{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:57Z","timestamp":1789706217735,"version":"4.0.1"},"reference-count":112,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00295","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:32:33Z","timestamp":1522283553000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes"],"prefix":"10.3389","volume":"9","author":[{"given":"Sotirios I.","family":"Sinis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissi","family":"Hatzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos I.","family":"Gourgoulianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios G.","family":"Zarogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1021\/acsami.5b11700","article-title":"Nickel nanoparticles entangled in carbon nanotubes: novel ink for nanotube printing","volume":"8","author":"Abdel Fattah","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1080\/15287394.2013.834855","article-title":"The role of iron impurities in the toxic effects exerted by short multiwalled carbon nanotubes (MWCNT) in murine alveolar macrophages","volume":"76","author":"Aldieri","year":"2013","journal-title":"J. Toxicol. Environ. Heal. A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.etap.2017.02.009","article-title":"Silver nanoparticles alter the permeability of sheep pleura and of sheep and human pleural mesothelial cell monolayers","volume":"50","author":"Arsenopoulou","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1539\/joh.L9150","article-title":"Genotoxicity and cytotoxicity of multi-wall carbon nanotubes in cultured Chinese hamster lung cells in comparison with chrysotile A fibers","volume":"52","author":"Asakura","year":"2010","journal-title":"J. Occup. Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1183\/16000617.0063-2016","article-title":"Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment","volume":"25","author":"Bibby","year":"2016","journal-title":"Eur. Respir. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3109\/17435390.2014.980760","article-title":"Molecular mechanism of silver nanoparticles in human intestinal cells","volume":"9","author":"B\u00f6hmert","year":"2015","journal-title":"Nanotoxicology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s00204-015-1518-5","article-title":"Progress and future of in vitro models to study translocation of nanoparticles","volume":"89","author":"Braakhuis","year":"2015","journal-title":"Arch. Toxicol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"8266","DOI":"10.1039\/c3cs60111k","article-title":"Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology","volume":"42","author":"Chen","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.3390\/ijms18071504","article-title":"Current Knowledge on the use of computational toxicology in hazard assessment of metallic engineered nanomaterials","volume":"18","author":"Chen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1007\/s00204-016-1717-8","article-title":"Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials","volume":"90","author":"Clippinger","year":"2016","journal-title":"Arch. Toxicol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/annhyg\/mer110","article-title":"Occupational exposure assessment in carbon nanotube and nanofiber primary and secondary manufacturers","volume":"56","author":"Dahm","year":"2012","journal-title":"Ann. Occup. Hyg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/annhyg\/mev020","article-title":"Carbon nanotube and nanofiber exposure assessments: an analysis of 14 site visits","volume":"59","author":"Dahm","year":"2015","journal-title":"Ann. Occup. Hyg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6105","DOI":"10.2147\/IJN.S85265","article-title":"Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model","volume":"10","author":"Dan","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"B15","first-page":"716","article-title":"Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008","volume-title":"Bull. World Health Organ.","author":"Delgermaa","year":"2011"},{"key":"B16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/mutage\/gep010","article-title":"Confounding experimental considerations in nanogenotoxicology","volume":"24","author":"Doak","year":"2009","journal-title":"Mutagenesis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nnano.2007.223","article-title":"Immunological properties of engineered nanomaterials","volume":"2","author":"Dobrovolskaia","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","article-title":"Mechanisms of Endocytosis","volume":"78","author":"Doherty","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1743-8977-7-5","article-title":"Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma","volume":"7","author":"Donaldson","year":"2010","journal-title":"Part. Fibre Toxicol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/toxsci\/55.1.24","article-title":"Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations","volume":"55","author":"Driscoll","year":"2000","journal-title":"Toxicol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4795","DOI":"10.3390\/ijms15034795","article-title":"Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies","volume":"15","author":"Fr\u00f6hlich","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.toxlet.2016.05.025","article-title":"Pulmonary and pleural inflammation after intratracheal instillation of short single-walled and multi-walled carbon nanotubes","volume":"257","author":"Fujita","year":"2016","journal-title":"Toxicol. Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00204-015-1458-0","article-title":"Towards understanding of nanoparticle\u2013protein corona","volume":"89","author":"Ge","year":"2015","journal-title":"Arch. Toxicol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1165\/rcmb.2012-0023OC","article-title":"Nickel nanoparticles enhance platelet-derived growth factor-induced chemokine expression by mesothelial cells via prolonged mitogen-activated protein kinase activation","volume":"47","author":"Glista-Baker","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1039\/C7MH00166E","article-title":"Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organism Caenorhabditis elegans","volume":"4","author":"Gonzalez-Moragas","year":"2017","journal-title":"Mater. Horiz."},{"key":"B26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.nantod.2015.06.006","article-title":"Nanoparticle uptake: the phagocyte problem","volume":"10","author":"Gustafson","year":"2015","journal-title":"Nano Today"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.2147\/ijn.s26573","article-title":"Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses","volume":"6","author":"Haniu","year":"","journal-title":"Int. J. Nanomed."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.2147\/IJN.S26689","article-title":"Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines","volume":"6","author":"Haniu","year":"","journal-title":"Int. J. Nanomed."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.2147\/IJN.S58661","article-title":"Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells","volume":"9","author":"Haniu","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"B30","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s11864-008-0072-2","article-title":"Peritoneal mesothelioma","volume":"9","author":"Hesdorffer","year":"2008","journal-title":"Curr. Treat. Options Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1016\/j.scitotenv.2010.01.035","article-title":"In vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines","volume":"408","author":"Hu","year":"2010","journal-title":"Sci. Total Environ."},{"key":"B32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12989-016-0158-0","article-title":"Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells","volume":"13","author":"Huaux","year":"2016","journal-title":"Fibre Toxicol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.bbrc.2017.01.114","article-title":"Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure","volume":"484","author":"Imai","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2747215","DOI":"10.1155\/2017\/2747215","article-title":"Different cellular response of human mesothelial cell MeT-5A to short-term and long-term multiwalled carbon nanotubes exposure","volume":"2017","author":"Ju","year":"2017","journal-title":"Biomed Res. Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s10856-007-3296-y","article-title":"Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture","volume":"19","author":"Kaiser","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3109\/17435390.2014.933903","article-title":"Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats","volume":"9","author":"Kasai","year":"2015","journal-title":"Nanotoxicology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12989-016-0164-2","article-title":"Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats","volume":"13","author":"Kasai","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2147\/ijn.s72998","article-title":"Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity","volume":"10","author":"Khang","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"B39","doi-asserted-by":"publisher","first-page":"236","DOI":"10.21037\/atm.2017.03.96","article-title":"Malignant peritoneal mesothelioma: a review","volume":"5","author":"Kim","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.vascn.2006.06.001","article-title":"Correlation of in vitro cytotoxicity with paracellular permeability in mortal rat intestinal cells","volume":"55","author":"Konsoula","year":"2007","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B41","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ejpb.2008.08.009","article-title":"Current in vitro methods in nanoparticle risk assessment: limitations and challenges","volume":"72","author":"Kroll","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1007\/s10439-013-0860-0","article-title":"Cellular function and adhesion mechanisms of human bone marrow mesenchymal stem cells on multi-walled carbon nanotubes","volume":"41","author":"Kroustalli","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"B43","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/toxsci\/kfv176","article-title":"Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice","volume":"148","author":"Li","year":"2015","journal-title":"Toxicol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"354","DOI":"10.2174\/138920012800166535","article-title":"Current methods and research progress in nanomaterials risk assessment","volume":"13","author":"Lin","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"B45","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tox.2012.12.008","article-title":"Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro","volume":"313","author":"Lindberg","year":"2013","journal-title":"Toxicology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7711","DOI":"10.1021\/nn402241b","article-title":"Chronic exposure to carbon nanotubes induces invasion of human mesothelial cells through matrix metalloproteinase-2","volume":"7","author":"Lohcharoenkal","year":"2013","journal-title":"ACS Nano"},{"key":"B47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fphys.2014.00222","article-title":"Role of H-Ras\/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells","volume":"5","author":"Lohcharoenkal","year":"2014","journal-title":"Front. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1089\/jamp.2013.1044","article-title":"Measurement techniques for respiratory tract deposition of airborne nanoparticles: a critical review","volume":"27","author":"L\u00f6ndahl","year":"2014","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"B49","doi-asserted-by":"publisher","first-page":"793186","DOI":"10.1155\/2015\/793186","article-title":"Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells","volume":"2015","author":"Maruyama","year":"2015","journal-title":"Biomed Res. Int."},{"key":"B50","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1743-8977-7-28","article-title":"Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes","volume":"7","author":"Mercer","year":"2010","journal-title":"Fibre Toxicol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1743-8977-10-38","article-title":"Extrapulmonary transport of MWCNT following inhalation exposure","volume":"10","author":"Mercer","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1007\/s00204-014-1356-x","article-title":"Role of oxidative stress in carbon nanotube-generated health effects","volume":"88","author":"M\u00f8ller","year":"2014","journal-title":"Arch. Toxicol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1093\/toxsci\/kfp100","article-title":"Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat","volume":"110","author":"Muller","year":"2009","journal-title":"Toxicol. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.ajpath.2011.02.040","article-title":"Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura","volume":"178","author":"Murphy","year":"2011","journal-title":"Am. J. Pathol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3109\/17435390.2012.713527","article-title":"Length-dependent pleural inflammation and parietal pleural responses after deposition of carbon nanotubes in the pulmonary airspaces of mice","volume":"7","author":"Murphy","year":"2013","journal-title":"Nanotoxicology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1743-8977-9-8","article-title":"The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells","volume":"9","author":"Murphy","year":"2012","journal-title":"Part. Fibre Toxicol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1046\/j.1440-1843.2002.00404.x","article-title":"Mesothelial cells: their structure, function and role in serosal repair","volume":"7","author":"Mutsaers","year":"2002","journal-title":"Respirology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/pin.12093","article-title":"Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats","volume":"63","author":"Nagai","year":"2013","journal-title":"Pathol. Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"E1330","DOI":"10.1073\/pnas.1110013108","article-title":"Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis","volume":"108","author":"Nagai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.1114397","article-title":"Toxic potential of materials at the nanolevel","volume":"311","author":"Nel","year":"2006","journal-title":"Science"},{"key":"B61","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2217\/nnm.11.87","article-title":"Imaging methods for determining uptake and toxicity of carbon nanotubes in vitro and in vivo","volume":"6","author":"Nerl","year":"2011","journal-title":"Nanomedicine"},{"key":"B62","doi-asserted-by":"publisher","first-page":"9353275","DOI":"10.1155\/2016\/9353275","article-title":"Nanosilica and polyacrylate\/nanosilica: a comparative study of acute toxicity","volume":"2016","author":"Niu","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1743-8977-11-4","article-title":"Free radical scavenging and formation by multi-walled carbon nanotubes in cell free conditions and in human bronchial epithelial cells","volume":"11","author":"Nymark","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1126\/science.1158398","article-title":"Immunology: how frustration leads to inflammation","volume":"320","author":"O'Neill","year":"2008","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1289\/ehp.7339","article-title":"Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles","volume":"113","author":"Oberd\u00f6rster","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"B66","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1743-8977-8-15","article-title":"Durability and inflammogenic impact of carbon nanotubes compared with asbestos fibres","volume":"8","author":"Osmond-McLeod","year":"2011","journal-title":"Part. Fibre Toxicol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/17435390802318356","article-title":"Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells","volume":"2","author":"Pacurari","year":"","journal-title":"Nanotoxicology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1289\/ehp.10924","article-title":"Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells","volume":"116","author":"Pacurari","year":"","journal-title":"Environ. Health Perspect."