{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:35:13Z","timestamp":1790516113710,"version":"4.1.0"},"reference-count":67,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00077","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T12:37:46Z","timestamp":1518439066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Participation of Arachidonic Acid Metabolism in the Aortic Aneurysm Formation in Patients with Marfan Syndrome"],"prefix":"10.3389","volume":"9","author":[{"given":"Mar\u00eda E.","family":"Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Guarner-Lans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Y.","family":"Herrera-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.vph.2011.12.002","article-title":"Endothelial nitric oxide and 15-lipoxygenase-1 metabolites independently mediate relaxation of the rabbit aorta","volume":"56","author":"Aggarwal","year":"2012","journal-title":"Vascul. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.cmet.2008.09.005","article-title":"Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis","volume":"8","author":"Babaev","year":"2008","journal-title":"Cell. Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.cellsig.2005.03.002","article-title":"Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells","volume":"17","author":"Balsinde","year":"2005","journal-title":"Cell. Signal."},{"key":"B4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.5603\/CJ.2013.0066","article-title":"The role of transforming growth factor-beta in Marfan syndrome","volume":"20","author":"Benke","year":"2013","journal-title":"Cardiol. J."},{"key":"B5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/thx.23.4.338","article-title":"A technique for complete replacement of the ascending aorta","volume":"23","author":"Bentall","year":"1968","journal-title":"Thorax"},{"key":"B6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.prostaglandins.2007.03.005","article-title":"Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice","volume":"84","author":"Cao","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B8","doi-asserted-by":"publisher","first-page":"H495","DOI":"10.1152\/ajpheart.00349.2009","article-title":"Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone","volume":"297","author":"Chawengsub","year":"2009","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3892\/ijmm.20.3.391","article-title":"Differential secretion of prostaglandin E(2), thromboxane A(2) and interleukin-6 in intact and ruptured abdominal aortic aneurysms","volume":"20","author":"Cheuk","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00268-007-9279-9","article-title":"Can local secretion of prostaglandin E2, thromboxane B2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?","volume":"32","author":"Cheuk","year":"2008","journal-title":"World. J. Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/sj.bjp.0707181","article-title":"Endothelial dysfunction and compromised eNOS\/Akt signaling in the thoracic aorta during the progression of Marfan syndrome","volume":"150","author":"Chung","year":"","journal-title":"Br. J. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/sj.bjp.0707391","article-title":"Imbalanced synthesis of cyclooxygenase-derived thromboxane A2 and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome","volume":"152","author":"Chung","year":"","journal-title":"Br. J. Pharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-\u03b2-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"G228","DOI":"10.1152\/ajpgi.00465.2011","article-title":"Arachidonic acid stimulates TNF\u03b1 production in Kupffer cells via a reactive oxygen species-pERK1\/2-Egr1-dependent mechanism","volume":"303","author":"Cubero","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver. Physiol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0952-3278(95)90123-X","article-title":"Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions","volume":"53","author":"Di Marzo","year":"1995","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"B16","doi-asserted-by":"crossref","first-page":"24897","DOI":"10.1016\/S0021-9258(18)35848-4","article-title":"Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle","volume":"267","author":"Dorn","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/mnfr.200800220","article-title":"Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells","volume":"53","author":"Fang","year":"2009","journal-title":"Mol. Nutr. Food. Res."},{"key":"B18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.14797\/mdcj-7-3-2","article-title":"Biology of aortic aneurysms and dissections","volume":"7","author":"Fernandez-Moure","year":"2011","journal-title":"Method. Debakey Cardiovasc. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1210\/jc.2005-1303","article-title":"Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers","volume":"91","author":"Ferrucci","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"B21","doi-asserted-by":"crossref","first-page":"31065","DOI":"10.1074\/jbc.272.49.31065","article-title":"Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase-2 expression and prostaglandin E2 synthesis","volume":"272","author":"Fournier","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.08.005","article-title":"Prostacyclin protects against elevated blood pressure and cardiac fibrosis","author":"Francois","year":"2005","journal-title":"Cell. Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ejphar.2008.07.039","article-title":"Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin","volume":"594","author":"Fujiwara","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science."},{"key":"B25","doi-asserted-by":"publisher","first-page":"H725","DOI":"10.1152\/ajpheart.00696.2009","article-title":"Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries","volume":"300","author":"Gauthier","year":"2011","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cardiores.2006.10.015","article-title":"Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice","volume":"73","author":"Gitlin","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ng.3723","article-title":"An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death","volume":"49","author":"Granata","year":"2016","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00380-015-0703-z","article-title":"Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?","volume":"31","author":"Grewal","year":"2016","journal-title":"Heart. Vessels."},{"key":"B29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0167-4889(02)00316-6","article-title":"Molecular mechanisms of cytokine receptor activation","volume":"1592","author":"Gr\u00f6tzinger","year":"2002","journal-title":"Biochim. Biophys. Acta."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1161\/CIRCULATIONAHA.105.601674","article-title":"Induction of macrophage chemotaxis by aortic extracts of the mgR Marfan mouse model and a GxxPG-containing fibrillin-1 fragment","volume":"114","author":"Guo","year":"2006","journal-title":"Circulation."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12945\/j.aorta.2013.13.007","article-title":"Indomethacin prevents the progression of thoracic aorti aneurysm in marfan syndrome mice","volume":"1","author":"Guo","year":"2013","journal-title":"Aorta (Stamford)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3390\/nu8040216","article-title":"The essentiality of arachidonic acid in infant development","volume":"8","author":"Hadley","year":"2016","journal-title":"Nutrients"},{"key":"B33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1476-511X-9-37","article-title":"Individual variation and vintraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle","volume":"9","author":"Haug","year":"2010","journal-title":"Lipids. Health. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/157016111301150303132348","article-title":"Inflammaging and proteases in abdominal aortic aneurysm","volume":"13","author":"Hendel","year":"2015","journal-title":"Curr. Vasc. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGF\u03b2 signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science."},{"key":"B36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1476-511X-12-40","article-title":"Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum","volume":"12","author":"H\u00f8stmark","year":"2013","journal-title":"Lipids. Health. Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.pharmthera.2017.05.005","article-title":"Cytochrome P450-derived eicosanoids and heart function","volume":"179","author":"Jamieson","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1139\/y06-088","article-title":"Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat","volume":"85","author":"Jiang","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1161\/01.ATV.0000116219.09040.8c","article-title":"Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids","volume":"24","author":"Kr\u00f6tz","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0006-2952(99)00158-6","article-title":"Cyclooxygenase knockout mice: models for elucidating isoform-specific functions","volume":"58","author":"Langenbach","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0092-8674(95)90126-4","article-title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","volume":"83","author":"Langenbach","year":"1995","journal-title":"Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1111\/j.1462-5822.2010.01505.x","article-title":"Cytosolic phospholipase A2 as a mediator of disease pathogenesis","volume":"12","author":"Linkous","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2174\/156720181301160314151554","article-title":"Effect of glycine on adipocyte hypertrophy in a metabolic syndrome rat model","volume":"13","author":"L\u00f3pez","year":"2016","journal-title":"Curr. Drug. Deliv"},{"key":"B44","doi-asserted-by":"publisher","first-page":"6145","DOI":"10.3892\/mmr.2015.4149","article-title":"Pravastatin inhibits fibrinogen- and FDP-induced inflammatory response via reducing the production of IL-6, TNF-\u03b1 and iNOS in vascular smooth muscle cells","volume":"12","author":"Lu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"433","DOI":"10.5604\/12321966.1167708","article-title":"Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis","volume":"22","author":"\u0141uczaj","year":"2015","journal-title":"Ann. Agric. Environ. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1146\/annurev.genom.8.080706.092303","article-title":"Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction","volume":"9","author":"Milewicz","year":"2008","journal-title":"Annu. Rev. Genomics. Hum. