{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:08:58Z","timestamp":1792674538172,"version":"4.5.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271223"],"award-info":[{"award-number":["31271223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671184"],"award-info":[{"award-number":["31671184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2016206477"],"award-info":[{"award-number":["H2016206477"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00249","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T10:43:52Z","timestamp":1522147432000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response Through Altering TASK Channel Expression"],"prefix":"10.3389","volume":"9","author":[{"given":"Fang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/apha.12257","article-title":"Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob\/ob) mice","volume":"211","author":"Bassi","year":"2014","journal-title":"Acta Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00424-012-1111-1","article-title":"Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight","volume":"464","author":"Bassi","year":"2012","journal-title":"Pflugers Arch."},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.lfs.2015.01.019","article-title":"Control of respiratory and cardiovascular functions by leptin","volume":"125","author":"Bassi","year":"2015","journal-title":"Life Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1152\/physrev.1971.51.3.598","article-title":"Genetically transmitted obesity in rodents","volume":"51","author":"Bray","year":"1971","journal-title":"Physiol. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fphys.2013.00016","article-title":"Systemic leptin produces a long-lasting increase in respiratory motor output in rats","volume":"4","author":"Chang","year":"2013","journal-title":"Front. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.peptides.2014.05.014","article-title":"Carotid chemoreceptor afferent projections to leptin receptor containing neurons in nucleus of the solitary tract","volume":"58","author":"Ciriello","year":"2014","journal-title":"Peptides"},{"key":"B7","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1164\/ajrccm.150.2.8049815","article-title":"Pulmonary ventilation and mechanics in morbidly obese Zucker rats","volume":"150","author":"Farkas","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.1113\/JP274437","article-title":"Chemosensitive Phox2b-expressing neurons are crucial for hypercapnic ventilatory response in the nucleus tractus solitarius","volume":"595","author":"Fu","year":"2017","journal-title":"J. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/19336950.2016.1164373","article-title":"Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential","volume":"10","author":"Gavello","year":"2016","journal-title":"Channels"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1073\/pnas.0910059107","article-title":"Task2 potassium channels set central respiratory CO2 and O2 sensitivity","volume":"107","author":"Gestreau","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/jcp.22528","article-title":"Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input","volume":"226","author":"Gonzalez-Martin","year":"2011","journal-title":"J. Cell Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1210\/endo.143.1.8589","article-title":"Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake","volume":"143","author":"Grill","year":"2002","journal-title":"Endocrinology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"17271","DOI":"10.1074\/jbc.R110.113175","article-title":"Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins","volume":"285","author":"Hall","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1126\/science.aaa0922","article-title":"Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons","volume":"348","author":"Kumar","year":"2015","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","article-title":"Obstructive sleep apnoea","volume":"360","author":"Malhotra","year":"2002","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.brainres.2013.03.022","article-title":"Effect of chronic intermittent hypoxia on leptin and leptin receptor protein expression in the carotid body","volume":"1513","author":"Messenger","year":"2013","journal-title":"Brain Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.neuroscience.2015.09.066","article-title":"Effects of angiotensin II on leptin and downstream leptin signaling in the carotid body during acute intermittent hypoxia","volume":"310","author":"Moreau","year":"2015","journal-title":"Neuroscience"},{"key":"B18","doi-asserted-by":"publisher","first-page":"E1247","DOI":"10.1152\/ajpendo.00274.2009","article-title":"Recent advances in understanding leptin signaling and leptin resistance","volume":"297","author":"Morris","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0034-5687(99)00111-5","article-title":"Leptin, obesity, and respiratory function","volume":"119","author":"O'Donnell","year":"2000","journal-title":"Respir. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1152\/japplphysiol.00454.2014","article-title":"Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure","volume":"117","author":"Olea","year":"2014","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/978-3-319-18440-1_43","article-title":"The carotid body does not mediate the acute ventilatory effects of leptin","volume":"860","author":"Olea","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fnbeh.2017.00113","article-title":"Long-term sex-dependent vulnerability to metabolic challenges in prenatally stressed rats","volume":"11","author":"Panetta","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1136\/thorax.57.1.75","article-title":"Association of serum leptin with hypoventilation in human obesity","volume":"57","author":"Phipps","year":"2002","journal-title":"Thorax"},{"key":"B24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.brainres.2011.02.028","article-title":"Expression of leptin and leptin receptor isoforms in the rat and human carotid body","volume":"1385","author":"Porzionato","year":"2011","journal-title":"Brain Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-319-18440-1_8","article-title":"Acutely administered leptin increases [Ca2+]i and BK Ca currents but does not alter chemosensory behavior in rat carotid body type I cells","volume":"860","author":"Pye","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/hy0202.102836","article-title":"Selective resistance to central neural administration of leptin in agouti obese mice","volume":"39","author":"Rahmouni","year":"2002","journal-title":"Hypertension"},{"key":"B27","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/01.HYP.0000254827.59792.b2","article-title":"Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin","volume":"49","author":"Rahmouni","year":"2007","journal-title":"Hypertension"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/JP275362","article-title":"High fat diet blunts the effects of leptin on ventilation and on carotid body activity","author":"Ribeiro","year":"2017","journal-title":"J. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1161\/CIRCRESAHA.109.206946","article-title":"Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR","volume":"106","author":"Tan","year":"2010","journal-title":"Circ. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1074\/jbc.272.10.6093","article-title":"The leptin receptor","volume":"272","author":"Tartaglia","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1378\/chest.127.3.716","article-title":"Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome","volume":"127","author":"Tatsumi","year":"2005","journal-title":"Chest"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8844","DOI":"10.1523\/JNEUROSCI.1810-08.2008","article-title":"A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing","volume":"28","author":"Trapp","year":"2008","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"16033","DOI":"10.1523\/JNEUROSCI.2451-13.2013","article-title":"TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons","volume":"33","author":"Wang","year":"2013","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"OF06","DOI":"10.7860\/JCDR\/2015\/15594.7003","article-title":"Dysregulation of glucose homeostasis following chronic exogenous administration of leptin in healthy sprague-dawley rats","volume":"9","author":"Wjidan","year":"2015","journal-title":"J. Clin. Diagn. Res."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00249\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T10:43:55Z","timestamp":1522147435000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00249\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":34,"alternative-id":["10.3389\/fphys.2018.00249"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00249","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,27]]},"article-number":"249"}}