{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:13Z","timestamp":1769040013595,"version":"3.49.0"},"reference-count":71,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE018900"],"award-info":[{"award-number":["R01DE018900"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00790","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T09:08:30Z","timestamp":1508231310000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Posttranslational Amelogenin Processing and Changes in Matrix Assembly during Enamel Development"],"prefix":"10.3389","volume":"8","author":[{"given":"Mirali","family":"Pandya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffani","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianquan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghong","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G. H.","family":"Diekwisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jsb.2005.06.007","article-title":"The onset of amelogenin nanosphere aggregation studied by small-angle X-ray scattering and dynamic light scattering","volume":"151","author":"Aichmayer","year":"2005","journal-title":"J. Struct. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jsb.2009.02.001","article-title":"Transient amorphous calcium phosphate in forming enamel","volume":"166","author":"Beniash","year":"2009","journal-title":"J. Struct. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jsb.2004.11.001","article-title":"The effect of recombinant mouse amelogenins on the formation and organization of hydroxyapatite crystals in vitro","volume":"149","author":"Beniash","year":"2005","journal-title":"J. Struct. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4231","DOI":"10.3390\/md12074231","article-title":"Understanding nanocalcification: a role suggested for crystal ghosts","volume":"12","author":"Bonucci","year":"2014","journal-title":"Mar. Drugs"},{"key":"B5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-198808000-00031","article-title":"The infrastructure of the organic phase associated with the inorganic substance in Calcified tissues","volume":"233","author":"Bonucci","year":"1988","journal-title":"Clin. Orthop. Relat. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"34643","DOI":"10.1074\/jbc.M111.250928","article-title":"Dissecting amelogenin protein nanospheres characterization of metastable oligomers","volume":"286","author":"Bromley","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1600-0722.2006.00311.x","article-title":"Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies","volume":"114","author":"Brookes","year":"2006","journal-title":"Eur. J. Oral Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.1073\/pnas.1401587111","article-title":"Structural motif of polyglutamine amyloid fibrils discerned with mixed-isotope infrared spectroscopy","volume":"111","author":"Buchanan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"23105","DOI":"10.1038\/srep23105","article-title":"Amyloid-like ribbons of amelogenins in enamel mineralization","volume":"6","author":"Carneiro","year":"2016","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"7391","DOI":"10.1021\/bi011772q","article-title":"Amyloid-like features of polyglutamine aggregates and their assembly kinetics","volume":"41","author":"Chen","year":"2002","journal-title":"Biochemistry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/03008209809017026","article-title":"Subunit compartments of secretory stage enamel matrix","volume":"38","author":"Diekwisch","year":"1998","journal-title":"Connect. Tissue Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/jemt.10218","article-title":"Membranes, minerals, and proteins of developing vertebrate enamel","volume":"59","author":"Diekwisch","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"B13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF00300701","article-title":"Initial enamel crystals are not spatially associated with mineralized dentine","volume":"279","author":"Diekwisch","year":"1995","journal-title":"Cell Tissue Res."},{"key":"B14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1242\/dev.117.2.471","article-title":"Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development","volume":"117","author":"Diekwisch","year":"1993","journal-title":"Development"},{"key":"B15","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/187411b0","article-title":"Organic matrix of tooth enamel","volume":"187","author":"Eastoe","year":"1960","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0003-9969(63)90078-5","article-title":"The amino acid composition of proteins from the oral tissues II: the matrix proteins in dentine and enamel from developing human deciduous teeth","volume":"8","author":"Eastoe","year":"1963","journal-title":"Arch. Oral Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/BF02553747","article-title":"Metabolic expression of intrinsic developmental programs for dentine and enamel biomineralization in serumless, chemically-defined, organotypic culture","volume":"42","author":"Evans","year":"1988","journal-title":"Calcif. Tissue Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"14097","DOI":"10.1073\/pnas.1106228108","article-title":"Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale","volume":"108","author":"Fang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B19","first-page":"1111","article-title":"Organic components of human dental enamel","volume":"42","author":"Fearnhead","year":"1963","journal-title":"J. Dent. Res.: Am. Assoc. Dent. Res."},{"key":"B20","first-page":"127","article-title":"The insoluble organic component of human enamel","author":"Fearnhead","year":"1965","journal-title":"Tooth Enamel"},{"key":"B21","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1006\/jsbi.1999.4130","article-title":"The structural biology of the developing dental enamel matrix","volume":"126","author":"Fincham","year":"1999","journal-title":"J. Struct. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1006\/jsbi.1995.1029","article-title":"Evidence for amelogenin\u201cnanospheres\u201d as functional components of secretory-stage enamel matrix","volume":"115","author":"Fincham","year":"1995","journal-title":"J. Struct. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/jsbi.1994.1011","article-title":"Self-assembly of a recombinant amelogenin protein generates supramolecular structures","volume":"112","author":"Fincham","year":"1994","journal-title":"J. Struct. Biol."},{"key":"B24","first-page":"2297","article-title":"Electron microscopy of the mode of secretion of the ameloblast bodies during amelogenesis","volume":"157","author":"Frank","year":"1963","journal-title":"C. R. Seances Soc. Biol. Fil."},{"key":"B25","first-page":"163","article-title":"Calcification of dental tissues with special reference to enamel ultrastructure","volume":"64","author":"Frank","year":"1960","journal-title":"Calcif. Biol. Syst"},{"key":"B26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0003-9969(64)90053-6","article-title":"The organic structure of human fetal enamel in the electron microscope","volume":"9","author":"Frank","year":"1964","journal-title":"Arch. Oral Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7541","DOI":"10.1002\/anie.201100181","article-title":"Single-molecule determination of the face-specific adsorption of Amelogenin's C-terminus on hydroxyapatite","volume":"50","author":"Friddle","year":"2011","journal-title":"Angewandte Chemie Int. Ed."},{"key":"B28","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1177\/154405910708600814","article-title":"Micelle structure of amelogenin in porcine secretory enamel","volume":"86","author":"Fukae","year":"2007","journal-title":"J. Dent. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1103\/RevModPhys.31.359","article-title":"Molecular biology of mineralized tissues with particular reference to bone","volume":"31","author":"Glimcher","year":"1959","journal-title":"Rev. Mod. Phys."},{"key":"B30","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fphys.2014.00430","article-title":"The expanded amelogenin polyproline region preferentially binds to apatite versus carbonate and promotes apatite crystal elongation","volume":"5","author":"Gopinathan","year":"2014","journal-title":"Front. Physiol."},{"key":"B31","first-page":"201","article-title":"Collegen and apatite in healthy and carious dentin","volume":"4","author":"Hohling","year":"1966","journal-title":"Adv. Fluorine Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1000262","DOI":"10.1371\/journal.pbio.1000262","article-title":"Elongated polyproline motifs facilitate enamel evolution through matrix subunit compaction","volume":"7","author":"Jin","year":"2009","journal-title":"PLoS Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1600-0722.2012.00941.x","article-title":"Biophysical characterization of synthetic amelogenin C-terminal peptides","volume":"120","author":"Khan","year":"2012","journal-title":"Eur. J. Oral Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1177\/0022034513504929","article-title":"Mineral association changes the secondary structure and dynamics of murine amelogenin","volume":"92","author":"Lu","year":"2013","journal-title":"J. Dent. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/BF02411214","article-title":"Neonatal hamster molar tooth development: extraction and characterization of amelogenins, enamelins, and soluble dentin proteins","volume":"34","author":"Lyaruu","year":"1982","journal-title":"Calcif. Tissue Int."},{"key":"B36","first-page":"257","article-title":"The Tomes' process: is stippled material a reality? The effect of fixative temperature on the structure of stippled material in enamel","volume-title":"Proceedings of the Second International Conference on Tooth Morphogenesis and Differentiation","author":"Lyaruu","year":"1984"},{"key":"B37","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-94-007-5416-4_10","article-title":"Fibrillogenesis of huntingtin and other glutamine containing proteins","volume":"65","author":"Lyubchenko","year":"2012","journal-title":"Subcell Biochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1177\/154405910608500902","article-title":"Role of macromolecular assembly of enamel matrix proteins in enamel formation","volume":"85","author":"Margolis","year":"2006","journal-title":"J. Dent. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1600-0722.2011.00907.x","article-title":"Self-assembly of amelogenin proteins at the water\u2013oil interface","volume":"119","author":"Martinez-Avila","year":"2011","journal-title":"Eur. J. Oral Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1021\/bm300942c","article-title":"Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils","volume":"13","author":"Martinez-Avila","year":"2012","journal-title":"Biomacromolecules"},{"key":"B41","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000091382","article-title":"Amelogenin supra-molecular assembly in vitro compared with the architecture of the forming enamel matrix","volume":"181","author":"Moradian-Oldak","year":"2005","journal-title":"Cells Tissues Organs."},{"key":"B42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0945-053X(01)00190-1","article-title":"Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal","volume":"21","author":"Moradian-Oldak","year":"2002","journal-title":"Matrix Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/00220345650440061101","article-title":"Purification and properties of protein from embryonic bovine enamel","volume":"44","author":"Nikiforuk","year":"1965","journal-title":"J. Dent. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1177\/00220345790580024601","article-title":"Matrix-Mineral Relationships-A. morphologist's viewpoint","volume":"58","author":"Nylen","year":"1979","journal-title":"J. Dent. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0945-053X(01)00153-6","article-title":"Regulated gene expression dictates enamel structure and tooth function","volume":"20","author":"Paine","year":"2001","journal-title":"Matrix Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/0022034509358392","article-title":"The amelogenin C-terminus is required for enamel development","volume":"89","author":"Pugach","year":"2010","journal-title":"J. Dent. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0022-5320(67)80138-2","article-title":"The early stage of amelogenesis as observed in molar teeth of young rats","volume":"17","author":"Reith","year":"1967","journal-title":"J. Ultrastruct. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1177\/154405910708600801","article-title":"Self-oriented assembly of nano-apatite particles: a subunit mechanism for building biological mineral crystals","volume":"86","author":"Robinson","year":"2007","journal-title":"J. Dent. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3389\/fphys.2014.00388","article-title":"Enamel maturation: a brief background with implications for some enamel dysplasias","volume":"5","author":"Robinson","year":"2014","journal-title":"Front. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/0003-9969(83)90053-5","article-title":"Changes in the protein components of rat incisor enamel during tooth development","volume":"28","author":"Robinson","year":"1983","journal-title":"Arch. Oral Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/BF02409483","article-title":"Histology of enamel organ and chemical composition of adjacent enamel in rat incisors","volume":"33","author":"Robinson","year":"1981","journal-title":"Calcif. Tissue Int."},{"key":"B52","first-page":"355","article-title":"Extracellular processing of enamel matrix proteins and the control of crystal growth","volume":"18","author":"Robinson","year":"1990","journal-title":"J. Biol. Buccale"},{"key":"B53","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0022-5320(62)80041-0","article-title":"III. The structure of the organic stroma of human enamel during amelogenesis","volume":"6","author":"Ronnholm","year":"1962","journal-title":"J. Ultrastruct. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1039\/C5TB00163C","article-title":"Amelogenin and enamel biomimetics","volume":"3","author":"Ruan","year":"2015","journal-title":"J. Mat. Chem. B"},{"key":"B55","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/0012-1606(83)90341-X","article-title":"DNA synthesis and cell generation cycle during determination and differentiation of the metanephric mesenchyme","volume":"98","author":"Saxen","year":"1983","journal-title":"Dev. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jmb.2011.06.045","article-title":"Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy","volume":"412","author":"Schneider","year":"2011","journal-title":"J. Mol. Biol."},{"key":"B57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF00295956","article-title":"Isolation and characterization of a mouse amelogenin expressed in Escherichia coli","volume":"54","author":"Simmer","year":"1994","journal-title":"Calcif. Tissue Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/258772a0","article-title":"Structural subunit in prisms of immature rat enamel","volume":"258","author":"Smales","year":"1975","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"10277","DOI":"10.1021\/bi0258905","article-title":"The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases","volume":"41","author":"Tanaka","year":"2002","journal-title":"Biochemistry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jsb.2009.10.007","article-title":"The leucine rich amelogenin protein (LRAP) adsorbs as monomers or dimers onto surfaces","volume":"169","author":"Tarasevich","year":"2010","journal-title":"J. Struct. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1021\/jp804548x","article-title":"Adsorption of amelogenin onto self-assembled and fluoroapatite surfaces","volume":"113","author":"Tarasevich","year":"","journal-title":"J. Phys. Chem. B"},{"key":"B62","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/bip.21095","article-title":"Changes in the quaternary structure of amelogenin when adsorbed onto surfaces","volume":"91","author":"Tarasevich","year":"","journal-title":"Biopolymers"},{"key":"B63","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1016\/S0021-9258(18)43458-8","article-title":"Properties of dissociatively extracted fetal tooth matrix proteins. I. principal molecular species in developing bovine enamel","volume":"255","author":"Termine","year":"1980","journal-title":"J. Biol. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1126\/science.200.4345.1059","article-title":"Mineralization kinetics: a constant composition approach","volume":"200","author":"Tomson","year":"1978","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1083\/jcb.23.3.447","article-title":"The structure and organization of, and the relationship between the organic matrix and the inorganic crystals of embryonic bovine enamel","volume":"23","author":"Travis","year":"1964","journal-title":"J. Cell Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0014-4827(54)90169-X","article-title":"A modified technique for organ culture in vitro","volume":"6","author":"Trowell","year":"1954","journal-title":"Exp. Cell Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1021\/la001281r","article-title":"Binding of matrix proteins to developing enamel crystals: an atomic force microscopy study","volume":"17","author":"Wallwork","year":"2001","journal-title":"Langmuir"},{"key":"B68","first-page":"127","article-title":"Chemically-defined organ culture of embryonic mouse tooth organs: morphogenesis, dentinogenesis and amelogenesis","volume":"8","author":"Yamada","year":"1980","journal-title":"J. Biol. Buccale"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1021\/jp910219s","article-title":"How amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite","volume":"114","author":"Yang","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e24952","DOI":"10.1371\/journal.pone.0024952","article-title":"Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS ONE"},{"key":"B71","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fphys.2014.00268","article-title":"Preferential and selective degradation and removal of amelogenin adsorbed on hydroxyapatites by MMP20 and KLK4 in vitro","volume":"5","author":"Zhu","year":"2014","journal-title":"Front. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00790\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T19:33:17Z","timestamp":1659641597000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00790\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":71,"alternative-id":["10.3389\/fphys.2017.00790"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00790","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]},"article-number":"790"}}