},{"key":"B69","doi-asserted-by":"publisher","first-page":"6861","DOI":"10.1021\/nn200595c","article-title":"Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism","volume":"5","author":"Palomaki","year":"2011","journal-title":"ACS Nano"},{"key":"B70","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2217\/nnm.09.40","article-title":"The status of in vitro toxicity studies in the risk assessment of nanomaterials","volume":"4","author":"Park","year":"2009","journal-title":"Nanomedicine"},{"key":"B71","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.yrtph.2009.12.012","article-title":"Multi-walled carbon nanotubes (Baytubes\u00ae): Approach for derivation of occupational exposure limit","volume":"57","author":"Pauluhn","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3109\/17435390.2011.626535","article-title":"Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity","volume":"6","author":"Poland","year":"2012","journal-title":"Nanotoxicology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nnano.2008.111","article-title":"Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study","volume":"3","author":"Poland","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12989-016-0131-y","article-title":"Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface","volume":"13","author":"Polk","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3109\/17435390.2012.719649","article-title":"Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes","volume":"7","author":"Porter","year":"2013","journal-title":"Nanotoxicology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.tox.2009.10.017","article-title":"Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes","volume":"269","author":"Porter","year":"2010","journal-title":"Toxicology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/crj.12028","article-title":"Asbestos and the lung in the 21st century: an update","volume":"8","author":"Prazakova","year":"2014","journal-title":"Clin. Respir. J."},{"key":"B78","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2217\/nnm.09.95","article-title":"Physicochemical properties affecting cellular uptake of carbon nanotubes","volume":"5","author":"Raffa","year":"2010","journal-title":"Nanomedicine"},{"key":"B79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.21037\/atm.2017.06.26","article-title":"Malignant pleural mesothelioma: predictors and staging","volume":"5","author":"Richards","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12989-014-0059-z","article-title":"The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats","volume":"11","author":"Rittinghausen","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nnano.2009.305","article-title":"Inhaled carbon nanotubes reach the subpleural tissue in mice","volume":"4","author":"Ryman-Rasmussen","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ijpharm.2016.01.064","article-title":"Carbon nanotubes from synthesis to in vivo biomedical applications","volume":"501","author":"Sajid","year":"2016","journal-title":"Int. J. Pharm."},{"key":"B83","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2131\/jts.34.65","article-title":"Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats","volume":"34","author":"Sakamoto","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12989-016-0162-4","article-title":"The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases","volume":"13","author":"Sayan","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1743-8977-9-34","article-title":"Use of back-scatter electron signals to visualise cell\/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo","volume":"9","author":"Schinwald","year":"2012","journal-title":"Part. Fibre Toxicol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1021\/nn204229f","article-title":"Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties","volume":"6","author":"Schinwald","year":"","journal-title":"ACS Nano"},{"key":"B87","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/toxsci\/kfs171","article-title":"The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma","volume":"128","author":"Schinwald","year":"","journal-title":"Toxicol. Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1007\/s00204-016-1742-7","article-title":"Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)","volume":"90","author":"Sharma","year":"2016","journal-title":"Arch. Toxicol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.taap.2012.03.023","article-title":"Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress","volume":"261","author":"Shvedova","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1183\/09031936.00178308","article-title":"Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma","volume":"34","author":"Song","year":"2009","journal-title":"Eur. Respir. J."