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat. Genet."},{"key":"B48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3565(24)37776-6","article-title":"Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice","volume":"287","author":"Obukowicz","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/BF00400654","article-title":"Regulatory role of eicosanoids in extracellular matrix overproduction induced by long-term exposure to high glucose in cultured rat mesangial cells","volume":"39","author":"Pricci","year":"1996","journal-title":"Diabetologia"},{"key":"B50","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1161\/01.HYP.0000231934.67549.b7","article-title":"Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta","volume":"48","author":"Qi","year":"2006","journal-title":"Hypertension"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e32963","DOI":"10.1371\/journal.pone.0032963","article-title":"Inflammation aggravates disease severity in Marfan syndrome patients","volume":"7","author":"Radonic","year":"2012","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ijcard.2015.03.423","article-title":"Molecular pathogenesis of Marfan syndrome","volume":"187","author":"Ramachandra","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/01902148709064310","article-title":"Cyclooxygenase metabolites contribute to oleic acid-induced lung edema by a pressure effect","volume":"13","author":"Selig","year":"1987","journal-title":"Exp. Lung. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0136201","DOI":"10.1371\/journal.pone.0136201","article-title":"Expression and Cellular Localization of 5-Hydroxy-Prostaglandin-Dehydrogenase in Abdominal Aortic Aneurysm","volume":"10","author":"Sol\u00e0-Vill\u00e0","year":"2015","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.prostaglandins.2016.05.001","article-title":"Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients","volume":"123","author":"Soto","year":"","journal-title":"Prostaglandins. Other. Lipid. Mediat."},{"key":"B57","doi-asserted-by":"publisher","first-page":"760694","DOI":"10.1155\/2014\/760694","article-title":"Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies","volume":"2014","author":"Soto","year":"2014","journal-title":"Oxid. Med. Cell. Longev"},{"key":"B58","doi-asserted-by":"publisher","first-page":"8625203","DOI":"10.1155\/2016\/8625203","article-title":"Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome","volume":"2016","author":"Soto","year":"","journal-title":"Med. Inflamm."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1073\/pnas.242716099","article-title":"Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis","volume":"100","author":"Spanbroek","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1053\/ejvs.2001.1352","article-title":"The inflammatory response and its consequence for the clinical outcome following aortic aneurysm repair","volume":"21","author":"Swartbol","year":"2001","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"B61","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-94-007-7893-1_8","article-title":"Connective tissue disorders and cardiovascular complications: The indomitable role of transforming growth factor-beta signaling","volume":"802","author":"Wheeler","year":"2014","journal-title":"In: Adv. Exp. Med. Biol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbrc.2005.08.021","article-title":"Cellular and molecular biology of prostacyclin synthase","volume":"338","author":"Wu","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.vph.2009.10.005","article-title":"Vasomotor dysfunction in the thoracic aorta of Marfan syndrome is associated with accumulation of oxidative stress","volume":"52","author":"Yang","year":"2010","journal-title":"Vascul. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1590\/S0102-76382011000100019","article-title":"Cystic medial necrosis: pathological findings and clinical implications","volume":"26","author":"Yuan","year":"2011","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"B65","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11010-012-1512-7","article-title":"Transforming growth factor-\u03b21 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cells via ROS-dependent ERK-NF-\u03baB pathways","volume":"375","author":"Zhang","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/nm1099","article-title":"The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm","volume":"10","author":"Zhao","year":"2004","journal-title":"Nat. Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1024\/0301-1526\/a000609","article-title":"Glutathione system participation in thoracic aneurysms from patients with Marfan syndrome","volume":"46","author":"Z\u00fa\u00f1iga-Mu\u00f1oz","year":"2017","journal-title":"Vasa"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00077\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:42:47Z","timestamp":1751395367000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00077\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":67,"alternative-id":["10.3389\/fphys.2018.00077"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00077","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]},"article-number":"77"}}