{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:12:22Z","timestamp":1789665142060,"version":"4.0.1"},"reference-count":44,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2015-64136-R"],"award-info":[{"award-number":["SAF2015-64136-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2014-56111-R"],"award-info":[{"award-number":["SAF2014-56111-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014SGR574"],"award-info":[{"award-number":["2014SGR574"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00933","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T04:31:36Z","timestamp":1510720296000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Differences in the Thoracic Aorta by Region and Sex in a Murine Model of Marfan Syndrome"],"prefix":"10.3389","volume":"8","author":[{"given":"Francesc","family":"Jim\u00e9nez-Altay\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Siegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bonorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayna","family":"Meirelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barber\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Dantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1161\/01.ATV.0000143386.26399.84","article-title":"Gender differences in experimental aortic aneurysm formation","volume":"24","author":"Ailawadi","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1097\/01.hjh.0000163145.12707.63","article-title":"Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses","volume":"23","author":"\u00c1lvarez","year":"2005","journal-title":"J. Hypertens."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/j.jbiomech.2015.11.059","article-title":"Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome","volume":"49","author":"Bellini","year":"2016","journal-title":"J. Biomech"},{"key":"B4","doi-asserted-by":"publisher","first-page":"9747","DOI":"10.1073\/pnas.97.17.9747","article-title":"An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice","volume":"97","author":"Brandes","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1161\/HYPERTENSIONAHA.112.200618","article-title":"\u03b1-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear","volume":"60","author":"Casey","year":"2012","journal-title":"Hypertension"},{"key":"B6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1210\/er.2001-0045","article-title":"Estrogen modulation of endothelial nitric oxide synthase","volume":"23","author":"Chambliss","year":"2002","journal-title":"Endocr. Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/sj.bjp.0702300","article-title":"Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice","volume":"126","author":"Chataigneau","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/sj.bjp.0707181","article-title":"Endothelial dysfunction and compromised eNOS\/Akt signaling in the thoracic aorta during the progression of Marfan syndrome","volume":"150","author":"Chung","year":"","journal-title":"Br. J. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1161\/CIRCRESAHA.107.157776","article-title":"Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome","volume":"101","author":"Chung","year":"","journal-title":"Circ. Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1161\/CIRCRESAHA.108.174367","article-title":"Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and\u22129","volume":"102","author":"Chung","year":"2008","journal-title":"Circ. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/sj.bjp.0707391","article-title":"Imbalanced synthesis of cyclooxygenase-derived thromboxane A2 and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome","volume":"152","author":"Chung","year":"","journal-title":"Br. J. Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1161\/ATVBAHA.114.304412","article-title":"Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome","volume":"35","author":"Crosas-Molist","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.prostaglandins.2012.02.002","article-title":"Functional alterations in endothelial NO, PGI2 and EDHF pathways in aorta in ApoE\/LDLR\u2212\/\u2212 mice","volume":"98","author":"Cs\u00e1nyi","year":"2012","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1093\/eurheartj\/ehq258","article-title":"Cardiovascular manifestations in men and women carrying a FBN1 mutation","volume":"31","author":"Detaint","year":"2010","journal-title":"Eur. Heart J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"B16","first-page":"23","article-title":"Hemodynamics and cardiac function during normal pregnancy and the puerperium","volume-title":"Cardiac Problems in Pregnancy","author":"Elkayam","year":"1998"},{"key":"B17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.7326\/0003-4819-123-2-199507150-00007","article-title":"Cardiovascular problems in pregnant women with Marfan syndrome","volume":"123","author":"Elkayam","year":"1995","journal-title":"Ann. Intern. Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1093\/eurheartj\/ehv739","article-title":"Genotype impacts survival in Marfan syndrome","volume":"37","author":"Franken","year":"2016","journal-title":"Eur. Heart J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/japplphysiol.00132.2017","article-title":"Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm","volume":"123","author":"Gibson","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1161\/CIRCULATIONAHA.104.493569","article-title":"Cardiovascular problems in pregnant women with marfan syndrome","volume":"119","author":"Goland","year":"2009","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/ajh.2010.154","article-title":"Sympathetic neural activity in hypertension and related diseases","volume":"23","author":"Grassi","year":"2010","journal-title":"Am. J. Hypertens"},{"key":"B22","first-page":"H928","article-title":"Regional