{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:36:15Z","timestamp":1789878975406,"version":"4.0.1"},"reference-count":64,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00566","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T03:54:11Z","timestamp":1502078051000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitro Models"],"prefix":"10.3389","volume":"8","author":[{"given":"Dominik","family":"Schreiber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Clasohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Weyland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Lilischkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Erkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Herbert","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1023\/A:1025088628787","article-title":"Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro","volume":"20","author":"Adachi","year":"2003","journal-title":"Pharm. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.2042-7158.2011.01391.x","article-title":"Everted gut sac model as a tool in pharmaceutical research: limitations and applications","volume":"64","author":"Alam","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.17305\/bjbms.2013.2402","article-title":"Nitric oxide as a potential biomarker in inflammatory bowel disease","volume":"13","author":"Avdagic","year":"2013","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"B5","first-page":"G776","article-title":"in vitro analysis of rat intestinal wall movements at rest and during propagated contraction: a new method","volume":"273","author":"Benard","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/ajg.2014.357","article-title":"Treatment of IBD: where we are and where we are going","volume":"110","author":"Bernstein","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0130401","DOI":"10.1371\/journal.pone.0130401","article-title":"Anti-inflammatory and anti-thrombotic effects of the fungal metabolite galiellalactone in apolipoprotein E-deficient mice","volume":"10","author":"Bollmann","year":"2015","journal-title":"PLoS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3748\/wjg.v17.i5.547","article-title":"Recent advances in cytokines: therapeutic implications for inflammatory bowel diseases","volume":"17","author":"Bouguen","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1053\/j.gastro.2011.02.045","article-title":"Conventional medical management of inflammatory bowel disease","volume":"140","author":"Burger","year":"2011","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/0394632015599707","article-title":"Enteric glia: A new player in inflammatory bowel diseases","volume":"28","author":"Capoccia","year":"2015","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1002\/ibd.22957","article-title":"Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease","volume":"18","author":"Christophi","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn's disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/00054725-200305000-00006","article-title":"Nitric oxide in inflammatory bowel disease","volume":"9","author":"Cross","year":"2003","journal-title":"Inflamm. Bowel Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1136\/gutjnl-2011-300904","article-title":"New therapies for inflammatory bowel disease: from the bench to the bedside","volume":"61","author":"Danese","year":"2011","journal-title":"Gut"},{"key":"B16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00401-013-1099-4","article-title":"Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivity","volume":"125","author":"Demir","year":"2013","journal-title":"Acta Neuropathol."},{"key":"B17","volume-title":"Isolation Neuer Naturstoffe aus Pilzen Mit potenziellen Pro-Apoptotischen und Anti-inflammatorischen Wirkungsweisen Sowie Deren Biologische Wirkorteingrenzung in Humanen Zellkulturmodellen","author":"Felix","year":"2013"},{"key":"B18","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1365-2982.2005.00684.x","article-title":"Motor patterns and propulsion in the rat intestine in vivo recorded by spatio-temporal maps","volume":"17","author":"Ferens","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"B19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00134-006-0452-7","article-title":"Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact","volume":"33","author":"Fruhwald","year":"2006","journal-title":"Intensive Care Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0016-5085(92)90832-J","article-title":"Major histocompatibility class II expression on the small intestinal nervous system in Crohn's disease","volume":"103","author":"Geboes","year":"1992","journal-title":"Gastroenterology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"9226","DOI":"10.1038\/srep09226","article-title":"Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract","volume":"5","author":"Grundmann","year":"2015","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.pupt.2007.08.003","article-title":"Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors","volume":"21","author":"Hamalainen","year":"2007","journal-title":"Pulm Pharmacol. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/intimm\/dxq451","article-title":"Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma","volume":"23","author":"Hausding","year":"2011","journal-title":"Int. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e22118","DOI":"10.1371\/journal.pone.0022118","article-title":"Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells","volume":"6","author":"Hellsten","year":"2011","journal-title":"PLoS ONE"},{"key":"B25","first-page":"1317","article-title":"Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease","volume-title":"Dig. Dis. Sci.","author":"Hirata","year":"1986"},{"key":"B26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pathophys.2014.05.002","article-title":"Immunopathological characterization of selected mouse models of inflammatory bowel disease: comparison to human disease","volume":"21","author":"Jones-Hall","year":"2014","journal-title":"Pathophysiology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1002\/mnfr.200800575","article-title":"Influence of apple polyphenols on inflammatory gene expression","volume":"53","author":"Jung","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1365-2982.2010.01498.x","article-title":"The intestinal barrier and its regulation by neuroimmune factors","volume":"22","author":"Keita","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"B29","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/0006-291X(91)91863-8","article-title":"The macrophage response to bacteria: flow of L-arginine through the nitric oxide and urea pathways and induction of tumoricidal activity","volume":"177","author":"Keller","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0026-895X(25)08682-1","article-title":"Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B","volume":"49","author":"Kleinert","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ejphar.2004.07.030","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"500","author":"Kleinert","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1515\/BC.2003.152","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"384","author":"Kleinert","year":"2003","journal-title":"Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"key":"B34","first-page":"493","article-title":"Sequential induction of MHC antigens on autochthonous cells of ileum affected by Crohn's disease","volume":"129","author":"Koretz","year":"1987","journal-title":"Am. J. Pathol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1742-2094-7-37","article-title":"Neuroinflammation in inflammatory bowel disease","volume":"7","author":"Lakhan","year":"2010","journal-title":"J. Neuroinflam."