},{"key":"B91","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1177\/0192623311413787","article-title":"Nanomaterials in humans: identification, characteristics, and potential damage","volume":"39","author":"Song","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"B92","first-page":"965","article-title":"Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals","volume":"67","author":"Stanton","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"key":"B93","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/cas.12954","article-title":"Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors","volume":"107","author":"Suzui","year":"2016","journal-title":"Cancer Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/15287390802476991","article-title":"Adverse effects of industrial multiwalled carbon nanotubes on human pulmonary cells","volume":"72","author":"Tabet","year":"2009","journal-title":"J. Toxicol. Environ. Health. A"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1111\/j.1349-7006.2012.02318.x","article-title":"Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice","volume":"103","author":"Takagi","year":"2012","journal-title":"Cancer Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2131\/jts.33.105","article-title":"Induction of mesothelioma in p53+\/- mouse by intraperitoneal application of multi-wall carbon nanotube","volume":"33","author":"Takagi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1179\/1351000213Y.0000000075","article-title":"Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis","volume":"19","author":"Toyokuni","year":"2014","journal-title":"Redox Rep."},{"key":"B98","first-page":"195","article-title":"Minimal inflammogenicity of pristine single-wall carbon nanotubes","volume":"77","author":"Toyokuni","year":"2015","journal-title":"Nagoya J. Med. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3762\/bjnano.6.88","article-title":"Protein corona \u2013 from molecular adsorption to physiological complexity","volume":"6","author":"Treuel","year":"2015","journal-title":"Beilstein J. Nanotechnol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbrc.2013.09.089","article-title":"Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells","volume":"440","author":"Tsukahara","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"w13698","DOI":"10.4414\/smw.2012.13698","article-title":"Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity","volume":"142","author":"van Berlo","year":"2012","journal-title":"Swiss Med. Wkly."},{"key":"B102","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/cas.12865","article-title":"Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis","volume":"107","author":"Wang","year":"2016","journal-title":"Cancer Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.toxlet.2006.08.019","article-title":"The degree and kind of agglomeration affect carbon nanotube cytotoxicity","volume":"168","author":"Wick","year":"2007","journal-title":"Toxicol. Lett."},{"key":"B104","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12951-016-0214-9","article-title":"Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium","volume":"14","author":"Williams","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1021\/nn700256c","article-title":"Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways","volume":"2","author":"Xia","year":"2008","journal-title":"ACS Nano"},{"key":"B106","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/cas.12437","article-title":"Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes","volume":"105","author":"Xu","year":"2014","journal-title":"Cancer Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1111\/cas.12005","article-title":"Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats","volume":"103","author":"Xu","year":"2012","journal-title":"Cancer Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1016\/j.rinp.2017.10.001","article-title":"Carbon nanotube synthesis via the catalytic chemical vapor deposition of methane in the presence of iron, molybdenum, and iron\u2013molybdenum alloy thin layer catalysts","volume":"7","author":"Yahyazadeh","year":"2017","journal-title":"Results Phys."},{"key":"B109","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s41021-015-0003-y","article-title":"Mechanism of induction of binucleated cells by multiwalled carbon nanotubes as revealed by live-cell imaging analysis","volume":"37","author":"Yasui","year":"2015","journal-title":"Genes Environ."},{"key":"B110","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/1091581815591223","article-title":"MWCNTs induce ROS generation, ERK phosphorylation, and SOD-2 expression in human mesothelial cells","volume":"35","author":"Yu","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"075010","DOI":"10.1088\/0960-1317\/25\/7\/075010","article-title":"Microfluidic gradient device for studying mesothelial cell migration and the effect of chronic carbon nanotube exposure","volume":"25","author":"Zhang","year":"2015","journal-title":"J. Micromech. Microeng."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.2147\/IJN.S102020","article-title":"Polyacrylate\/nanosilica causes pleural and pericardial effusion, and pulmonary fibrosis and granuloma in rats similar to those observed in exposed workers","volume":"11","author":"Zhu","year":"2016","journal-title":"Int. J. Nanomed."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00295\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:32:33Z","timestamp":1522283553000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2018.00295\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,29]]},"references-count":112,"alternative-id":["10.3389\/fphys.2018.00295"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00295","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,29]]},"article-number":"295"}}