differences in alpha 1-adrenoceptor numbers and responses in canine aorta","volume":"247","author":"Griendling","year":"1984","journal-title":"Am. J. Physiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00392-016-1028-3","article-title":"Aortic events in a nationwide Marfan syndrome cohort","volume":"106","author":"Groth","year":"2017","journal-title":"Clin. Res. Cardiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1172\/JCI200420641","article-title":"Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome","volume":"114","author":"Judge","year":"2004","journal-title":"J. Clin. Invest"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0164778","DOI":"10.1371\/journal.pone.0164778","article-title":"Aortic and cardiac structure and function using high-resolution echocardiography and optical coherence tomography in a mouse model of Marfan syndrome","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS ONE"},{"key":"B26","first-page":"336","article-title":"Histopathologic findings in human aortic media associated with pregnancy","volume":"83","author":"Manalo-Estrella","year":"1967","journal-title":"Arch. Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00246-012-0593-0","article-title":"Impact of age and gender on cardiac pathology in children and adolescents with Marfan syndrome","volume":"34","author":"Mueller","year":"2013","journal-title":"Pediatr. Cardiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1056\/NEJM197204132861502","article-title":"Life expectancy and causes of death in the Marfan syndrome","volume":"286","author":"Murdoch","year":"1972","journal-title":"N. Engl. J. Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1161\/HYPERTENSIONAHA.110.151969","article-title":"Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17\u03b2-estradiol","volume":"56","author":"Novensa","year":"2010","journal-title":"Hypertension"},{"key":"B30","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nm.4266","article-title":"Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome","volume":"23","author":"Oller","year":"2017","journal-title":"Nat. Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.exger.2013.09.004","article-title":"Western-type diet induces senescence, modifies vascular function in non-senescence mice and triggers adaptive mechanisms in senescent ones","volume":"48","author":"Onetti","year":"2013","journal-title":"Exp. Gerontol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00018-016-2324-9","article-title":"Vascular smooth muscle cells in Marfan syndrome aneurysm: the broken bricks in the aortic wall","volume":"74","author":"Perrucci","year":"2017","journal-title":"Cell. Mol. Life Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1161\/01.RES.27.1.121","article-title":"Hydrodynamic forces in dissecting aneurysms","volume":"27","author":"Prokop","year":"1970","journal-title":"in vitro. Circ. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.tcm.2015.12.003","article-title":"Recent progress in understanding the natural and clinical histories of the Marfan syndrome","volume":"26","author":"Pyeritz","year":"2016","journal-title":"Trends Cardiovasc. Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.pcad.2013.04.002","article-title":"Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin","volume":"56","author":"Ruddy","year":"2013","journal-title":"Prog. Cardiovasc. Dis"},{"key":"B36","first-page":"422","article-title":"Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice","volume":"24","author":"Shen","year":"2003","journal-title":"Acta Pharmacol. Sin"},{"key":"B37","first-page":"391","article-title":"Importance of endothelium-derived hyperpolarizing factor in human arteries","volume-title":"Endothelium-Derived Hyperpolarizing Factor","author":"Shimokawa","year":"1999"},{"key":"B38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.prostaglandins.2016.05.001","article-title":"Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients","volume":"123","author":"Soto","year":"2016","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1084\/jem.20080106","article-title":"Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice","volume":"205","author":"Takaki","year":"2008","journal-title":"J. Exp. Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1073\/pnas.94.7.3336","article-title":"Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential","volume":"94","author":"Tsujii","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B41","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.cjca.2015.09.003","article-title":"Pregnancy and thoracic aortic disease: managing the risks","volume":"32","author":"Wanga","year":"2016","journal-title":"Can. J. Cardiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1111\/j.1476-5381.2009.00443.x","article-title":"Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome","volume":"158","author":"Yang","year":"2009","journal-title":"Br. J. Pharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jtcvs.2009.10.039","article-title":"Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome","volume":"140","author":"Yang","year":"","journal-title":"J. Thorac. Cardiovasc. Surg"},{"key":"B44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.vph.2009.10.005","article-title":"Vasomotor dysfunction in the thoracic aorta of Marfan syndrome is associated with accumulation of oxidative stress","volume":"52","author":"Yang","year":"","journal-title":"Vascul. Pharmacol"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T04:31:39Z","timestamp":1510720299000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":44,"alternative-id":["10.3389\/fphys.2017.00933"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00933","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]},"article-number":"933"}}