{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:39:06Z","timestamp":1790523546608,"version":"4.1.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00011","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T09:06:16Z","timestamp":1518080776000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":122,"title":["Intracranial Pressure Is a Determinant of Sympathetic Activity"],"prefix":"10.3389","volume":"9","author":[{"given":"Eric A.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Despas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Pavy-Le Traon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Rahmouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Senard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.ijcard.2014.07.279","article-title":"Incidence and clinical characteristics of takotsubo cardiomyopathy post-aneurysmal subarachnoid hemorrhage","volume":"176","author":"Abd","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<62::AID-CNE6>3.0.CO;2-B","article-title":"Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: comparison with input from the caudal ventrolateral medulla","volume":"373","author":"Aicher","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.resp.2004.06.016","article-title":"Pontine influences on breathing: an overview","volume":"143","author":"Alheid","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1088\/1361-6579\/aa638c","article-title":"Cerebrovascular and cardiovascular variability interactions investigated through conditional joint transfer entropy in subjects prone to postural syncope","volume":"38","author":"Bari","year":"2017","journal-title":"Physiol. Meas."},{"key":"B5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1152\/jappl.1987.62.2.389","article-title":"Central chemoreceptors","volume":"62","author":"Bruce","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1113\/jphysiol.2005.104075","article-title":"Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans","volume":"572","author":"Charkoudian","year":"2006","journal-title":"J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/01.RES.32.5.564","article-title":"Role of the baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs","volume":"32","author":"Cowley","year":"1973","journal-title":"Circ. Res."},{"key":"B8","first-page":"290","article-title":"Concerning a definite regulatory mechanism of vasomotor centre which controls blood pressure during cerebral compression","volume":"12","author":"Cushing","year":"1901","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"B9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1046\/j.1440-1681.2002.03640.x","article-title":"Central mechanisms underlying short- and long-term regulation of the cardiovascular system","volume":"29","author":"Dampney","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0006-8993(82)90056-7","article-title":"Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study","volume":"249","author":"Dampney","year":"1982","journal-title":"Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0034-5687(01)00327-9","article-title":"Respiratory influences on sympathetic vasomotor outflow in humans","volume":"130","author":"Dempsey","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/HJH.0b013e328350136c","article-title":"Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure","volume":"30","author":"Despas","year":"2012","journal-title":"J. Hypertens."},{"key":"B13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1042\/cs0600471","article-title":"Neurogenic hypertension revisited","volume":"60","author":"Dickinson","year":"1981","journal-title":"Clin. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1042\/cs0790543","article-title":"Reappraisal of the Cushing reflex: the most powerful neural blood pressure stabilizing system","volume":"79","author":"Dickinson","year":"1990","journal-title":"Clin. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1161\/01.RES.12.2.190","article-title":"Pressor effect of increased cerebrospinal fluid pressure and vertebral artery occlusion with and without anesthesia","volume":"12","author":"Dickinson","year":"1963","journal-title":"Circ. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0006-8993(72)90655-5","article-title":"Localization within the lower brainstem of a receptive area mediating the pressor response to increased intracranial pressure. (the Cushing response)","volume":"47","author":"Doba","year":"1972","journal-title":"Brain Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1177\/0271678X16639060","article-title":"Cerebral haemodynamics during experimental intracranial hypertension","volume":"37","author":"Donnelly","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1002\/cphy.c100015","article-title":"Pontine mechanisms of respiratory control","volume":"2","author":"Dutschmann","year":"2012","journal-title":"Compr. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1748-1716.1971.tb05050.x","article-title":"Modification of kaolin-induced intracranial hypertension at various time-periods after superior cervical sympathectomy in rabbits","volume":"83","author":"Edvinsson","year":"1971","journal-title":"Acta Physiol. Scand."},{"key":"B20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1136\/jnnp.41.4.340","article-title":"Systemic vascular responses to increased intracranial pressure. 3. Effects of individual balloon inflations on intracranial pressure and the systemic effects","volume":"41","author":"Fitch","year":"1977","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1161\/01.HYP.0000255983.32896.b9","article-title":"Excessive sympathetic activation in heart failure with obesity and metabolic syndrome: characteristics and mechanisms","volume":"49","author":"Grassi","year":"2007","journal-title":"Hypertension"},{"key":"B22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0034-5687(00)00125-0","article-title":"Neural structures that mediate sympathoexcitation during hypoxia","volume":"121","author":"Guyenet","year":"2000","journal-title":"Respir. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1161\/STROKEAHA.110.607721","article-title":"High NIHSS values predict impairment of cardiovascular autonomic control","volume":"42","author":"Hilz","year":"2011","journal-title":"Stroke"},{"key":"B25","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1001\/archneur.1970.00480270038006","article-title":"Localization of regions mediating the Cushing response in CNS of cat","volume":"23","author":"Hoff","year":"1970","journal-title":"Arch. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1109\/TBME.2007.900802","article-title":"Characterization of interdependency between intracranial pressure and heart variability signals: a causal spectral measure and a generalized synchronization measure","volume":"54","author":"Hu","year":"2007","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"B27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-201X.2003.01088.x","article-title":"Neurophysiological analysis of target-related sympathetic pathways from animal to human: similarities and differences","volume":"177","author":"J\u00e4nig","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"B28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/00000658-198508000-00018","article-title":"Neurogenic hypertension: etiology and surgical treatment. II. Observation in an experimental non-human primate model","volume":"202","author":"Jannetta","year":"1985","journal-title":"Ann. Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3181\/00379727-37-9531","article-title":"Adrenalectomy in experimental hypertension from kaolin","volume":"37","author":"Jeffers","year":"1937","journal-title":"Exp. Biol. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1212\/01.wnl.0000250270.54587.71","article-title":"CSF pressure assessed by lumbar puncture agrees with intracranial pressure","volume":"68","author":"Lenfeldt","year":"2007","journal-title":"Neurology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3171\/jns.1976.44.6.0698","article-title":"Body position and cerebrospinal fluid pressure. Part 2: clinical studies on orthostatic pressure and the hydrostatic indifferent point","volume":"44","author":"Magnaes","year":"1976","journal-title":"J. Neurosurg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/978-3-319-22533-3_54","article-title":"Intracranial hypertension is painless!","volume":"122","author":"Manet","year":"2016","journal-title":"Acta Neurochir. Suppl."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1152\/ajpregu.00541.2015","article-title":"Calibrated variability of muscle sympathetic nerve activity during graded head-up tilt in humans and its link with noradrenaline data and cardiovascular rhythms","volume":"310","author":"Marchi","year":"","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3389\/fphys.2016.00438","article-title":"Simultaneous characterization of sympathetic and cardiac arms of the baroreflex through sequence techniques during incremental Head-Up Tilt","volume":"7","author":"Marchi","year":"","journal-title":"Front. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1227\/01.NEU.0000168184.01002.60","article-title":"The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus","volume":"57","author":"Marmarou","year":"2005","journal-title":"Neurosurgery"},{"key":"B37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/apha.12706","article-title":"Intracranial mechanisms for preserving brain blood flow in health and disease","volume":"219","author":"McBryde","year":"2017","journal-title":"Acta Physiol. (Oxf)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3171\/jns.1978.48.5.0730","article-title":"The relation of cerebral ischemia, hypoxia, and hypercarbia to the Cushing response","volume":"48","author":"McGillicuddy","year":"1978","journal-title":"J. Neurosurg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3171\/jns.1984.60.3.0566","article-title":"Acute intracranial hypertension and brain-stem blood flow. An experimental study","volume":"60","author":"Nagao","year":"1984","journal-title":"J. Neurosurg"},{"key":"B40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1161\/01.HYP.10.6.635","article-title":"Pressor response to small elevations of cerebroventricular pressure in conscious rats","volume":"10","author":"Nakamura","year":"1987","journal-title":"Hypertension"},{"key":"B41","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1161\/01.CIR.98.8.772","article-title":"Sympathetic activity in obese subjects with and without obstructive sleep apnea","volume":"98","author":"Narkiewicz","year":"1998","journal-title":"Circulation"},{"key":"B42","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1440-1681.2005.04200.x","article-title":"Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney","volume":"32","author":"Osborn","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1113\/expphysiol.2008.043455","article-title":"Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing 'Cushing's mechanism'","volume":"94","author":"Paton","year":"2009","journal-title":"Exp. Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.2337\/diabetes.54.7.2012","article-title":"Role of selective leptin resistance in diet-induced obesity hypertension","volume":"54","author":"Rahmouni","year":"2005","journal-title":"Diabetes"},{"key":"B45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ncl.2008.02.003","article-title":"Management of intracranial hypertension","volume":"26","author":"Rangel-Castilla","year":"2008","journal-title":"Neurol. Clin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1056\/NEJM197212282872616","article-title":"Hypertension as a localizing sign of mass lesions of brainstem","volume":"287","author":"Reis","year":"1972","journal-title":"N. Engl. J. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1111\/psyp.12898","article-title":"Time domain measurement of the vascular and myocardial branches of the baroreflex: a study in physically active versus sedentary individuals","volume":"54","author":"Reyes Del Paso","year":"2017","journal-title":"Psychophysiology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1161\/01.CIR.12.5.883","article-title":"Pressor mechanisms induced by intracranial compression","volume":"12","author":"Rodbard","year":"1955","journal-title":"Circulation"},{"key":"B49","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00701-012-1441-y","article-title":"Characterisation of the intracranial pressure waveform during infusion studies by means of central tendency measure","volume":"154","author":"Santamarta","year":"2012","journal-title":"Acta Neurochir."},{"key":"B50","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/3-211-32318-X_51","article-title":"Intracranial baroreflex yielding an early Cushing response in human","volume":"95","author":"Schmidt","year":"2005","journal-title":"Acta Neurochir. Suppl."},{"key":"B51","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fphys.2017.00163","article-title":"Physiological mechanisms mediating the coupling between heart period and arterial pressure in response to postural changes in humans","volume":"8","author":"Silvani","year":"2017","journal-title":"Front. Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3171\/jns.1959.16.6.0664","article-title":"Dynamic axial brainstem distortion as a mechanism explaining the cardiorespiratory changes in increased intracranial pressure","volume":"16","author":"Thompson","year":"1959","journal-title":"J. Neurosurg."},{"key":"B54","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3171\/jns.1993.79.5.0705","article-title":"Catecholamine response to a gradual increase of intracranial pressure","volume":"79","author":"Van Loon","year":"1993","journal-title":"J. Neurosurg."},{"key":"B55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.autneu.2015.08.004","article-title":"Sympathetic nervous system and blood pressure in humans. Individualized patterns of regulation and their implications","volume":"193","author":"White","year":"2015","journal-title":"Auton. Neurosci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00011\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T12:22:35Z","timestamp":1526386955000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00011\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":54,"alternative-id":["10.3389\/fphys.2018.00011"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00011","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]},"article-number":"11"}}