{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:16:35Z","timestamp":1753892195544,"version":"3.41.2"},"reference-count":144,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00693","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T04:43:51Z","timestamp":1528778631000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS"],"prefix":"10.3389","volume":"9","author":[{"given":"Mar\u00eda E.","family":"Riveros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio A.","family":"Retamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6110100","article-title":"Oxidative stress: mechanistic insights into inherited mitochondrial disorders and Parkinson\u2019s disease.","volume":"6","author":"Al Shahrani","year":"2017","journal-title":"J. Clin. Med."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-014-0034-y","article-title":"Histaminergic system in brain disorders: lessons from the translational approach and future perspectives.","volume":"13","author":"Baronio","year":"2014","journal-title":"Ann. Gen. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease.","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1212\/WNL.0b013e3181f884b1","article-title":"Histamine in the CNS: multiple functions and potential neurologic implications.","volume":"75","author":"Benarroch","year":"2010","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s11064-005-2684-2","article-title":"Modulation of aspartate release by ascorbic acid and endobain E, an endogenous Na+, K+-ATPase inhibitor.","volume":"30","author":"Bersier","year":"2005","journal-title":"Neurochem. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11064-007-9412-z","article-title":"The expression of NMDA receptor subunits in cerebral cortex and hippocampus is differentially increased by administration of endobain E, a Na+, K+-ATPase inhibitor.","volume":"33","author":"Bersier","year":"2008","journal-title":"Neurochem. Res."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2461","article-title":"Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.","volume":"4","author":"Blouin","year":"2013","journal-title":"Nat. Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/nm741","article-title":"Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.","volume":"8","author":"Borowsky","year":"2002","journal-title":"Nat. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","article-title":"The physiology of brain histamine.","volume":"63","author":"Brown","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.pnpbp.2012.03.005","article-title":"Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain.","volume":"38","author":"Br\u00fcning","year":"2012","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1499S","DOI":"10.1093\/ajcn\/83.6.1499S","article-title":"N-3 fatty acids and the metabolic syndrome.","author":"Carpentier","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0361-9230(01)00551-2","article-title":"The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects.","volume":"56","author":"Carver","year":"2001","journal-title":"Brain Res. Bull."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149033","article-title":"Polyunsaturated fatty acids attenuate diet induced obesity and insulin resistance, modulating mitochondrial respiratory uncoupling in rat skeletal muscle.","volume":"11","author":"Cavaliere","year":"2016","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.plefa.2006.07.005","article-title":"Omega-3 fatty acids and monoamine neurotransmission.","volume":"75","author":"Chalon","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14162-w","article-title":"Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.","volume":"7","author":"Chikahisa","year":"2017","journal-title":"Sci. Rep."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078434","article-title":"Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states.","volume":"8","author":"Chikahisa","year":"2013","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0924-977X(02)00130-X","article-title":"Polyunsaturated fatty acid deficit in patients with bipolar mania.","volume":"13","author":"Chiu","year":"2003","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/0306-9877(93)90089-9","article-title":"Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar illness.","volume":"41","author":"Christo","year":"1993","journal-title":"Med. Hypotheses"},{"key":"B19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/J.PSCYCHRESNS.2013.03.004","article-title":"Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder.","volume":"213","author":"Chu","year":"2013","journal-title":"Psychiatry Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"14085","DOI":"10.1073\/pnas.0904817106","article-title":"Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.","volume":"106","author":"Clapcote","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling.","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"8842","DOI":"10.1021\/bi010541g","article-title":"Modulation of Na,K-ATPase and Na-ATPase activity by phospholipids and cholesterol. I. Steady-State Kinetics.","volume":"40","author":"Cornelius","year":"2001","journal-title":"Biochemistry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1021\/BI702128X","article-title":"Cholesterol-dependent interaction of polyunsaturated phospholipids with Na,K-ATPase.","volume":"47","author":"Cornelius","year":"2008","journal-title":"Am. Chem. Soc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1046\/j.1471-4159.1995.64052097.x","article-title":"Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain.","volume":"64","author":"Cousin","year":"1995","journal-title":"J. Neurochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/S0140-6736(13)60855-7","article-title":"Genetics of bipolar disorder.","volume":"381","author":"Craddock","year":"2013","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1111\/j.1471-4159.1991.tb02083.x","article-title":"Characterization