{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:54:13Z","timestamp":1784127253950,"version":"3.55.0"},"reference-count":36,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00359","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T03:47:47Z","timestamp":1496720867000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine"],"prefix":"10.3389","volume":"8","author":[{"given":"Yanzhenzi","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ivell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Janowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Anand-Ivell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2007.04.001","article-title":"Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway","volume":"272","author":"Anand-Ivell","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e19821","DOI":"10.1371\/journal.pone.0019821","article-title":"INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue","volume":"6","author":"Anand-Ivell","year":"2011","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.mce.2013.08.010","article-title":"Regulation of the reproductive cycle and early pregnancy by relaxin family peptides","volume":"382","author":"Anand-Ivell","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1095\/biolreprod.105.048165","article-title":"Expression of the Insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis","volume":"74","author":"Anand-Ivell","year":"2006","journal-title":"Biol. Reprod."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1095\/biolreprod55.6.1452","article-title":"The relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and mRNA analysis","volume":"55","author":"Bathgate","year":"1996","journal-title":"Biol. Reprod"},{"key":"B6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1124\/pr.58.1.9","article-title":"International Union of Pharmacology. Recommendations for the nomenclature of receptors for relaxin family peptides","volume":"58","author":"Bathgate","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1095\/biolreprod61.4.1090","article-title":"Expression and regulation of relaxin like factor (RLF) gene transcripts in the bovine ovary: differentiation dependent expression in theca cell cultures","volume":"61","author":"Bathgate","year":"1999","journal-title":"Biol. Reprod."},{"key":"B8","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.2460\/javma.1996.208.12.2027","article-title":"Hormonal indicators of pregnancy in llamas and alpacas","volume":"208","author":"Bravo","year":"1996","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/ki.2013.518","article-title":"Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis","volume":"86","author":"Chow","year":"2014","journal-title":"Kidney Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1210\/me.2013-1093","article-title":"Research resource: preovulatory LH surge effects on follicular theca and granulosa transcriptomes","volume":"27","author":"Christenson","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1210\/endo-107-4-869","article-title":"Evidence for relaxin in corpora lutea of late pregnant cows","volume":"107","author":"Fields","year":"1980","journal-title":"Endocrinology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1477-7827-5-29","article-title":"Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat","volume":"5","author":"Filonzi","year":"2007","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"E1426","DOI":"10.1073\/pnas.1222216110","article-title":"A functional link between Bone Morphogenetic Protein and Insulin-like Peptide 3 signaling in modulating ovarian androgen production","volume":"110","author":"Glister","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/path.4257","article-title":"C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells","volume":"231","author":"Glogowska","year":"2013","journal-title":"J. Pathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1124\/pr.114.009472","article-title":"International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides","volume":"67","author":"Halls","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"B16","first-page":"439","article-title":"The search for ruminant relaxin","volume-title":"Progress in Relaxin Research","author":"Hartung","year":"1995"},{"key":"B17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/molehr\/gan051","article-title":"Relaxin signalling in primary cultures of human myometrial cells","volume":"14","author":"Heng","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1210\/endo-125-5-2612","article-title":"Oxytocin production and oxytocin mRNA levels in bovine granulosa cells are regulated by insulin and insulin like growth factor I: dependence on developmental status of the ovarian follicle","volume":"125","author":"Holtorf","year":"1989","journal-title":"Endocrinology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1095\/biolreprod62.4.839","article-title":"Ruminant relaxin in the pregnant one-humped camel (Camelus dromedarius)","volume":"62","author":"Hombach-Klonisch","year":"2000","journal-title":"Biol. Reprod."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1210\/mend.14.8.0510","article-title":"The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7","volume":"14","author":"Hsu","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1126\/science.1065654","article-title":"Activation of orphan receptors by the hormone relaxin","volume":"295","author":"Hsu","year":"2002","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/molehr\/gaq086","article-title":"Relaxin family peptides in the male reproductive system \u2013 a critical appraisal","volume":"17","author":"Ivell","year":"2011","journal-title":"Mol. Hum. Reprod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/267544a0","article-title":"Primary structure of porcine relaxin: homology with insulin and related growth factors","volume":"267","author":"James","year":"1977","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.theriogenology.2012.03.012","article-title":"Incidence of apoptosis and transcript abundance in bovine follicular cells is associated with the quality of the enclosed oocyte","volume":"78","author":"Janowski","year":"2012","journal-title":"Theriogenology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"7323","DOI":"10.1073\/pnas.0307061101","article-title":"Paracrine regulation of mammalian oocyte maturation and male germ cell survival","volume":"101","author":"Kawamura","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1749-6632.2008.03826.x","article-title":"Mechanisms of relaxin receptor (LGR7\/RXFP1) expression and function","volume":"1160","author":"Kern","year":"2009","journal-title":"Ann N.Y. Acad. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1365-2605.2003.00409.x","article-title":"Seminal immunoreactive relaxin in domestic animals and its relationship to sperm motility as a possible index for predicting the fertilizing ability of sires","volume":"26","author":"Kohsaka","year":"2003","journal-title":"Int. J. Androl."},{"key":"B28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuroscience.2014.10.006","article-title":"Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats","volume":"284","author":"Meadows","year":"2015","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.tvjl.2007.12.032","article-title":"Prevalence and risk factors for dystocia in dairy cattle: a review","volume":"176","author":"Mee","year":"2008","journal-title":"Vet. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.anireprosci.2011.03.010","article-title":"Intracellular signaling cascades induced by relaxin in the stimulation of capacitation and acrosome reaction in fresh and frozen-thawed bovine spermatozoa","volume":"125","author":"Miah","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"B31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1530\/acta.0.1220396","article-title":"Relaxin and prostaglandin on oxytocin secretion from bovine luteal cells during different stages of gestation","volume":"122","author":"Musah","year":"1990","journal-title":"Acta Endocrinol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1095\/biolreprod37.4.797","article-title":"Induction of parturition, progesterone secretion, and delivery of placenta in beef heifers given relaxin with cloprostenol or dexamethasone","volume":"37","author":"Musah","year":"1987","journal-title":"Biol. Reprod."},{"key":"B33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0303-7207(93)90250-N","article-title":"A single-copy relaxin-like gene sequence is present in sheep","volume":"91","author":"Roche","year":"1993","journal-title":"Mol. Cell. Endocrinol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1210\/endo-129-1-375","article-title":"Affinity purification and sequence determination of equine relaxin","volume":"129","author":"Stewart","year":"1991","journal-title":"Endocrinology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1210\/en.2013-1491","article-title":"Insulin-like 3-induced rat preantral follicular growth is mediated by growth differentiation factor 9","volume":"155","author":"Xue","year":"2014","journal-title":"Endocrinology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.molimm.2005.02.003","article-title":"NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells","volume":"43","author":"Yang","year":"2006","journal-title":"Mol. Immunol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00359\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:08:12Z","timestamp":1750291692000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00359\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":36,"alternative-id":["10.3389\/fphys.2017.00359"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00359","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,6]]},"article-number":"359"}}