},{"key":"B36","doi-asserted-by":"publisher","first-page":"G898","DOI":"10.1152\/ajpgi.00070.2005","article-title":"Spatial and temporal coupling between slow waves and pendular contractions","volume":"289","author":"Lammers","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-925X-7-2","article-title":"Stimulation and analysis of spatio-temporal maps of gastrointestinal motility","volume":"7","author":"Lammers","year":"2008","journal-title":"Biomed. End. Online"},{"key":"B38","doi-asserted-by":"publisher","first-page":"G304","DOI":"10.1152\/ajpgi.00313.2009","article-title":"A model of the isolated perfused rat small intestine","volume":"298","author":"Lautenschlager","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"A17","DOI":"10.1016\/S0167-5699(05)80006-4","article-title":"Nonspecific defence mechanism: the role of nitric oxide","volume":"12","author":"Liew","year":"1991","journal-title":"Immunol. Today"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1365-2982.2004.00607.x","article-title":"Plasticity of the enteric nervous system during intestinal inflammation","volume":"17","author":"Lomax","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"B41","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s10517-006-0183-3","article-title":"Role of extracellular and intracellular nitric oxide in the regulation of macrophage responses","volume":"141","author":"Malysheva","year":"2006","journal-title":"Bull. Exp. Biol. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1053\/j.gastro.2011.04.047","article-title":"Enteric neuronal density contributes to the severity of intestinal inflammation","volume":"141","author":"Margolis","year":"2011","journal-title":"Gastroenterology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0024-3205(01)01196-1","article-title":"Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells","volume":"69","author":"Matsumura","year":"2001","journal-title":"Life Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/B978-0-12-394596-9.00009-3","article-title":"Animal models of inflammatory bowel disease","volume":"105","author":"Mizoguchi","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/gut.2010.224154","article-title":"Guidelines for the management of inflammatory bowel disease in adults","volume":"60","author":"Mowat","year":"2011","journal-title":"Gut"},{"key":"B46","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1590\/S1413-86702006000400014","article-title":"Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection","volume":"10","author":"Nahrevanian","year":"2006","journal-title":"Braz. J. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cyto.2012.10.011","article-title":"Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone","volume":"61","author":"Rudolph","year":"2012","journal-title":"Cytokine"},{"key":"B50","doi-asserted-by":"crossref","first-page":"G1163","DOI":"10.1152\/ajpgi.2001.280.6.G1163","article-title":"Interleukin-6 expression and regulation in rat enteric glial cells","volume":"280","author":"Ruhl","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4280","DOI":"10.3748\/wjg.14.4280","article-title":"Role of cytokines in inflammatory bowel disease","volume":"14","author":"Sanchez-Mu\u00f1oz","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ydbio.2012.01.012","article-title":"The enteric nervous system","volume":"366","author":"Sasselli","year":"2012","journal-title":"Dev. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1124\/jpet.112.192047","article-title":"The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis","volume":"343","author":"Schmidt","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(12)62654-7","article-title":"Mo1801 A model of in vitro perfused mouse intestine suitable for pharmacological testing of anti-inflammatory drugs","author":"Schreiber","year":"2012","journal-title":"Gastroenterology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.aanat.2014.02.008","article-title":"The mesenterially perfused rat small intestine: a versatile approach for pharmacological testings","volume":"196","author":"Schreiber","year":"2014","journal-title":"Ann. Anat."},{"key":"B56","author":"Schreiber","year":"2016","journal-title":"Etablierung und Validierung eines Darmperfusionssystems und Evaluierung Von Neuen Antiinflammatorischen Wirkstoffen aus Pilzen zur Behandlung entz\u00fcndlicher Darmerkrankungen"},{"key":"B57","doi-asserted-by":"publisher","first-page":"G1043","DOI":"10.1152\/ajpgi.00205.2005","article-title":"Spatiotemporal electrical and motility mapping of distension-induced propagating oscillations in the murine small intestine","volume":"289","author":"Seerden","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.autneu.2013.12.006","article-title":"Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract","volume":"181","author":"Sharkey","year":"2014","journal-title":"Auton. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4064","DOI":"10.3748\/wjg.v12.i25.4064","article-title":"Intestinal permeability of metformin using single-pass intestinal perfusion in rats","volume":"12","author":"Song","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","article-title":"Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases","volume":"140","author":"Strober","year":"2011","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/BF02233721","article-title":"A method for the analysis of intestinal motility records","volume":"10","author":"Vantrappen","year":"1965","journal-title":"Dig. Dis. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.autneu.2006.02.025","article-title":"Enteric neuroplasticity evoked by inflammation","volume":"127","author":"Vasina","year":"2006","journal-title":"Auton. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/gut.2003.012625","article-title":"Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia","volume":"53","author":"von Boyen","year":"2004","journal-title":"Gut"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-5793(00)02115-3","article-title":"Inhibition of interleukin-6 signaling by galiellalactone","volume":"484","author":"Weidler","year":"2000","journal-title":"FEBS Lett."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00566\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T20:47:35Z","timestamp":1750798055000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00566\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":64,"alternative-id":["10.3389\/fphys.2017.00566"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00566","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"article-number":"566"}}