of extracellular histamine in the striatum and bed nucleus of the stria terminalis of the rat: an in vivo microdialysis study.","volume":"56","author":"Cumming","year":"1991","journal-title":"J. Neurochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.neuropharm.2015.08.025","article-title":"Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition.","volume":"106","author":"De Luca","year":"2016","journal-title":"Neuropharmacology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.tips.2005.07.002","article-title":"The histamine H receptor as a new therapeutic target for inflammation.","volume":"26","author":"Deesch","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainresbull.2015.09.005","article-title":"Lifelong consumption of trans fatty acids promotes striatal impairments on Na+\/K+ ATPase activity and BDNF mRNA expression in an animal model of mania.","volume":"118","author":"Dias","year":"2015","journal-title":"Brain Res. Bull."},{"key":"B30","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/386824a0","article-title":"Subgenual prefrontal cortex abnormalities in mood disorders.","volume":"386","author":"Drevets","year":"1997","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.mam.2004.03.001","article-title":"Mitochondria in health and disease: perspectives on a new mitochondrial biology.","volume":"25","author":"Duchen","year":"2004","journal-title":"Mol. Aspects Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.plefa.2012.05.006","article-title":"Omega-3 fatty acids in neurodegenerative diseases: focus on mitochondria.","volume":"88","author":"Eckert","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.pnpbp.2006.04.003","article-title":"Efficacy of olanzapine and haloperidol in an animal model of mania.","volume":"30","author":"El-Mallakh","year":"2006","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0278-5846(95)00123-D","article-title":"An animal model for mania: preliminary results.","volume":"19","author":"el-Mallakh","year":"1995","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jpsychires.2014.06.001","article-title":"Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism.","volume":"57","author":"Evans","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv032","article-title":"Hippocampal-dependent antidepressant action of the H3 receptor antagonist clobenpropit in a rat model of depression.","volume":"18","author":"Femen\u00eda","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/ars.2010.3750","article-title":"Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism.","volume":"16","author":"Feng","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1111\/j.1460-9568.2011.07893.x","article-title":"The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study.","volume":"34","author":"Flik","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11010-010-0455-0","article-title":"Evaluation of citrate synthase activity in brain of rats submitted to an animal model of mania induced by ouabain.","volume":"341","author":"Freitas","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1399-5618.2006.00370.x","article-title":"Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations.","volume":"8","author":"Frye","year":"2006","journal-title":"Bipolar Disord."},{"key":"B41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.abb.2015.05.009","article-title":"Knockout of cyclophilin D in Ppif-\/- mice increases stability of brain mitochondria against Ca2+ stress.","volume":"579","author":"Gainutdinov","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"B42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.chemphyslip.2008.02.016","article-title":"Structure and dynamics of polyunsaturated hydrocarbon chains in lipid bilayers\u2014significance for GPCR function.","volume":"153","author":"Gawrisch","year":"2008","journal-title":"Chem. Phys. Lipids"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","article-title":"Treatment of bipolar disorder.","volume":"381","author":"Geddes","year":"2013","journal-title":"Lancet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1046\/j.1471-4159.1998.71020732.x","article-title":"Alterations of Na,K-ATPase isoenzymes in the rat diabetic neuropathy: protective effect of dietary supplementation with N-3 fatty acids.","volume":"71","author":"Gerbi","year":"1998","journal-title":"J. Neurochem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"S93","DOI":"10.1007\/BF02562243","article-title":"Neuroprotective effect of fish oil in diabetic neuropathy.","author":"Gerbi","year":"1999","journal-title":"Lipids"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1176\/appi.ajp.161.9.1537","article-title":"Antidepressants for bipolar depression: a systematic review of randomized, controlled trials.","volume":"161","author":"Gijsman","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.biopsych.2008.10.033","article-title":"Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.","volume":"65","author":"Goldstein","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"18802","DOI":"10.1074\/jbc.M512524200","article-title":"Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons.","volume":"281","author":"Gong","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/srep19839","article-title":"Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors.","volume":"6","author":"Guix\u00e0-Gonz\u00e1lez","year":"2016","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system.","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"key":"B51","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0006-3223(89)90274-6","article-title":"Are disturbances in lipid-protein interactions by phospholipase-A2 a predisposing factor in affective illness?","volume":"25","author":"Hibbeln","year":"1989","journal-title":"Biol. Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1476-5381.1980.tb10861.x","article-title":"Histamine H1-receptors in the brain of the guinea-pig and the rat: differences in ligand binding properties and regional distribution.","volume":"68","author":"Hill","year":"1980","journal-title":"Br. J. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0304-3940(99)00052-X","article-title":"Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of fischer rat.","volume":"262","author":"Ito","year":"1999","journal-title":"Neurosci. Lett."},{"key":"B54","first-page":"1765","article-title":"Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice.","volume":"16","author":"Jiang","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1476-5381.2009.00149.x","article-title":"Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases.","volume":"157","author":"Jin","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jpsychires.2009.11.002","article-title":"Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain.","volume":"44","author":"Jornada","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1001\/archpsyc.59.6.530","article-title":"The long-term natural history of the weekly symptomatic status of bipolar I disorder.","volume":"59","author":"Judd","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/sj.mp.4001824","article-title":"Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.","volume":"11","author":"Kasahara","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s004060050054","article-title":"Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity.","volume":"248","author":"Kato","year":"1998","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0165-0327(92)90099-R","article-title":"Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy.","volume":"26","author":"Kato","year":"1992","journal-title":"J. Affect. Disord."},{"key":"B61","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0165-0327(94)90116-3","article-title":"Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy.","volume":"31","author":"Kato","year":"1994","journal-title":"J. Affect. Disord."},{"key":"B62","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0304-3940(90)90213-S","article-title":"Histamine excites pedunculopontine neurones in guinea pig brainstem slices.","volume":"112","author":"Khateb","year":"1990","journal-title":"Neurosci. Lett."},{"key":"B63","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/mp.2009.137","article-title":"Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients.","volume":"16","author":"Kim","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","first-page":"18144","DOI":"10.1073\/pnas.1108416108","article-title":"Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase \u03b13 sodium pump.","volume":"108","author":"Kirshenbaum","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B65","doi-asserted-by":"publisher","first-page":"12314","DOI":"10.1523\/JNEUROSCI.3933-06.2006","article-title":"Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.","volume":"26","author":"Kubota","year":"2006","journal-title":"J. Neurosci."},{"key":"B66","doi-asserted-by":"crossref","first-page":"40","DOI":"10.55782\/ane-2012-1879","article-title":"Long-lasting stress, quantitative changes in nitric oxide concentration and functional state of brain mitochondria.","volume":"72","author":"Kuchukashvili","year":"2012","journal-title":"Acta Neurobiol. Exp."},{"key":"B67","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bbr.2010.10.035","article-title":"Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test.","volume":"218","author":"Lagos","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/285135","article-title":"Omega-3 PUFAs lower the propensity for arachidonic acid cascade overreactions.","volume":"2015","author":"Lands","year":"2015","journal-title":"BioMed Res. Int."},{"key":"B69","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/mp.2008.117","article-title":"Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to \u2018switching\u2019 in bipolar disorder?","volume":"15","author":"Lee","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00300","article-title":"Histamine increases neuronal excitability and sensitivity of the lateral vestibular nucleus and promotes motor behaviors via HCN channel coupled to H2 receptor.","volume":"10","author":"Li","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1096\/fj.00-0545fje","article-title":"Increased brain histamine in an alcohol-preferring rat line and modulation of ethanol consumption by H(3) receptor mechanisms.","volume":"15","author":"Lintunen","year":"2001","journal-title":"FASEB J."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/all.13110","article-title":"Vitamin D contributes to mast cell stabilization.","volume":"72","author":"Liu","year":"2017","journal-title":"Allergy"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13204","article-title":"The histaminergic system is involved in psychological stress-induced hyperthermia in rats.","volume":"5","author":"Lkhagvasuren","year":"2017","journal-title":"Physiol. Rep."},{"key":"B74","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6","article-title":"Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness.","volume":"5","author":"Looney","year":"1997","journal-title":"Depress. Anxiety"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0342-4","article-title":"Histamine H2 receptor activation exacerbates myocardial ischemia\/reperfusion injury by disturbing mitochondrial and endothelial function.","volume":"108","author":"Luo","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"B76","first-page":"564","article-title":"Histamine H3 receptors and its antagonism as a novel mechanism for antipsychotic effect: a current preclinical & clinical perspective.","volume":"10","author":"Mahmood","year":"2016","journal-title":"Int. J. Health Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"H1479","DOI":"10.1152\/ajpheart.1992.263.5.H1479","article-title":"Influence of dietary fish oil on mitochondrial function and response to ischemia.","author":"McMillin","year":"1992","journal-title":"Am. J. Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.jad.2010.03.015","article-title":"Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder.","volume":"126","author":"McNamara","year":"2010","journal-title":"J. Affect. Disord."},{"key":"B79","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/syn.20542","article-title":"Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA\/2J mice: relationship with ventral striatum dopamine concentrations.","volume":"62","author":"McNamara","year":"2008","journal-title":"Synapse"},{"key":"B80","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/bdi.12386","article-title":"Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder.","volume":"18","author":"McNamara","year":"2016","journal-title":"Bipolar Disord."},{"key":"B81","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.jacc.2003.07.050","article-title":"Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.","volume":"43","author":"Meier-Ewert","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plipres.2017.01.001","article-title":"Polyunsaturated fatty acids and recurrent mood disorders: phenomenology, mechanisms, and clinical application.","volume":"66","author":"Messamore","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005169.pub2","article-title":"Omega-3 fatty acids for bipolar disorder.","volume":"2","author":"Montgomery","year":"2008","journal-title":"Cochrane Database Syst. Rev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.pnpbp.2014.09.003","article-title":"Increased REM sleep after intra-locus coeruleus nucleus microinjection of melanin-concentrating hormone (MCH) in the rat.","volume":"56","author":"Monti","year":"2015","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2017.01.014","article-title":"A model of the mitochondrial basis of bipolar disorder.","author":"Morris","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1399-5618.2004.00160.x","article-title":"GAMIAN-Europe\/BEAM survey II: cross-national analysis of unemployment, family history, treatment satisfaction and impact of the bipolar disorder on life style.","volume":"6","author":"Morselli","year":"2004","journal-title":"Bipolar Disord."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.lfs.2007.03.013","article-title":"The digitalis-like steroid hormones: new mechanisms of action and biological significance.","volume":"80","author":"Nesher","year":"2007","journal-title":"Life Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1007\/s11064-010-0274-4","article-title":"Cardiac glycosides ouabain and digoxin interfere with the regulation of glutamate transporter GLAST in astrocytes cultured from neonatal rat brain.","volume":"35","author":"Nguyen","year":"2010","journal-title":"Neurochem. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3177\/jnsv.59.115","article-title":"Relationship between dietary patterns and depressive symptoms: difference by gender, and unipolar and bipolar depression.","volume":"59","author":"Noguchi","year":"2013","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"B90","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)39620-6","article-title":"Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin.","volume":"6","author":"O\u2019Brien","year":"","journal-title":"J. Lipid Res."},{"key":"B91","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-2275(20)39619-X","article-title":"Lipid composition of the normal human brain: gray matter, white matter, and myelin.","volume":"6","author":"O\u2019Brien","year":"","journal-title":"J. Lipid Res."},{"key":"B92","first-page":"5","article-title":"Vitamin C prevents sleep deprivation-induced elevation in cortisol and lipid peroxidation in the rat plasma.","volume":"30","author":"Olayaki","year":"2015","journal-title":"Niger. J. Physiol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.smrv.2012.11.001","article-title":"REM sleep dysregulation in depression: state of the art.","volume":"17","author":"Palagini","year":"2013","journal-title":"Sleep Med. Rev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrn3526","article-title":"The histaminergic network in the brain: basic organization and role in disease.","volume":"14","author":"Panula","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1113\/jphysiol.2013.268771","article-title":"Histamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal.","volume":"592","author":"Parks","year":"2014","journal-title":"J. Physiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.neuropharm.2015.04.026","article-title":"Amphetamine sensitization in mice is sufficient to produce both manic- and depressive-related behaviors as well as changes in the functional connectivity of corticolimbic structures.","volume":"95","author":"Pathak","year":"2015","journal-title":"Neuropharmacology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.5665\/sleep.3196","article-title":"MCH neurons are the primary sleep-promoting group.","volume":"36","author":"Pelluru","year":"2013","journal-title":"Sleep"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s00894-009-0624-9","article-title":"Histamine (Re)uptake by astrocytes: an experimental and computational study.","volume":"16","author":"Perdan-Pirkmajer","year":"2010","journal-title":"J. Mol. Model."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/S0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions.","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"B100","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/sj.mp.4001887","article-title":"Dietary N-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex.","volume":"12","author":"Rao","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"B101","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/sj.tpj.6500391","article-title":"Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.","volume":"6","author":"Rao","year":"2006","journal-title":"Pharmacogenomics J."