{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:38:17Z","timestamp":1768315097885,"version":"3.49.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5 101 BX001000-06"],"award-info":[{"award-number":["5 101 BX001000-06"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"DOI":"10.3389\/fphys.2018.00849","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T04:37:11Z","timestamp":1531283831000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Probenecid Pre-treatment Downregulates the Kidney Cl-\/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis"],"prefix":"10.3389","volume":"9","author":[{"given":"Sharon","family":"Barone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamyar","family":"Zahedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marybeth","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoocher","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181376","article-title":"The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.","volume":"12","author":"Alshahrani","year":"2017","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1159\/000479296","article-title":"Ablation of the Cl-\/HCO3- exchanger pendrin enhances hydrochlorothiazide-induced diuresis.","volume":"42","author":"Alshahrani","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"C33","DOI":"10.1152\/ajpcell.00033.2010","article-title":"Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl-\/HCO3- exchanger activity and impairs bicarbonate secretion in kidney collecting duct.","volume":"299","author":"Amlal","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/BOR.0000000000000035","article-title":"Uricosuric drugs: the once and future therapy for hyperuricemia?","volume":"26","author":"Bach","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"F1028","DOI":"10.1152\/ajprenal.0148.2001","article-title":"Localization of thiazide sensitive Na+-Cl- cotransport and associated gene products in mouse DCT.","volume":"281","author":"C\u00e2mpean","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"E9989","DOI":"10.1073\/pnas.1710964114","article-title":"of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1023\/A:1015820316660","article-title":"Evaluation of \u201ctrue\u201d creatinine clearance in rats reveals extensive renal secretion.","volume":"8","author":"Darling","year":"1991","journal-title":"Pharm. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1093\/oxfordjournals.ndt.a027081","article-title":"The Na-(K)-Cl cotransporter family in the mammalian kidney: molecular identification and function(s).","volume":"11","author":"Delpire","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"B9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1681\/ASN.V142538","article-title":"The thiazide-sensitive na-cl cotransporter and human disease: reemergence of an old player.","volume":"14","author":"Ellison","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/bod.2510090107","article-title":"Dose-dependent pharmacokinetics of probenecid in the rat.","volume":"9","author":"Emanuelsson","year":"1988","journal-title":"Biopharm. Drug Dispos."},{"key":"B11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1152\/physrev.00011.2004","article-title":"Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.","volume":"85","author":"Gamba","year":"2005","journal-title":"Physiol. Rev."},{"key":"B12","first-page":"473","article-title":"The effects of probenecid and thiazides and their combination on the urinary excretion of electrolytes and on acid-base equilibrium.","volume":"103","author":"Garcia","year":"1970","journal-title":"Can. Med. Assoc. J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"F89","DOI":"10.1152\/ajprenal.1995.268.1.F89","article-title":"Sodium entry mechanisms in distal convoluted tubule cells.","author":"Gesek","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"R1372","DOI":"10.1152\/ajpregu.1996.271.5.R1372","article-title":"Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation.","author":"Halpin","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-3565(24)34933-X","article-title":"The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies.","volume":"290","author":"Hesselink","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"F744","DOI":"10.1152\/ajprenal.00037.2002","article-title":"Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney.","volume":"283","author":"Kim","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"9425","DOI":"10.1073\/pnas.141241098","article-title":"Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells.","volume":"98","author":"Knauf","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.yjmcc.2012.04.011","article-title":"Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.","volume":"53","author":"Koch","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1172\/JCI40145","article-title":"The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.","volume":"120","author":"Leviel","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1097\/01.ASN.0000138234.18569.63","article-title":"Altered renal distal tubule structure and renal Na+ and Ca2+ handling in a mouse model for Gitelman\u2019s syndrome.","volume":"15","author":"Loffing","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150918","article-title":"The role of epithelial sodium channel ENaC and the Apical Cl-\/HCO3- exchanger pendrin in compensatory salt reabsorption in the setting of Na-Cl cotransporter (NCC) inactivation.","volume":"11","author":"Patel-Chamberlin","year":"2016","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"F103","DOI":"10.1152\/ajprenal.00205.2002","article-title":"Regulation