally turning?","volume":"127","author":"Morillo","year":"2013","journal-title":"Circulation"},{"key":"B40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1475-2840-12-89","article-title":"Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model","volume":"12","author":"Morvan","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"B41","first-page":"54","article-title":"The implication of alterations in leukocyte subset counts on immune function","volume":"12","author":"Nagatomi","year":"2006","journal-title":"Exerc. Immunol. Rev."},{"key":"B42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/clinchem\/44.3.679","article-title":"Semiautomated measurement of nitrate in biological fluids","volume":"44","author":"Navarro-Gonzalvez","year":"1998","journal-title":"Clin. Chem."},{"key":"B43","first-page":"R365","article-title":"Effect of exercise training on RSNA, baroreflex control, and blood pressure responsiveness","volume":"265","author":"Negrao","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B44","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1152\/jappl.1992.72.5.1749","article-title":"Vagal function impairment after exercise training","volume":"72","author":"Negrao","year":"1992","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.lfs.2016.03.053","article-title":"Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy","volume":"152","author":"Novaes","year":"2016","journal-title":"Life Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1590\/S0074-02762009000800002","article-title":"Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection","volume":"104","author":"Oliveira","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.exppara.2010.06.030","article-title":"Trypanosoma cruzi: effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice","volume":"127","author":"Panis","year":"2011","journal-title":"Exp. Parasitol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0020-7519(02)00283-7","article-title":"Severity of chronic Chagas disease is associated with cytokine\/antioxidant imbalance in chronically infected individuals","volume":"33","author":"Perez-Fuentes","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"B49","first-page":"440","article-title":"Identifying Chagas disease in Australia: an emerging challenge for general practitioners","volume":"43","author":"Pinto","year":"2014","journal-title":"Aust. Fam. Physician"},{"key":"B50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fphys.2016.00221","article-title":"Swimming Training Modulates Nitric Oxide-Glutamate Interaction in the Rostral Ventrolateral Medulla in Normotensive Conscious Rats","volume":"7","author":"Raquel Hde","year":"2016","journal-title":"Front. Physiol."},{"key":"B51","first-page":"709","article-title":"Clinical phases and forms of Chagas disease","author":"Rassi","year":"2010","journal-title":"American trypanosomiasis (Chagas Disease). One Hundred Years of Research, 1st Edn."},{"key":"B52","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.4049\/jimmunol.153.7.3135","article-title":"IL-10 mediates susceptibility to Trypanosoma cruzi infection","volume":"153","author":"Reed","year":"1994","journal-title":"J. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e1492","DOI":"10.1371\/journal.pntd.0001492","article-title":"NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection","volume":"6","author":"Santiago","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/B978-0-12-385895-5.00005-0","article-title":"Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways","volume":"76","author":"Scharfstein","year":"2011","journal-title":"Adv. Parasitol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1139\/H09-053","article-title":"Preinfection aerobic treadmill training improves resistance against Trypanosoma cruzi infection in mice","volume":"34","author":"Schebeleski-Soares","year":"2009","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B56","first-page":"191","article-title":"Sobre a cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco","volume":"20","author":"Silva","year":"1953","journal-title":"Folia Clin. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1590\/S0066-782X2007001400005","article-title":"Nitric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic training","volume":"89","author":"Souza","year":"2007","journal-title":"Arq. Bras. Cardiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1055\/s-0032-1329992","article-title":"Exercise improves the Th1 response by modulating cytokine and NO production in BALB\/c mice","volume":"34","author":"Terra","year":"2013","journal-title":"Int. J. Sports Med."},{"key":"B59","first-page":"H2627","article-title":"Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats","volume":"273","author":"Veras-Silva","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B60","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1128\/IAI.62.11.5177-5182.1994","article-title":"Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro","volume":"62","author":"Vespa","year":"1994","journal-title":"Infect. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1159\/000430391","article-title":"Regular exercise enhances the immune response against microbial antigens through up-regulation of toll-like receptor signaling pathways","volume":"37","author":"Zheng","year":"2015","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00315\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:34:56Z","timestamp":1692808496000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00315\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,18]]},"references-count":61,"alternative-id":["10.3389\/fphys.2017.00315"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00315","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,18]]},"article-number":"315"}}