{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:13:50Z","timestamp":1753892030661,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.00991","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T04:28:08Z","timestamp":1512361688000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum"],"prefix":"10.3389","volume":"8","author":[{"given":"Rachel M.","family":"Gwynne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenny D. K. N.","family":"Ly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel C.","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/neuro.21.003.2009","article-title":"The cornucopia of intestinal chemosensory transduction","volume":"3","author":"Bertrand","year":"2009","journal-title":"Front. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0165-1838(95)00043-W","article-title":"Expression of mRNA for the N-methyl-D-aspartate (NMDAR1) receptor and vasoactive intestinal polypeptide (VIP) co-exist in enteric neurons of the rat","volume":"55","author":"Burns","year":"1995","journal-title":"J. Auton. Nerv. Syst."},{"key":"B3","first-page":"G122","article-title":"Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine","volume":"274","author":"Chattopadhyay","year":"1998","journal-title":"Am. J. Physiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"738S","DOI":"10.3945\/ajcn.2009.27462H","article-title":"Taste receptors for umami: the case for multiple receptors","volume":"90","author":"Chaudhari","year":"2009","journal-title":"Am. J. Clin. Nutr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"G60","DOI":"10.1152\/ajpgi.00425.2011","article-title":"Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system","volume":"303","author":"Cheng","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"G240","DOI":"10.1152\/ajpgi.00500.2001","article-title":"Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion","volume":"283","author":"Cheng","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.tem.2006.10.012","article-title":"Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors","volume":"17","author":"Conigrave","year":"2006","journal-title":"Trends Endocrinol. Metab"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1073\/pnas.97.9.4814","article-title":"L-amino acid sensing by the extracellular Ca2+-sensing receptor","volume":"97","author":"Conigrave","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"G271","DOI":"10.1152\/ajpgi.00074.2012","article-title":"Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion","volume":"304","author":"Daly","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1042\/BST0330302","article-title":"Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells","volume":"33","author":"Dyer","year":"2005","journal-title":"Biochem. Soc. Trans"},{"key":"B11","first-page":"129","article-title":"Mechanisms of excitatory synaptic transmission in the enteric nervous system","volume":"23","author":"Galligan","year":"1998","journal-title":"Tokai J. Exp. Clin. Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/S0024-3205(00)00760-8","article-title":"Glutamate receptors of the AMPA type modulate neurotransmitter release and peristalsis in the guinea-pig isolated colon","volume":"67","author":"Giaroni","year":"2000","journal-title":"Life Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1053\/j.gastro.2005.11.005","article-title":"GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow","volume":"130","author":"Guan","year":"2006","journal-title":"Gastroenterology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"G1660","DOI":"10.1152\/ajpgi.00580.2006","article-title":"Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum","volume":"292","author":"Gwynne","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"G179","DOI":"10.1152\/ajpgi.90700.2008","article-title":"Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons","volume":"297","author":"Gwynne","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B16","first-page":"A223","article-title":"Video mapping and extracellular recording studies of nutrient-induced segmentation in isolated guinea-pig small intestine","volume":"126","author":"Gwynne","year":"","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1113\/jphysiol.2003.057182","article-title":"Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum","volume":"556","author":"Gwynne","year":"","journal-title":"J. Physiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4620","DOI":"10.1111\/j.1742-4658.2008.06604.x","article-title":"Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells","volume":"275","author":"Hira","year":"2008","journal-title":"FEBS J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.3390\/s120404661","article-title":"Quorum quenching revisited\u2013from signal decays to signalling confusion","volume":"12","author":"Hong","year":"2012","journal-title":"Sensors"},{"key":"B20","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00441-005-0140-x","article-title":"Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine","volume":"324","author":"Karaki","year":"2006","journal-title":"Cell Tissue Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"G1100","DOI":"10.1152\/ajpgi.00251.2014","article-title":"Activation of the umami taste receptor (T1R1\/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon","volume":"307","author":"Kendig","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S1471-4892(01)00101-1","article-title":"Glutamate in the enteric nervous system","volume":"1","author":"Kirchgessner","year":"2001","journal-title":"Curr. Opin. Pharmacol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"G538","DOI":"10.1152\/ajpgi.00342.2010","article-title":"The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells","volume":"300","author":"Liou","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B24","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1523\/JNEUROSCI.17-12-04764.1997","article-title":"Glutamatergic enteric neurons","volume":"17","author":"Liu","year":"1997","journal-title":"J. Neurosci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nature726","article-title":"An amino-acid taste receptor","volume":"416","author":"Nelson","year":"2002","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1172\/JCI119413","article-title":"Expression of the calcium-sensing receptor on human antral gastrin cells in culture","volume":"99","author":"Ray","year":"1997","journal-title":"J. Clin. Invest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.coph.2007.10.002","article-title":"Taste receptor signaling in the mammalian gut","volume":"7","author":"Rozengurt","year":"2007","journal-title":"Curr. Opin. Pharmacol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/nmo.12768","article-title":"Immunolocalization of AMPA receptor subunits within the enteric nervous system of the mouse colon and the effect of their activation on spontaneous colonic contractions","volume":"28","author":"Seifi","year":"2016","journal-title":"Neurogastroenterol. Motil"},{"key":"B29","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1177\/002215540004800503","article-title":"Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa","volume":"48","author":"Sheinin","year":"2000","journal-title":"J. Histochem. Cytochem"},{"key":"B30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/MED.0b013e3282f43a73","article-title":"Enteroendocrine cells: a site of \u2018taste' in gastrointestinal chemosensing","volume":"15","author":"Sternini","year":"2008","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes"},{"key":"B31","doi-asserted-by":"publisher","first-page":"G528","DOI":"10.1152\/ajpgi.00387.2010","article-title":"Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor","volume":"300","author":"Wang","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1124\/mol.109.055244","article-title":"Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients","volume":"76","author":"Wellendorph","year":"2009","journal-title":"Mol. Pharmacol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"20930","DOI":"10.1073\/pnas.0810174106","article-title":"Molecular mechanism for the umami taste synergism","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00991\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T09:15:35Z","timestamp":1570439735000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00991\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":33,"alternative-id":["10.3389\/fphys.2017.00991"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.00991","relation":{},"ISSN":["1664-042X"],"issn-type":[{"type":"electronic","value":"1664-042X"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"article-number":"991"}}