of the apical Cl-\/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis.","volume":"284","author":"Petrovic","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.2215\/CJN.04670510","article-title":"The evidence-based use of thiazide diuretics in hypertension and nephrolithiasis.","volume":"5","author":"Reilly","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrrheum.2014.124","article-title":"Improving cardiovascular and renal outcomes in gout: what should we target?","volume":"10","author":"Richette","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"E25","DOI":"10.1152\/ajpendo.00383.2002","article-title":"Prolactin regulation of the pendrin-iodide transporter in the mammary gland.","volume":"284","author":"Rillema","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1073\/pnas.071516798","article-title":"Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion.","volume":"98","author":"Royaux","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"H574","DOI":"10.1152\/ajpheart.00854.2013","article-title":"Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance.","volume":"306","author":"Rubinstein","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"29150","DOI":"10.1074\/jbc.273.44.29150","article-title":"Phenotype resembling Gitelman\u2019s syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule.","volume":"273","author":"Schultheis","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/j.1751-7176.2011.00512.x","article-title":"Thiazide and loop diuretics.","volume":"13","author":"Sica","year":"2011","journal-title":"J. Clin. Hypertens."},{"key":"B30","doi-asserted-by":"publisher","first-page":"C761","DOI":"10.1152\/ajpcell.00227.2008","article-title":"Probenecid, a gout remedy, inhibits pannexin 1 channels.","volume":"295","author":"Silverman","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1093\/ndt\/gfu307","article-title":"The multiple roles of pendrin in the kidney.","author":"Soleimani","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159804","article-title":"Prostaglandin-E2 mediated increase in calcium and phosphate excretion in a mouse model of distal nephron salt wasting.","volume":"11","author":"Soleimani","year":"2011","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"13368","DOI":"10.1073\/pnas.1202671109","article-title":"Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure.","volume":"109","author":"Soleimani","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"F356","DOI":"10.1152\/ajprenal.2001.280.2.F356","article-title":"Pendrin: an apical Cl-\/OH-\/HCO3- exchanger in the kidney cortex.","volume":"280","author":"Soleimani","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"30363","DOI":"10.1074\/jbc.R110.155341","article-title":"Role of epithelial sodium channels and their regulators in hypertension.","volume":"285","author":"Soundararajan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00424-014-1661-5","article-title":"Urinary serine proteases and activation of ENaC in kidney\u2013implications for physiological renal salt handling and hypertensive disorders with albuminuria.","volume":"467","author":"Svenningsen","year":"2015","journal-title":"Pflugers Arch."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1681\/ASN.2005101054","article-title":"Pendrin regulation in mouse kidney primarily is chloride-dependent.","volume":"17","author":"Vallet","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"F1293","DOI":"10.1152\/ajprenal.00013.2012","article-title":"A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.","volume":"302","author":"Vallon","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1161\/01.HYP.0000088321.67254.B7","article-title":"Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension.","volume":"179","author":"Verlander","year":"2003","journal-title":"Hypertension"},{"key":"B40","doi-asserted-by":"publisher","first-page":"F229","DOI":"10.1152\/ajprenal.00147.2002","article-title":"Localization of pendrin in mouse kidney.","volume":"284","author":"Wall","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1161\/01.HYP.0000145863.96091.89","article-title":"NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation.","volume":"44","author":"Wall","year":"2004","journal-title":"Hypertension"},{"key":"B42","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1172\/JCI10366","article-title":"The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon.","volume":"108","author":"Wang","year":"2001","journal-title":"J. Clin. Invest."},{"key":"B43","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/ki.2011.196","article-title":"Slc26a11, a chloride transporter, localizes with the vacuolar H+-ATPase of A-intercalated cells of the kidney.","volume":"80","author":"Xu","year":"2011","journal-title":"Kidney Int."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079327","article-title":"Potentiation of the effect of thiazide derivatives by carbonic anhydrase inhibitors: molecular mechanisms and potential clinical implications.","volume":"8","author":"Zahedi","year":"2013","journal-title":"PLoS One"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00849\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T17:58:52Z","timestamp":1751738332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fphys.2018.00849\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":44,"alternative-id":["10.3389\/fphys.2018.00849"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2018.00849","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"article-number":"849"}}