{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:51:56Z","timestamp":1783338716699,"version":"3.54.6"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["4702957"],"award-info":[{"award-number":["4702957"]}],"id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["257472"],"award-info":[{"award-number":["257472"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH2015319"],"award-info":[{"award-number":["TYH2015319"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2017.01036","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T11:59:27Z","timestamp":1513684767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets"],"prefix":"10.3389","volume":"8","author":[{"given":"Lotta K.","family":"Veistinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuija","family":"Mustonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Rakibul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit","family":"Takatalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiho","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rthe A.","family":"Kesper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vortkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1242\/dev.002709","article-title":"Regulation of skeletogenic differentiation in cranial dermal bone","volume":"134","author":"Abzhanov","year":"2007","journal-title":"Development"},{"key":"B2","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S1534-5807(04)00058-9","article-title":"A twist code determines the onset of osteoblast differentiation","volume":"6","author":"Bialek","year":"2004","journal-title":"Dev. Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/hmg\/7.6.945","article-title":"The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome","volume":"7","author":"Bourgeois","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ydbio.2013.04.025","article-title":"Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants","volume":"379","author":"Cao","year":"2013","journal-title":"Dev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1242\/dev.076729","article-title":"Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1","volume":"139","author":"Deckelbaum","year":"2012","journal-title":"Development"},{"key":"B6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/dvg.22416","article-title":"The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects","volume":"51","author":"Feng","year":"2013","journal-title":"Genesis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0167-4781(99)00113-X","article-title":"Isolation and characterization of the distal promoter region of mouse Cbfa1","volume":"1446","author":"Fujiwara","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"B8","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/scd.2014.0266","article-title":"Endogenously produced Indian hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal\/stem cells","volume":"24","author":"Handorf","year":"2015","journal-title":"Stem Cells Dev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1242\/dev.02025","article-title":"Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development","volume":"132","author":"Hilton","year":"2005","journal-title":"Development"},{"key":"B10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/ejhg.2011.13","article-title":"Metopic and sagittal synostosis in greig cephalopolysyndactyly syndrome: five cases with intragenic mutations or complete deletions of GLI3","volume":"19","author":"Hurst","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1242\/dev.079806","article-title":"Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone","volume":"139","author":"Huycke","year":"2012","journal-title":"Development"},{"key":"B12","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1242\/dev.041624","article-title":"The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization","volume":"136","author":"Joeng","year":"2009","journal-title":"Development"},{"key":"B13","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1242\/dev.125.7.1241","article-title":"FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development","volume":"125","author":"Kim","year":"1998","journal-title":"Development"},{"key":"B14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ajhg.2010.11.006","article-title":"Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis","volume":"88","author":"Klopocki","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.1242\/dev.02097","article-title":"Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation","volume":"132","author":"Koziel","year":"2005","journal-title":"Development"},{"key":"B16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ydbio.2007.08.028","article-title":"Cell fate specification during calvarial bone and suture development","volume":"311","author":"Lana-Elola","year":"2007","journal-title":"Dev. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1242\/dev.120154","article-title":"Hedgehog signalling","volume":"143","author":"Lee","year":"2016","journal-title":"Development"},{"key":"B18","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/dvg.20768","article-title":"Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling","volume":"49","author":"Lenton","year":"2011","journal-title":"Genesis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nature01033","article-title":"Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity","volume":"418","author":"Litingtung","year":"2002","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"a008334","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.devcel.2012.01.006","article-title":"GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis","volume":"22","author":"Lopez-Rios","year":"2012","journal-title":"Dev. Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bone.2011.07.023","article-title":"Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects","volume":"49","author":"Maeno","year":"2011","journal-title":"Bone"},{"key":"B23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/dbio.1996.0300","article-title":"Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development","volume":"180","author":"Marigo","year":"1996","journal-title":"Dev. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"10526","DOI":"10.1038\/ncomms10526","article-title":"Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration","volume":"7","author":"Maruyama","year":"2016","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1002\/ajmg.a.33495","article-title":"Metopic craniosynostosis due to mutations in GLI3: a novel association","author":"McDonald-McGinn","year":"2010","journal-title":"Am. J. Med. Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.devcel.2008.03.007","article-title":"Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity","volume":"14","author":"Ohba","year":"2008","journal-title":"Dev. Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1359\/jbmr.2001.16.5.885","article-title":"Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis","volume":"16","author":"Park","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"B28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.127.9.1845","article-title":"Integration of FGF and TWIST in calvarial bone and suture development","volume":"127","author":"Rice","year":"2000","journal-title":"Development"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.1093\/hmg\/ddq258","article-title":"Gli3Xt-J\/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation","volume":"19","author":"Rice","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/0000115030","article-title":"Locate, condense, differentiate, grow and confront: developmental mechanisms controlling intramembranous bone and suture formation and function","volume":"12","author":"Rice","year":"2008","journal-title":"Front. Oral Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.modgep.2005.06.005","article-title":"Expression patterns of hedgehog signalling pathway members during mouse palate development","volume":"6","author":"Rice","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1073\/pnas.1600958113","article-title":"Development of the turtle plastron, the order-defining skeletal structure","volume":"113","author":"Rice","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0012-1606(03)00355-5","article-title":"Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4","volume":"262","author":"Rice","year":"2003","journal-title":"Dev. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2010.04.007","article-title":"Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head","volume":"343","author":"Roybal","year":"2010","journal-title":"Dev. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1091\/mbc.E06-08-0743","article-title":"Ihh\/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function","volume":"18","author":"Shimoyama","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"B36","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.13.16.2072","article-title":"Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation","volume":"13","author":"St-Jacques","year":"1999","journal-title":"Genes Dev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.devcel.2013.05.021","article-title":"Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes","volume":"25","author":"Tabler","year":"2013","journal-title":"Dev. Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"21429","DOI":"10.1074\/jbc.M112.362145","article-title":"Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2)","volume":"287","author":"Tanimoto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1101\/gad.219202","article-title":"Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling","volume":"16","author":"te Welscher","year":"2002","journal-title":"Genes Dev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphys.2012.00121","article-title":"Loss-of-Function of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal suture","volume":"3","author":"Veistinen","year":"2012","journal-title":"Front. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0092-8674(00)80678-9","article-title":"Hedgehog-regulated processing of Gli3 produces an anterior\/posterior repressor gradient in the developing vertebrate limb","volume":"100","author":"Wang","year":"2000","journal-title":"Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1101\/gad.1174704","article-title":"Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog","volume":"18","author":"Yoshida","year":"2004","journal-title":"Genes Dev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1359\/jbmr.090502","article-title":"Dose-dependent effects of Runx2 on bone development","volume":"24","author":"Zhang","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/ncb3139","article-title":"The suture provides a niche for mesenchymal stem cells of craniofacial bones","volume":"17","author":"Zhao","year":"2015","journal-title":"Nat. Cell Biol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.01036\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T21:17:18Z","timestamp":1660166238000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.01036\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":44,"alternative-id":["10.3389\/fphys.2017.01036"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2017.01036","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]},"article-number":"1036"}}