{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:10Z","timestamp":1753892050207,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-1-0525"],"award-info":[{"award-number":["W81XWH-12-1-0525"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00692","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T04:21:27Z","timestamp":1505276487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in Anesthetized Male Rabbits"],"prefix":"10.3389","volume":"8","author":[{"given":"Yi","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Ratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria A.","family":"Locke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Barbee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/cc6919","article-title":"Bench-to-bedside review: latest results in hemorrhagic shock","volume":"12","author":"Angele","year":"2008","journal-title":"Crit. Care"},{"key":"B2","doi-asserted-by":"publisher","first-page":"567","DOI":"10.2337\/diabetes.51.3.567","article-title":"Effect of AICAR treatment on glycogen metabolism in skeletal muscle","volume":"51","author":"Aschenbach","year":"2002","journal-title":"Diabetes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/SHK.0b013e3181b8569d","article-title":"Assessing shock resuscitation strategies by oxygen debt repayment","volume":"33","author":"Barbee","year":"2010","journal-title":"Shock"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/0026-0495(73)90012-7","article-title":"Inhibition of insulin release during hypovolemic shock","volume":"22","author":"Cerchio","year":"1973","journal-title":"Metab. Clin. Exp."},{"key":"B5","doi-asserted-by":"publisher","first-page":"E1131","DOI":"10.1152\/ajpendo.00518.2005","article-title":"Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion","volume":"291","author":"Christopher","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000368932","article-title":"Beneficial effects of AMP-activated protein kinase agonists in kidney ischemia-reperfusion: autophagy and cellular stress markers","author":"Decleves","year":"2014","journal-title":"Nephron Exp. Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S0039-6060(96)80117-6","article-title":"Acadesine and lipopolysaccharide-evoked pulmonary dysfunction after resuscitation from traumatic shock","volume":"119","author":"Fabian","year":"1996","journal-title":"Surgery"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1001\/jama.290.15.2041","article-title":"Glucose control and mortality in critically ill patients","volume":"290","author":"Finney","year":"2003","journal-title":"JAMA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1161\/ATVBAHA.111.228304","article-title":"AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol","volume":"31","author":"Gayard","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1172\/JCI107692","article-title":"Adrenergic modulation of pancreatic glucagon secretion in man","volume":"53","author":"Gerich","year":"1974","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism: a new paradigm for the third millennium","volume":"558","author":"Gladden","year":"2004","journal-title":"J. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1042\/BST20130244","article-title":"AMPK: a cellular energy sensor primarily regulated by AMP","volume":"42","author":"Gowans","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/iub.135","article-title":"Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators","volume":"61","author":"Guigas","year":"2009","journal-title":"IUBMB Life"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","author":"Hardie","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9493","DOI":"10.1073\/pnas.93.18.9493","article-title":"Unifying theory of hypoxia tolerance: molecular\/metabolic defense and rescue mechanisms for surviving oxygen lack","volume":"93","author":"Hochachka","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"E578","DOI":"10.1152\/ajpendo.00093.2009","article-title":"The Randle cycle revisited: a new head for an old hat","volume":"297","author":"Hue","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2119\/molmed.2014.00134","article-title":"AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion","volume":"20","author":"Idrovo","year":"2014","journal-title":"Mol. Med."},{"key":"B18","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1016\/S0021-9258(18)32632-2","article-title":"Beta-Adrenergic receptors in rabbit liver plasma membranes. predominance of beta 2-receptors and mediation of adrenergic regulation of hepatic glycogenolysis","volume":"258","author":"Kawai","year":"1983","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1165\/rcmb.2016-0118OC","article-title":"Age-dependent changes in AMPK metabolic pathways in the lung in a mouse model of hemorrhagic shock","volume":"56","author":"Klingbeil","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1111\/bph.12413","article-title":"Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models","volume":"171","author":"Komen","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/nature03967","article-title":"The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism","volume":"437","author":"Koo","year":"2005","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1249\/01.MSS.0000132387.25853.3B","article-title":"Sending the signal: molecular mechanisms regulating glucose uptake","volume":"36","author":"Krook","year":"2004","journal-title":"Med. Sci. Sports Exerc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/01.shk.0000191411.48719.ab","article-title":"Shock and hemorrhage: an overview of animal models","volume":"24","author":"Lomas-Niera","year":"2005","journal-title":"Shock"},{"key":"B24","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1006\/jsre.1995.1079","article-title":"Defining the relationship of oxygen delivery and consumption: use of biologic system models","volume":"58","author":"Lubarsky","year":"1995","journal-title":"J. Surg. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"S650","DOI":"10.3978\/j.issn.2072-1439.2013.10.08","article-title":"Minimal-access median sternotomy for aortic valve replacement","volume":"5","author":"Luciani","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/SHK.0000000000000730","article-title":"The AMPK activator aicar ameliorates age-dependent myocardial injury in murine hemorrhagic shock","volume":"47","author":"Matsiukevich","year":"2017","journal-title":"Shock"},{"key":"B27","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/ijo.2011.172","article-title":"Regulation of LKB1 expression by sex hormones in adipocytes","volume":"36","author":"Mcinnes","year":"2012","journal-title":"Int. J. Obes."},{"key":"B28","first-page":"43","article-title":"Influence of hyperglycemia on survival after hemorrhagic shock","volume":"1","author":"Menguy","year":"1978","journal-title":"Adv. Shock Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.anclin.2012.10.007","article-title":"Trauma and aggressive homeostasis management","volume":"31","author":"Neligan","year":"2013","journal-title":"Anesthesiol. Clin."},{"key":"B30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10557-010-6222-3","article-title":"Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction","volume":"24","author":"Paiva","year":"2010","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.2527\/jas.2009-1989","article-title":"Chronic activation of 5\u2032-AMP-activated protein kinase changes myosin heavy chain expression in growing pigs","volume":"87","author":"Park","year":"2009","journal-title":"J. Anim. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1097\/00003246-200012000-00023","article-title":"Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation","volume":"28","author":"Ragsdale","year":"2000","journal-title":"Crit. Care Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1152\/japplphysiol.00500.2007","article-title":"Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism","volume":"104","author":"Rantzau","year":"2008","journal-title":"J. Appl. Physiol (1985)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"H157","DOI":"10.1152\/ajpheart.00926.2015","article-title":"Vascular smooth muscle desensitization in rabbit epigastric and mesenteric arteries during hemorrhagic shock","volume":"311","author":"Ratz","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B35","first-page":"E25","article-title":"Muscle glycogenolysis during exercise: dual control by epinephrine and contractions","volume":"242","author":"Richter","year":"1982","journal-title":"Am. J. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00005373-199502000-00006","article-title":"Epidemiology of trauma deaths: a reassessment","volume":"38","author":"Sauaia","year":"1995","journal-title":"J. Trauma"},{"key":"B37","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1001\/archsurg.1993.01420170107016","article-title":"The epidemiology of traumatic death. a population-based analysis","volume":"128","author":"Shackford","year":"1993","journal-title":"Arch. Surg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.biocel.2009.04.023","article-title":"RNA interference as a gene knockdown technique","volume":"42","author":"Shan","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1097\/00003246-199704000-00026","article-title":"Maximizing oxygen delivery in high-risk surgical patients","volume":"25","author":"Shoemaker","year":"1997","journal-title":"Crit. Care Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/SHK.0b013e3182205d7d","article-title":"Acute therapeutic use of 5-aminoimidazole-4-carboxamide ribonucleoside extends survival interval in response to severe hemorrhagic shock","volume":"36","author":"Sonneborn","year":"2011","journal-title":"Shock"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1097\/TA.0b013e31817db0de","article-title":"Characterization of persistent hyperglycemia: what does it mean postinjury?","volume":"66","author":"Sperry","year":"2009","journal-title":"J. Trauma"},{"key":"B42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/TA.0b013e31812e51fc","article-title":"Early hyperglycemia predicts multiple organ failure and mortality but not infection","volume":"63","author":"Sperry","year":"2007","journal-title":"J. Trauma"},{"key":"B43","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1189\/jlb.0607360","article-title":"Gender dimorphism following injury: making the connection from bench to bedside","volume":"83","author":"Sperry","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"B44","first-page":"29","article-title":"Resuscitation of hemorrhagic shock with hypertonic saline\/dextran or lactated ringer's supplemented with AICA riboside","volume":"40","author":"Spiers","year":"1993","journal-title":"Circ. Shock"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in health and disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiol. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"E524","DOI":"10.1152\/ajpendo.00605.2011","article-title":"The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism","volume":"303","author":"Szekeres","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2741\/3229","article-title":"AMPK: lessons from transgenic and knockout animals","volume":"14","author":"Viollet","year":"2009","journal-title":"Front. Biosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1042\/CS20080066","article-title":"AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease","volume":"116","author":"Wong","year":"2009","journal-title":"Clin. Sci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00692\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T19:31:26Z","timestamp":1659468686000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00692\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":48,"alternative-id":["10.3389\/fphys.2017.00692"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00692","relation":{},"ISSN":["1664-042X"],"issn-type":[{"type":"electronic","value":"1664-042X"}],"subject":[],"published":{"date-parts":[[2017,9,13]]},"article-number":"692"}}