},{"key":"B102","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.plefa.2008.09.010","article-title":"Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease.","volume":"79","author":"Rapoport","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B103","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.biopsych.2008.11.010","article-title":"Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis.","volume":"65","author":"Regenold","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1001\/jama.1990.03450190043026","article-title":"Comorbidity of mental disorders with alcohol and other drug abuse. Results from the epidemiologic catchment area (ECA) study.","volume":"264","author":"Regier","year":"1990","journal-title":"JAMA"},{"key":"B105","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ijdevneu.2010.02.002","article-title":"Intracerebroventricular ouabain administration induces oxidative stress in the rat brain.","volume":"28","author":"Riegel","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1097\/FBP.0000000000000129","article-title":"Infralimbic cortex activation and motivated arousal induce histamine release.","volume":"26","author":"Riveros","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/S0006-3223(97)00440-X","article-title":"Alpha 2 isoform of the Na,K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals.","volume":"44","author":"Rose","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"B108","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.1523\/JNEUROSCI.1081-09.2009","article-title":"Glutamate transporter coupling to Na,K-ATPase.","volume":"29","author":"Rose","year":"2009","journal-title":"J. Neurosci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000119128","article-title":"Decreased activity of erythrocyte membrane ATPases in depression and schizophrenia.","volume":"30","author":"Rybakowski","year":"1994","journal-title":"Neuropsychobiology"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016268","article-title":"Dietary fat intake and the risk of depression: the SUN project.","volume":"6","author":"S\u00e1nchez-Villegas","year":"2011","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1248\/bpb.31.2163","article-title":"Histamine H3 receptor antagonists go to clinics.","volume":"31","author":"Sander","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"B112","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4088\/JCP.10r06710","article-title":"Omega-3 for bipolar disorder.","volume":"73","author":"Sarris","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"B113","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuropharm.2015.05.004","article-title":"The histamine H4-receptor and the central and peripheral nervous system: a critical analysis of the literature.","volume":"106","author":"Schneider","year":"2016","journal-title":"Neuropharmacology"},{"key":"B114","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/cap.2014.0110","article-title":"Vitamin D 3 supplemental treatment for mania in youth with bipolar spectrum disorders.","volume":"25","author":"Sikoglu","year":"2015","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/15622975.2016.1149218","article-title":"Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: pros and cons of fluoxetine.","volume":"18","author":"Sonei","year":"2017","journal-title":"World J. Biol. Psychiatry"},{"key":"B116","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0197-0186(97)00037-5","article-title":"Influence of dietary fat on the activities of subcellular membrane-bound enzymes from different regions of rat brain.","volume":"31","author":"Srinivasarao","year":"1997","journal-title":"Neurochem. Int."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0009-3084(03)00101-4","article-title":"Docosahexaenoic acid: membrane properties of a unique fatty acid.","volume":"126","author":"Stillwell","year":"2003","journal-title":"Chem. Phys. Lipids"},{"key":"B118","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.plefa.2010.02.020","article-title":"N-3 vs. saturated fatty acids: effects on the arterial wall.","volume":"82","author":"Sudheendran","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B119","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1179\/1476830514Y.0000000111","article-title":"Rats given linseed oil in microemulsion forms enriches the brain synaptic membrane with docosahexaenoic acid and enhances the neurotransmitter levels in the brain.","volume":"18","author":"Sugasini","year":"2015","journal-title":"Nutr. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1172\/JCI115856","article-title":"Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia.","volume":"90","author":"Suomalainen","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1046\/j.1471-4159.2002.01031.x","article-title":"Activity-dependent NMDA receptor-mediated activation of protein kinase B\/Akt in cortical neuronal cultures.","volume":"82","author":"Sutton","year":"2002","journal-title":"J. Neurochem."},{"key":"B122","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuropharm.2015.04.011","article-title":"Histamine receptor signaling in energy homeostasis.","volume":"106","author":"Tabarean","year":"2016","journal-title":"Neuropharmacology"},{"key":"B123","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neuropharm.2012.02.006","article-title":"Mechanism of H2 histamine receptor dependent modulation of body temperature and neuronal activity in the medial preoptic nucleus.","volume":"63","author":"Tabarean","year":"2012","journal-title":"Neuropharmacology"},{"key":"B124","doi-asserted-by":"publisher","first-page":"10292","DOI":"10.1523\/JNEUROSCI.2341-06.2006","article-title":"Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse.","volume":"26","author":"Takahashi","year":"2006","journal-title":"J. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00051","article-title":"Histamine and motivation.","volume":"6","author":"Torrealba","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.brainres.2009.02.055","article-title":"MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep.","volume":"1268","author":"Torterolo","year":"2009","journal-title":"Brain Res."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00475","article-title":"Melanin-concentrating hormone (MCH): role in REM sleep and depression.","volume":"9","author":"Torterolo","year":"2015","journal-title":"Front. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1515\/JBCPP.2000.11.4.375","article-title":"The mood cycle hypothesis: possible involvement of steroid hormones in mood regulation by means of Na+, K+-ATPase inhibition.","volume":"11","author":"Traub","year":"2000","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neuroscience.2014.11.059","article-title":"Cross-generational trans fat intake facilitates mania-like behavior: oxidative and molecular markers in brain cortex.","volume":"286","author":"Trevizol","year":"2015","journal-title":"Neuroscience"},{"key":"B130","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1248\/bpb.18.664","article-title":"Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain\u2013modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP.","volume":"18","author":"Tsutsumi","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cpr.2008.04.004","article-title":"Dysregulation of the behavioral approach system (BAS) in bipolar spectrum disorders: review of theory and evidence.","volume":"28","author":"Uro\u0161evi\u0107","year":"2008","journal-title":"Clin. Psychol. Rev."},{"key":"B132","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.neuroscience.2005.03.013","article-title":"Somatic Ca2+ dynamics in response to choline-mediated excitation in histaminergic tuberomammillary neurons.","volume":"134","author":"Uteshev","year":"2005","journal-title":"Neuroscience"},{"key":"B133","doi-asserted-by":"publisher","first-page":"320","DOI":"10.4103\/0019-5545.104807","article-title":"A bibliometric analysis of bipolar affective disorders using density-equalizing mapping and output benchmarking.","volume":"54","author":"Vogelzang","year":"2012","journal-title":"Indian J. Psychiatry"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.jnutbio.2015.07.027","article-title":"N-3 polyunsaturated fatty acids inhibit Fc \u03b5 receptor I-mediated mast cell activation.","volume":"26","author":"Wang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejphar.2016.03.062","article-title":"Dietary N-3 long chain polyunsaturated fatty acids in allergy prevention and asthma treatment.","volume":"785","author":"Willemsen","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s12263-009-0141-6","article-title":"Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain.","volume":"4","author":"Willis","year":"2009","journal-title":"Genes Nutr."},{"key":"B137","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.brainresbull.2013.06.003","article-title":"Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats.","volume":"97","author":"Wu","year":"2013","journal-title":"Brain Res. Bull."},{"key":"B138","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0022-2275(20)38713-7","article-title":"Effect of dietary alpha-linolenate\/linoleate balance on brain lipid compositions and learning ability of rats.","volume":"28","author":"Yamamoto","year":"1987","journal-title":"J. Lipid Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/glia.22484","article-title":"Molecular mechanism of histamine clearance by primary human astrocytes.","volume":"61","author":"Yoshikawa","year":"2013","journal-title":"Glia"},{"key":"B140","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.peptides.2005.02.028","article-title":"The neuronal histamine H1 and pro-opiomelanocortin\u2013melanocortin 4 receptors: independent regulation of food intake and energy expenditure.","volume":"27","author":"Yoshimatsu","year":"2006","journal-title":"Peptides"},{"key":"B141","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.neuint.2011.08.011","article-title":"Intracerebroventricular administration of ouabain, a Na\/K-ATPase inhibitor, activates tyrosine hydroxylase through extracellular signal-regulated kinase in rat striatum.","volume":"59","author":"Yu","year":"2011","journal-title":"Neurochem. Int."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1007\/s12035-015-9096-3","article-title":"Selective modulation of histaminergic inputs on projection neurons of cerebellum rapidly promotes motor coordination via HCN channels.","volume":"53","author":"Zhang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1472-8206.2011.00947.x","article-title":"Na+\/K+-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons.","volume":"26","author":"Zhang","year":"2012","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1097\/WNR.0000000000000631","article-title":"Frontal cortical mitochondrial dysfunction and mitochondria-related \u03b2-amyloid accumulation by chronic sleep restriction in mice.","volume":"27","author":"Zhao","year":"2016","journal-title":"Neuroreport"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00693\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:39:48Z","timestamp":1751683188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00693\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":144,"alternative-id":["10.3389\/fphys.2018.00693"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00693","relation":{},"ISSN":["1664-042X"],"issn-type":[{"type":"electronic","value":"1664-042X"}],"subject":[],"published":{"date-parts":[[2018,6,12]]},"article-number":"693"}}