{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:30Z","timestamp":1791772350386,"version":"4.3.4"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR41705"],"award-info":[{"award-number":["R01 AR41705"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00738","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:24:29Z","timestamp":1506299069000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture"],"prefix":"10.3389","volume":"8","author":[{"given":"Robert W.","family":"Jackman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Floro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Yoshimine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Zitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maythita","family":"Eiampikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"El-Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle N.","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Kandarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1096\/fj.201600250RR","article-title":"Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia","volume":"30","author":"Bohnert","year":"2016","journal-title":"FASEB J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e22538","DOI":"10.1371\/journal.pone.0022538","article-title":"STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia","volume":"6","author":"Bonetto","year":"2011","journal-title":"PLoS ONE"},{"key":"B3","first-page":"131","article-title":"Cachexia: novel perspectives for an old syndrome","volume":"16","author":"Coletti","year":"2006","journal-title":"Basic Appl. Myol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e87776","DOI":"10.1371\/journal.pone.0087776","article-title":"C26 cancer-induced muscle wasting is IKK\u03b2-dependent and NF-kappaB-independent","volume":"9","author":"Cornwell","year":"2014","journal-title":"PLoS ONE"},{"key":"B5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/jcsm.12124","article-title":"Cancer cachexia-when proteasomal inhibition is not enough","volume":"7","author":"Fielitz","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"B7","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nm.4093","article-title":"Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia","volume":"22","author":"Fukawa","year":"2016","journal-title":"Nat. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.semcdb.2015.09.002","article-title":"Experimental cancer cachexia: evolving strategies for getting closer to the human scenario","volume":"54","author":"Penna","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1096\/fj.13-240580","article-title":"Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma-induced cachexia","volume":"28","author":"Puppa","year":"2014","journal-title":"FASEB J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10544-012-9709-9","article-title":"Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices","volume":"15","author":"Rao","year":"2013","journal-title":"Biomed. Microdevices"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e54356","DOI":"10.3791\/54356","article-title":"Development of an insert co-culture system of two cellular types in the absence of cell-cell contact","volume":"113","author":"Renaud","year":"2016","journal-title":"J. Vis. Exp."},{"key":"B13","doi-asserted-by":"publisher","first-page":"19976","DOI":"10.1074\/jbc.M115.638411","article-title":"A key role for leukemia inhibitory factor in C26 cancer cachexia","volume":"290","author":"Seto","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"11177","DOI":"10.1074\/jbc.M115.641514","article-title":"Inhibition of stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia","volume":"290","author":"Silva","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0014-5793(84)80619-5","article-title":"Characterization of a factor inducing differentiation of mouse myeloid leukemic cells purified from conditioned medium of mouse Ehrlich ascites tumor cells","volume":"178","author":"Tomida","year":"1984","journal-title":"FEBS Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1038\/emboj.2011.292","article-title":"C\/EBP\u03b2 mediates tumour-induced ubiquitin ligase atrogin1\/MAFbx upregulation and muscle wasting","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J."}],"updated-by":[{"DOI":"10.3389\/fphys.2019.00394","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000}}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2017.00738\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T04:06:07Z","timestamp":1554782767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2017.00738\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,25]]},"references-count":17,"alternative-id":["10.3389\/fphys.2017.00738"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00738","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731932398.793546306","asserted-by":"object"}]},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,25]]},"article-number":"738"}}