{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:50:04Z","timestamp":1771473004555,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["SAF2006-9127"],"award-info":[{"award-number":["SAF2006-9127"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00384","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T03:51:29Z","timestamp":1496807489000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Bile Acids Do Not Contribute to the Altered Calcium Homeostasis of Platelets from Rats with Biliary Cirrhosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Paola","family":"Romec\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther G.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Clara","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Iy\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Garc\u00eda-Esta\u00f1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noem\u00ed M.","family":"Atucha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12038-008-0020-0","article-title":"Changes in the level of cytosolic calcium, nitric oxide and nitric oxide synthase activity during platelet aggregation: an in vitro study in platelets from normal subjects and those with cirrhosis","volume":"33","author":"Annie-Jeyachristy","year":"2008","journal-title":"J. Biosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/CS20060226","article-title":"Altered calcium signalling in platelets from bile-duct-ligated rats","volume":"112","author":"Atucha","year":"2007","journal-title":"Clin. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0143-4160(02)00206-3","article-title":"Altered calcium regulation in freshly isolated aortic smooth muscle cells from bile duct-ligated rats: Role of nitric oxide","volume":"33","author":"Atucha","year":"2003","journal-title":"Cell Calcium"},{"key":"B4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0038-1650084","article-title":"In vitro inhibition of platelet aggregation by bile salts","volume":"44","author":"Baele","year":"1980","journal-title":"Thromb. Haemost."},{"key":"B5","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/S0168-8278(97)80319-4","article-title":"Platelet cytosolic calcium concentration in patients with liver cirrhosis. Relationship with hepatic and systemic hemodynamics","volume":"27","author":"Bandi","year":"1997","journal-title":"J. Hepatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/S0168-8278(97)80420-5","article-title":"Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosis cholangitis evaluated by thrombelastography","volume":"26","author":"Ben-Ari","year":"1997","journal-title":"J. Hepatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0049-3848(88)90137-5","article-title":"Platelet functional changes secondary to hepatocholestasis and elevation of serum bile acids","volume":"52","author":"Bowen","year":"1988","journal-title":"Thromb. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/0005-2736(93)90367-9","article-title":"The mode of action of primary bile salts on human platelets","volume":"1146","author":"Shiao","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/j.bpj.2014.03.028","article-title":"Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entry","volume":"106","author":"Dolan","year":"2014","journal-title":"Biophys. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1085\/jgp.20028537","article-title":"Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells","volume":"119","author":"Dopico","year":"2002","journal-title":"J. Gen. Physiol."},{"key":"B11","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1194\/jlr.R900007-JLR200","article-title":"Bile acids as regulatory molecules","volume":"50","author":"Hylemon","year":"2009","journal-title":"J. Lipid Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1478-811X-2-1","article-title":"Altered calcium signaling in platelets from nitric oxide-deficient hypertensive rats","volume":"2","author":"Iy\u00fa","year":"2004","journal-title":"Cell Commun. Signal."},{"key":"B14","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1053\/j.gastro.2004.12.046","article-title":"Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca2+ entry at plasma membrane","volume":"128","author":"Lau","year":"2005","journal-title":"Gastroenterology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4196\/kjpp.2012.16.1.25","article-title":"Bile acid inhibition of N-type calcium channel currents from sympathetic ganglion neurons","volume":"16","author":"Lee","year":"2012","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"B16","first-page":"438","article-title":"A comparison of the effects of dietary short and long chain saturated fatty acids on platelet functions, platelet phospholipids, and blood coagulation in rats","volume":"43","author":"McGregor","year":"1980","journal-title":"Lab. Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1161\/ATVBAHA.116.308093","article-title":"Farnesoid X receptor and its ligands inhibit the function of platelets","volume":"36","author":"Moraes","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/sj.bjp.0704504","article-title":"Interaction of nitric oxide with calcium in the mesenteric bed of bile duct-ligated rats","volume":"135","author":"Nadal","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"B19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/cs0910733","article-title":"Vascular hyporesponsiveness in aortic rings from cirrhotic rats: role of nitric oxide and endothelium","volume":"91","author":"Ort\u00edz","year":"1996","journal-title":"Clin. Sci."},{"key":"B20","first-page":"818","article-title":"Activation of blood platelets in chronic hepatitis and liver cirrhosis P-selectin expression on blood platelets and secretory activity of beta-thromboglobulin and platelet factor-4","volume":"48","author":"Panasiuk","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"B21","first-page":"177","article-title":"Haemostasis Impairment in Patients with Obstructive Jaundice","volume":"16","author":"Papadopoulos","year":"2007","journal-title":"J. Gastrointestin Liver Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S0168-8278(02)00239-8","article-title":"Platelet function rather than plasmatic coagulation explains hypercoagulable state in cholestatic liver disease","volume":"37","author":"Pihusch","year":"2002","journal-title":"J. Hepatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1136\/heartjnl-2013-304163","article-title":"Bile acids induce arrhythmias in human atrial myocardium\u2013implications for altered serum bile acid composition in patients with atrial fibrillation","volume":"99","author":"Rainer","year":"2013","journal-title":"Heart"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09537104.2016.1265920","article-title":"Role of homocysteine and folic acid on the altered calcium homeostasis of platelets from rats with biliary cirrhosis","volume":"2","author":"Romec\u00edn","year":"2017","journal-title":"Platelets"},{"key":"B25","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1017\/CBO9780511545283.018","article-title":"Platelet signalling: calcium","volume-title":"Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics","author":"Rosado","year":"2002"},{"key":"B26","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1113\/expphysiol.1997.sp004066","article-title":"Calcium entry mechanisms in human platelets (The Wellcome Prize Lecture)","volume":"82","author":"Sage","year":"1997","journal-title":"Exp. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"P22","DOI":"10.1186\/1753-6561-6-S4-P22","article-title":"Bile acids differentially impact on platelet activation","volume":"6","author":"Tan","year":"2012","journal-title":"BMC Proc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1111\/j.1538-7836.2011.04429.x","article-title":"Hypercoagulability in cirrhosis: causes and consequences","volume":"9","author":"Tripodi","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"B29","first-page":"466","article-title":"Soluble P selectin levels in chronic liver disease: relationship to disease severity","volume":"54","author":"Vardareli","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"97S","DOI":"10.1097\/00000374-199803001-00004","article-title":"Relationship between platelet membrane lipid compositions and platelet aggregability in alcoholic liver disease","volume":"22","author":"Watanabe","year":"1998","journal-title":"Alcohol Clin. Exp. Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1538-7836.2009.03684.x","article-title":"ADP-degrading enzymes inhibit platelet activation in bile duct-ligated rats","volume":"8","author":"Witters","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.4314\/ahs.v13i4.31","article-title":"Changes in platelet functional parameters and CD62 P expression in liver cirrhosis","volume":"13","author":"Xianghong","year":"2013","journal-title":"Afr. Health Sci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00384\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T05:51:09Z","timestamp":1659073869000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00384\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":32,"alternative-id":["10.3389\/fphys.2017.00384"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00384","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]},"article-number":"384"}}